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The map label for this gene is zraS [C]

Identifier: 39996351

GI number: 39996351

Start: 1350455

End: 1352029

Strand: Direct

Name: zraS [C]

Synonym: GSU1249

Alternate gene names: 39996351

Gene position: 1350455-1352029 (Clockwise)

Preceding gene: 39996349

Following gene: 39996352

Centisome position: 35.41

GC content: 59.37

Gene sequence:

>1575_bases
ATGACCAATCCCGAGCGGGCCGCACGGCGCGCGGCGCGAAAAATACGTTTCTACGAGTCACCGGTCAGGATCACCATCGC
CCTGGGCGGCATTATCTTCGTGGCCGAAGCCGTTGTTATGGTCGTGATGGTGCATGTCCTGCGTTTCCCGGGCAGGGCAC
CCGTTGTCGACCTGTTTACCGATTCGCTGATGCTGCTTCTGCTCATCGCCCCGTTTCTCCACCGATTCATCTTCAAACCG
ATGGCCGCCCAGATCGCCCAGCGAGAAGAGGCCGAGACCCGCCTAAGGAGGTATCAGTCCAACCTGGAATCGCTGGTGGA
GGACCGGACTGCCCGACTGACCGAGGCAATCGAGGAGCTGGAGCGTGAAATCGTCGAGCGGAAACGGACCGAAGAGGCGC
TTCTCAGGAGCGAGGAGCGTTTCCGTCAACTGTTCGAACAGACCGAGGATGCCATTATCCTCTTTCGCCCCGGCGGGTGT
CGCATCATCGACGTGAATCCGGTTGCGGAGAGACTCTACGGCTTTTCCAAAAAGGAGTTCTTCGAGCTTGGGCTCGAGTC
GTTGATGGGCCCCAGTGATCTCGATACGTTCTGCCGGGCCATCGGCCAGGTCAGGATGGGAGACTCGATCCGGATCGACA
CCATGACCCACACCCGCAAGGACGGCTCGGAAGTCATCGTTTCGGTGCGGGGCAAAATGGTTACGATCCAGCAGGTTGAC
ATGGTTTACTGCACTATCCGCGACATTTCGAAGCGGATTCGCCTCGAGAAGGAAAGCCGGCTGATCCAGGCAAGGCTCAT
TCATACCAACAAGATGACCTCCCTGGGGGTGCTCGTGGCCAGCATCGCCCACGAGATCAACAACCCGAACAACTACATCA
TGGTCAACTCGGAGATACTGCGCCGTTCCTGGAACGACATCTATCCGATCCTGCGCGACTATTACGACGAACATGGTGAC
TTTACCATTGGCGGCATCCCTTTTTCGGAGATGCGGGAGGCCTTCCCCGAACTGATTGCAGGGGTCCACGACGGTGCGCG
CAGGATTCGCGATATCGTCAACAATCTCAAGGATTTTGCGCGCAACGAGGCTTGCTCAATCGCGGGAAACGTGGACGTGA
ACCGGGCCATAACCATGGCGGCGACCATGCTGAACCACCAGATCCGCAAGCATACGCGGCATTTCCGGCTGGAACTCGCC
GAAGATCTCCCGCTTGTCCGGGGGAGCCTCCAGCAGCTCGAACAGGTCATCATCAACCTGATCATGAATGCAATCCAGGC
GTTGCCCACCGAGGAGCGGGGCGTAACGGTTTCGACCACCCGCGACGGGAACGACGGGGGGGTAGTGATCAGGGTTGCGG
ACCAGGGCAGCGGCATTCCGATCGAGATCTCCGACAGCATTCTGGAGCCGTTTTTTACGACGCGCCTCGACAGCGGCGGC
ACGGGGCTGGGGCTCGCCATCTGCCATTCGATCGTCCGGGATCATGGGGGGGACCTGGAGTTCACGTCAGTGCCGGGCGA
AGGAACTATCTTTACCGTACACCTGCCTGCCGCGAGCAATCAGGGGGTGGCATGA

Upstream 100 bases:

