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The map label for this gene is ctaB

Identifier: 39995333

GI number: 39995333

Start: 231371

End: 232183

Strand: Direct

Name: ctaB

Synonym: GSU0223

Alternate gene names: 39995333

Gene position: 231371-232183 (Clockwise)

Preceding gene: 39995332

Following gene: 39995335

Centisome position: 6.07

GC content: 70.6

Gene sequence:

>813_bases
GTGACCCGGCAGGACCTTGTTCTCTTCAGGCCCCGGCTGGCGCTGCTGAATGGCATCGCGGCGGTGGCGGGGCATGCCCT
TGTCCCCGATGCCGCACATGCGACTCTCTGGGTGGCGCTGGCGGGCGTCGCGATCCTGGCCGCGGGGGGCTCGGCCCTTA
ACCAGGTGCTGGAGCGGGACCTGGACCGCCTCATGGAGCGGACCAGGCAACGGCCCCTGCCCCGGGGCGATCTCTCTCCC
GCCATGGCCACTGCCCTTGGCTGTGCCTGCATCGGGACGGGCCTTTTGGTGCTTGCCGCTGGCGGCCCCGTCCCCCCGCT
GCTCGGTGCCGTGGCGCTCGCCTGGTACCTGGCGGTCTATACGCCGCTCAAGCGCCGCACCTCCCTGGCCCTGGCCATCG
GGGCCGTGAGCGGCGCACTTCCGCCGGTGATCGGCTGGACCCTTGCCGGGGGCGCGCCCGGAGATTATCGGATCATCCTC
CTGGCGGGCATCTTCTTTCTCTGGCAGGTTCCCCACTTCTGGCTGTTCCAGCGCCGTCACGCCGACGACTACCGGCGGGC
GGGCATCCCGCTGTTCACCCCGGGGGCGGGGAGACTCGGGCCTTCCTTCCATGTGCGGCTCTGGCTGGGCGCGCTCGCGG
CGAGTGTTCTGCTCCTCCCCGCCTTCGGCCTCATGGCTCCGCGCATGGCCCCGTGGATCGCCGCGGTGCCGCTCCTGCTC
CTCCCGGTCTGCCGTCCTCGCTCCGAAGCAACGCTTTTTTCCTGCCTCAATGCATTTCCGCCCCTGATGGCCCTGGCGCT
GCTCCTCCGATAA

Upstream 100 bases:

>100_bases
CGGCCCAGGTTGTCAAGGGATTCCCGCCGGTCATGCCGCCCTATCCGGGACTTAGCGATGAAGAGGTGGAGGAGATGGTG
GAATTCATCAGGGAGCTCAA

Downstream 100 bases:

>100_bases
GGGAGCAGCGCCGGTACCCGTCAGGCCCTGATCATCACCAGCAGCATCTTGAACCGTTCCACGGCCCTCAGAGCGTGGGG
GCGATCCGCGGGCATGATGA

Product: protoheme IX farnesyl transferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MTRQDLVLFRPRLALLNGIAAVAGHALVPDAAHATLWVALAGVAILAAGGSALNQVLERDLDRLMERTRQRPLPRGDLSP
AMATALGCACIGTGLLVLAAGGPVPPLLGAVALAWYLAVYTPLKRRTSLALAIGAVSGALPPVIGWTLAGGAPGDYRIIL
LAGIFFLWQVPHFWLFQRRHADDYRRAGIPLFTPGAGRLGPSFHVRLWLGALAASVLLLPAFGLMAPRMAPWIAAVPLLL
LPVCRPRSEATLFSCLNAFPPLMALALLLR

Sequences:

>Translated_270_residues
MTRQDLVLFRPRLALLNGIAAVAGHALVPDAAHATLWVALAGVAILAAGGSALNQVLERDLDRLMERTRQRPLPRGDLSP
AMATALGCACIGTGLLVLAAGGPVPPLLGAVALAWYLAVYTPLKRRTSLALAIGAVSGALPPVIGWTLAGGAPGDYRIIL
LAGIFFLWQVPHFWLFQRRHADDYRRAGIPLFTPGAGRLGPSFHVRLWLGALAASVLLLPAFGLMAPRMAPWIAAVPLLL
LPVCRPRSEATLFSCLNAFPPLMALALLLR
>Mature_269_residues
TRQDLVLFRPRLALLNGIAAVAGHALVPDAAHATLWVALAGVAILAAGGSALNQVLERDLDRLMERTRQRPLPRGDLSPA
MATALGCACIGTGLLVLAAGGPVPPLLGAVALAWYLAVYTPLKRRTSLALAIGAVSGALPPVIGWTLAGGAPGDYRIILL
AGIFFLWQVPHFWLFQRRHADDYRRAGIPLFTPGAGRLGPSFHVRLWLGALAASVLLLPAFGLMAPRMAPWIAAVPLLLL
PVCRPRSEATLFSCLNAFPPLMALALLLR

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=155, Percent_Identity=38.7096774193548, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1786631, Length=228, Percent_Identity=34.2105263157895, Blast_Score=107, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI71998235, Length=197, Percent_Identity=34.5177664974619, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325085, Length=237, Percent_Identity=32.4894514767932, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19921064, Length=192, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_GEOSL (Q74GM3)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_951284.1
- GeneID:   2687731
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU0223
- NMPDR:   fig|243231.1.peg.222
- TIGR:   GSU0223
- HOGENOM:   HBG656003
- OMA:   HADDYRR
- ProtClustDB:   CLSK743077
- BioCyc:   GSUL243231:GSU_0223-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 28623; Mature: 28491

Theoretical pI: Translated: 11.56; Mature: 11.56

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x91f9ed4)-; HASH(0xbc6ee2c)-; HASH(0xc15e25c)-; HASH(0xbd50ffc)-; HASH(0xc323c64)-; HASH(0xc19c3e8)-; HASH(0xbe1895c)-;

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRQDLVLFRPRLALLNGIAAVAGHALVPDAAHATLWVALAGVAILAAGGSALNQVLERD
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LDRLMERTRQRPLPRGDLSPAMATALGCACIGTGLLVLAAGGPVPPLLGAVALAWYLAVY
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHH
TPLKRRTSLALAIGAVSGALPPVIGWTLAGGAPGDYRIILLAGIFFLWQVPHFWLFQRRH
HHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ADDYRRAGIPLFTPGAGRLGPSFHVRLWLGALAASVLLLPAFGLMAPRMAPWIAAVPLLL
HHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPVCRPRSEATLFSCLNAFPPLMALALLLR
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
>Mature Secondary Structure 
TRQDLVLFRPRLALLNGIAAVAGHALVPDAAHATLWVALAGVAILAAGGSALNQVLERD
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LDRLMERTRQRPLPRGDLSPAMATALGCACIGTGLLVLAAGGPVPPLLGAVALAWYLAVY
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHH
TPLKRRTSLALAIGAVSGALPPVIGWTLAGGAPGDYRIILLAGIFFLWQVPHFWLFQRRH
HHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ADDYRRAGIPLFTPGAGRLGPSFHVRLWLGALAASVLLLPAFGLMAPRMAPWIAAVPLLL
HHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPVCRPRSEATLFSCLNAFPPLMALALLLR
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA