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The map label for this gene is nuoL-1 [H]

Identifier: 39995458

GI number: 39995458

Start: 377757

End: 379757

Strand: Direct

Name: nuoL-1 [H]

Synonym: GSU0349

Alternate gene names: 39995458

Gene position: 377757-379757 (Clockwise)

Preceding gene: 39995457

Following gene: 39995459

Centisome position: 9.9

GC content: 51.17

Gene sequence:

>2001_bases
ATGTTCGAGTACGTATGGCTGATACCCCTGTTTCCCCTGATCGGTGTCATTATTAATGGCCTATTTGGGAAATCAATCAA
GAACGAGAAGGTCATTGGTGGCATTGGCGCACTGATGGTGTTCTGTTCATTTCTCGTGTCGTGCGGAATTCTCATTCAGT
TGCTTTCACTCCCTGTGGAGGAGAGGTTCTTTGAGAAGTCCCTCTTCACATGGATCGCTGCCGGTACATTTAAGACTGAC
ATTGGTTTCCTCATCGACCCGCTCTCGACACTTATGATCATGGTGGTAACCGGTGTCGGTTTCCTGATTCACGTTTACTC
CATAGGCTACATGCACGGCGAAGAAGGGTTTTACCGGTACTTTACTTACCTGAACCTCTTCACGTTCTCCATGCTTTTGC
TGGTCCTGGGCAGTAACCTGCTCCTGATGTTTGTCGGTTGGGAAGGTGTCGGTCTCTGTTCCTATCTGCTCATCGGTTAC
TACTTCCATAAAAAATCCGCTGGTGATGCTGGCAAAAAAGCATTCGTGATGAACCGGGTCGGTGATTTTGGCTTCCTTCT
CGGTACATTTACGCTGTTCTGGTATCTTGGCCAGAACCATAATGTATGGACCATCAACTTCCGTGAGCTTTCCGCTAATG
CACACTTGCTGCCCGTAGGTGGGATAGTTACGGTAATCACGCTCTGCTTCTTCCTGGGAGCCACCGGCAAATCTGCACAG
ATACCCCTCTATACATGGCTTCCCGACGCCATGGAGGGTCCCACACCCGTATCAGCCCTCATCCATGCCGCAACAATGGT
TACTGCGGGTGTGTACATGATTGGCCGCCTGAATTTCGTGTACATCAGATCGCATGAAACAATGATGATTGTTGCAATTA
TCGGTGCGGCAACCGCGATTTTCGCCGCGACCATCGGTACGGCTCAGAATGATATCAAGCGAGTTCTGGCATACTCCACG
GTTTCTCAGCTCGGGTTCATGTTCCTTGCAATGGGCGTTGGTGCATTCACTGCAGGTATCTTCCACCTCATGACCCACGC
CTTTTTCAAGGCATGTCTGTTCCTTGGTTCCGGTTCGGTTATCCATGCAATGCACCATGCACTCCATCATGCGCACTCTC
ATGATGACCCGCAAGACATGCGCAACATGGGCGGTCTGCGCAAGGCCATGCCGATTACCTTCCTGACATTCCTTGCTTCA
ACCATTGCTATTGCAGGTATTCCCGGCTTCTCCGGCTTCTTCTCAAAGGACGAGATTCTCTGGCAAGCGTTTGCCAACCC
CCTGCATGGCAGTCTCAATATGATTCTGTGGGGTACTGGTGCCGTTGCCGCAGGGTTCACAGCCTTCTACATGTTCCGCT
TGGTGTTCATGACGTTCACTGGCGAGTGCCGGATTAACCCGAAGGCCAAGGATCATCTCCATGAGTCACCCTTTGTTATA
ACGTTCCCTCTTATTGTCCTTGGCATACTCGCCGTAGTTGGAGGCTATGTGGGGATGCCCAAGGTTCTGGGCATGCTGCC
CAACTACCTTGAGCACTATCTTGAGCCTGTCTTTGTTGGGTCCCACGAGTTCATGCAGCAGCAGCTGCAAGGGCATGGTG
AAGCACATCACAGCCACGCACTTGAGTTTGGACTCATGGGACTGTCGGTACTCATTGCACTGGTGGGTATATCGATTGCC
TATGTCCTCTATGTGATGTCTCCGTCACTGCCCGCAAAGTTTACAGCCGCGTTCCCGGCGCTCCACAGGGCTGTATACAA
TAAGTGGTACGTGGATGAGCTCTATGATTTCCTCTTCGTTAATCCGTGCAAGGCTCTCGGCAATTTCCTGTGGAAAGGAT
TCGACGTTGTAGTCGTCGATGGTATGGTCAATGGAGTTGCCGCTGTTGTGAAAGGATTCGGGAGTGTTCTTCGGAACACC
CAGACCGGTTACGTGCACAACTATGCCTTCTCCATGGCTGTTGGCGTGGTGGTGATCGTAGCGTTTTACCTCTTCCGCTA
A

Upstream 100 bases:

>100_bases
ACCGTGAGTCCATAGACGTAGAAGATGTCAAGCTCATGAAGCTGTAGCCGAGAGAGCAGATATAAGAATTCTGAATTTCT
CGCTATAAAAGGAGTCAGGA

Downstream 100 bases:

>100_bases
CAAAGTATTACTAGGACTAAAGGAGCAGAGTTCATGAGCCAGTTTCCGTTAATCAGCGTGATGACCTTTCTTCCACTCCT
GGGGGTCGTACTGCTCTTCT

Product: NADH dehydrogenase I subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 666; Mature: 666

Protein sequence:

>666_residues
MFEYVWLIPLFPLIGVIINGLFGKSIKNEKVIGGIGALMVFCSFLVSCGILIQLLSLPVEERFFEKSLFTWIAAGTFKTD
IGFLIDPLSTLMIMVVTGVGFLIHVYSIGYMHGEEGFYRYFTYLNLFTFSMLLLVLGSNLLLMFVGWEGVGLCSYLLIGY
YFHKKSAGDAGKKAFVMNRVGDFGFLLGTFTLFWYLGQNHNVWTINFRELSANAHLLPVGGIVTVITLCFFLGATGKSAQ
IPLYTWLPDAMEGPTPVSALIHAATMVTAGVYMIGRLNFVYIRSHETMMIVAIIGAATAIFAATIGTAQNDIKRVLAYST
VSQLGFMFLAMGVGAFTAGIFHLMTHAFFKACLFLGSGSVIHAMHHALHHAHSHDDPQDMRNMGGLRKAMPITFLTFLAS
TIAIAGIPGFSGFFSKDEILWQAFANPLHGSLNMILWGTGAVAAGFTAFYMFRLVFMTFTGECRINPKAKDHLHESPFVI
TFPLIVLGILAVVGGYVGMPKVLGMLPNYLEHYLEPVFVGSHEFMQQQLQGHGEAHHSHALEFGLMGLSVLIALVGISIA
YVLYVMSPSLPAKFTAAFPALHRAVYNKWYVDELYDFLFVNPCKALGNFLWKGFDVVVVDGMVNGVAAVVKGFGSVLRNT
QTGYVHNYAFSMAVGVVVIVAFYLFR

Sequences:

>Translated_666_residues
MFEYVWLIPLFPLIGVIINGLFGKSIKNEKVIGGIGALMVFCSFLVSCGILIQLLSLPVEERFFEKSLFTWIAAGTFKTD
IGFLIDPLSTLMIMVVTGVGFLIHVYSIGYMHGEEGFYRYFTYLNLFTFSMLLLVLGSNLLLMFVGWEGVGLCSYLLIGY
YFHKKSAGDAGKKAFVMNRVGDFGFLLGTFTLFWYLGQNHNVWTINFRELSANAHLLPVGGIVTVITLCFFLGATGKSAQ
IPLYTWLPDAMEGPTPVSALIHAATMVTAGVYMIGRLNFVYIRSHETMMIVAIIGAATAIFAATIGTAQNDIKRVLAYST
VSQLGFMFLAMGVGAFTAGIFHLMTHAFFKACLFLGSGSVIHAMHHALHHAHSHDDPQDMRNMGGLRKAMPITFLTFLAS
TIAIAGIPGFSGFFSKDEILWQAFANPLHGSLNMILWGTGAVAAGFTAFYMFRLVFMTFTGECRINPKAKDHLHESPFVI
TFPLIVLGILAVVGGYVGMPKVLGMLPNYLEHYLEPVFVGSHEFMQQQLQGHGEAHHSHALEFGLMGLSVLIALVGISIA
YVLYVMSPSLPAKFTAAFPALHRAVYNKWYVDELYDFLFVNPCKALGNFLWKGFDVVVVDGMVNGVAAVVKGFGSVLRNT
QTGYVHNYAFSMAVGVVVIVAFYLFR
>Mature_666_residues
MFEYVWLIPLFPLIGVIINGLFGKSIKNEKVIGGIGALMVFCSFLVSCGILIQLLSLPVEERFFEKSLFTWIAAGTFKTD
IGFLIDPLSTLMIMVVTGVGFLIHVYSIGYMHGEEGFYRYFTYLNLFTFSMLLLVLGSNLLLMFVGWEGVGLCSYLLIGY
YFHKKSAGDAGKKAFVMNRVGDFGFLLGTFTLFWYLGQNHNVWTINFRELSANAHLLPVGGIVTVITLCFFLGATGKSAQ
IPLYTWLPDAMEGPTPVSALIHAATMVTAGVYMIGRLNFVYIRSHETMMIVAIIGAATAIFAATIGTAQNDIKRVLAYST
VSQLGFMFLAMGVGAFTAGIFHLMTHAFFKACLFLGSGSVIHAMHHALHHAHSHDDPQDMRNMGGLRKAMPITFLTFLAS
TIAIAGIPGFSGFFSKDEILWQAFANPLHGSLNMILWGTGAVAAGFTAFYMFRLVFMTFTGECRINPKAKDHLHESPFVI
TFPLIVLGILAVVGGYVGMPKVLGMLPNYLEHYLEPVFVGSHEFMQQQLQGHGEAHHSHALEFGLMGLSVLIALVGISIA
YVLYVMSPSLPAKFTAAFPALHRAVYNKWYVDELYDFLFVNPCKALGNFLWKGFDVVVVDGMVNGVAAVVKGFGSVLRNT
QTGYVHNYAFSMAVGVVVIVAFYLFR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=476, Percent_Identity=34.453781512605, Blast_Score=258, Evalue=1e-68,
Organism=Escherichia coli, GI1788614, Length=653, Percent_Identity=41.6539050535988, Blast_Score=407, Evalue=1e-114,
Organism=Escherichia coli, GI1788829, Length=360, Percent_Identity=34.1666666666667, Blast_Score=171, Evalue=2e-43,
Organism=Escherichia coli, GI1788831, Length=355, Percent_Identity=30.4225352112676, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1788827, Length=445, Percent_Identity=27.6404494382022, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI2367154, Length=460, Percent_Identity=25, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1788613, Length=385, Percent_Identity=26.7532467532467, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI145693160, Length=320, Percent_Identity=26.5625, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 73250; Mature: 73250

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEYVWLIPLFPLIGVIINGLFGKSIKNEKVIGGIGALMVFCSFLVSCGILIQLLSLPVE
CCCEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ERFFEKSLFTWIAAGTFKTDIGFLIDPLSTLMIMVVTGVGFLIHVYSIGYMHGEEGFYRY
HHHHHHHHHHHHHCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCHHHHH
FTYLNLFTFSMLLLVLGSNLLLMFVGWEGVGLCSYLLIGYYFHKKSAGDAGKKAFVMNRV
HHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHC
GDFGFLLGTFTLFWYLGQNHNVWTINFRELSANAHLLPVGGIVTVITLCFFLGATGKSAQ
CHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCEEEECCHHHHHHHHHHHHCCCCCCCC
IPLYTWLPDAMEGPTPVSALIHAATMVTAGVYMIGRLNFVYIRSHETMMIVAIIGAATAI
CCEEEECCHHCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEHHHHHHHHHH
FAATIGTAQNDIKRVLAYSTVSQLGFMFLAMGVGAFTAGIFHLMTHAFFKACLFLGSGSV
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
IHAMHHALHHAHSHDDPQDMRNMGGLRKAMPITFLTFLASTIAIAGIPGFSGFFSKDEIL
HHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
WQAFANPLHGSLNMILWGTGAVAAGFTAFYMFRLVFMTFTGECRINPKAKDHLHESPFVI
HHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHCCCCCCEE
TFPLIVLGILAVVGGYVGMPKVLGMLPNYLEHYLEPVFVGSHEFMQQQLQGHGEAHHSHA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHCCCCHHHHHH
LEFGLMGLSVLIALVGISIAYVLYVMSPSLPAKFTAAFPALHRAVYNKWYVDELYDFLFV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NPCKALGNFLWKGFDVVVVDGMVNGVAAVVKGFGSVLRNTQTGYVHNYAFSMAVGVVVIV
CHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
AFYLFR
HHHHCC
>Mature Secondary Structure
MFEYVWLIPLFPLIGVIINGLFGKSIKNEKVIGGIGALMVFCSFLVSCGILIQLLSLPVE
CCCEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ERFFEKSLFTWIAAGTFKTDIGFLIDPLSTLMIMVVTGVGFLIHVYSIGYMHGEEGFYRY
HHHHHHHHHHHHHCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCHHHHH
FTYLNLFTFSMLLLVLGSNLLLMFVGWEGVGLCSYLLIGYYFHKKSAGDAGKKAFVMNRV
HHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHC
GDFGFLLGTFTLFWYLGQNHNVWTINFRELSANAHLLPVGGIVTVITLCFFLGATGKSAQ
CHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCEEEECCHHHHHHHHHHHHCCCCCCCC
IPLYTWLPDAMEGPTPVSALIHAATMVTAGVYMIGRLNFVYIRSHETMMIVAIIGAATAI
CCEEEECCHHCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEHHHHHHHHHH
FAATIGTAQNDIKRVLAYSTVSQLGFMFLAMGVGAFTAGIFHLMTHAFFKACLFLGSGSV
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
IHAMHHALHHAHSHDDPQDMRNMGGLRKAMPITFLTFLASTIAIAGIPGFSGFFSKDEIL
HHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
WQAFANPLHGSLNMILWGTGAVAAGFTAFYMFRLVFMTFTGECRINPKAKDHLHESPFVI
HHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHCCCCCCEE
TFPLIVLGILAVVGGYVGMPKVLGMLPNYLEHYLEPVFVGSHEFMQQQLQGHGEAHHSHA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHCCCCHHHHHH
LEFGLMGLSVLIALVGISIAYVLYVMSPSLPAKFTAAFPALHRAVYNKWYVDELYDFLFV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NPCKALGNFLWKGFDVVVVDGMVNGVAAVVKGFGSVLRNTQTGYVHNYAFSMAVGVVVIV
CHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
AFYLFR
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]