>100_bases
TTCCTGATGGCATGTTTTCTGCTGGATTCGCAGGTTAGGGCAGGCCGGCTGCAGGATGGGAGTCCCTGAGCCCTGTCAAA
TATCGGAGCAGTGAGTTGTC

Downstream 100 bases:

>100_bases
TATCGTACACGTCGGGGGAGGTGTTACATGACAACTGAGACGGCGCAGACCATCGTGCTGGTGGATGACGAGGAAAACAT
ACTCAAGGCATCGCGTCTGA

Product: sensory box histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:

>524_residues
MTNPERAARRAARKIRFYESPVRITIALGGIIFVAEAVVMVVMVHVLRFPGRAPVVDLFTDSLMLLLLIAPFLHRFIFKP
MAAQIAQREEAETRLRRYQSNLESLVEDRTARLTEAIEELEREIVERKRTEEALLRSEERFRQLFEQTEDAIILFRPGGC
RIIDVNPVAERLYGFSKKEFFELGLESLMGPSDLDTFCRAIGQVRMGDSIRIDTMTHTRKDGSEVIVSVRGKMVTIQQVD
MVYCTIRDISKRIRLEKESRLIQARLIHTNKMTSLGVLVASIAHEINNPNNYIMVNSEILRRSWNDIYPILRDYYDEHGD
FTIGGIPFSEMREAFPELIAGVHDGARRIRDIVNNLKDFARNEACSIAGNVDVNRAITMAATMLNHQIRKHTRHFRLELA
EDLPLVRGSLQQLEQVIINLIMNAIQALPTEERGVTVSTTRDGNDGGVVIRVADQGSGIPIEISDSILEPFFTTRLDSGG
TGLGLAICHSIVRDHGGDLEFTSVPGEGTIFTVHLPAASNQGVA

Sequences:

>Translated_524_residues
MTNPERAARRAARKIRFYESPVRITIALGGIIFVAEAVVMVVMVHVLRFPGRAPVVDLFTDSLMLLLLIAPFLHRFIFKP
MAAQIAQREEAETRLRRYQSNLESLVEDRTARLTEAIEELEREIVERKRTEEALLRSEERFRQLFEQTEDAIILFRPGGC
RIIDVNPVAERLYGFSKKEFFELGLESLMGPSDLDTFCRAIGQVRMGDSIRIDTMTHTRKDGSEVIVSVRGKMVTIQQVD
MVYCTIRDISKRIRLEKESRLIQARLIHTNKMTSLGVLVASIAHEINNPNNYIMVNSEILRRSWNDIYPILRDYYDEHGD
FTIGGIPFSEMREAFPELIAGVHDGARRIRDIVNNLKDFARNEACSIAGNVDVNRAITMAATMLNHQIRKHTRHFRLELA
EDLPLVRGSLQQLEQVIINLIMNAIQALPTEERGVTVSTTRDGNDGGVVIRVADQGSGIPIEISDSILEPFFTTRLDSGG
TGLGLAICHSIVRDHGGDLEFTSVPGEGTIFTVHLPAASNQGVA
>Mature_523_residues
TNPERAARRAARKIRFYESPVRITIALGGIIFVAEAVVMVVMVHVLRFPGRAPVVDLFTDSLMLLLLIAPFLHRFIFKPM
AAQIAQREEAETRLRRYQSNLESLVEDRTARLTEAIEELEREIVERKRTEEALLRSEERFRQLFEQTEDAIILFRPGGCR
IIDVNPVAERLYGFSKKEFFELGLESLMGPSDLDTFCRAIGQVRMGDSIRIDTMTHTRKDGSEVIVSVRGKMVTIQQVDM
VYCTIRDISKRIRLEKESRLIQARLIHTNKMTSLGVLVASIAHEINNPNNYIMVNSEILRRSWNDIYPILRDYYDEHGDF
TIGGIPFSEMREAFPELIAGVHDGARRIRDIVNNLKDFARNEACSIAGNVDVNRAITMAATMLNHQIRKHTRHFRLELAE
DLPLVRGSLQQLEQVIINLIMNAIQALPTEERGVTVSTTRDGNDGGVVIRVADQGSGIPIEISDSILEPFFTTRLDSGGT
GLGLAICHSIVRDHGGDLEFTSVPGEGTIFTVHLPAASNQGVA

Specific function: Member Of The Two-Component Regulatory System Zras/Zrar. May Function As A Membrane-Associated Protein Kinase That Phosphorylates Zrar In Response To High Concentrations Of Zinc Or Lead In The Medium. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=263, Percent_Identity=30.0380228136882, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788549, Length=254, Percent_Identity=28.3464566929134, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1790300, Length=370, Percent_Identity=24.5945945945946, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI145693157, Length=291, Percent_Identity=25.085910652921, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI48994928, Length=508, Percent_Identity=23.2283464566929, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1788713, Length=125, Percent_Identity=33.6, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI87081816, Length=264, Percent_Identity=26.5151515151515, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789149, Length=182, Percent_Identity=27.4725274725275, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001638
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00497 SBP_bac_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 58988; Mature: 58857

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPERAARRAARKIRFYESPVRITIALGGIIFVAEAVVMVVMVHVLRFPGRAPVVDLFT
CCCHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
DSLMLLLLIAPFLHRFIFKPMAAQIAQREEAETRLRRYQSNLESLVEDRTARLTEAIEEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EREIVERKRTEEALLRSEERFRQLFEQTEDAIILFRPGGCRIIDVNPVAERLYGFSKKEF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCHHHHHHHCCCHHHH
FELGLESLMGPSDLDTFCRAIGQVRMGDSIRIDTMTHTRKDGSEVIVSVRGKMVTIQQVD
HHHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCEEEEECCCEEEEEEHH
MVYCTIRDISKRIRLEKESRLIQARLIHTNKMTSLGVLVASIAHEINNPNNYIMVNSEIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEECHHHH
RRSWNDIYPILRDYYDEHGDFTIGGIPFSEMREAFPELIAGVHDGARRIRDIVNNLKDFA
HCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNEACSIAGNVDVNRAITMAATMLNHQIRKHTRHFRLELAEDLPLVRGSLQQLEQVIINL
CCCHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
IMNAIQALPTEERGVTVSTTRDGNDGGVVIRVADQGSGIPIEISDSILEPFFTTRLDSGG
HHHHHHHCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCEEECHHHHHHHHHHCCCCCC
TGLGLAICHSIVRDHGGDLEFTSVPGEGTIFTVHLPAASNQGVA
CCHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEECCCCCCCCC
>Mature Secondary Structure 
TNPERAARRAARKIRFYESPVRITIALGGIIFVAEAVVMVVMVHVLRFPGRAPVVDLFT
CCHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
DSLMLLLLIAPFLHRFIFKPMAAQIAQREEAETRLRRYQSNLESLVEDRTARLTEAIEEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EREIVERKRTEEALLRSEERFRQLFEQTEDAIILFRPGGCRIIDVNPVAERLYGFSKKEF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCHHHHHHHCCCHHHH
FELGLESLMGPSDLDTFCRAIGQVRMGDSIRIDTMTHTRKDGSEVIVSVRGKMVTIQQVD
HHHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCEEEEECCCEEEEEEHH
MVYCTIRDISKRIRLEKESRLIQARLIHTNKMTSLGVLVASIAHEINNPNNYIMVNSEIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEECHHHH
RRSWNDIYPILRDYYDEHGDFTIGGIPFSEMREAFPELIAGVHDGARRIRDIVNNLKDFA
HCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNEACSIAGNVDVNRAITMAATMLNHQIRKHTRHFRLELAEDLPLVRGSLQQLEQVIINL
CCCHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
IMNAIQALPTEERGVTVSTTRDGNDGGVVIRVADQGSGIPIEISDSILEPFFTTRLDSGG
HHHHHHHCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCEEECHHHHHHHHHHCCCCCC
TGLGLAICHSIVRDHGGDLEFTSVPGEGTIFTVHLPAASNQGVA
CCHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1333793 [H]