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The map label for this gene is atoC [H]

Identifier: 39995407

GI number: 39995407

Start: 327608

End: 328606

Strand: Direct

Name: atoC [H]

Synonym: GSU0298

Alternate gene names: 39995407

Gene position: 327608-328606 (Clockwise)

Preceding gene: 39995401

Following gene: 39995409

Centisome position: 8.59

GC content: 58.16

Gene sequence:

>999_bases
ATGGAGACACCGAGGCTGCTCATTGCCGATGATGACAAGAAAACTCGAGATTTTGTCACGGCGTTTCTGAAGTACAAGGG
GTACGATGTCGTCCAGGCCTTTGACGGTCAGGATGCCTTGGAAAAGCTCGAAGTCGAGGATGTCCACCTGGTTATTACCG
ACCTGATGATGCCACGGGTCAACGGCCTCGAATTCGTCAAGAAATTGAAGGCCATGCGTCCCGGCACGGTGGTCATCGCC
TACAGCGCCTTCGGCAACTACGAAATGACCTCAAACCTGCTCAAGGCGGGGGTCTTTTTCTATCTCGAAAAACCGTTCAA
CCTCGACGAGCTTGAAACCCACGTGAAGCGGGGCCTCGAGCACCAGTCGCTCCAGAGCCAGACCTACCGGAGCAAACCGG
CCCTCAAGAGCCGCTCCCTCATCCCCAACATCATCGGTGAAAGCCCCCGGATGCTCTCCCTTTTCGAGCTGATCGAGAAG
GTCGCCGAGTCCGACTCCACCGTGCTCATCCAGGGAGAATCGGGGACCGGCAAGGAGTTGGTCGCGCGGGCGGTCCATGA
CCTGAGCAACCGGAAAAACCGTAACTTCGTGCCGGTCAACTGTGCCGCCATTCCGGACGAGCTGCTGGAAAGCGAACTCT
TCGGCCATGTGAAGGGTTCGTTCACCGGAGCCATCGCCACCCGCATCGGCCGGTTCGAGATGGCTGACAAAGGGACCCTG
TTCCTCGACGAAATCGGCGATATGAAGCCCAACCTGCAAGTAAAGCTCCTGCGGGTGCTGCAGAACAGAGAACTGGAGCC
GGTGGGGGCAACCCGTTCCAAGAAGGTGGATGTGCGCATTATCGCCGCCACCAACCAGAACCTGGAAAAGCTCGTGGCGT
CCAAGCAGTTCCGGGAAGACCTCTTCTACCGGATCTCGGTCATCCCCATCTTCATCCCGCCCCTGAGGGATCGCAGGGAG
GACATCCCCCTTCTGGTCAACACCACTGCTGTCCCATAG

Upstream 100 bases:

>100_bases
GTCATTTTGTTGACCTTTGTCATAAATATGACTAATATGGGGTCCAGTCGACCGCGTAAGGGTTCGGGCCAAGCTCACGT
CATGCCGTCAAGGGGAGAAC

Downstream 100 bases:

>100_bases
TTTCTAAAGCAGCACCAGTTGTGGCGAAGCCTCTACTTTCGGTGGTTTGAATAGGCTTTCAAGGTCTCGCCGCTCGAACA
AATTCAGCTGTAATAACCGT

Product: sigma-54 dependent DNA-binding response regulator, interruption-C

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
METPRLLIADDDKKTRDFVTAFLKYKGYDVVQAFDGQDALEKLEVEDVHLVITDLMMPRVNGLEFVKKLKAMRPGTVVIA
YSAFGNYEMTSNLLKAGVFFYLEKPFNLDELETHVKRGLEHQSLQSQTYRSKPALKSRSLIPNIIGESPRMLSLFELIEK
VAESDSTVLIQGESGTGKELVARAVHDLSNRKNRNFVPVNCAAIPDELLESELFGHVKGSFTGAIATRIGRFEMADKGTL
FLDEIGDMKPNLQVKLLRVLQNRELEPVGATRSKKVDVRIIAATNQNLEKLVASKQFREDLFYRISVIPIFIPPLRDRRE
DIPLLVNTTAVP

Sequences:

>Translated_332_residues
METPRLLIADDDKKTRDFVTAFLKYKGYDVVQAFDGQDALEKLEVEDVHLVITDLMMPRVNGLEFVKKLKAMRPGTVVIA
YSAFGNYEMTSNLLKAGVFFYLEKPFNLDELETHVKRGLEHQSLQSQTYRSKPALKSRSLIPNIIGESPRMLSLFELIEK
VAESDSTVLIQGESGTGKELVARAVHDLSNRKNRNFVPVNCAAIPDELLESELFGHVKGSFTGAIATRIGRFEMADKGTL
FLDEIGDMKPNLQVKLLRVLQNRELEPVGATRSKKVDVRIIAATNQNLEKLVASKQFREDLFYRISVIPIFIPPLRDRRE
DIPLLVNTTAVP
>Mature_332_residues
METPRLLIADDDKKTRDFVTAFLKYKGYDVVQAFDGQDALEKLEVEDVHLVITDLMMPRVNGLEFVKKLKAMRPGTVVIA
YSAFGNYEMTSNLLKAGVFFYLEKPFNLDELETHVKRGLEHQSLQSQTYRSKPALKSRSLIPNIIGESPRMLSLFELIEK
VAESDSTVLIQGESGTGKELVARAVHDLSNRKNRNFVPVNCAAIPDELLESELFGHVKGSFTGAIATRIGRFEMADKGTL
FLDEIGDMKPNLQVKLLRVLQNRELEPVGATRSKKVDVRIIAATNQNLEKLVASKQFREDLFYRISVIPIFIPPLRDRRE
DIPLLVNTTAVP

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=325, Percent_Identity=46.1538461538462, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI1790437, Length=323, Percent_Identity=44.8916408668731, Blast_Score=274, Evalue=7e-75,
Organism=Escherichia coli, GI1788905, Length=322, Percent_Identity=45.0310559006211, Blast_Score=270, Evalue=9e-74,
Organism=Escherichia coli, GI1790299, Length=326, Percent_Identity=44.1717791411043, Blast_Score=264, Evalue=5e-72,
Organism=Escherichia coli, GI87082117, Length=205, Percent_Identity=58.5365853658537, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1789087, Length=182, Percent_Identity=62.6373626373626, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1789233, Length=208, Percent_Identity=55.2884615384615, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI87082152, Length=185, Percent_Identity=56.7567567567568, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1786524, Length=210, Percent_Identity=45.7142857142857, Blast_Score=177, Evalue=6e-46,
Organism=Escherichia coli, GI87081872, Length=189, Percent_Identity=46.031746031746, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI1787583, Length=189, Percent_Identity=42.8571428571429, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1789828, Length=187, Percent_Identity=40.1069518716578, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI87081858, Length=181, Percent_Identity=36.4640883977901, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788713, Length=112, Percent_Identity=33.9285714285714, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1786784, Length=112, Percent_Identity=33.9285714285714, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082012, Length=123, Percent_Identity=30.8943089430894, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1790863, Length=154, Percent_Identity=30.5194805194805, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 37434; Mature: 37434

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METPRLLIADDDKKTRDFVTAFLKYKGYDVVQAFDGQDALEKLEVEDVHLVITDLMMPRV
CCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCHHHHHHHHHHHCCC
NGLEFVKKLKAMRPGTVVIAYSAFGNYEMTSNLLKAGVFFYLEKPFNLDELETHVKRGLE
CHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHCCH
HQSLQSQTYRSKPALKSRSLIPNIIGESPRMLSLFELIEKVAESDSTVLIQGESGTGKEL
HHHHHHHHHHCCCCHHHHCCCHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHH
VARAVHDLSNRKNRNFVPVNCAAIPDELLESELFGHVKGSFTGAIATRIGRFEMADKGTL
HHHHHHHHHCCCCCCEEEEEHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCEEECCCCCE
FLDEIGDMKPNLQVKLLRVLQNRELEPVGATRSKKVDVRIIAATNQNLEKLVASKQFRED
EEHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
LFYRISVIPIFIPPLRDRREDIPLLVNTTAVP
HHEEEEEEEEEECCCCCCCCCCCEEEECCCCC
>Mature Secondary Structure
METPRLLIADDDKKTRDFVTAFLKYKGYDVVQAFDGQDALEKLEVEDVHLVITDLMMPRV
CCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCHHHHHHHHHHHCCC
NGLEFVKKLKAMRPGTVVIAYSAFGNYEMTSNLLKAGVFFYLEKPFNLDELETHVKRGLE
CHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHCCH
HQSLQSQTYRSKPALKSRSLIPNIIGESPRMLSLFELIEKVAESDSTVLIQGESGTGKEL
HHHHHHHHHHCCCCHHHHCCCHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHH
VARAVHDLSNRKNRNFVPVNCAAIPDELLESELFGHVKGSFTGAIATRIGRFEMADKGTL
HHHHHHHHHCCCCCCEEEEEHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCEEECCCCCE
FLDEIGDMKPNLQVKLLRVLQNRELEPVGATRSKKVDVRIIAATNQNLEKLVASKQFRED
EEHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
LFYRISVIPIFIPPLRDRREDIPLLVNTTAVP
HHEEEEEEEEEECCCCCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]