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The map label for this gene is czcC [H]

Identifier: 39995934

GI number: 39995934

Start: 887631

End: 888917

Strand: Direct

Name: czcC [H]

Synonym: GSU0828

Alternate gene names: 39995934

Gene position: 887631-888917 (Clockwise)

Preceding gene: 39995933

Following gene: 39995935

Centisome position: 23.27

GC content: 64.49

Gene sequence:

>1287_bases
GTGTCTGGAGCAGTCCATCTGTTCCTGACAGCTGTAATTCTCGCCCCACTGGGGGCTTCAGGCGAGGTTCGCACACTGAC
CCTGCCGCAGGCGGTTGAGTATGCCCTGGCACACAACGGCGAGCTGAAGGCTCTGCGCAACGAAAAGGACGTGGCGCGGG
CAGGGCTGGAGCGCGCCGTGCTTCTGCCCAATCCTACCCTGGAGTTGTCGGCCGACTCCGGCGTCATGACCGGCAGTCCC
GACGAAACCGCCCTTTCCATCGGCATTTCTCAGGAGTTCCTGACCGGCGGCAAGCGGGCCAAGCGCCGGGCCGTTGCCGA
ACGCGAGGCGGAGGCGGTTCATTTCCAGATCGCCGACCGTGAGCGGCAGCTCTCCCTGGATGTAAAGAGTTCTTTCTCCG
AACTGATTCTGGCTCAGAAACGGCGGGAACTCGCCGGGCGTGCAGTGGAGCTGAACGGAAAGCTGCTGGAGATAACACGG
GAGCGTCTGGCAGCGGGCGATATTCCGGAACTGGAGGTTAACCTTGCCCGGGTGGAGGTGGCCCGGAGCGAAGGACGCAA
AATCGAGGCGGAACGGGAGTTCGCTCCGCTGCTGGCCAGGCTGAGGACTCTGCTGGGGGTTCCGGCGGGGGAGGAGATCG
GTTTCGACGGCATTCCCGAGCAGTCGCCCCTGTCGATTTCCCTTGACGATCTCATTCGTCTGGCCCTGGAGAACCGGCCC
GATCTGAAGGCATTCCAGGCCACCAGCGCAAAGGGTGAGGCCGCCGTTGAGCTGGCCGAGGCGGAGCGCATCCCGAACGT
GACGCTCGGCCTCGGCTTCACCCACGAGCGGAGCACGGACGCCACCGGCTCCGGCGATGAAAAGACCCGCGATAACCTGC
TGGGGGTGACCCTGTCTATTCCGCTCCCCCTTTTCGACCGCAATCAGGCCGGCATCCGCGAGGCCCGGGCCGTCAGGCAG
GGGGCCGACAACCGGCTGGAGTTCGCCCGTTCGAGCGTGCCCCGGGAGATCGAGGGCGATTACGCGCGGCTTGCAGCGGC
CGAGAAGACCCTCAGGCTCTACGCCGACGGCATTCTTCCCCAGCTTGAGGACAACCTGAAGCTCGTCCAGGAGGCGTACC
GGCTGGGCGAGGTCGGAATCCTCGCAGTCATTGAAGAGCAGAAAAAGTATATCGAAGTCAACGACGGTTACCTTGTCGCC
CTCGCCGAGCGGCAGGCGGCCCTGGCCCGGCTCGAAGCCTCTGTCGGGACCGATTTCCAGAACAGAACCAACGGAGGTGC
GCAGTGA

Upstream 100 bases:

>100_bases
CGCCCGGATTCCCATTCTTCAGCACTCCTTCGTTTTCCCCAACCAATCGGACATTGAATACCTGCAAGGAGGTACTGTCT
TGGTACGAGCATCTCGTTTC

Downstream 100 bases:

>100_bases
ACAGGAAACGTGGGATCATTATCGGCCTTGTCCTGGCCATGGCCCTGGGGGGTGGTTTCTTCGCCTATCGTTCCACCCAG
GTGACGGACGGCGCCGGCGG

Product: metal ion efflux outer membrane protein family protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSGAVHLFLTAVILAPLGASGEVRTLTLPQAVEYALAHNGELKALRNEKDVARAGLERAVLLPNPTLELSADSGVMTGSP
DETALSIGISQEFLTGGKRAKRRAVAEREAEAVHFQIADRERQLSLDVKSSFSELILAQKRRELAGRAVELNGKLLEITR
ERLAAGDIPELEVNLARVEVARSEGRKIEAEREFAPLLARLRTLLGVPAGEEIGFDGIPEQSPLSISLDDLIRLALENRP
DLKAFQATSAKGEAAVELAEAERIPNVTLGLGFTHERSTDATGSGDEKTRDNLLGVTLSIPLPLFDRNQAGIREARAVRQ
GADNRLEFARSSVPREIEGDYARLAAAEKTLRLYADGILPQLEDNLKLVQEAYRLGEVGILAVIEEQKKYIEVNDGYLVA
LAERQAALARLEASVGTDFQNRTNGGAQ

Sequences:

