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The map label for this gene is serA [H]

Identifier: 39996300

GI number: 39996300

Start: 1301218

End: 1302846

Strand: Direct

Name: serA [H]

Synonym: GSU1198

Alternate gene names: 39996300

Gene position: 1301218-1302846 (Clockwise)

Preceding gene: 39996297

Following gene: 39996301

Centisome position: 34.12

GC content: 61.33

Gene sequence:

>1629_bases
ATGAAAATCATCGTTACTGACGAGGTGGCTCAAGAAGGATTGGCACTTCTTGCCCAGGATCCGCGTGTTGAGCTCGATGT
GAAGCTCGGCCTCAAGAAGGAGGAACTCCTCGCAATAATCGGCGATTACGACGTCATCATCACCCGCAGCGGCACCACCG
TGAATCGGGAGCTTCTGGACGCGGGGAAAAAGCTGAGGCTCGTGGCCCGGGCGGGCGTGGGCATCGACAACGTTGACGTT
GACTACGCAAGTTCCCGCGGCGTCATCGTGGTGAACGCTCCTTTCGGCAATACCAACAGCGCGGCCGAGCATGCCATGGC
GCTGCTGCTCTCCTTCTGCCGCAACGTGACCCGCGCCAACGGCAGCCTGAAGAGCGGCGAGTGGAAGCGGGCTCCGTTCA
CCGGCTACGAGCTCAAGGGTAAGACGGCCGGCGTCATCGGCCTCGGCAAGGTCGGCGGCCGGGTAGCCACGCGGCTCAAG
GCCTTCGAGTGCGACGTGCTCGCCTGCGATCCCTACATCGCCGTGAAGCGGGCCCATGACCTGGGGGTCAAGCTGGTCTC
CCACGACGAGATTTACAAGAACTGCGACATCATCACCGTCCACACCCCTCTCACCGACGAGACTCGCAACATGATCGGCG
AGCGTGAGCTGGCTATGATGAAGGACGGCGTCATCATCGTGAACGCCGCCCGGGGCGGCATCATCGAAGAGGCGGCCCTG
CTGAAGTATCTGGAGTCGGGCAAGGTGGCCGGAGCCGCTGTGGACGTGTTCAGCGAGGAGCCCCCCAAGAGCGAGTATCT
GAAGAAGCTCATCGGCCACGAGAGGGTCGTGGTGACGCCGCATCTGGGGGCAAATACCTTTGAGGCCCAGGTGAACGTGG
CTGTGGACGTATCCCGCGAGATTCTCAACTACCTGGACGACCAGCCCCTGGAGAACGCCGTGAACATTCCGCGCTTCGAC
TTGGCACTCATGGACCAGATGCGGCCGTTCCTCAACCTCATGAACACCCTGTGCGAATTCGGCATTCAGTTGCTGGACGC
CAATATCTCGAAGATCGTCTTCGGCTTCTCGGGCTCCATCGCCCACTACGACTGCACCCCGCTTACCGTCTGCGGCCTGG
CGTCGATCCTTAACCGGATGGTCGACCAGGACGTGAACATGGTGAACGCTTCTCTCATCGCCGAAGGGATGGGCATTGTG
GTGGAGGAGTCCAAGACGACTCATGCCGACGCCTTCTCCAACCTCATCACGATCGTGGTGGAAGGAGAGGGGGGCAAGCG
CCGCACCATCTCGGGCACCCTTTTCGAGGGGCTGCCCCGCATCGTACGGCTGCGCGACTACTCCATGGACTTTGCGCCCG
AGGAGCACATGCTGCTGCTCCACTACGCCGACCGGCCGGGTATGATCGGCAAGATCGGCACAATCATGGGACAACATGAG
ATCAATATTGCCTCCATGAACCTGGGACGCAGCGAAAAGAAAGGGGAAGCCATGGTCATCCTTTCCCTTGATTCGGCTGT
ACCTCCCCAAGTGCTTGAGGAGGTGCGCGCCGCAACCGACGCCACCTTCATCAAGGCCATTCACATGCCGGGTGCCCGGT
GCAGCCGGAGCTGCGGCTGCACCGCCTGA

Upstream 100 bases:

>100_bases
GGGTCTATTATTAGCGCTTCTCCGCAGCCTCGCAAAGCACTTTCTTGCCATCGGGTTATACCGGCTACTCATTACCATTC
CACACCACAGGGGATCATCA

Downstream 100 bases:

>100_bases
TCCGCGGACATTCCCTTGTTTGATGTGCGGGGGCCGGTCTTCCTTTGGGGGGCCGGCCCCTTTGCGCAGGAGGCTGACGA
ATGAAGAACACGCTCTGGCT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 542; Mature: 542

Protein sequence:

>542_residues
MKIIVTDEVAQEGLALLAQDPRVELDVKLGLKKEELLAIIGDYDVIITRSGTTVNRELLDAGKKLRLVARAGVGIDNVDV
DYASSRGVIVVNAPFGNTNSAAEHAMALLLSFCRNVTRANGSLKSGEWKRAPFTGYELKGKTAGVIGLGKVGGRVATRLK
AFECDVLACDPYIAVKRAHDLGVKLVSHDEIYKNCDIITVHTPLTDETRNMIGERELAMMKDGVIIVNAARGGIIEEAAL
LKYLESGKVAGAAVDVFSEEPPKSEYLKKLIGHERVVVTPHLGANTFEAQVNVAVDVSREILNYLDDQPLENAVNIPRFD
LALMDQMRPFLNLMNTLCEFGIQLLDANISKIVFGFSGSIAHYDCTPLTVCGLASILNRMVDQDVNMVNASLIAEGMGIV
VEESKTTHADAFSNLITIVVEGEGGKRRTISGTLFEGLPRIVRLRDYSMDFAPEEHMLLLHYADRPGMIGKIGTIMGQHE
INIASMNLGRSEKKGEAMVILSLDSAVPPQVLEEVRAATDATFIKAIHMPGARCSRSCGCTA

Sequences:

>Translated_542_residues
MKIIVTDEVAQEGLALLAQDPRVELDVKLGLKKEELLAIIGDYDVIITRSGTTVNRELLDAGKKLRLVARAGVGIDNVDV
DYASSRGVIVVNAPFGNTNSAAEHAMALLLSFCRNVTRANGSLKSGEWKRAPFTGYELKGKTAGVIGLGKVGGRVATRLK
AFECDVLACDPYIAVKRAHDLGVKLVSHDEIYKNCDIITVHTPLTDETRNMIGERELAMMKDGVIIVNAARGGIIEEAAL
LKYLESGKVAGAAVDVFSEEPPKSEYLKKLIGHERVVVTPHLGANTFEAQVNVAVDVSREILNYLDDQPLENAVNIPRFD
LALMDQMRPFLNLMNTLCEFGIQLLDANISKIVFGFSGSIAHYDCTPLTVCGLASILNRMVDQDVNMVNASLIAEGMGIV
VEESKTTHADAFSNLITIVVEGEGGKRRTISGTLFEGLPRIVRLRDYSMDFAPEEHMLLLHYADRPGMIGKIGTIMGQHE
INIASMNLGRSEKKGEAMVILSLDSAVPPQVLEEVRAATDATFIKAIHMPGARCSRSCGCTA
>Mature_542_residues
MKIIVTDEVAQEGLALLAQDPRVELDVKLGLKKEELLAIIGDYDVIITRSGTTVNRELLDAGKKLRLVARAGVGIDNVDV
DYASSRGVIVVNAPFGNTNSAAEHAMALLLSFCRNVTRANGSLKSGEWKRAPFTGYELKGKTAGVIGLGKVGGRVATRLK
AFECDVLACDPYIAVKRAHDLGVKLVSHDEIYKNCDIITVHTPLTDETRNMIGERELAMMKDGVIIVNAARGGIIEEAAL
LKYLESGKVAGAAVDVFSEEPPKSEYLKKLIGHERVVVTPHLGANTFEAQVNVAVDVSREILNYLDDQPLENAVNIPRFD
LALMDQMRPFLNLMNTLCEFGIQLLDANISKIVFGFSGSIAHYDCTPLTVCGLASILNRMVDQDVNMVNASLIAEGMGIV
VEESKTTHADAFSNLITIVVEGEGGKRRTISGTLFEGLPRIVRLRDYSMDFAPEEHMLLLHYADRPGMIGKIGTIMGQHE
INIASMNLGRSEKKGEAMVILSLDSAVPPQVLEEVRAATDATFIKAIHMPGARCSRSCGCTA

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=411, Percent_Identity=36.7396593673966, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI4557497, Length=276, Percent_Identity=33.3333333333333, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI61743967, Length=276, Percent_Identity=33.3333333333333, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI6912396, Length=324, Percent_Identity=29.320987654321, Blast_Score=129, Evalue=9e-30,
Organism=Homo sapiens, GI145580578, Length=299, Percent_Identity=31.7725752508361, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI4557499, Length=299, Percent_Identity=31.7725752508361, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI145580575, Length=299, Percent_Identity=31.7725752508361, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1789279, Length=326, Percent_Identity=31.5950920245399, Blast_Score=165, Evalue=7e-42,
Organism=Escherichia coli, GI87082289, Length=275, Percent_Identity=31.2727272727273, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI1787645, Length=262, Percent_Identity=30.5343511450382, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1788660, Length=260, Percent_Identity=31.9230769230769, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87081824, Length=240, Percent_Identity=29.1666666666667, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17532191, Length=304, Percent_Identity=42.7631578947368, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI25147481, Length=258, Percent_Identity=30.6201550387597, Blast_Score=116, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320925, Length=332, Percent_Identity=31.6265060240964, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6322116, Length=336, Percent_Identity=29.4642857142857, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324055, Length=258, Percent_Identity=34.4961240310078, Blast_Score=136, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6324964, Length=317, Percent_Identity=28.7066246056782, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6325144, Length=150, Percent_Identity=34, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=186, Percent_Identity=28.494623655914, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921140, Length=302, Percent_Identity=46.3576158940397, Blast_Score=253, Evalue=3e-67,
Organism=Drosophila melanogaster, GI28571528, Length=312, Percent_Identity=31.4102564102564, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24646446, Length=282, Percent_Identity=29.4326241134752, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646448, Length=282, Percent_Identity=29.4326241134752, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646452, Length=282, Percent_Identity=29.4326241134752, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646450, Length=282, Percent_Identity=29.4326241134752, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI62472511, Length=282, Percent_Identity=29.4326241134752, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI28574284, Length=322, Percent_Identity=27.0186335403727, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45551003, Length=322, Percent_Identity=27.0186335403727, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45552429, Length=322, Percent_Identity=27.0186335403727, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24585514, Length=322, Percent_Identity=27.0186335403727, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI28574282, Length=322, Percent_Identity=27.0186335403727, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24585516, Length=282, Percent_Identity=25.531914893617, Blast_Score=116, Evalue=5e-26,
Organism=Drosophila melanogaster, GI28574286, Length=318, Percent_Identity=27.6729559748428, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 58759; Mature: 58759

