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The map label for this gene is atoC [H]

Identifier: 39996231

GI number: 39996231

Start: 1212287

End: 1213648

Strand: Reverse

Name: atoC [H]

Synonym: GSU1129

Alternate gene names: 39996231

Gene position: 1213648-1212287 (Counterclockwise)

Preceding gene: 39996255

Following gene: 39996227

Centisome position: 31.82

GC content: 59.4

Gene sequence:

>1362_bases
ATGAAAGAGCGGACCAAAATCCTCCTGATCGACGATGAAGAAACGGGACGCGAAGCCCTCACCCTCCTGCTGAAGGCGGC
CGGTCATGCGGTGAAAAGCGCCGGGGCGGGCAGCGAGGCCTTCCAGACCCTTACTCGCGACACCTTCGACATTGTCATTA
CCGACCTTTTTCTCCCCGACGCCAGCGGTATCGACATCCTGAAAAAAGTCAAGGAAGACGCCCCGCTCACCGAAGTGATC
CTCATCACCGGCCACGCCTCGGCAGAAACGGCAGTGAAGGCGATGAAAGAGGGTGCTTTCGACTACATCACCAAACCCCT
CAACTTCGACGAACTGAAGATCATTATCGGCAAGGCCGTGGAGAAGCGGCAGCTCTTGTCCGAAAACGTCTACCTCCGGA
AGCAGCTGCGCGACAAGTTCGAATTCGCCAATATCATCGGCAGCTCTCCCGCCATGCAGCACGTCTTCGCCCTCATGAAG
CGGATCGTCAAAACCGACTCGACCGTGCTGATAGCCGGCGAATCGGGGACCGGCAAAGAATTGGTGGCCAAGGCGATCCA
CTTCAACGGCGGGCGACGCGACAAACCGTTCATTGCCGTCCACTGCGGGGCTATCCCGGAAAACCTGCTGGAATCGGAAC
TTTTCGGCTACGTCAAGGGTGCGTTCACCGGTGCGATGCGGGACAAAATCGGCAAGTTCGAAGCAGCCAACGGCGGAACC
ATCTTCCTCGATGAAATCGGCACCATGCCGATGCAGTTGCAGACAAAGCTCCTGCGCGTGCTTCAGGAAGAGGAAGTGGA
ACGAGTGGGCTCCACCCGCCCCGTCAAGATCGATGTCCGGATCATATCGGCCACCAACCTGGATCTGGCGGAGGAGGTCA
AAAAGGGCAACTTCAGGGAAGATCTCTTTTACCGGCTCAACGTGATCCCCCTGCAGCTCCCCCCCTTGAGGGAGCGGGTC
GAGGACATCCTCCCCCTGGCCAAACACTTTCTTGCCAAGTACTGCAAGGAGATGCAGCGACGGAACATGTCGCTTGCCAG
CGACACGCTCGAGGCACTGGAAAGCTACCAGTGGCCCGGTAACGTGCGGGAGCTGGAGAACGTCATGGAGCGGGTGGCGG
CCCTTACCGAAGACAACACCGTTACCGTTCAGGACCTGCCGCACAATATCCGGGAGGAGGGATTGACCCGCCTGACCGGC
AAGGGGGTCGACCTCGTAAAGGTGCTGGCTGAAATCGAGCGGGGGATGATCAGGGACGCGCTGGTCCTGTCAGAGGGGGT
CAAGGCTAGGGCCGCGGCGCTGCTCAACCTGAACAGGACAACCCTGGTGGAAAAGATGCGGCGGCTCGGCATGCCGCTCT
GA

Upstream 100 bases:

>100_bases
GAACGTTTACCAGAGCCCCTTCACGCACTGCCGCGGCTACGGGATGCTTGCCAATCGTACCCGATTGATGCTATGTATCA
GGCCTATCCGCGGAGGTGCC

Downstream 100 bases:

>100_bases
CAGGATTTGCCCCTATCTGATGCTTCAGTAGATTACGCCCGGCGTTATGACGGGGTGACGGGCTGATGGGGGCAACACCG
CGGGCATACACTCCCGAACG

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MKERTKILLIDDEETGREALTLLLKAAGHAVKSAGAGSEAFQTLTRDTFDIVITDLFLPDASGIDILKKVKEDAPLTEVI
LITGHASAETAVKAMKEGAFDYITKPLNFDELKIIIGKAVEKRQLLSENVYLRKQLRDKFEFANIIGSSPAMQHVFALMK
RIVKTDSTVLIAGESGTGKELVAKAIHFNGGRRDKPFIAVHCGAIPENLLESELFGYVKGAFTGAMRDKIGKFEAANGGT
IFLDEIGTMPMQLQTKLLRVLQEEEVERVGSTRPVKIDVRIISATNLDLAEEVKKGNFREDLFYRLNVIPLQLPPLRERV
EDILPLAKHFLAKYCKEMQRRNMSLASDTLEALESYQWPGNVRELENVMERVAALTEDNTVTVQDLPHNIREEGLTRLTG
KGVDLVKVLAEIERGMIRDALVLSEGVKARAAALLNLNRTTLVEKMRRLGMPL

Sequences:

>Translated_453_residues
MKERTKILLIDDEETGREALTLLLKAAGHAVKSAGAGSEAFQTLTRDTFDIVITDLFLPDASGIDILKKVKEDAPLTEVI
LITGHASAETAVKAMKEGAFDYITKPLNFDELKIIIGKAVEKRQLLSENVYLRKQLRDKFEFANIIGSSPAMQHVFALMK
RIVKTDSTVLIAGESGTGKELVAKAIHFNGGRRDKPFIAVHCGAIPENLLESELFGYVKGAFTGAMRDKIGKFEAANGGT
IFLDEIGTMPMQLQTKLLRVLQEEEVERVGSTRPVKIDVRIISATNLDLAEEVKKGNFREDLFYRLNVIPLQLPPLRERV
EDILPLAKHFLAKYCKEMQRRNMSLASDTLEALESYQWPGNVRELENVMERVAALTEDNTVTVQDLPHNIREEGLTRLTG
KGVDLVKVLAEIERGMIRDALVLSEGVKARAAALLNLNRTTLVEKMRRLGMPL
>Mature_453_residues
MKERTKILLIDDEETGREALTLLLKAAGHAVKSAGAGSEAFQTLTRDTFDIVITDLFLPDASGIDILKKVKEDAPLTEVI
LITGHASAETAVKAMKEGAFDYITKPLNFDELKIIIGKAVEKRQLLSENVYLRKQLRDKFEFANIIGSSPAMQHVFALMK
RIVKTDSTVLIAGESGTGKELVAKAIHFNGGRRDKPFIAVHCGAIPENLLESELFGYVKGAFTGAMRDKIGKFEAANGGT
IFLDEIGTMPMQLQTKLLRVLQEEEVERVGSTRPVKIDVRIISATNLDLAEEVKKGNFREDLFYRLNVIPLQLPPLRERV
EDILPLAKHFLAKYCKEMQRRNMSLASDTLEALESYQWPGNVRELENVMERVAALTEDNTVTVQDLPHNIREEGLTRLTG
KGVDLVKVLAEIERGMIRDALVLSEGVKARAAALLNLNRTTLVEKMRRLGMPL

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=453, Percent_Identity=43.2671081677704, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI1790299, Length=473, Percent_Identity=41.014799154334, Blast_Score=352, Evalue=4e-98,
Organism=Escherichia coli, GI1790437, Length=442, Percent_Identity=40.9502262443439, Blast_Score=340, Evalue=8e-95,
Organism=Escherichia coli, GI1788905, Length=442, Percent_Identity=39.1402714932127, Blast_Score=311, Evalue=4e-86,
Organism=Escherichia coli, GI87082117, Length=363, Percent_Identity=46.0055096418733, Blast_Score=301, Evalue=8e-83,
Organism=Escherichia coli, GI1789087, Length=334, Percent_Identity=47.6047904191617, Blast_Score=284, Evalue=1e-77,
Organism=Escherichia coli, GI1789233, Length=363, Percent_Identity=42.9752066115703, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI1786524, Length=254, Percent_Identity=51.1811023622047, Blast_Score=258, Evalue=6e-70,
Organism=Escherichia coli, GI87082152, Length=321, Percent_Identity=41.7445482866044, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI87081872, Length=229, Percent_Identity=46.7248908296943, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI1787583, Length=241, Percent_Identity=45.2282157676349, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI87081858, Length=311, Percent_Identity=31.5112540192926, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI1789828, Length=297, Percent_Identity=32.3232323232323, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1789809, Length=124, Percent_Identity=32.258064516129, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87082012, Length=107, Percent_Identity=33.6448598130841, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1786784, Length=107, Percent_Identity=33.6448598130841, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1787375, Length=107, Percent_Identity=29.9065420560748, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790863, Length=126, Percent_Identity=32.5396825396825, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50402; Mature: 50402

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKERTKILLIDDEETGREALTLLLKAAGHAVKSAGAGSEAFQTLTRDTFDIVITDLFLPD
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC
ASGIDILKKVKEDAPLTEVILITGHASAETAVKAMKEGAFDYITKPLNFDELKIIIGKAV
CCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHH
EKRQLLSENVYLRKQLRDKFEFANIIGSSPAMQHVFALMKRIVKTDSTVLIAGESGTGKE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
LVAKAIHFNGGRRDKPFIAVHCGAIPENLLESELFGYVKGAFTGAMRDKIGKFEAANGGT
HHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
IFLDEIGTMPMQLQTKLLRVLQEEEVERVGSTRPVKIDVRIISATNLDLAEEVKKGNFRE
EEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCHHHHHHCCCCHH
DLFYRLNVIPLQLPPLRERVEDILPLAKHFLAKYCKEMQRRNMSLASDTLEALESYQWPG
HHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
NVRELENVMERVAALTEDNTVTVQDLPHNIREEGLTRLTGKGVDLVKVLAEIERGMIRDA
CHHHHHHHHHHHHHHCCCCEEEEHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LVLSEGVKARAAALLNLNRTTLVEKMRRLGMPL
HHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKERTKILLIDDEETGREALTLLLKAAGHAVKSAGAGSEAFQTLTRDTFDIVITDLFLPD
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC
ASGIDILKKVKEDAPLTEVILITGHASAETAVKAMKEGAFDYITKPLNFDELKIIIGKAV
CCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHH
EKRQLLSENVYLRKQLRDKFEFANIIGSSPAMQHVFALMKRIVKTDSTVLIAGESGTGKE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
LVAKAIHFNGGRRDKPFIAVHCGAIPENLLESELFGYVKGAFTGAMRDKIGKFEAANGGT
HHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
IFLDEIGTMPMQLQTKLLRVLQEEEVERVGSTRPVKIDVRIISATNLDLAEEVKKGNFRE
EEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCHHHHHHCCCCHH
DLFYRLNVIPLQLPPLRERVEDILPLAKHFLAKYCKEMQRRNMSLASDTLEALESYQWPG
HHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
NVRELENVMERVAALTEDNTVTVQDLPHNIREEGLTRLTGKGVDLVKVLAEIERGMIRDA
CHHHHHHHHHHHHHHCCCCEEEEHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LVLSEGVKARAAALLNLNRTTLVEKMRRLGMPL
HHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]