Click here to switch to the map view.

The map label for this gene is prsA [H]

Identifier: 39995767

GI number: 39995767

Start: 698000

End: 698944

Strand: Direct

Name: prsA [H]

Synonym: GSU0661

Alternate gene names: 39995767

Gene position: 698000-698944 (Clockwise)

Preceding gene: 39995766

Following gene: 39995768

Centisome position: 18.3

GC content: 59.15

Gene sequence:

>945_bases
ATGAATCAGAAAATCAGGGTGTTCAGTGGCAATTCCAACCGGAGCTTGGCGGAAAGTATCTGCGCCAACCTGGGTCTTCC
CCTCGGCAAAGCCAACGTCAAGACCTTTTCTGACGGCGAGGTCATGGTGGAAATCGGCGAAAACGTCCGTGGGCGCGATA
CCTACGTGGTGCAGTCCACCTGCGCCCCCACCAACAACAATCTCATGGAGCTCCTGATAATGATGGATGCTCTGAAGCGC
GCGTCGGCGGCAACCATCACGGCGGTGATCCCCTATTACGGCTACGCCCGGCAGGATCGCAAGGTCGCGCCCCGAACACC
CATTACGTCCAAGCTGGTGGCCGACCTGATCACCACCGCCGGGGCGGACCGGGTGGTAACCGTCGACCTCCACGCGGGGC
AGATCCAGGGATTCTTCAATATCCCCGTTGACAACCTCTATGCCGCACCGGTTATCCTCGAGCACCTCAAGCAGCGCTTC
CCCGAGAACTCCATCGTGATGGTTTCCCCCGATGCTGGTGGAACCGAGCGGGCACGGGCCTTTGCCAAGCGCCTCGGTTG
TACGCTGGCGGTCATCGACAAGCGCCGGACCGGACCCAACGTGGCCGAAGTGATGCACCTTATCGGCGATGTGACGGATA
AGACGGCCATTATTCTCGATGACATGATCGACACGGCAGGAACTCTCACCCAGGCTGCCCGCGCGCTCAAAGAGCACGGT
GCCAAGACCATTTATGCCTGTGCCACCCACGGCGTCCTTTCCGGCCCGGCCATAGAGAGGATCAACAATTCCGACATCGA
AGCGGTAGTGATAACTGACACGGTTCCCCTTGGCGACAAGGAGCAGCAGACCAGCAAGGTAAAGGTGCTGTCCGTGGCCA
ACCTTCTTGCCGAGGCAATCCGGCGGATTCATGAGGATGAATCGGTAAGCTCGCTGTTTGTGTAA

Upstream 100 bases:

>100_bases
GGCATTCCAAGGTTCGAATCCTTGCACCCCAGCCACTTTACCCACTCATTTCCATCCGGCTCGTCCGATGGAAATTATTT
TTTGTGGCAAGGCAGCGGTC

Downstream 100 bases:

>100_bases
TCTGGCGACCATAACGTAACGACTGATACTGGAGGATGTAATGGAACAGAAAACGATGAGCATAGAACTGAGGGAGAAGA
ACGGCAAGGGCGTTGCCCGT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MNQKIRVFSGNSNRSLAESICANLGLPLGKANVKTFSDGEVMVEIGENVRGRDTYVVQSTCAPTNNNLMELLIMMDALKR
ASAATITAVIPYYGYARQDRKVAPRTPITSKLVADLITTAGADRVVTVDLHAGQIQGFFNIPVDNLYAAPVILEHLKQRF
PENSIVMVSPDAGGTERARAFAKRLGCTLAVIDKRRTGPNVAEVMHLIGDVTDKTAIILDDMIDTAGTLTQAARALKEHG
AKTIYACATHGVLSGPAIERINNSDIEAVVITDTVPLGDKEQQTSKVKVLSVANLLAEAIRRIHEDESVSSLFV

Sequences:

>Translated_314_residues
MNQKIRVFSGNSNRSLAESICANLGLPLGKANVKTFSDGEVMVEIGENVRGRDTYVVQSTCAPTNNNLMELLIMMDALKR
ASAATITAVIPYYGYARQDRKVAPRTPITSKLVADLITTAGADRVVTVDLHAGQIQGFFNIPVDNLYAAPVILEHLKQRF
PENSIVMVSPDAGGTERARAFAKRLGCTLAVIDKRRTGPNVAEVMHLIGDVTDKTAIILDDMIDTAGTLTQAARALKEHG
AKTIYACATHGVLSGPAIERINNSDIEAVVITDTVPLGDKEQQTSKVKVLSVANLLAEAIRRIHEDESVSSLFV
>Mature_314_residues
MNQKIRVFSGNSNRSLAESICANLGLPLGKANVKTFSDGEVMVEIGENVRGRDTYVVQSTCAPTNNNLMELLIMMDALKR
ASAATITAVIPYYGYARQDRKVAPRTPITSKLVADLITTAGADRVVTVDLHAGQIQGFFNIPVDNLYAAPVILEHLKQRF
PENSIVMVSPDAGGTERARAFAKRLGCTLAVIDKRRTGPNVAEVMHLIGDVTDKTAIILDDMIDTAGTLTQAARALKEHG
AKTIYACATHGVLSGPAIERINNSDIEAVVITDTVPLGDKEQQTSKVKVLSVANLLAEAIRRIHEDESVSSLFV

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=310, Percent_Identity=53.2258064516129, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI4506129, Length=310, Percent_Identity=51.9354838709677, Blast_Score=333, Evalue=9e-92,
Organism=Homo sapiens, GI84875539, Length=313, Percent_Identity=51.4376996805112, Blast_Score=328, Evalue=4e-90,
Organism=Homo sapiens, GI28557709, Length=310, Percent_Identity=51.2903225806452, Blast_Score=327, Evalue=7e-90,
Organism=Homo sapiens, GI4506133, Length=342, Percent_Identity=39.1812865497076, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI194018537, Length=344, Percent_Identity=40.406976744186, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI310128524, Length=147, Percent_Identity=35.3741496598639, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI310115209, Length=147, Percent_Identity=35.3741496598639, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI310118259, Length=147, Percent_Identity=35.3741496598639, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI310119946, Length=147, Percent_Identity=35.3741496598639, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1787458, Length=311, Percent_Identity=55.9485530546624, Blast_Score=351, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI25149168, Length=310, Percent_Identity=50.9677419354839, Blast_Score=322, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI17554702, Length=310, Percent_Identity=50.9677419354839, Blast_Score=320, Evalue=4e-88,
Organism=Caenorhabditis elegans, GI71989924, Length=310, Percent_Identity=50.9677419354839, Blast_Score=319, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI17554704, Length=308, Percent_Identity=50.974025974026, Blast_Score=319, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI17570245, Length=335, Percent_Identity=37.0149253731343, Blast_Score=213, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6321776, Length=310, Percent_Identity=49.3548387096774, Blast_Score=298, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6319403, Length=312, Percent_Identity=47.7564102564103, Blast_Score=285, Evalue=6e-78,
Organism=Saccharomyces cerevisiae, GI6320946, Length=311, Percent_Identity=46.6237942122186, Blast_Score=281, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6322667, Length=198, Percent_Identity=41.4141414141414, Blast_Score=161, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6324511, Length=109, Percent_Identity=48.6238532110092, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21355239, Length=311, Percent_Identity=53.6977491961415, Blast_Score=328, Evalue=4e-90,
Organism=Drosophila melanogaster, GI45551540, Length=334, Percent_Identity=50, Blast_Score=316, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24651458, Length=354, Percent_Identity=37.2881355932203, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24651456, Length=354, Percent_Identity=37.2881355932203, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI281362873, Length=354, Percent_Identity=37.2881355932203, Blast_Score=225, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24651454, Length=354, Percent_Identity=37.2881355932203, Blast_Score=225, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24651462, Length=373, Percent_Identity=35.3887399463807, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI24651464, Length=373, Percent_Identity=35.3887399463807, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI45552010, Length=373, Percent_Identity=35.3887399463807, Blast_Score=217, Evalue=7e-57,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33838; Mature: 33838

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQKIRVFSGNSNRSLAESICANLGLPLGKANVKTFSDGEVMVEIGENVRGRDTYVVQST
CCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCEEECCCCEEEEECCCCCCCCEEEEEEE
CAPTNNNLMELLIMMDALKRASAATITAVIPYYGYARQDRKVAPRTPITSKLVADLITTA
CCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
GADRVVTVDLHAGQIQGFFNIPVDNLYAAPVILEHLKQRFPENSIVMVSPDAGGTERARA
CCCEEEEEEECCCEECEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHH
FAKRLGCTLAVIDKRRTGPNVAEVMHLIGDVTDKTAIILDDMIDTAGTLTQAARALKEHG
HHHHHCCEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCC
AKTIYACATHGVLSGPAIERINNSDIEAVVITDTVPLGDKEQQTSKVKVLSVANLLAEAI
CCEEEEEHHCCCCCCHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
RRIHEDESVSSLFV
HHHCCCCCHHHHCC
>Mature Secondary Structure
MNQKIRVFSGNSNRSLAESICANLGLPLGKANVKTFSDGEVMVEIGENVRGRDTYVVQST
CCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCEEECCCCEEEEECCCCCCCCEEEEEEE
CAPTNNNLMELLIMMDALKRASAATITAVIPYYGYARQDRKVAPRTPITSKLVADLITTA
CCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
GADRVVTVDLHAGQIQGFFNIPVDNLYAAPVILEHLKQRFPENSIVMVSPDAGGTERARA
CCCEEEEEEECCCEECEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHH
FAKRLGCTLAVIDKRRTGPNVAEVMHLIGDVTDKTAIILDDMIDTAGTLTQAARALKEHG
HHHHHCCEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCC
AKTIYACATHGVLSGPAIERINNSDIEAVVITDTVPLGDKEQQTSKVKVLSVANLLAEAI
CCEEEEEHHCCCCCCHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
RRIHEDESVSSLFV
HHHCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA