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The map label for this gene is typA [H]

Identifier: 39995607

GI number: 39995607

Start: 533056

End: 534852

Strand: Direct

Name: typA [H]

Synonym: GSU0500

Alternate gene names: 39995607

Gene position: 533056-534852 (Clockwise)

Preceding gene: 39995605

Following gene: 39995608

Centisome position: 13.98

GC content: 60.82

Gene sequence:

>1797_bases
ATGCAGGAGAGAATCAGAAACATCGCCATCATTGCCCACGTTGACCACGGCAAGACCACTCTCGTGGATGCCATGCTCAA
GCACGCCGGAGTGTTCCGGGAAAACGAAGCCATCACCGAGCGGGTCATGGATTCCAACGACCTGGAGAAGGAGCGGGGCA
TCACCATCCTGGCAAAAAACCTGTCGGTCCACCATGGCCGCTACAAGATCAACATTGTCGATACCCCGGGCCACGCCGAC
TTCGGCGGCGAGGTGGAGCGGGTGCTCAAGATGGTCGATTCGGTGCTGCTTCTGGTCGATGCCCTGGACGGCCCCATGCC
CCAGACCCGCTTCGTGCTCAAGAAGTCCCTCGACCTCGGTCTGAAGCCGATCGTGGTCATCAATAAGATTGACCGCCCCG
GTTCACGCCCCGACGAGGTGGTGGACATGGTTTTCGACCTGTTTTGCGAACTGAACGCGACCGATGAGCAGCTCGACTTC
CCCATCGTCTATACCAGTGCCAAGCTCGGATTCGCCAAACTCGACCTCAATTCCGACTCTAACAGCATGGAGCCCCTCTT
CGCGGTAATCGAGAGTAACGTCCATCCGCCGGCCGGCGATTCGAAGGCCCCGTTCCAGCTCCTCGTGACCAATATCGACT
ACAACGACTACATCGGCCGGATCGCCACCGGCAGGATATTCAACGGCCGGGTGAAGGCCGGCGAGACCGTGGCGCTCGTG
CGGCGCGACGGGAGCATCGAGCGGGGACGCATCACCAAGCTCCTGGGATACGAGGGGCTCAAGCAGGTGGAGATCCCCGA
GGCGTGTACCGGCGACATCGTTACCGTGGCCGGTTTTGACGACGTGGGCATCGGCGAGACGCTGGCCGCTGCAGACAATC
CGGTGGCGCTTCCCTATGTGTCGATCGACGAGCCGACCATTTCAATGAACTTCATTGTCAATTCCTCCCCCTTTGCCGGC
CGTGAGGGGAAGTTCGTCACCTCCCGCAACATCCGGGAGCGCCTTGACCGGGAGTTGCGCACCAACGTGTCGCTACGGGT
GGAGGATACGGCCAACGCGGACACGTTCAAGGTTTCCGGCAGGGGCGAGCTTCACCTGTCCATCCTTATCGAGAACATGC
GGCGCGAAGGATTCGAGATGGCGGTTTCCAAGCCGGAGGTCATCTTGCGGGTGATCGACGGCACGAAGATGGAGCCGATG
GAGTACCTGGTGGTGGACGTTCCCTCCGAGTTCCAGGGTGCCATCATCGAGAAGATGGGACCTCGCAAGGGGGAGATGAC
CTCCCTGCAGCCCATGGGCGAGACAGTGCGGCTGGAGTTTGTCGTGCCGGCCCGGGGGCTCATCGGGCTGCGGGGAGAAC
TCCTCACCGAGACGCGGGGCACTGCGGTCATGACCCACACCTTCCACGACTATGCCCCTTACAAGGGTGATATCCCGGGG
CGCAAGAACGGCGTCCTCATTGCCATGGAACTCGGCGAAACCACTGCCTATGCCCTCGACGCACTCCAGCCCCGGGGAAT
CCTCTTCATCGGTCCCGGTGTGGAAGTCTACGGGGGGATGATCATCGGCCAGCACGCCAAGGACAACGATCTGGACGTGA
ACCCCTGCAAGGGAAAGAAACTTACCAATGTCCGTGCCTCCGGTTCGGACGACGCCATCAAGCTCACCCCGCCGCGCATC
CTTACCCTGGAGCAGGCCCTGGAGTTCATTGACGACGACGAACTGGTAGAAGTGACCCCGCAGTCCATCAGGCTCAGAAA
GAAAGAACTCGACCCGAACAAGCGGAAACGGAAGTGA

Upstream 100 bases:

>100_bases
GTCATAGTGACCATACTTTGAAGACGGGCGTCACGCTCGTCTTTTGTTTTTTACCGGTCCGCGCACAGCGGCCGTACCCT
TCAGTCAGGAGTCGCGTTTC

Downstream 100 bases:

>100_bases
AAGGAGACGCTTCACCGGTGTGTAAAGTTCCCCCGGCTCCGGCTAGGGAACTTTACTTGACTTTGCCGGGTGATTTTTCT
ACTTTCATCAGTGATATCCG

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MQERIRNIAIIAHVDHGKTTLVDAMLKHAGVFRENEAITERVMDSNDLEKERGITILAKNLSVHHGRYKINIVDTPGHAD
FGGEVERVLKMVDSVLLLVDALDGPMPQTRFVLKKSLDLGLKPIVVINKIDRPGSRPDEVVDMVFDLFCELNATDEQLDF
PIVYTSAKLGFAKLDLNSDSNSMEPLFAVIESNVHPPAGDSKAPFQLLVTNIDYNDYIGRIATGRIFNGRVKAGETVALV
RRDGSIERGRITKLLGYEGLKQVEIPEACTGDIVTVAGFDDVGIGETLAAADNPVALPYVSIDEPTISMNFIVNSSPFAG
REGKFVTSRNIRERLDRELRTNVSLRVEDTANADTFKVSGRGELHLSILIENMRREGFEMAVSKPEVILRVIDGTKMEPM
EYLVVDVPSEFQGAIIEKMGPRKGEMTSLQPMGETVRLEFVVPARGLIGLRGELLTETRGTAVMTHTFHDYAPYKGDIPG
RKNGVLIAMELGETTAYALDALQPRGILFIGPGVEVYGGMIIGQHAKDNDLDVNPCKGKKLTNVRASGSDDAIKLTPPRI
LTLEQALEFIDDDELVEVTPQSIRLRKKELDPNKRKRK

Sequences:

>Translated_598_residues
MQERIRNIAIIAHVDHGKTTLVDAMLKHAGVFRENEAITERVMDSNDLEKERGITILAKNLSVHHGRYKINIVDTPGHAD
FGGEVERVLKMVDSVLLLVDALDGPMPQTRFVLKKSLDLGLKPIVVINKIDRPGSRPDEVVDMVFDLFCELNATDEQLDF
PIVYTSAKLGFAKLDLNSDSNSMEPLFAVIESNVHPPAGDSKAPFQLLVTNIDYNDYIGRIATGRIFNGRVKAGETVALV
RRDGSIERGRITKLLGYEGLKQVEIPEACTGDIVTVAGFDDVGIGETLAAADNPVALPYVSIDEPTISMNFIVNSSPFAG
REGKFVTSRNIRERLDRELRTNVSLRVEDTANADTFKVSGRGELHLSILIENMRREGFEMAVSKPEVILRVIDGTKMEPM
EYLVVDVPSEFQGAIIEKMGPRKGEMTSLQPMGETVRLEFVVPARGLIGLRGELLTETRGTAVMTHTFHDYAPYKGDIPG
RKNGVLIAMELGETTAYALDALQPRGILFIGPGVEVYGGMIIGQHAKDNDLDVNPCKGKKLTNVRASGSDDAIKLTPPRI
LTLEQALEFIDDDELVEVTPQSIRLRKKELDPNKRKRK
>Mature_598_residues
MQERIRNIAIIAHVDHGKTTLVDAMLKHAGVFRENEAITERVMDSNDLEKERGITILAKNLSVHHGRYKINIVDTPGHAD
FGGEVERVLKMVDSVLLLVDALDGPMPQTRFVLKKSLDLGLKPIVVINKIDRPGSRPDEVVDMVFDLFCELNATDEQLDF
PIVYTSAKLGFAKLDLNSDSNSMEPLFAVIESNVHPPAGDSKAPFQLLVTNIDYNDYIGRIATGRIFNGRVKAGETVALV
RRDGSIERGRITKLLGYEGLKQVEIPEACTGDIVTVAGFDDVGIGETLAAADNPVALPYVSIDEPTISMNFIVNSSPFAG
REGKFVTSRNIRERLDRELRTNVSLRVEDTANADTFKVSGRGELHLSILIENMRREGFEMAVSKPEVILRVIDGTKMEPM
EYLVVDVPSEFQGAIIEKMGPRKGEMTSLQPMGETVRLEFVVPARGLIGLRGELLTETRGTAVMTHTFHDYAPYKGDIPG
RKNGVLIAMELGETTAYALDALQPRGILFIGPGVEVYGGMIIGQHAKDNDLDVNPCKGKKLTNVRASGSDDAIKLTPPRI
LTLEQALEFIDDDELVEVTPQSIRLRKKELDPNKRKRK

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=304, Percent_Identity=33.2236842105263, Blast_Score=129, Evalue=9e-30,
Organism=Homo sapiens, GI94966754, Length=132, Percent_Identity=43.1818181818182, Blast_Score=124, Evalue=4e-28,
Organism=Homo sapiens, GI4503483, Length=144, Percent_Identity=36.1111111111111, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI18390331, Length=140, Percent_Identity=40.7142857142857, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI310132016, Length=110, Percent_Identity=40.9090909090909, Blast_Score=97, Evalue=6e-20,
Organism=Homo sapiens, GI310110807, Length=110, Percent_Identity=40.9090909090909, Blast_Score=97, Evalue=6e-20,
Organism=Homo sapiens, GI310123363, Length=110, Percent_Identity=40.9090909090909, Blast_Score=97, Evalue=6e-20,
Organism=Homo sapiens, GI25306287, Length=161, Percent_Identity=33.5403726708075, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI19923640, Length=161, Percent_Identity=33.5403726708075, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI25306283, Length=161, Percent_Identity=33.5403726708075, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI34147630, Length=250, Percent_Identity=30.4, Blast_Score=90, Evalue=8e-18,
Organism=Homo sapiens, GI94966752, Length=83, Percent_Identity=43.3734939759036, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI217272892, Length=140, Percent_Identity=35, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI217272894, Length=140, Percent_Identity=34.2857142857143, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI53729339, Length=152, Percent_Identity=33.5526315789474, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI53729337, Length=152, Percent_Identity=33.5526315789474, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI48994988, Length=599, Percent_Identity=58.0968280467446, Blast_Score=697, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=506, Percent_Identity=28.0632411067194, Blast_Score=149, Evalue=6e-37,
Organism=Escherichia coli, GI1789738, Length=153, Percent_Identity=35.9477124183007, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1790412, Length=242, Percent_Identity=30.5785123966942, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1789737, Length=240, Percent_Identity=30.8333333333333, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1790835, Length=145, Percent_Identity=31.7241379310345, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789559, Length=165, Percent_Identity=31.5151515151515, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17557151, Length=477, Percent_Identity=27.4633123689727, Blast_Score=126, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI71988811, Length=130, Percent_Identity=41.5384615384615, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71988819, Length=130, Percent_Identity=41.5384615384615, Blast_Score=107, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17556745, Length=143, Percent_Identity=37.0629370629371, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17533571, Length=165, Percent_Identity=37.5757575757576, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17506493, Length=159, Percent_Identity=32.7044025157233, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17556456, Length=260, Percent_Identity=28.8461538461538, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17552882, Length=135, Percent_Identity=34.0740740740741, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994658, Length=130, Percent_Identity=36.1538461538462, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323320, Length=509, Percent_Identity=28.8801571709234, Blast_Score=141, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6324707, Length=144, Percent_Identity=38.8888888888889, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320593, Length=144, Percent_Identity=38.8888888888889, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322359, Length=149, Percent_Identity=39.5973154362416, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323098, Length=150, Percent_Identity=36, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324166, Length=142, Percent_Identity=38.0281690140845, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324761, Length=270, Percent_Identity=29.2592592592593, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324550, Length=251, Percent_Identity=28.2868525896414, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI78706572, Length=523, Percent_Identity=26.9598470363289, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28574573, Length=140, Percent_Identity=38.5714285714286, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24582462, Length=147, Percent_Identity=40.1360544217687, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24585709, Length=151, Percent_Identity=35.0993377483444, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24585711, Length=151, Percent_Identity=35.0993377483444, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24585713, Length=151, Percent_Identity=35.0993377483444, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI281363316, Length=268, Percent_Identity=29.4776119402985, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17864358, Length=268, Percent_Identity=29.4776119402985, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21357743, Length=134, Percent_Identity=38.0597014925373, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI221458488, Length=164, Percent_Identity=37.1951219512195, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19921738, Length=231, Percent_Identity=30.7359307359307, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 66032; Mature: 66032

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQERIRNIAIIAHVDHGKTTLVDAMLKHAGVFRENEAITERVMDSNDLEKERGITILAKN
CCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHCCEEEEEEC
LSVHHGRYKINIVDTPGHADFGGEVERVLKMVDSVLLLVDALDGPMPQTRFVLKKSLDLG
CEEECCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
LKPIVVINKIDRPGSRPDEVVDMVFDLFCELNATDEQLDFPIVYTSAKLGFAKLDLNSDS
CCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEECCCCC
NSMEPLFAVIESNVHPPAGDSKAPFQLLVTNIDYNDYIGRIATGRIFNGRVKAGETVALV
CCCCHHHHHHHCCCCCCCCCCCCCEEEEEEECCCHHHHCCEEECEEECCEECCCCEEEEE
RRDGSIERGRITKLLGYEGLKQVEIPEACTGDIVTVAGFDDVGIGETLAAADNPVALPYV
ECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHCCCCCEEEEEE
SIDEPTISMNFIVNSSPFAGREGKFVTSRNIRERLDRELRTNVSLRVEDTANADTFKVSG
ECCCCEEEEEEEEECCCCCCCCCCEEECCHHHHHHHHHHHCCEEEEEECCCCCCEEEECC
RGELHLSILIENMRREGFEMAVSKPEVILRVIDGTKMEPMEYLVVDVPSEFQGAIIEKMG
CCCEEEEEEEHHHHHCCHHEECCCCEEEEEEECCCCCCCEEEEEEECCCHHHHHHHHHCC
PRKGEMTSLQPMGETVRLEFVVPARGLIGLRGELLTETRGTAVMTHTFHDYAPYKGDIPG
CCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHEECCCCCEEEEEECCCCCCCCCCCCC
RKNGVLIAMELGETTAYALDALQPRGILFIGPGVEVYGGMIIGQHAKDNDLDVNPCKGKK
CCCCEEEEEECCCCHHHHHHCCCCCCEEEECCCHHHHCCEEEECCCCCCCCCCCCCCCCE
LTNVRASGSDDAIKLTPPRILTLEQALEFIDDDELVEVTPQSIRLRKKELDPNKRKRK
EEEEECCCCCCEEEECCCCEEEHHHHHHHCCCCCEEEECCHHHHHHHHHCCCCHHCCC
>Mature Secondary Structure
MQERIRNIAIIAHVDHGKTTLVDAMLKHAGVFRENEAITERVMDSNDLEKERGITILAKN
CCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHCCEEEEEEC
LSVHHGRYKINIVDTPGHADFGGEVERVLKMVDSVLLLVDALDGPMPQTRFVLKKSLDLG
CEEECCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
LKPIVVINKIDRPGSRPDEVVDMVFDLFCELNATDEQLDFPIVYTSAKLGFAKLDLNSDS
CCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEECCCCC
NSMEPLFAVIESNVHPPAGDSKAPFQLLVTNIDYNDYIGRIATGRIFNGRVKAGETVALV
CCCCHHHHHHHCCCCCCCCCCCCCEEEEEEECCCHHHHCCEEECEEECCEECCCCEEEEE
RRDGSIERGRITKLLGYEGLKQVEIPEACTGDIVTVAGFDDVGIGETLAAADNPVALPYV
ECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHCCCCCEEEEEE
SIDEPTISMNFIVNSSPFAGREGKFVTSRNIRERLDRELRTNVSLRVEDTANADTFKVSG
ECCCCEEEEEEEEECCCCCCCCCCEEECCHHHHHHHHHHHCCEEEEEECCCCCCEEEECC
RGELHLSILIENMRREGFEMAVSKPEVILRVIDGTKMEPMEYLVVDVPSEFQGAIIEKMG
CCCEEEEEEEHHHHHCCHHEECCCCEEEEEEECCCCCCCEEEEEEECCCHHHHHHHHHCC
PRKGEMTSLQPMGETVRLEFVVPARGLIGLRGELLTETRGTAVMTHTFHDYAPYKGDIPG
CCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHEECCCCCEEEEEECCCCCCCCCCCCC
RKNGVLIAMELGETTAYALDALQPRGILFIGPGVEVYGGMIIGQHAKDNDLDVNPCKGKK
CCCCEEEEEECCCCHHHHHHCCCCCCEEEECCCHHHHCCEEEECCCCCCCCCCCCCCCCE
LTNVRASGSDDAIKLTPPRILTLEQALEFIDDDELVEVTPQSIRLRKKELDPNKRKRK
EEEEECCCCCCEEEECCCCEEEHHHHHHHCCCCCEEEECCHHHHHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]