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The map label for this gene is argH [H]

Identifier: 39995267

GI number: 39995267

Start: 173833

End: 175209

Strand: Direct

Name: argH [H]

Synonym: GSU0156

Alternate gene names: 39995267

Gene position: 173833-175209 (Clockwise)

Preceding gene: 39995266

Following gene: 39995268

Centisome position: 4.56

GC content: 63.62

Gene sequence:

>1377_bases
ATGGCACACGAAAAACTGTGGGGCGGCCGCTTTTCCGAGCCGACCGACCAATTCGTCGAGGAATTCACCGCTTCCATCGA
CTTCGACAAGCGGCTCTACCACCAGGACATCCGGGGCTCCATCGCCCACGCGCGGATGCTGGGCAAGCAAGGCATCCTCC
CCATGGCTGAGGTCGAAAAGATCGTGGCGGGGCTCCAGGAGGTCCTTGCCCGGATCGAGGCCGGGAAATTTGACTTCTCC
GTGGCCCTGGAAGACATCCACATGAACATCGAGGCGCGTCTCACGGAGAAGATCGGCGAGGCCGGCAAGCGGCTCCACAC
CGGCCGTTCCCGCAACGACCAGGTTGCCCTCGACATCCGCCTCTACCTGCGGGACGAGATCGTGGAGATCTCCGCCTACC
TGGATATGTTGGTGGACTCCCTCATTTACCAGGCGGAAGCCAACCTGGGCGTCATCATGCCCGGCTACACCCACCTGCAG
ACCGCCCAGCCCATCCTCTTCTCCCACCACATGATGGCCTACGTGGAGATGTTCACCAGGGACAAGGGGCGGATGGAGGA
CTGCCTGCGGCGGATGAACGTCCTTCCGCTCGGCGCCGGCGCCCTGGCCGGGACCACCTTCCCCATCGACCGGGAACACG
TGGCCGAGCTGCTGGACTTCCCCGGCGTGACCCGCAATTCCCTCGATTCGGTATCGGACCGGGACTTCGCCCTGGAGTTC
ATGGGGGCCTCCTCGATCCTGATGATGCACCTCTCCCGTTTCTCCGAGGAGCTGATCCTCTGGTCCACCAGCGAGTTCAA
GTTCGTGGAGCTGACCGATTCCTTCTGCACCGGCTCCTCGATCATGCCCCAGAAGAAGAACCCGGACGTGCCGGAACTGG
TCCGCGGCAAAACCGGCCGGGTCTACGGCAACCTCATGGCGCTCCTCACGGTCATGAAGGCCCTGCCCCTGGCTTACAAC
AAGGACATGCAGGAAGACAAGGAGCCTCTCTTCGACACCATCGACACCGTGAAGGGGAGCCTCAAGATTTTCGCCGACAT
GGTGCGGGAGATGCGGATCAACGCCGGGAACATGCGGGCCGCGGCCGCCAAGGGTTTCTCCACCGCCACCGACGTGGCCG
ACTACCTGGTCCGCCAGGGGATGCCCTTCCGCGACGCCCACGAGGTGGTGGGGAAGACCGTGGCCTACTGTATCGCCAAC
GGCAAGGATCTCCCGGATCTGACCATGGATGAATGGCAGGGGTTCTCGGACAAGATCGGCGAGGACATCTTCGACGCGAT
TACCCTGGAAGCGTCGGTCAACGCCCGCGTCGCCACCGGCGGCACGGCCCTGGAGCGCGTCAAGGCGGAGATCGAGCGGG
CCAAGGTGGGGAGATAG

Upstream 100 bases:

>100_bases
CCCGTCCCGGGACGGCGGCTGGGTCAAGATCAGCGGGGATGAGCTGGTGGCGGGGTTCGAGATCGCGCAGAACATGTAAT
CACACCATCAGGAGATAGTC

Downstream 100 bases:

>100_bases
CGTGATTCGCGTCGCGGCACAGGGCCGGGGAGGGGACAGTGGGCGGTAATCATCGGATCGTAGTCAAGCTCGTCGCCGGA
ATCGCACTTGCGGCCGCCCT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MAHEKLWGGRFSEPTDQFVEEFTASIDFDKRLYHQDIRGSIAHARMLGKQGILPMAEVEKIVAGLQEVLARIEAGKFDFS
VALEDIHMNIEARLTEKIGEAGKRLHTGRSRNDQVALDIRLYLRDEIVEISAYLDMLVDSLIYQAEANLGVIMPGYTHLQ
TAQPILFSHHMMAYVEMFTRDKGRMEDCLRRMNVLPLGAGALAGTTFPIDREHVAELLDFPGVTRNSLDSVSDRDFALEF
MGASSILMMHLSRFSEELILWSTSEFKFVELTDSFCTGSSIMPQKKNPDVPELVRGKTGRVYGNLMALLTVMKALPLAYN
KDMQEDKEPLFDTIDTVKGSLKIFADMVREMRINAGNMRAAAAKGFSTATDVADYLVRQGMPFRDAHEVVGKTVAYCIAN
GKDLPDLTMDEWQGFSDKIGEDIFDAITLEASVNARVATGGTALERVKAEIERAKVGR

Sequences:

>Translated_458_residues
MAHEKLWGGRFSEPTDQFVEEFTASIDFDKRLYHQDIRGSIAHARMLGKQGILPMAEVEKIVAGLQEVLARIEAGKFDFS
VALEDIHMNIEARLTEKIGEAGKRLHTGRSRNDQVALDIRLYLRDEIVEISAYLDMLVDSLIYQAEANLGVIMPGYTHLQ
TAQPILFSHHMMAYVEMFTRDKGRMEDCLRRMNVLPLGAGALAGTTFPIDREHVAELLDFPGVTRNSLDSVSDRDFALEF
MGASSILMMHLSRFSEELILWSTSEFKFVELTDSFCTGSSIMPQKKNPDVPELVRGKTGRVYGNLMALLTVMKALPLAYN
KDMQEDKEPLFDTIDTVKGSLKIFADMVREMRINAGNMRAAAAKGFSTATDVADYLVRQGMPFRDAHEVVGKTVAYCIAN
GKDLPDLTMDEWQGFSDKIGEDIFDAITLEASVNARVATGGTALERVKAEIERAKVGR
>Mature_457_residues
AHEKLWGGRFSEPTDQFVEEFTASIDFDKRLYHQDIRGSIAHARMLGKQGILPMAEVEKIVAGLQEVLARIEAGKFDFSV
ALEDIHMNIEARLTEKIGEAGKRLHTGRSRNDQVALDIRLYLRDEIVEISAYLDMLVDSLIYQAEANLGVIMPGYTHLQT
AQPILFSHHMMAYVEMFTRDKGRMEDCLRRMNVLPLGAGALAGTTFPIDREHVAELLDFPGVTRNSLDSVSDRDFALEFM
GASSILMMHLSRFSEELILWSTSEFKFVELTDSFCTGSSIMPQKKNPDVPELVRGKTGRVYGNLMALLTVMKALPLAYNK
DMQEDKEPLFDTIDTVKGSLKIFADMVREMRINAGNMRAAAAKGFSTATDVADYLVRQGMPFRDAHEVVGKTVAYCIANG
KDLPDLTMDEWQGFSDKIGEDIFDAITLEASVNARVATGGTALERVKAEIERAKVGR

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=457, Percent_Identity=44.6389496717724, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI68303542, Length=457, Percent_Identity=44.6389496717724, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI68303547, Length=457, Percent_Identity=42.4507658643326, Blast_Score=356, Evalue=3e-98,
Organism=Homo sapiens, GI68303549, Length=457, Percent_Identity=42.2319474835886, Blast_Score=352, Evalue=5e-97,
Organism=Escherichia coli, GI1790398, Length=451, Percent_Identity=47.2283813747228, Blast_Score=430, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6321806, Length=457, Percent_Identity=46.3894967177243, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI221473854, Length=439, Percent_Identity=41.4578587699317, Blast_Score=348, Evalue=3e-96,
Organism=Drosophila melanogaster, GI78706858, Length=439, Percent_Identity=41.4578587699317, Blast_Score=348, Evalue=3e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51149; Mature: 51018

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHEKLWGGRFSEPTDQFVEEFTASIDFDKRLYHQDIRGSIAHARMLGKQGILPMAEVEK
CCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
IVAGLQEVLARIEAGKFDFSVALEDIHMNIEARLTEKIGEAGKRLHTGRSRNDQVALDIR
HHHHHHHHHHHHHCCCCCCEEEHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
LYLRDEIVEISAYLDMLVDSLIYQAEANLGVIMPGYTHLQTAQPILFSHHMMAYVEMFTR
EEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHCCHHHHHHHHHHHHHHHHC
DKGRMEDCLRRMNVLPLGAGALAGTTFPIDREHVAELLDFPGVTRNSLDSVSDRDFALEF
CCCHHHHHHHHCCCCCCCCCHHCCCCCCCCHHHHHHHHHCCCCCCCCHHCCCCCCHHHHH
MGASSILMMHLSRFSEELILWSTSEFKFVELTDSFCTGSSIMPQKKNPDVPELVRGKTGR
HCHHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHCCCCCH
VYGNLMALLTVMKALPLAYNKDMQEDKEPLFDTIDTVKGSLKIFADMVREMRINAGNMRA
HHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
AAAKGFSTATDVADYLVRQGMPFRDAHEVVGKTVAYCIANGKDLPDLTMDEWQGFSDKIG
HHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHH
EDIFDAITLEASVNARVATGGTALERVKAEIERAKVGR
HHHHHHHEEEECCCEEEECCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AHEKLWGGRFSEPTDQFVEEFTASIDFDKRLYHQDIRGSIAHARMLGKQGILPMAEVEK
CCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
IVAGLQEVLARIEAGKFDFSVALEDIHMNIEARLTEKIGEAGKRLHTGRSRNDQVALDIR
HHHHHHHHHHHHHCCCCCCEEEHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
LYLRDEIVEISAYLDMLVDSLIYQAEANLGVIMPGYTHLQTAQPILFSHHMMAYVEMFTR
EEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHCCHHHHHHHHHHHHHHHHC
DKGRMEDCLRRMNVLPLGAGALAGTTFPIDREHVAELLDFPGVTRNSLDSVSDRDFALEF
CCCHHHHHHHHCCCCCCCCCHHCCCCCCCCHHHHHHHHHCCCCCCCCHHCCCCCCHHHHH
MGASSILMMHLSRFSEELILWSTSEFKFVELTDSFCTGSSIMPQKKNPDVPELVRGKTGR
HCHHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHCCCCCH
VYGNLMALLTVMKALPLAYNKDMQEDKEPLFDTIDTVKGSLKIFADMVREMRINAGNMRA
HHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
AAAKGFSTATDVADYLVRQGMPFRDAHEVVGKTVAYCIANGKDLPDLTMDEWQGFSDKIG
HHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHH
EDIFDAITLEASVNARVATGGTALERVKAEIERAKVGR
HHHHHHHEEEECCCEEEECCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA