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The map label for this gene is atoC [H]

Identifier: 39996352

GI number: 39996352

Start: 1352057

End: 1353466

Strand: Direct

Name: atoC [H]

Synonym: GSU1250

Alternate gene names: 39996352

Gene position: 1352057-1353466 (Clockwise)

Preceding gene: 39996351

Following gene: 39996353

Centisome position: 35.45

GC content: 61.35

Gene sequence:

>1410_bases
ATGACAACTGAGACGGCGCAGACCATCGTGCTGGTGGATGACGAGGAAAACATACTCAAGGCATCGCGTCTGATTCTGCT
CGGCAACGGCTTCGGCAACGTGGTGACGCTGCAGGACAGCAGGCAGCTGATGCCCCTGCTGGAGCAGGGAGGCGTGGCGG
CAGTGGTACTCGACCTGTTTATGCCCCACCTGTCGGGGACCGAGCTTCTCCCCCTGATAGTGGAGCGTTTTCCCCACATT
CCGGCCATCGTCATGACCGCCGTCGATGAAACCGAGACCGCCGTCACCTGCATGAAGTCAGGGGCCTTTGACTACCTGGT
GAAGCCGGTGGAATCGGGGCGCCTGATCGCCAGCGTGACCAAGGCGCTGGAGATGGGAGCCATGAGTCGCGAGCTGAATT
CCCTGAAAGAATGCCTTCTGGACGACCGGCTCGACCATCCCGAGGCCTTCGCGTCCATCGTCACCGACAGCAAGAAGATG
CGTGCGGTGTTCCAGTACCTGGAGGTGGTCTCCCGTTCCCGCCAGCCGATTCTGGTTACGGGCGAAACCGGAGTGGGCAA
GGAGCTGTTTGCCCGGGCGGTGCACGAACTGAGCGGCGTCAGGGGTGAGTTCGTGGCAGTGAATGTGGCCGGGCTCGACG
ATGTCATGTTCTCGGACACCCTGTTCGGGCACAAGAAGGGGGCGTTCACCGGTGCCGACCAGGCCCGTGACGGCCTCATC
GCGAGGGCGGCCGGCGGCACGCTCTTCCTCGACGAGATCGGAGACCTGAACGAGGCTTCCCAGATCAAGCTGTTGCGGCT
GTTGCAGGAAAAGGAATACTATCCGGTGGGGTCCGACATGGCGCGCAAGAGCGAAGCACGGATAGTCTGCGCCACCAACC
GGGATCTCAAGAAGCAGATCGAGAAAGAGGCGTTCCGCAACGACCTCTATTACCGGCTCTGCGCCCACCAGGTCCAGATT
CCGCCCCTGCGGGAGCGTCTGGAGGACCTGCCGCTGCTGATCGATTATTTTCTGGGAGAGGCAGCCGCCTCTCTGGGCCG
GAAAAAGCCGACACCTCCTCCCGAACTCCTGACGCTGCTCTCGGTCTATTCCTTCCCGGGAAACGTCAGGGAGCTGCAGG
CACTTATCCATGACGCCGTGGCCAGGCACGGTTCTGGGGTCCTTTCCCTCGACAGTTTCAGGAACATCATCGGCGGCGAT
GCCGTCCAGCTCATCCCACAGACCGCCGTCACATCTTCCGATGATCCCCTGTCCGCCATTTTCGGCCGTTTCCCCACGGT
GAGAGAGGTGGAAGATTACCTGATGGCTGAGGCCATGAAGCGGGCCAGAGGAAATCAGGGAATCGCCGCAACCATGCTCG
GCATCACCCGCCAGACGCTTAACAAGCGCCTTCAGGCGAAAAAAGGGTAA

Upstream 100 bases:

>100_bases
CACGTCAGTGCCGGGCGAAGGAACTATCTTTACCGTACACCTGCCTGCCGCGAGCAATCAGGGGGTGGCATGATATCGTA
CACGTCGGGGGAGGTGTTAC

Downstream 100 bases:

>100_bases
CCCGCCGCCGTCCCCTATCCCATCAACCGCCCTGCATGACCGTCGTGCTTGCGGGGCTGGGCCGCAATGGCCTGCCACCT
CGATTCACCGTGTAACGAAT

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MTTETAQTIVLVDDEENILKASRLILLGNGFGNVVTLQDSRQLMPLLEQGGVAAVVLDLFMPHLSGTELLPLIVERFPHI
PAIVMTAVDETETAVTCMKSGAFDYLVKPVESGRLIASVTKALEMGAMSRELNSLKECLLDDRLDHPEAFASIVTDSKKM
RAVFQYLEVVSRSRQPILVTGETGVGKELFARAVHELSGVRGEFVAVNVAGLDDVMFSDTLFGHKKGAFTGADQARDGLI
ARAAGGTLFLDEIGDLNEASQIKLLRLLQEKEYYPVGSDMARKSEARIVCATNRDLKKQIEKEAFRNDLYYRLCAHQVQI
PPLRERLEDLPLLIDYFLGEAAASLGRKKPTPPPELLTLLSVYSFPGNVRELQALIHDAVARHGSGVLSLDSFRNIIGGD
AVQLIPQTAVTSSDDPLSAIFGRFPTVREVEDYLMAEAMKRARGNQGIAATMLGITRQTLNKRLQAKKG

Sequences:

>Translated_469_residues
MTTETAQTIVLVDDEENILKASRLILLGNGFGNVVTLQDSRQLMPLLEQGGVAAVVLDLFMPHLSGTELLPLIVERFPHI
PAIVMTAVDETETAVTCMKSGAFDYLVKPVESGRLIASVTKALEMGAMSRELNSLKECLLDDRLDHPEAFASIVTDSKKM
RAVFQYLEVVSRSRQPILVTGETGVGKELFARAVHELSGVRGEFVAVNVAGLDDVMFSDTLFGHKKGAFTGADQARDGLI
ARAAGGTLFLDEIGDLNEASQIKLLRLLQEKEYYPVGSDMARKSEARIVCATNRDLKKQIEKEAFRNDLYYRLCAHQVQI
PPLRERLEDLPLLIDYFLGEAAASLGRKKPTPPPELLTLLSVYSFPGNVRELQALIHDAVARHGSGVLSLDSFRNIIGGD
AVQLIPQTAVTSSDDPLSAIFGRFPTVREVEDYLMAEAMKRARGNQGIAATMLGITRQTLNKRLQAKKG
>Mature_468_residues
TTETAQTIVLVDDEENILKASRLILLGNGFGNVVTLQDSRQLMPLLEQGGVAAVVLDLFMPHLSGTELLPLIVERFPHIP
AIVMTAVDETETAVTCMKSGAFDYLVKPVESGRLIASVTKALEMGAMSRELNSLKECLLDDRLDHPEAFASIVTDSKKMR
AVFQYLEVVSRSRQPILVTGETGVGKELFARAVHELSGVRGEFVAVNVAGLDDVMFSDTLFGHKKGAFTGADQARDGLIA
RAAGGTLFLDEIGDLNEASQIKLLRLLQEKEYYPVGSDMARKSEARIVCATNRDLKKQIEKEAFRNDLYYRLCAHQVQIP
PLRERLEDLPLLIDYFLGEAAASLGRKKPTPPPELLTLLSVYSFPGNVRELQALIHDAVARHGSGVLSLDSFRNIIGGDA
VQLIPQTAVTSSDDPLSAIFGRFPTVREVEDYLMAEAMKRARGNQGIAATMLGITRQTLNKRLQAKKG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=460, Percent_Identity=34.5652173913044, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1790437, Length=463, Percent_Identity=35.6371490280778, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1790299, Length=469, Percent_Identity=33.2622601279318, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1788905, Length=385, Percent_Identity=37.6623376623377, Blast_Score=221, Evalue=9e-59,
Organism=Escherichia coli, GI1789087, Length=280, Percent_Identity=42.5, Blast_Score=205, Evalue=6e-54,
Organism=Escherichia coli, GI87082117, Length=348, Percent_Identity=36.7816091954023, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1789233, Length=326, Percent_Identity=35.8895705521472, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI87082152, Length=225, Percent_Identity=44, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI87081872, Length=291, Percent_Identity=37.8006872852234, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1786524, Length=390, Percent_Identity=31.025641025641, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1787583, Length=235, Percent_Identity=36.1702127659575, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1789828, Length=240, Percent_Identity=39.1666666666667, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI87081858, Length=317, Percent_Identity=27.1293375394322, Blast_Score=96, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51376; Mature: 51245

