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The map label for this gene is atpA [H]

Identifier: 39995222

GI number: 39995222

Start: 125151

End: 126662

Strand: Direct

Name: atpA [H]

Synonym: GSU0111

Alternate gene names: 39995222

Gene position: 125151-126662 (Clockwise)

Preceding gene: 39995221

Following gene: 39995223

Centisome position: 3.28

GC content: 59.85

Gene sequence:

>1512_bases
ATGGAAATCAGAGCCGAAGAAATCAGCGAAATTATCCGTAAGCAGATCAAGGAGTACGGCAAGGAGGTAGAGGTTGCCGA
GACCGGCACCATCATCTCCGTCGGTGACGGTATCGCCCGTATCCACGGCCTGGACAAGGCCATGGCCGGCGAGCTCCTGG
AGTTCCCCGGCGGGGTCTCCGGCATGGTTCTCAACCTCGAAGAGGACAACGTCGGTGCGGCGATCCTCGGTGAAGACAAC
GAGAACATCAAGGAAGGGACCACCGTCAAGCGGACCGGCAGGATCGTGGAGGTTCCGGTAGGCGAAGCCCTCATCGGTCG
CGTGGTCAACGCCATCGGCCAGCCCATCGACGGTAAGGGGCCGATCAATACCACCACCTTCGGCAAGGTCGAAGTCAAGG
CCCCCGGTATCGTCAAGCGGAAGTCGGTCCATCAGCCGATGCAGACCGGCCTCAAGGCCATCGACTCCATGGTGCCGATC
GGCCGCGGTCAGCGGGAGCTCATCATCGGCGACCGCCAGACCGGTAAGACCGCTGTTGCCATCGACACCATCATCAATCA
GAAGGGCGGCGACCTGATCTGCATTTACGTCGCCATCGGCCAAAAGCGTTCCACTGTTGCCCAGGTGGTGAGCAAGCTGC
AGGAATACGGCGCGATGGATTACACCATCGTCGTATCCGCTTCCGCTTCCGAGCCGGCACCGCTCCAGTTCATCGCTCCC
TATACCGGCGTCACCATGGGCGAGTACTTCCGGGACAACGGCAAGCATGCTCTCATCATTTACGATGACCTGTCCAAGCA
GGCCGTTGCCTACCGTCAGCTCTCCCTGCTCCTCCGTCGTCCGCCGGGACGTGAAGCCTATCCGGGTGACGTCTTCTACC
TGCACAGCCGTCTCCTCGAGCGTGCCGCCAAGCTCTCCGACGACTGCGGAGCCGGATCGCTTACGGCGCTCCCGATCATC
GAGACCCAGGCCGGTGACGTTTCCGCCTACATTCCGACCAACGTTATTTCTATTACCGACGGCCAGATTTATCTGGAGAG
CGACCTGTTCTACTCAGGTGTGCGTCCGGCCATCAACGTCGGTCTCTCGGTTTCCCGGGTCGGTGGCTCTGCCCAGGTAA
AAGCCATGAAGCAGGTTGCCGGTACGCTCCGTCTGAACCTCGCCCAGTATCGCGAGATGGCTGCGTTCGCCCAGTTCGGT
TCCGACCTGGACAAGGCGACCCAGATGCAGCTTGCCCGTGGCGAGCGTCTGGTCGAGATCCTCAAGCAGCCCCAGTATCG
GCCGATCCCGAACGAGAAGCAGGTTCTCGTCATCTTCGCCGCCAACAACGGCTTTGTTGACGAGTATCCCGTCTCCTCCC
TGCGTCGCTATGAAAGTGAGCTCTACTCCTTCTTCGACAGCAGAAAGGCCGATATCCTCGCCGAACTGCGTGACAAGAAG
GCCATTGACGACGATCTGAAGGCAAAGATGATCGCCGCTCTGGAAGAGCTGAAGAAGGAATTTACTGCGTAA

Upstream 100 bases:

>100_bases
GCGGAGTGGTCACCAAGATTGGCGACAAGGTATTTGACGGCAGCGTACGGACCCAGTTGAACAGGATTCAGGATATATTA
CAGAAGGGGTGAGAGGTTCC

Downstream 100 bases:

>100_bases
TCTAAGGACGGTCCTCACCATATGGCAAGCCTTAAAAGCATAAAAAAGCGTATTGTCTCGGTCAAAAATACCAGACAGAT
AACCAAGGCCATGAAAATGG

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MEIRAEEISEIIRKQIKEYGKEVEVAETGTIISVGDGIARIHGLDKAMAGELLEFPGGVSGMVLNLEEDNVGAAILGEDN
ENIKEGTTVKRTGRIVEVPVGEALIGRVVNAIGQPIDGKGPINTTTFGKVEVKAPGIVKRKSVHQPMQTGLKAIDSMVPI
GRGQRELIIGDRQTGKTAVAIDTIINQKGGDLICIYVAIGQKRSTVAQVVSKLQEYGAMDYTIVVSASASEPAPLQFIAP
YTGVTMGEYFRDNGKHALIIYDDLSKQAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDDCGAGSLTALPII
ETQAGDVSAYIPTNVISITDGQIYLESDLFYSGVRPAINVGLSVSRVGGSAQVKAMKQVAGTLRLNLAQYREMAAFAQFG
SDLDKATQMQLARGERLVEILKQPQYRPIPNEKQVLVIFAANNGFVDEYPVSSLRRYESELYSFFDSRKADILAELRDKK
AIDDDLKAKMIAALEELKKEFTA

Sequences:

>Translated_503_residues
MEIRAEEISEIIRKQIKEYGKEVEVAETGTIISVGDGIARIHGLDKAMAGELLEFPGGVSGMVLNLEEDNVGAAILGEDN
ENIKEGTTVKRTGRIVEVPVGEALIGRVVNAIGQPIDGKGPINTTTFGKVEVKAPGIVKRKSVHQPMQTGLKAIDSMVPI
GRGQRELIIGDRQTGKTAVAIDTIINQKGGDLICIYVAIGQKRSTVAQVVSKLQEYGAMDYTIVVSASASEPAPLQFIAP
YTGVTMGEYFRDNGKHALIIYDDLSKQAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDDCGAGSLTALPII
ETQAGDVSAYIPTNVISITDGQIYLESDLFYSGVRPAINVGLSVSRVGGSAQVKAMKQVAGTLRLNLAQYREMAAFAQFG
SDLDKATQMQLARGERLVEILKQPQYRPIPNEKQVLVIFAANNGFVDEYPVSSLRRYESELYSFFDSRKADILAELRDKK
AIDDDLKAKMIAALEELKKEFTA
>Mature_503_residues
MEIRAEEISEIIRKQIKEYGKEVEVAETGTIISVGDGIARIHGLDKAMAGELLEFPGGVSGMVLNLEEDNVGAAILGEDN
ENIKEGTTVKRTGRIVEVPVGEALIGRVVNAIGQPIDGKGPINTTTFGKVEVKAPGIVKRKSVHQPMQTGLKAIDSMVPI
GRGQRELIIGDRQTGKTAVAIDTIINQKGGDLICIYVAIGQKRSTVAQVVSKLQEYGAMDYTIVVSASASEPAPLQFIAP
YTGVTMGEYFRDNGKHALIIYDDLSKQAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDDCGAGSLTALPII
ETQAGDVSAYIPTNVISITDGQIYLESDLFYSGVRPAINVGLSVSRVGGSAQVKAMKQVAGTLRLNLAQYREMAAFAQFG
SDLDKATQMQLARGERLVEILKQPQYRPIPNEKQVLVIFAANNGFVDEYPVSSLRRYESELYSFFDSRKADILAELRDKK
AIDDDLKAKMIAALEELKKEFTA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit [H]

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=505, Percent_Identity=64.7524752475248, Blast_Score=645, Evalue=0.0,
Organism=Homo sapiens, GI4757810, Length=505, Percent_Identity=64.7524752475248, Blast_Score=645, Evalue=0.0,
Organism=Homo sapiens, GI19913428, Length=300, Percent_Identity=30.3333333333333, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI19913426, Length=300, Percent_Identity=29.6666666666667, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI32189394, Length=415, Percent_Identity=24.8192771084337, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI19913424, Length=245, Percent_Identity=26.1224489795918, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1790172, Length=509, Percent_Identity=57.1709233791749, Blast_Score=595, Evalue=1e-171,
Organism=Escherichia coli, GI1788251, Length=324, Percent_Identity=28.7037037037037, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1790170, Length=357, Percent_Identity=25.2100840336134, Blast_Score=112, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71988063, Length=492, Percent_Identity=64.4308943089431, Blast_Score=640, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988080, Length=492, Percent_Identity=64.4308943089431, Blast_Score=639, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988074, Length=492, Percent_Identity=60.1626016260163, Blast_Score=586, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI17510931, Length=364, Percent_Identity=26.3736263736264, Blast_Score=122, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17570191, Length=324, Percent_Identity=27.7777777777778, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI25144756, Length=367, Percent_Identity=25.3405994550409, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=74, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17565854, Length=250, Percent_Identity=26.8, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71988068, Length=73, Percent_Identity=42.4657534246575, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=503, Percent_Identity=63.0218687872763, Blast_Score=648, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319603, Length=336, Percent_Identity=28.2738095238095, Blast_Score=116, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6322581, Length=367, Percent_Identity=25.6130790190736, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6320016, Length=154, Percent_Identity=31.1688311688312, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24658560, Length=495, Percent_Identity=63.4343434343434, Blast_Score=629, Evalue=1e-180,
Organism=Drosophila melanogaster, GI281361666, Length=301, Percent_Identity=28.9036544850498, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646341, Length=301, Percent_Identity=28.9036544850498, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI17136796, Length=301, Percent_Identity=28.9036544850498, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24638766, Length=367, Percent_Identity=25.0681198910082, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI28574560, Length=389, Percent_Identity=24.6786632390745, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24583992, Length=371, Percent_Identity=26.4150943396226, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24583988, Length=251, Percent_Identity=26.6932270916335, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583986, Length=251, Percent_Identity=26.6932270916335, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583984, Length=251, Percent_Identity=26.6932270916335, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI20129479, Length=238, Percent_Identity=26.890756302521, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 54753; Mature: 54753

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRAEEISEIIRKQIKEYGKEVEVAETGTIISVGDGIARIHGLDKAMAGELLEFPGGVS
CCCCHHHHHHHHHHHHHHHCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCC
GMVLNLEEDNVGAAILGEDNENIKEGTTVKRTGRIVEVPVGEALIGRVVNAIGQPIDGKG
EEEEEEECCCCCEEEECCCCCCCCCCCEEECCCCEEEECCCHHHHHHHHHHHCCCCCCCC
PINTTTFGKVEVKAPGIVKRKSVHQPMQTGLKAIDSMVPIGRGQRELIIGDRQTGKTAVA
CCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEE
IDTIINQKGGDLICIYVAIGQKRSTVAQVVSKLQEYGAMDYTIVVSASASEPAPLQFIAP
EEHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEECC
YTGVTMGEYFRDNGKHALIIYDDLSKQAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLLE
CCCCCHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
RAAKLSDDCGAGSLTALPIIETQAGDVSAYIPTNVISITDGQIYLESDLFYSGVRPAINV
HHHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEECCCHHCCCCHHHHC
GLSVSRVGGSAQVKAMKQVAGTLRLNLAQYREMAAFAQFGSDLDKATQMQLARGERLVEI
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LKQPQYRPIPNEKQVLVIFAANNGFVDEYPVSSLRRYESELYSFFDSRKADILAELRDKK
HHCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
AIDDDLKAKMIAALEELKKEFTA
CCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEIRAEEISEIIRKQIKEYGKEVEVAETGTIISVGDGIARIHGLDKAMAGELLEFPGGVS
CCCCHHHHHHHHHHHHHHHCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCC
GMVLNLEEDNVGAAILGEDNENIKEGTTVKRTGRIVEVPVGEALIGRVVNAIGQPIDGKG
EEEEEEECCCCCEEEECCCCCCCCCCCEEECCCCEEEECCCHHHHHHHHHHHCCCCCCCC
PINTTTFGKVEVKAPGIVKRKSVHQPMQTGLKAIDSMVPIGRGQRELIIGDRQTGKTAVA
CCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEE
IDTIINQKGGDLICIYVAIGQKRSTVAQVVSKLQEYGAMDYTIVVSASASEPAPLQFIAP
EEHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEECC
YTGVTMGEYFRDNGKHALIIYDDLSKQAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLLE
CCCCCHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
RAAKLSDDCGAGSLTALPIIETQAGDVSAYIPTNVISITDGQIYLESDLFYSGVRPAINV
HHHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEECCCHHCCCCHHHHC
GLSVSRVGGSAQVKAMKQVAGTLRLNLAQYREMAAFAQFGSDLDKATQMQLARGERLVEI
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LKQPQYRPIPNEKQVLVIFAANNGFVDEYPVSSLRRYESELYSFFDSRKADILAELRDKK
HHCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
AIDDDLKAKMIAALEELKKEFTA
CCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA