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The map label for this gene is ppiA [H]

Identifier: 39995999

GI number: 39995999

Start: 957394

End: 957909

Strand: Direct

Name: ppiA [H]

Synonym: GSU0894

Alternate gene names: 39995999

Gene position: 957394-957909 (Clockwise)

Preceding gene: 39995997

Following gene: 39996002

Centisome position: 25.1

GC content: 59.11

Gene sequence:

>516_bases
ATGAGCGAAGAGCAGAACCCCCGGGTCATGCTTGAGACCTCCCAGGGGAACATCACCATCGAACTGTTCAGGGACAAGGC
GCCGATTTCCGCCCGCAATTTCCTCTCTTACGTGAAGGACGGCTACTATGACGGTCTCATCTTCCACCGGGTCATCAAGG
GATTCATGGTCCAGGGGGGCGGGATGGACGAAAACATGCAACCCCGGAAGACCAAGTTCGCCATCAAGAACGAGGCGACC
AACGGCCTCTCCAACAAGCGGGGGACTCTGGCCATGGCCCGGACCGCGGTGGTCGACAGCGCCACGTCCCAGTTCTTCAT
CAACCTGGTGGACAACGCGTTTCTCGATAACCGGGGCAAGACTCCCGATCTTTTCGGCTATGCCGTGTTCGGACAGGTCG
TGGAGGGGATGGAGGTAGTGGACGCCATTGCCGGGGTTAAGACCGGCAACAGGGCGGGCCACTCGGATGTGCCGGTGGAG
AACGTGTTTATCACCAGGGCTTCGGTGATCGAATAA

Upstream 100 bases:

>100_bases
ACAGACGATGCAAGCCGAGAAAAGGGTGTTCGCCGTCCGTCTTTTGTGATACACCTTGAGCCTCACAGTGTCATCTGATG
ATTACAGAAAGGAGCATGCC

Downstream 100 bases:

>100_bases
GGTTCAGCTGCGTAATGAGGTCGCATAAAAAAGGCCGTCCGATCGGGCGGCCTTTTTTCATGGCAGGTTGAGCGCCGTTT
TGAAGCGGGAGATCTGCTCG

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin-type

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MSEEQNPRVMLETSQGNITIELFRDKAPISARNFLSYVKDGYYDGLIFHRVIKGFMVQGGGMDENMQPRKTKFAIKNEAT
NGLSNKRGTLAMARTAVVDSATSQFFINLVDNAFLDNRGKTPDLFGYAVFGQVVEGMEVVDAIAGVKTGNRAGHSDVPVE
NVFITRASVIE

Sequences:

>Translated_171_residues
MSEEQNPRVMLETSQGNITIELFRDKAPISARNFLSYVKDGYYDGLIFHRVIKGFMVQGGGMDENMQPRKTKFAIKNEAT
NGLSNKRGTLAMARTAVVDSATSQFFINLVDNAFLDNRGKTPDLFGYAVFGQVVEGMEVVDAIAGVKTGNRAGHSDVPVE
NVFITRASVIE
>Mature_170_residues
SEEQNPRVMLETSQGNITIELFRDKAPISARNFLSYVKDGYYDGLIFHRVIKGFMVQGGGMDENMQPRKTKFAIKNEATN
GLSNKRGTLAMARTAVVDSATSQFFINLVDNAFLDNRGKTPDLFGYAVFGQVVEGMEVVDAIAGVKTGNRAGHSDVPVEN
VFITRASVIE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This protein is not essential for growth. Presumably plays a role in signal transduction [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=166, Percent_Identity=34.9397590361446, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI24308049, Length=169, Percent_Identity=35.5029585798817, Blast_Score=88, Evalue=4e-18,
Organism=Homo sapiens, GI19557636, Length=139, Percent_Identity=37.410071942446, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=33.5365853658537, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=33.5365853658537, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=33.5365853658537, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI64276486, Length=132, Percent_Identity=36.3636363636364, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI310110104, Length=149, Percent_Identity=35.5704697986577, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI310129267, Length=149, Percent_Identity=34.8993288590604, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI310120620, Length=149, Percent_Identity=34.8993288590604, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI10863927, Length=161, Percent_Identity=35.4037267080745, Blast_Score=70, Evalue=7e-13,
Organism=Escherichia coli, GI1789763, Length=170, Percent_Identity=54.7058823529412, Blast_Score=184, Evalue=3e-48,
Organism=Escherichia coli, GI1786736, Length=163, Percent_Identity=54.601226993865, Blast_Score=182, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71980594, Length=146, Percent_Identity=35.6164383561644, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=35.6164383561644, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17506311, Length=167, Percent_Identity=33.5329341317365, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17539496, Length=151, Percent_Identity=34.4370860927152, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17532641, Length=170, Percent_Identity=32.9411764705882, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532643, Length=167, Percent_Identity=36.5269461077844, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71997782, Length=131, Percent_Identity=35.8778625954198, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17565860, Length=178, Percent_Identity=34.2696629213483, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17551284, Length=178, Percent_Identity=30.3370786516854, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17551282, Length=178, Percent_Identity=30.3370786516854, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=156, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320510, Length=164, Percent_Identity=34.1463414634146, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17986117, Length=166, Percent_Identity=36.7469879518072, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI19922912, Length=159, Percent_Identity=37.1069182389937, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19922376, Length=167, Percent_Identity=29.3413173652695, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357249, Length=144, Percent_Identity=32.6388888888889, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24652460, Length=161, Percent_Identity=31.055900621118, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18802; Mature: 18670

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEEQNPRVMLETSQGNITIELFRDKAPISARNFLSYVKDGYYDGLIFHRVIKGFMVQGG
CCCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
GMDENMQPRKTKFAIKNEATNGLSNKRGTLAMARTAVVDSATSQFFINLVDNAFLDNRGK
CCCCCCCCCHHEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TPDLFGYAVFGQVVEGMEVVDAIAGVKTGNRAGHSDVPVENVFITRASVIE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHHCC
>Mature Secondary Structure 
SEEQNPRVMLETSQGNITIELFRDKAPISARNFLSYVKDGYYDGLIFHRVIKGFMVQGG
CCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
GMDENMQPRKTKFAIKNEATNGLSNKRGTLAMARTAVVDSATSQFFINLVDNAFLDNRGK
CCCCCCCCCHHEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TPDLFGYAVFGQVVEGMEVVDAIAGVKTGNRAGHSDVPVENVFITRASVIE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 8581173 [H]