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The map label for this gene is tadA [H]

Identifier: 39995176

GI number: 39995176

Start: 81425

End: 81964

Strand: Direct

Name: tadA [H]

Synonym: GSU0065

Alternate gene names: 39995176

Gene position: 81425-81964 (Clockwise)

Preceding gene: 39995174

Following gene: 39995177

Centisome position: 2.13

GC content: 58.15

Gene sequence:

>540_bases
ATGTCATCTTTGAAAAAGACCCCCATTCGCGACGATGCCTATTGGATGGGAAAGGCGATTCGAGAAGCCGCAAAAGCTGC
AGCCCGTGACGAAGTTCCCATCGGGGCCGTTATCGTGCGTGACGGTGCAGTGATCGGGAGGGGGCACAACCTCCGCGAGG
GTAGCAATGATCCCTCTGCCCATGCCGAAATGATCGCCATCCGGCAGGCCGCCCGCAGGTCGGCAAACTGGCGTCTTACG
GGCGCAACTCTGTATGTGACGCTGGAACCGTGCCTCATGTGCATGGGGGCTATTATCCTCGCACGACTGGAACGGGTCGT
TTTCGGCTGTTATGACCCCAAGGGGGGCGCAGCAGGGTCACTCTACGATCTCTCCGCGGACCCGCGCCTGAATCATCAGG
TAAGGTTATCGCCCGGCGTCTGTCAGGAAGAATGTGGCACGATGCTGAGTGACTTTTTTCGTGATCTTCGCCGCAGGAAA
AAGGCCAAGGCTACCCCCGCGCTTTTCATCGATGAAAGGAAAGTGCCACCAGAGCCTTGA

Upstream 100 bases:

>100_bases
TATCAGAGGGGCTAGGCAGATTGCCTAGCCCCTTTTTCTATCCGAGGCCGCTCGGGCAGGGTGGATTAACGTGACCTACC
GGGAGCATGGCGACAGAGGA

Downstream 100 bases:

>100_bases
GTTTTTTTTGTAAATGAGGTATAAACGACCCGCATTCCATGCAGGGTCCAGCAATGTTACGGAGAGATGGCCGAGTGGTC
GAAGGCGGCAGACTCGAAAT

Product: cytidine/deoxycytidylate deaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 179; Mature: 178

Protein sequence:

>179_residues
MSSLKKTPIRDDAYWMGKAIREAAKAAARDEVPIGAVIVRDGAVIGRGHNLREGSNDPSAHAEMIAIRQAARRSANWRLT
GATLYVTLEPCLMCMGAIILARLERVVFGCYDPKGGAAGSLYDLSADPRLNHQVRLSPGVCQEECGTMLSDFFRDLRRRK
KAKATPALFIDERKVPPEP

Sequences:

>Translated_179_residues
MSSLKKTPIRDDAYWMGKAIREAAKAAARDEVPIGAVIVRDGAVIGRGHNLREGSNDPSAHAEMIAIRQAARRSANWRLT
GATLYVTLEPCLMCMGAIILARLERVVFGCYDPKGGAAGSLYDLSADPRLNHQVRLSPGVCQEECGTMLSDFFRDLRRRK
KAKATPALFIDERKVPPEP
>Mature_178_residues
SSLKKTPIRDDAYWMGKAIREAAKAAARDEVPIGAVIVRDGAVIGRGHNLREGSNDPSAHAEMIAIRQAARRSANWRLTG
ATLYVTLEPCLMCMGAIILARLERVVFGCYDPKGGAAGSLYDLSADPRLNHQVRLSPGVCQEECGTMLSDFFRDLRRRKK
AKATPALFIDERKVPPEP

Specific function: Deaminates adenosine-34 to inosine in tRNA-Arg2 [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI124107608, Length=149, Percent_Identity=34.2281879194631, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI145693172, Length=150, Percent_Identity=51.3333333333333, Blast_Score=155, Evalue=1e-39,
Organism=Escherichia coli, GI1786616, Length=156, Percent_Identity=32.0512820512821, Blast_Score=64, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17554608, Length=96, Percent_Identity=45.8333333333333, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17541138, Length=149, Percent_Identity=33.5570469798658, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17555996, Length=120, Percent_Identity=34.1666666666667, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322425, Length=176, Percent_Identity=30.1136363636364, Blast_Score=71, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6325319, Length=100, Percent_Identity=38, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355527, Length=148, Percent_Identity=29.7297297297297, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: NA

Molecular weight: Translated: 19649; Mature: 19518

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLKKTPIRDDAYWMGKAIREAAKAAARDEVPIGAVIVRDGAVIGRGHNLREGSNDPSA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEECCCCCCCCCCCCHH
HAEMIAIRQAARRSANWRLTGATLYVTLEPCLMCMGAIILARLERVVFGCYDPKGGAAGS
HHHHHHHHHHHHCCCCEEEECEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
LYDLSADPRLNHQVRLSPGVCQEECGTMLSDFFRDLRRRKKAKATPALFIDERKVPPEP
EEECCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
SSLKKTPIRDDAYWMGKAIREAAKAAARDEVPIGAVIVRDGAVIGRGHNLREGSNDPSA
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEECCCCCCCCCCCCHH
HAEMIAIRQAARRSANWRLTGATLYVTLEPCLMCMGAIILARLERVVFGCYDPKGGAAGS
HHHHHHHHHHHHCCCCEEEECEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
LYDLSADPRLNHQVRLSPGVCQEECGTMLSDFFRDLRRRKKAKATPALFIDERKVPPEP
EEECCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1698458; 7584024; 9384377 [H]