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The map label for this gene is atoC [H]

Identifier: 39996066

GI number: 39996066

Start: 1038168

End: 1039571

Strand: Direct

Name: atoC [H]

Synonym: GSU0963

Alternate gene names: 39996066

Gene position: 1038168-1039571 (Clockwise)

Preceding gene: 39996065

Following gene: 39996069

Centisome position: 27.22

GC content: 62.11

Gene sequence:

>1404_bases
GTGCCGATCGTGTCAGATAAAAAGCGCATCATGCTTATCGATAACGAAGAAGGGCTCTGCCGCATGATGGAGGCGGTGCT
CGCCGACAGCGGCTATGCCGTGAAGGGGTATACCCGCTCCTTCGAGGCGGTGGAGGAGTTCAAGGCCGGCGATTGGGATC
TGGTGGTGAGCGACATCAAGATGCCCGGCATGGACGGTCTTGAGGTGCTCCAGCGGATCAAGGCCAAGGATCCCCTTGTC
CCGGTCATCATGATCACCGCCTACGCCACGGTGGAGACCTCGATCCAGGCGCTCCGGCGCGGGGCCTACGACATGGTCAC
CAAGCCCTTCGAGCCCGAGGAGCTCCTCTACCGGGTCAAGAACGCCCTCAAGCACACCCAGCTTCTGGAAGAGAACCGGG
AACTGCGGGAAGAGCTGGTGGGCAAGTTCCGCTTCGACAACATCATCGGCGCATCCACCGGCCTCAAGGATGTGCTGGAC
AAGGTTGAGAAGATCGCTATCCGCGACACGTCGGTCCTGATCACCGGCGAGTCCGGGACCGGCAAGGAGCTCATCGCCCA
GGCCATCCATTACAACTCGCTGCGCAAGGAAAAGAAGTTCGTGGCCATCAACTGCGGGGCGCTGCCCGAATCGCTGCTGG
AGAGCGAGTTGTTCGGCTACCGCAAGGGGGCCTTTACCGGCGCCAAGGAGAACCGCCAGGGGCTCCTGGAGGCGGCCGAC
GGCGGCACGCTCTTTCTGGACGAGGCGGGCAACCTCCCCATGAACGTGCAGAAGACGCTGCTCCGCTTTCTCCAGGAACA
GGAGTTTCTGCGCATCGGCGACACCACCCCCACCAAGGTCGACGTGCGGATCATCTCCGCCACCAATGCCGAGCTGAAGG
AGGCGGTCAAGAGCGGTGCCTTCCGCGAGGATCTTTACTACCGGCTCAACGTGCTGAATCTTCACCTGCCCCCCCTGCGG
GAGCGGCGGGCCGACATCCCGCTGCTGGCGGCCCACTTCATCACGCTGCAGAACAAGAAATTCGGCACCGCCATCAAGGG
GCTCGCCCCCGACGCGTTGGAGGCGGTCATGGAGTTCTCCTGGCCGGGGAATATCCGCCAGCTCAAGAACGTGATCGAAG
CCTGCACCGCCATGGAAAACGGTGATTATCTCTCGCTGGCCGTGCTTTCGCAGTTCATCGAGATATCTCACCATGTGCCC
GGGGAAGAAGGGGACACGGCCGGCGATGTGGATGAGAGCGACTATTCCCAGGCCCTGTCGCGGTTCGAGGTCGACTACCT
GAAGGGGCTCCTGCGCAAGAATCGCGGCAACGTGGAGGCTGCGGCCCGCGATGCGGGGATGAACATGGCCACCATCTACC
GCAAGCTCAAGAAGTACAATATCCGCCGCGAAGACTACGCCTGA

Upstream 100 bases:

>100_bases
GGCCGCATCGCCATCGACAGCGAGGTGGGGCGCGGCACCGACGTTACCGTGCGCCTGCCCCTGGAGCCGGAAGAGCTGTA
GCGTTAATATCAGTTGAGAG

Downstream 100 bases:

>100_bases
CGGTTTCAGGGGCCCCTCTCGGGGCCGTCCTCTCTTGTGCCGGATTACCCATGGCGTTCCACCTCCTCTCACGGTCGAAG
CGGGTTCGCATTTCTGCAAA

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MPIVSDKKRIMLIDNEEGLCRMMEAVLADSGYAVKGYTRSFEAVEEFKAGDWDLVVSDIKMPGMDGLEVLQRIKAKDPLV
PVIMITAYATVETSIQALRRGAYDMVTKPFEPEELLYRVKNALKHTQLLEENRELREELVGKFRFDNIIGASTGLKDVLD
KVEKIAIRDTSVLITGESGTGKELIAQAIHYNSLRKEKKFVAINCGALPESLLESELFGYRKGAFTGAKENRQGLLEAAD
GGTLFLDEAGNLPMNVQKTLLRFLQEQEFLRIGDTTPTKVDVRIISATNAELKEAVKSGAFREDLYYRLNVLNLHLPPLR
ERRADIPLLAAHFITLQNKKFGTAIKGLAPDALEAVMEFSWPGNIRQLKNVIEACTAMENGDYLSLAVLSQFIEISHHVP
GEEGDTAGDVDESDYSQALSRFEVDYLKGLLRKNRGNVEAAARDAGMNMATIYRKLKKYNIRREDYA

Sequences:

>Translated_467_residues
MPIVSDKKRIMLIDNEEGLCRMMEAVLADSGYAVKGYTRSFEAVEEFKAGDWDLVVSDIKMPGMDGLEVLQRIKAKDPLV
PVIMITAYATVETSIQALRRGAYDMVTKPFEPEELLYRVKNALKHTQLLEENRELREELVGKFRFDNIIGASTGLKDVLD
KVEKIAIRDTSVLITGESGTGKELIAQAIHYNSLRKEKKFVAINCGALPESLLESELFGYRKGAFTGAKENRQGLLEAAD
GGTLFLDEAGNLPMNVQKTLLRFLQEQEFLRIGDTTPTKVDVRIISATNAELKEAVKSGAFREDLYYRLNVLNLHLPPLR
ERRADIPLLAAHFITLQNKKFGTAIKGLAPDALEAVMEFSWPGNIRQLKNVIEACTAMENGDYLSLAVLSQFIEISHHVP
GEEGDTAGDVDESDYSQALSRFEVDYLKGLLRKNRGNVEAAARDAGMNMATIYRKLKKYNIRREDYA
>Mature_466_residues
PIVSDKKRIMLIDNEEGLCRMMEAVLADSGYAVKGYTRSFEAVEEFKAGDWDLVVSDIKMPGMDGLEVLQRIKAKDPLVP
VIMITAYATVETSIQALRRGAYDMVTKPFEPEELLYRVKNALKHTQLLEENRELREELVGKFRFDNIIGASTGLKDVLDK
VEKIAIRDTSVLITGESGTGKELIAQAIHYNSLRKEKKFVAINCGALPESLLESELFGYRKGAFTGAKENRQGLLEAADG
GTLFLDEAGNLPMNVQKTLLRFLQEQEFLRIGDTTPTKVDVRIISATNAELKEAVKSGAFREDLYYRLNVLNLHLPPLRE
RRADIPLLAAHFITLQNKKFGTAIKGLAPDALEAVMEFSWPGNIRQLKNVIEACTAMENGDYLSLAVLSQFIEISHHVPG
EEGDTAGDVDESDYSQALSRFEVDYLKGLLRKNRGNVEAAARDAGMNMATIYRKLKKYNIRREDYA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=453, Percent_Identity=43.4878587196468, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1790299, Length=467, Percent_Identity=39.6145610278373, Blast_Score=343, Evalue=2e-95,
Organism=Escherichia coli, GI1790437, Length=456, Percent_Identity=39.4736842105263, Blast_Score=337, Evalue=8e-94,
Organism=Escherichia coli, GI1788905, Length=457, Percent_Identity=40.4814004376368, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI87082117, Length=259, Percent_Identity=50.1930501930502, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1789233, Length=326, Percent_Identity=41.7177914110429, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1789087, Length=278, Percent_Identity=47.4820143884892, Blast_Score=250, Evalue=2e-67,
Organism=Escherichia coli, GI87082152, Length=321, Percent_Identity=40.4984423676012, Blast_Score=221, Evalue=6e-59,
Organism=Escherichia coli, GI1786524, Length=339, Percent_Identity=38.9380530973451, Blast_Score=217, Evalue=2e-57,
Organism=Escherichia coli, GI87081872, Length=229, Percent_Identity=47.5982532751092, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI1787583, Length=321, Percent_Identity=37.6947040498442, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1789828, Length=246, Percent_Identity=33.739837398374, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87081858, Length=292, Percent_Identity=30.4794520547945, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI87082012, Length=127, Percent_Identity=29.9212598425197, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789809, Length=117, Percent_Identity=29.9145299145299, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790552, Length=116, Percent_Identity=33.6206896551724, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786784, Length=116, Percent_Identity=25.8620689655172, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790860, Length=121, Percent_Identity=26.4462809917355, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789402, Length=119, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788191, Length=116, Percent_Identity=33.6206896551724, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786599, Length=119, Percent_Identity=29.4117647058824, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1788394, Length=138, Percent_Identity=26.8115942028986, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 52275; Mature: 52144

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIVSDKKRIMLIDNEEGLCRMMEAVLADSGYAVKGYTRSFEAVEEFKAGDWDLVVSDIK
CCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCEEECHHHHHHHHHHHCCCCCEEEEECCC
MPGMDGLEVLQRIKAKDPLVPVIMITAYATVETSIQALRRGAYDMVTKPFEPEELLYRVK
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHH
NALKHTQLLEENRELREELVGKFRFDNIIGASTGLKDVLDKVEKIAIRDTSVLITGESGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEECCEEEEECCCCC
GKELIAQAIHYNSLRKEKKFVAINCGALPESLLESELFGYRKGAFTGAKENRQGLLEAAD
CHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHEECC
GGTLFLDEAGNLPMNVQKTLLRFLQEQEFLRIGDTTPTKVDVRIISATNAELKEAVKSGA
CCEEEEECCCCCCCHHHHHHHHHHHHHHHEECCCCCCCEEEEEEEECCCHHHHHHHHCCC
FREDLYYRLNVLNLHLPPLRERRADIPLLAAHFITLQNKKFGTAIKGLAPDALEAVMEFS
HHHHHHHEEEEEEECCCCHHHHCCCCCHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHCC
WPGNIRQLKNVIEACTAMENGDYLSLAVLSQFIEISHHVPGEEGDTAGDVDESDYSQALS
CCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
RFEVDYLKGLLRKNRGNVEAAARDAGMNMATIYRKLKKYNIRREDYA
HHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PIVSDKKRIMLIDNEEGLCRMMEAVLADSGYAVKGYTRSFEAVEEFKAGDWDLVVSDIK
CCCCCCCEEEEEECCCHHHHHHHHHHCCCCCEEECHHHHHHHHHHHCCCCCEEEEECCC
MPGMDGLEVLQRIKAKDPLVPVIMITAYATVETSIQALRRGAYDMVTKPFEPEELLYRVK
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHH
NALKHTQLLEENRELREELVGKFRFDNIIGASTGLKDVLDKVEKIAIRDTSVLITGESGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEECCEEEEECCCCC
GKELIAQAIHYNSLRKEKKFVAINCGALPESLLESELFGYRKGAFTGAKENRQGLLEAAD
CHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHEECC
GGTLFLDEAGNLPMNVQKTLLRFLQEQEFLRIGDTTPTKVDVRIISATNAELKEAVKSGA
CCEEEEECCCCCCCHHHHHHHHHHHHHHHEECCCCCCCEEEEEEEECCCHHHHHHHHCCC
FREDLYYRLNVLNLHLPPLRERRADIPLLAAHFITLQNKKFGTAIKGLAPDALEAVMEFS
HHHHHHHEEEEEEECCCCHHHHCCCCCHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHCC
WPGNIRQLKNVIEACTAMENGDYLSLAVLSQFIEISHHVPGEEGDTAGDVDESDYSQALS
CCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
RFEVDYLKGLLRKNRGNVEAAARDAGMNMATIYRKLKKYNIRREDYA
HHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]