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTETAQTIVLVDDEENILKASRLILLGNGFGNVVTLQDSRQLMPLLEQGGVAAVVLDLF
CCCCCCCEEEEECCCHHHHHHCEEEEEECCCCCEEEECCCHHHHHHHHCCCHHHHHHHHH
MPHLSGTELLPLIVERFPHIPAIVMTAVDETETAVTCMKSGAFDYLVKPVESGRLIASVT
HHCCCCCHHHHHHHHHCCCCCEEEHHHCCCHHHHHHHHHCCCHHHHHCCCCCCHHHHHHH
KALEMGAMSRELNSLKECLLDDRLDHPEAFASIVTDSKKMRAVFQYLEVVSRSRQPILVT
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEE
GETGVGKELFARAVHELSGVRGEFVAVNVAGLDDVMFSDTLFGHKKGAFTGADQARDGLI
CCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCHHHCCEE
ARAAGGTLFLDEIGDLNEASQIKLLRLLQEKEYYPVGSDMARKSEARIVCATNRDLKKQI
EEECCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEECCHHHHHHH
EKEAFRNDLYYRLCAHQVQIPPLRERLEDLPLLIDYFLGEAAASLGRKKPTPPPELLTLL
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
SVYSFPGNVRELQALIHDAVARHGSGVLSLDSFRNIIGGDAVQLIPQTAVTSSDDPLSAI
HHHCCCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHCCCHHHHCCHHHCCCCCCHHHHH
FGRFPTVREVEDYLMAEAMKRARGNQGIAATMLGITRQTLNKRLQAKKG
HCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTETAQTIVLVDDEENILKASRLILLGNGFGNVVTLQDSRQLMPLLEQGGVAAVVLDLF
CCCCCCEEEEECCCHHHHHHCEEEEEECCCCCEEEECCCHHHHHHHHCCCHHHHHHHHH
MPHLSGTELLPLIVERFPHIPAIVMTAVDETETAVTCMKSGAFDYLVKPVESGRLIASVT
HHCCCCCHHHHHHHHHCCCCCEEEHHHCCCHHHHHHHHHCCCHHHHHCCCCCCHHHHHHH
KALEMGAMSRELNSLKECLLDDRLDHPEAFASIVTDSKKMRAVFQYLEVVSRSRQPILVT
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEE
GETGVGKELFARAVHELSGVRGEFVAVNVAGLDDVMFSDTLFGHKKGAFTGADQARDGLI
CCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCHHHCCEE
ARAAGGTLFLDEIGDLNEASQIKLLRLLQEKEYYPVGSDMARKSEARIVCATNRDLKKQI
EEECCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEECCHHHHHHH
EKEAFRNDLYYRLCAHQVQIPPLRERLEDLPLLIDYFLGEAAASLGRKKPTPPPELLTLL
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
SVYSFPGNVRELQALIHDAVARHGSGVLSLDSFRNIIGGDAVQLIPQTAVTSSDDPLSAI
HHHCCCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHCCCHHHHCCHHHCCCCCCHHHHH
FGRFPTVREVEDYLMAEAMKRARGNQGIAATMLGITRQTLNKRLQAKKG
HCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]