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The map label for this gene is coaE

Identifier: 39995620

GI number: 39995620

Start: 547440

End: 548033

Strand: Direct

Name: coaE

Synonym: GSU0513

Alternate gene names: 39995620

Gene position: 547440-548033 (Clockwise)

Preceding gene: 39995619

Following gene: 39995622

Centisome position: 14.35

GC content: 63.97

Gene sequence:

>594_bases
ATGAACATAATCGGACTTACCGGTGGGATCGCTTCGGGGAAGAGTACGGTGTCGCGGATTCTTGAGCGGCTCGGAGCGGT
GGTGATTGATGCGGATCAGCTGGCCCGTGAGGCGGTCATGCCGGGTACGTCCGCCCATCGGTCCATCGTGGCGGCCTTCG
GCGAGGGGATTCTGCTGCCTGACGGTGCCATTGACCGGAAGGCTCTCGGCAGCATCATCTTCGCCGACTCCTCTGCCCGG
AAACGGCTGGAGGCGATAACACACCCGGCCATCAGGGACCTTGCCGAGCTGCGTCTTGCCGAGCTGCGCCGGTCCGGCGT
GCCGGTTGCCGTGTACATGGCTGCGCTCCTGATCGAAGCAGGCGCAACCGATCGGGTTGACGAGGTCTGGGTAGTGTATG
TGGACCGGGAAACTCAGGTCCGGCGTGTAATGGCGCGGGATGGTCTGAGCCGCTCGGAGGCCGAGCAGCGGCTGGCGGCC
CAGATGCCCATGGAGGAGAAGGCTGCGAGGGGGCAGGTGGTCATAGACAACAACGGCACACCTGAAGAGTTGGAGCGACG
GATCGAGGAGATCTGGGCGAAGCGCTTCCCATGA

Upstream 100 bases:

>100_bases
CAAGCGGTGCATTGCGGCTTCCGCCGTTCTCCCCCTGATTGCCGTTGACACCGGCAACCGACTGTGAAATGGTTCCTGAC
CAGGGAGGTTTGGATAAGCC

Downstream 100 bases:

>100_bases
AAAAAGCCCCCGGTAGACGGGGGCTTTTCTGTTACCGATGAAAGCCGAGCTTCATGGATATCTCGTCGGCAGCCTTTTTG
ACAAGCGGTATCAACTCTTT

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MNIIGLTGGIASGKSTVSRILERLGAVVIDADQLAREAVMPGTSAHRSIVAAFGEGILLPDGAIDRKALGSIIFADSSAR
KRLEAITHPAIRDLAELRLAELRRSGVPVAVYMAALLIEAGATDRVDEVWVVYVDRETQVRRVMARDGLSRSEAEQRLAA
QMPMEEKAARGQVVIDNNGTPEELERRIEEIWAKRFP

Sequences:

>Translated_197_residues
MNIIGLTGGIASGKSTVSRILERLGAVVIDADQLAREAVMPGTSAHRSIVAAFGEGILLPDGAIDRKALGSIIFADSSAR
KRLEAITHPAIRDLAELRLAELRRSGVPVAVYMAALLIEAGATDRVDEVWVVYVDRETQVRRVMARDGLSRSEAEQRLAA
QMPMEEKAARGQVVIDNNGTPEELERRIEEIWAKRFP
>Mature_197_residues
MNIIGLTGGIASGKSTVSRILERLGAVVIDADQLAREAVMPGTSAHRSIVAAFGEGILLPDGAIDRKALGSIIFADSSAR
KRLEAITHPAIRDLAELRLAELRRSGVPVAVYMAALLIEAGATDRVDEVWVVYVDRETQVRRVMARDGLSRSEAEQRLAA
QMPMEEKAARGQVVIDNNGTPEELERRIEEIWAKRFP

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=203, Percent_Identity=40.8866995073892, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI191252795, Length=203, Percent_Identity=40.8866995073892, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI110227607, Length=200, Percent_Identity=40, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI110227605, Length=200, Percent_Identity=40, Blast_Score=134, Evalue=7e-32,
Organism=Homo sapiens, GI110227603, Length=200, Percent_Identity=40, Blast_Score=134, Evalue=7e-32,
Organism=Homo sapiens, GI110227601, Length=200, Percent_Identity=40, Blast_Score=134, Evalue=7e-32,
Organism=Homo sapiens, GI205277394, Length=200, Percent_Identity=40, Blast_Score=133, Evalue=8e-32,
Organism=Escherichia coli, GI1786292, Length=194, Percent_Identity=37.6288659793814, Blast_Score=121, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17554944, Length=193, Percent_Identity=40.4145077720207, Blast_Score=152, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI25143409, Length=194, Percent_Identity=35.0515463917526, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320402, Length=203, Percent_Identity=39.4088669950739, Blast_Score=123, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24644728, Length=186, Percent_Identity=43.010752688172, Blast_Score=153, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24658602, Length=192, Percent_Identity=40.625, Blast_Score=131, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_GEOSL (Q74FU2)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_951571.1
- ProteinModelPortal:   Q74FU2
- SMR:   Q74FU2
- GeneID:   2687132
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU0513
- NMPDR:   fig|243231.1.peg.509
- TIGR:   GSU0513
- HOGENOM:   HBG650290
- OMA:   VVVYCDP
- ProtClustDB:   CLSK827890
- BioCyc:   GSUL243231:GSU_0513-MONOMER
- BRENDA:   2.7.1.24
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 21481; Mature: 21481

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS51219 DPCK; PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIIGLTGGIASGKSTVSRILERLGAVVIDADQLAREAVMPGTSAHRSIVAAFGEGILLP
CCEEECCCCCCCCHHHHHHHHHHHCCEEECHHHHHHHHHCCCCHHHHHHHHHHCCCEECC
DGAIDRKALGSIIFADSSARKRLEAITHPAIRDLAELRLAELRRSGVPVAVYMAALLIEA
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
GATDRVDEVWVVYVDRETQVRRVMARDGLSRSEAEQRLAAQMPMEEKAARGQVVIDNNGT
CCCCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHCCCCEEECCCCC
PEELERRIEEIWAKRFP
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNIIGLTGGIASGKSTVSRILERLGAVVIDADQLAREAVMPGTSAHRSIVAAFGEGILLP
CCEEECCCCCCCCHHHHHHHHHHHCCEEECHHHHHHHHHCCCCHHHHHHHHHHCCCEECC
DGAIDRKALGSIIFADSSARKRLEAITHPAIRDLAELRLAELRRSGVPVAVYMAALLIEA
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
GATDRVDEVWVVYVDRETQVRRVMARDGLSRSEAEQRLAAQMPMEEKAARGQVVIDNNGT
CCCCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHCCCCEEECCCCC
PEELERRIEEIWAKRFP
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA