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The map label for this gene is rpfC [H]

Identifier: 39996367

GI number: 39996367

Start: 1375825

End: 1377162

Strand: Reverse

Name: rpfC [H]

Synonym: GSU1265

Alternate gene names: 39996367

Gene position: 1377162-1375825 (Counterclockwise)

Preceding gene: 39996370

Following gene: 39996366

Centisome position: 36.11

GC content: 61.73

Gene sequence:

>1338_bases
ATGATGCTTCAACGCTCTTCCGGCCAGCACCAGACCAACGACAACGGCTCCGACAGTCGACACGGCTTCGTATCGTCAAC
GGACCTGAACCGGATCAGAGATCTCGAATGCCGGCTGGCAGACCTTCTGGGCGAGAATGAACGGCTCCGGGCCGTGGAGC
AGGAACTCCGTACCGCAGCAACAGCGGCTGAGGCGGCCACCACAGCGAAGAGCGAACTTCTGGCCCACGTCAGCCACGAG
ATCCGATCGCAGCTCCAATTGATTTCCGGAGCCGTCGATCTCTTCCGCCAGACCCGCCTCGATGAAATCCAGCGCCACTA
CCTGGAGGGATTCCAGCACGCCAATGAGCTCCTTCTCTGTCTCGTGAACGACATTCTGGACACGTCACGCCTGGAAGCCG
GCCATTTGCGCCTGGAAAGCCTTCCCTTCGACCTGGCCGGCCTTGTTGCAGCCACGGGAACCCAGCTTCTCTGGCAGGCA
CAGCGCAAGGGACTGGAGCTCTCGTGGCAGGTGTCGCCGGATGTCCCATCGCGCCTTTTGGGCGATCAGGCGCGGGTCCA
GCAGGTGATCGTCAATCTTGCCGGGAATGCAATAAAATTCACCCGGGAGGGGGCGGTAACGATCCGCGTCGAGAGGGTCC
CCGACCCGCTGACGGCTTCATCGCTGGCAATGATACGCTTCGTCATTGAAGACACGGGTATCGGTATCCCGGTCGACAGA
CTGGGCGGAATATTCGAACGCTATGACCGGGGATCGCCCGAAACTTCCAAGCTCTTCGGCGGAACCGGCCTCGGGCTTGC
CATCGCCAAAGGGCTTATCGAAGCCATGGACGGCGACATCACCGTGGAGAGTTACGAAGGCAGGGGAAGCCGCTTCATTG
TGACGATCCCGTTCTGTCTCACCATTACCGGCGACCGGCAGGCACCCGCCGACGGCCAGGAGAAGGAATCGGAATCCGTC
GCTCCGCTACGGGTGCTGGTGGCCGAGGATGCGGAGGACATCCGGCTGCTGATCGCCGCCTTCCTTCGCGGCGCATCCCA
CCAAGTATGCAGTGCCGGCAACGGCCAAGAGGCGCTGGACATGTTCATGGCCGAAGACTTCGACCTGGTGCTGATGGATA
TCCAGATGCCGGTGATGGACGGCTACACCGCTACCCGGGCTCTGCGAGAGTGGGAACGGCAACGGGGGCGCACGCCGGTG
CCGGTGGTGGCACTCACCGCATGCGCTGAAAAGAGCGATTCCCTGAAAACCATTGAAGCGGGATGCACGAGCCATCTCTC
GAAACCGATCAGAAAGGACACCCTGCTGCGCACGGTGGCAGAACTGGCGCGGCAGTAA

Upstream 100 bases:

>100_bases
ATATCGAACTTTTCCATTTACCGCACCCCGAAAATTTTGATATAAATTTAATGTAATTTTATCAAAGTAACGTCTGTTAA
CGGAACCAGATACAATCCCC

Downstream 100 bases:

>100_bases
CAGGGAGACCGCATGGCAGGACGACCCCCCAGGACATACCGGGTCAAGGTTGACCCCGAACTCATCGACATCGTGCCGGT
GTTCATTGAGCGACGCCGGC

Product: sensor histidine kinase/response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MMLQRSSGQHQTNDNGSDSRHGFVSSTDLNRIRDLECRLADLLGENERLRAVEQELRTAATAAEAATTAKSELLAHVSHE
IRSQLQLISGAVDLFRQTRLDEIQRHYLEGFQHANELLLCLVNDILDTSRLEAGHLRLESLPFDLAGLVAATGTQLLWQA
QRKGLELSWQVSPDVPSRLLGDQARVQQVIVNLAGNAIKFTREGAVTIRVERVPDPLTASSLAMIRFVIEDTGIGIPVDR
LGGIFERYDRGSPETSKLFGGTGLGLAIAKGLIEAMDGDITVESYEGRGSRFIVTIPFCLTITGDRQAPADGQEKESESV
APLRVLVAEDAEDIRLLIAAFLRGASHQVCSAGNGQEALDMFMAEDFDLVLMDIQMPVMDGYTATRALREWERQRGRTPV
PVVALTACAEKSDSLKTIEAGCTSHLSKPIRKDTLLRTVAELARQ

Sequences:

>Translated_445_residues
MMLQRSSGQHQTNDNGSDSRHGFVSSTDLNRIRDLECRLADLLGENERLRAVEQELRTAATAAEAATTAKSELLAHVSHE
IRSQLQLISGAVDLFRQTRLDEIQRHYLEGFQHANELLLCLVNDILDTSRLEAGHLRLESLPFDLAGLVAATGTQLLWQA
QRKGLELSWQVSPDVPSRLLGDQARVQQVIVNLAGNAIKFTREGAVTIRVERVPDPLTASSLAMIRFVIEDTGIGIPVDR
LGGIFERYDRGSPETSKLFGGTGLGLAIAKGLIEAMDGDITVESYEGRGSRFIVTIPFCLTITGDRQAPADGQEKESESV
APLRVLVAEDAEDIRLLIAAFLRGASHQVCSAGNGQEALDMFMAEDFDLVLMDIQMPVMDGYTATRALREWERQRGRTPV
PVVALTACAEKSDSLKTIEAGCTSHLSKPIRKDTLLRTVAELARQ
>Mature_445_residues
MMLQRSSGQHQTNDNGSDSRHGFVSSTDLNRIRDLECRLADLLGENERLRAVEQELRTAATAAEAATTAKSELLAHVSHE
IRSQLQLISGAVDLFRQTRLDEIQRHYLEGFQHANELLLCLVNDILDTSRLEAGHLRLESLPFDLAGLVAATGTQLLWQA
QRKGLELSWQVSPDVPSRLLGDQARVQQVIVNLAGNAIKFTREGAVTIRVERVPDPLTASSLAMIRFVIEDTGIGIPVDR
LGGIFERYDRGSPETSKLFGGTGLGLAIAKGLIEAMDGDITVESYEGRGSRFIVTIPFCLTITGDRQAPADGQEKESESV
APLRVLVAEDAEDIRLLIAAFLRGASHQVCSAGNGQEALDMFMAEDFDLVLMDIQMPVMDGYTATRALREWERQRGRTPV
PVVALTACAEKSDSLKTIEAGCTSHLSKPIRKDTLLRTVAELARQ

Specific function: Involved in the positive regulation of synthesis of extracellular enzymes and polysaccharide, and hence in pathogenicity. Can restore function to the non-pathogenic mutant 8237 [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=381, Percent_Identity=34.1207349081365, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1789149, Length=253, Percent_Identity=39.9209486166008, Blast_Score=171, Evalue=8e-44,
Organism=Escherichia coli, GI1788713, Length=430, Percent_Identity=32.093023255814, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI145693157, Length=284, Percent_Identity=36.9718309859155, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI87081816, Length=337, Percent_Identity=32.0474777448071, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1786600, Length=233, Percent_Identity=28.3261802575107, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788393, Length=252, Percent_Identity=25, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788549, Length=255, Percent_Identity=29.8039215686275, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790436, Length=238, Percent_Identity=30.672268907563, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1786783, Length=247, Percent_Identity=26.7206477732794, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1786912, Length=234, Percent_Identity=26.9230769230769, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1788550, Length=112, Percent_Identity=32.1428571428571, Blast_Score=65, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323034, Length=149, Percent_Identity=30.2013422818792, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322044, Length=148, Percent_Identity=31.7567567567568, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48778; Mature: 48778

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLQRSSGQHQTNDNGSDSRHGFVSSTDLNRIRDLECRLADLLGENERLRAVEQELRTAA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TAAEAATTAKSELLAHVSHEIRSQLQLISGAVDLFRQTRLDEIQRHYLEGFQHANELLLC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVNDILDTSRLEAGHLRLESLPFDLAGLVAATGTQLLWQAQRKGLELSWQVSPDVPSRLL
HHHHHHHHHCCCCCCEEHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHH
GDQARVQQVIVNLAGNAIKFTREGAVTIRVERVPDPLTASSLAMIRFVIEDTGIGIPVDR
CCHHHHHHHHHHHCCCEEEEEECCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHH
LGGIFERYDRGSPETSKLFGGTGLGLAIAKGLIEAMDGDITVESYEGRGSRFIVTIPFCL
HHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEEEEE
TITGDRQAPADGQEKESESVAPLRVLVAEDAEDIRLLIAAFLRGASHQVCSAGNGQEALD
EEECCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCHHHCCCCCHHHHH
MFMAEDFDLVLMDIQMPVMDGYTATRALREWERQRGRTPVPVVALTACAEKSDSLKTIEA
HHHHCCCCEEEEEEECHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHH
GCTSHLSKPIRKDTLLRTVAELARQ
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMLQRSSGQHQTNDNGSDSRHGFVSSTDLNRIRDLECRLADLLGENERLRAVEQELRTAA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TAAEAATTAKSELLAHVSHEIRSQLQLISGAVDLFRQTRLDEIQRHYLEGFQHANELLLC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVNDILDTSRLEAGHLRLESLPFDLAGLVAATGTQLLWQAQRKGLELSWQVSPDVPSRLL
HHHHHHHHHCCCCCCEEHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHH
GDQARVQQVIVNLAGNAIKFTREGAVTIRVERVPDPLTASSLAMIRFVIEDTGIGIPVDR
CCHHHHHHHHHHHCCCEEEEEECCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHH
LGGIFERYDRGSPETSKLFGGTGLGLAIAKGLIEAMDGDITVESYEGRGSRFIVTIPFCL
HHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEEEEE
TITGDRQAPADGQEKESESVAPLRVLVAEDAEDIRLLIAAFLRGASHQVCSAGNGQEALD
EEECCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCHHHCCCCCHHHHH
MFMAEDFDLVLMDIQMPVMDGYTATRALREWERQRGRTPVPVVALTACAEKSDSLKTIEA
HHHHCCCCEEEEEEECHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHH
GCTSHLSKPIRKDTLLRTVAELARQ
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1645442 [H]