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIVTDEVAQEGLALLAQDPRVELDVKLGLKKEELLAIIGDYDVIITRSGTTVNRELLD
CEEEEEHHHHHCCHHEEECCCCEEEEEEECCCHHHHEEEECCCEEEEECCCCCCCHHHHH
AGKKLRLVARAGVGIDNVDVDYASSRGVIVVNAPFGNTNSAAEHAMALLLSFCRNVTRAN
CCCEEEEEEECCCCCCCCCCEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
GSLKSGEWKRAPFTGYELKGKTAGVIGLGKVGGRVATRLKAFECDVLACDPYIAVKRAHD
CCCCCCCCCCCCCCCEEECCCCCCEEEECCCCHHHHHHHHHEECCEEECCCHHEEEEHHC
LGVKLVSHDEIYKNCDIITVHTPLTDETRNMIGERELAMMKDGVIIVNAARGGIIEEAAL
CCEEEEECHHHHHCCCEEEEECCCCHHHHHHHCCHHHHHHCCCEEEEEECCCCCHHHHHH
LKYLESGKVAGAAVDVFSEEPPKSEYLKKLIGHERVVVTPHLGANTFEAQVNVAVDVSRE
HHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCEEEEEEEEEEEHHHH
ILNYLDDQPLENAVNIPRFDLALMDQMRPFLNLMNTLCEFGIQLLDANISKIVFGFSGSI
HHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCE
AHYDCTPLTVCGLASILNRMVDQDVNMVNASLIAEGMGIVVEESKTTHADAFSNLITIVV
EEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCHHHHHCCEEEEEE
EGEGGKRRTISGTLFEGLPRIVRLRDYSMDFAPEEHMLLLHYADRPGMIGKIGTIMGQHE
ECCCCCEEEECCHHHHCCHHHEEHCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHCCCE
INIASMNLGRSEKKGEAMVILSLDSAVPPQVLEEVRAATDATFIKAIHMPGARCSRSCGC
EEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCHHEEHEECCCCHHHCCCCCC
TA
CC
>Mature Secondary Structure
MKIIVTDEVAQEGLALLAQDPRVELDVKLGLKKEELLAIIGDYDVIITRSGTTVNRELLD
CEEEEEHHHHHCCHHEEECCCCEEEEEEECCCHHHHEEEECCCEEEEECCCCCCCHHHHH
AGKKLRLVARAGVGIDNVDVDYASSRGVIVVNAPFGNTNSAAEHAMALLLSFCRNVTRAN
CCCEEEEEEECCCCCCCCCCEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
GSLKSGEWKRAPFTGYELKGKTAGVIGLGKVGGRVATRLKAFECDVLACDPYIAVKRAHD
CCCCCCCCCCCCCCCEEECCCCCCEEEECCCCHHHHHHHHHEECCEEECCCHHEEEEHHC
LGVKLVSHDEIYKNCDIITVHTPLTDETRNMIGERELAMMKDGVIIVNAARGGIIEEAAL
CCEEEEECHHHHHCCCEEEEECCCCHHHHHHHCCHHHHHHCCCEEEEEECCCCCHHHHHH
LKYLESGKVAGAAVDVFSEEPPKSEYLKKLIGHERVVVTPHLGANTFEAQVNVAVDVSRE
HHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCEEEEEEEEEEEHHHH
ILNYLDDQPLENAVNIPRFDLALMDQMRPFLNLMNTLCEFGIQLLDANISKIVFGFSGSI
HHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCE
AHYDCTPLTVCGLASILNRMVDQDVNMVNASLIAEGMGIVVEESKTTHADAFSNLITIVV
EEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCHHHHHCCEEEEEE
EGEGGKRRTISGTLFEGLPRIVRLRDYSMDFAPEEHMLLLHYADRPGMIGKIGTIMGQHE
ECCCCCEEEECCHHHHCCHHHEEHCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHCCCE
INIASMNLGRSEKKGEAMVILSLDSAVPPQVLEEVRAATDATFIKAIHMPGARCSRSCGC
EEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCHHEEHEECCCCHHHCCCCCC
TA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]