>Translated_428_residues
MSGAVHLFLTAVILAPLGASGEVRTLTLPQAVEYALAHNGELKALRNEKDVARAGLERAVLLPNPTLELSADSGVMTGSP
DETALSIGISQEFLTGGKRAKRRAVAEREAEAVHFQIADRERQLSLDVKSSFSELILAQKRRELAGRAVELNGKLLEITR
ERLAAGDIPELEVNLARVEVARSEGRKIEAEREFAPLLARLRTLLGVPAGEEIGFDGIPEQSPLSISLDDLIRLALENRP
DLKAFQATSAKGEAAVELAEAERIPNVTLGLGFTHERSTDATGSGDEKTRDNLLGVTLSIPLPLFDRNQAGIREARAVRQ
GADNRLEFARSSVPREIEGDYARLAAAEKTLRLYADGILPQLEDNLKLVQEAYRLGEVGILAVIEEQKKYIEVNDGYLVA
LAERQAALARLEASVGTDFQNRTNGGAQ
>Mature_427_residues
SGAVHLFLTAVILAPLGASGEVRTLTLPQAVEYALAHNGELKALRNEKDVARAGLERAVLLPNPTLELSADSGVMTGSPD
ETALSIGISQEFLTGGKRAKRRAVAEREAEAVHFQIADRERQLSLDVKSSFSELILAQKRRELAGRAVELNGKLLEITRE
RLAAGDIPELEVNLARVEVARSEGRKIEAEREFAPLLARLRTLLGVPAGEEIGFDGIPEQSPLSISLDDLIRLALENRPD
LKAFQATSAKGEAAVELAEAERIPNVTLGLGFTHERSTDATGSGDEKTRDNLLGVTLSIPLPLFDRNQAGIREARAVRQG
ADNRLEFARSSVPREIEGDYARLAAAEKTLRLYADGILPQLEDNLKLVQEAYRLGEVGILAVIEEQKKYIEVNDGYLVAL
AERQAALARLEASVGTDFQNRTNGGAQ

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 46414; Mature: 46283

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
0.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGAVHLFLTAVILAPLGASGEVRTLTLPQAVEYALAHNGELKALRNEKDVARAGLERAV
CCCHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHCCCCEEECCCHHHHHHHCCCCEE
LLPNPTLELSADSGVMTGSPDETALSIGISQEFLTGGKRAKRRAVAEREAEAVHFQIADR
ECCCCCEEEECCCCCCCCCCCCCEEEECCCHHHHCCCHHHHHHHHHHHHHHEEEEEEECC
ERQLSLDVKSSFSELILAQKRRELAGRAVELNGKLLEITRERLAAGDIPELEVNLARVEV
CCEEEEHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHCCCCCCCEEEHHHHHH
ARSEGRKIEAEREFAPLLARLRTLLGVPAGEEIGFDGIPEQSPLSISLDDLIRLALENRP
HHHCCCEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECHHHHHHHHHCCCC
DLKAFQATSAKGEAAVELAEAERIPNVTLGLGFTHERSTDATGSGDEKTRDNLLGVTLSI
CCHHHHCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHHCEEEEEEEC
PLPLFDRNQAGIREARAVRQGADNRLEFARSSVPREIEGDYARLAAAEKTLRLYADGILP
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCH
QLEDNLKLVQEAYRLGEVGILAVIEEQKKYIEVNDGYLVALAERQAALARLEASVGTDFQ
HHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEECCCEEEEEEHHHHHHHHHHHHHCCCCC
NRTNGGAQ
CCCCCCCC
>Mature Secondary Structure 
SGAVHLFLTAVILAPLGASGEVRTLTLPQAVEYALAHNGELKALRNEKDVARAGLERAV
CCHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHCCCCEEECCCHHHHHHHCCCCEE
LLPNPTLELSADSGVMTGSPDETALSIGISQEFLTGGKRAKRRAVAEREAEAVHFQIADR
ECCCCCEEEECCCCCCCCCCCCCEEEECCCHHHHCCCHHHHHHHHHHHHHHEEEEEEECC
ERQLSLDVKSSFSELILAQKRRELAGRAVELNGKLLEITRERLAAGDIPELEVNLARVEV
CCEEEEHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHCCCCCCCEEEHHHHHH
ARSEGRKIEAEREFAPLLARLRTLLGVPAGEEIGFDGIPEQSPLSISLDDLIRLALENRP
HHHCCCEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECHHHHHHHHHCCCC
DLKAFQATSAKGEAAVELAEAERIPNVTLGLGFTHERSTDATGSGDEKTRDNLLGVTLSI
CCHHHHCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHHCEEEEEEEC
PLPLFDRNQAGIREARAVRQGADNRLEFARSSVPREIEGDYARLAAAEKTLRLYADGILP
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCH
QLEDNLKLVQEAYRLGEVGILAVIEEQKKYIEVNDGYLVALAERQAALARLEASVGTDFQ
HHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEECCCEEEEEEHHHHHHHHHHHHHCCCCC
NRTNGGAQ
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]