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The map label for this gene is gyrA [H]

Identifier: 39995115

GI number: 39995115

Start: 6417

End: 8990

Strand: Direct

Name: gyrA [H]

Synonym: GSU0004

Alternate gene names: 39995115

Gene position: 6417-8990 (Clockwise)

Preceding gene: 39995114

Following gene: 39995116

Centisome position: 0.17

GC content: 62.55

Gene sequence:

>2574_bases
ATGCTTGAACAATCCCTGAACAAGACAGCCGTCAACATCGAAGACGAGATGAAGCGCTCGTACATGGACTATGCCATGAG
CGTCATCATCGGCCGGGCCCTCCCCGATGTGCGGGACGGGCTCAAGCCGGTGCACCGCCGCTGCCTCTACGCCATGTACG
ACATGGGCAATGATTACAACAAGCCCTACAAGAAATCGGCCCGGGTGGTCGGGGACGTGATCGGTAAGTATCACCCCCAC
GGCGACGCGGCGGCCTACGATACCATCGTCCGGATGGCCCAGGACTTCTCCCTCCGCTATCCACTGGTGGACGGCCAGGG
GAACTTCGGCTCCGTGGACGGCGACTCGCCGGCGGCCATGCGGTACACCGAGATCCGGATGGAGCAGTTGGCCCACGAGC
TCCTGAACGACCTGGAGAAGGAGACCGTGGACCTGGGGCCCAACTACGACGGCTCCCTCACGGAGCCCCTGGTGCTTCCC
TCCAAGTTCCCGAACCTCCTGGTGAACGGCTCCTCCGGCATCGCCGTCGGCATGGCCACCAACATACCTCCCCACAACCT
TACGGAGGTCATCAACGGGATTATCGCCACCATCGAGAATCCGAATATCAGCTTCGAGGAGCTCCTGGCCCTCATCCCCG
GCCCCGATTTCCCCACCGGCGGGTTCATCTACGGCCGGGAGGGAATCCTCCAGGGGTACCGGACCGGCCGCGGCATCGTC
CAGATGCGGGCCCGGGCCTCCATCGAGACCCACAAGAAGACCGAGCGCCAGTCCATCATCGTCACCGAGATCCCCTATCA
GGTGAACAAGGCGAACCTCATCACCAAGATCGCCGAACTGGTGCGGGAGAAGAAGCTGGAGGGGATCAGCGACATCCGCG
ACGAGTCCGACCGGGACGGGATGCGGATCGTCATTGATCTCAAGCGGGACGAGAATCCCCAGGTGATCCTGAATCACCTC
TACAAGCAGACCCAGATGCAGACCTCCTTCGGCATCAACATGCTCGCCATTGTGGCGGGGCGGCCGCGGGTCCTGACGCT
TCGGGATGCCATCGGCCACTTCATCGACCACCGGCGGGAGATCGTCACCCGGCGCACCATCTTTGATCTCAAGAAGGCCG
AGGCCAGGGCCCACATCCTGGAAGGGTACAAGATCGCCCTGGACTGGCTCGACGCGGTCATCGAGCTGATCCGCGGGTCC
AAGACCCCGGCCGAGGCCAAGGAAGGGCTCATGTCGGGCCTCTTCTCCGACGAGGAGTGGCTGCGGAAGATGGGACTCCC
GCTGCCGGCCATCCACAGCCAGTACCAGAAACCGGTTCGGCTCACCGAGGTCCAGGCCCAGGAGATCCTGAACCTGCGGC
TCCACCGCCTGACAGGCCTGGAGCGGGACAAGATCCTCCAGGAGTACGACGACATCCTCAAATACATCGCCCGGCTCAAG
GAAATCCTCGCCTCCGAGGCGGAGATCCTCAAGATCATCGTGGGTGAGCTGCGGGAGCTGAAGGAGAAGTTCGGCGACGA
GCGCCGCACCGAGATCGTGGACCGGAGCGCCGAGATCTCCCTGGAGGACACCATTGTCGAGGAGGACGTGGTGGTCACCG
TCTCCCACACCGGCTACATCAAGCGGACCGCAGTTTCCCAGTACCGCTCCCAGCGCAGGGGGGGCAAGGGGAAGACCGGC
ATGAAGACCAAGGAGGAGGATTTCGTCGAGCACCTCTTCGTCGCCTCCAGCAAGGACTTCATGCTCTTTTTCACCGACGC
CGGCAAGGTCTACCAGATCAAGGTCTACGAGATCCCCGAGGGGGGCCGGGCCACCCGTGGCAAGGCCATTGTCAACCTTC
TGAACCTTCAGGAGAATGAGCAGATCACCGCCATTCTCTCGGTGAAGGGATTCGACGACGACCGCAATATCATCATGGCA
ACCCGGCTCGGAGTGGTGAAGAAGAGTCCCCTGCGGGAATATGCCAACATCCGCAGCGGCGGGATCATTGCCGTGAATCT
GGACGATGGGGACAAGCTGATTGCCGTGGCCCTGACCGATGGCAGGCAGGACGTGCTCCTGGCATCGAAGAACGGCAAGT
CGATCCGCTTCCACGAGGATGACGCCCGACCCATGGGCCGGGTCTCCCGCGGTGTGCGGGGAATGTCCCTGGAGGACGAC
GACGTGGTCATCGGCATGGAGATCATCAATCCCAACGCCACTGGCTCCACCATTTTCACCGTCACCGAGAATGGCTTCGG
CAAGCGGACCGAACTGGATGAGTACCGGGTCCAGTCCCGCGGCGGCAAGGGGATCATCACCATCAAGACCACCGAGCGCA
ACGGCTGCGTGGTGGACATCATGCAAGTAACCGATGAAAACGACCTGATGCTCATCACCGACCAGGGGAAGATCCTCCGG
ATTCCCGTGGCCCAGTTCTCGGTCATCGGCCGCAACACCCAGGGGGTGAGGCTCATGACCGCCGAGCAGAACGAGCGGAT
CGTGGCCGTGGCAAAGCTGGCCGAGAAGGATGAAGGGGACGACGGCGCCGACGGAGGCGATGATCTCCCCGACGCGGAGG
TCGTGGAGGAGTAG

Upstream 100 bases:

>100_bases
CGCCCGGGTGCAATGAATCACACCCCTACGGGTGCCATGCCGTTATCGGGCGAGGCATCGTCTCGACCCTACATGTATTT
GGAAATAAAGAGGTTTATGA

Downstream 100 bases:

>100_bases
CCGCGACGGGCCGCGATCCGTAACCGGATTATTTATTCCGGTCCGCGGTTTCCGGTCCCAGGCCCCCGTTATGGAACGTC
ACCGTACCATCGACATGAGC

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 857; Mature: 857

Protein sequence:

>857_residues
MLEQSLNKTAVNIEDEMKRSYMDYAMSVIIGRALPDVRDGLKPVHRRCLYAMYDMGNDYNKPYKKSARVVGDVIGKYHPH
GDAAAYDTIVRMAQDFSLRYPLVDGQGNFGSVDGDSPAAMRYTEIRMEQLAHELLNDLEKETVDLGPNYDGSLTEPLVLP
SKFPNLLVNGSSGIAVGMATNIPPHNLTEVINGIIATIENPNISFEELLALIPGPDFPTGGFIYGREGILQGYRTGRGIV
QMRARASIETHKKTERQSIIVTEIPYQVNKANLITKIAELVREKKLEGISDIRDESDRDGMRIVIDLKRDENPQVILNHL
YKQTQMQTSFGINMLAIVAGRPRVLTLRDAIGHFIDHRREIVTRRTIFDLKKAEARAHILEGYKIALDWLDAVIELIRGS
KTPAEAKEGLMSGLFSDEEWLRKMGLPLPAIHSQYQKPVRLTEVQAQEILNLRLHRLTGLERDKILQEYDDILKYIARLK
EILASEAEILKIIVGELRELKEKFGDERRTEIVDRSAEISLEDTIVEEDVVVTVSHTGYIKRTAVSQYRSQRRGGKGKTG
MKTKEEDFVEHLFVASSKDFMLFFTDAGKVYQIKVYEIPEGGRATRGKAIVNLLNLQENEQITAILSVKGFDDDRNIIMA
TRLGVVKKSPLREYANIRSGGIIAVNLDDGDKLIAVALTDGRQDVLLASKNGKSIRFHEDDARPMGRVSRGVRGMSLEDD
DVVIGMEIINPNATGSTIFTVTENGFGKRTELDEYRVQSRGGKGIITIKTTERNGCVVDIMQVTDENDLMLITDQGKILR
IPVAQFSVIGRNTQGVRLMTAEQNERIVAVAKLAEKDEGDDGADGGDDLPDAEVVEE

Sequences:

>Translated_857_residues
MLEQSLNKTAVNIEDEMKRSYMDYAMSVIIGRALPDVRDGLKPVHRRCLYAMYDMGNDYNKPYKKSARVVGDVIGKYHPH
GDAAAYDTIVRMAQDFSLRYPLVDGQGNFGSVDGDSPAAMRYTEIRMEQLAHELLNDLEKETVDLGPNYDGSLTEPLVLP
SKFPNLLVNGSSGIAVGMATNIPPHNLTEVINGIIATIENPNISFEELLALIPGPDFPTGGFIYGREGILQGYRTGRGIV
QMRARASIETHKKTERQSIIVTEIPYQVNKANLITKIAELVREKKLEGISDIRDESDRDGMRIVIDLKRDENPQVILNHL
YKQTQMQTSFGINMLAIVAGRPRVLTLRDAIGHFIDHRREIVTRRTIFDLKKAEARAHILEGYKIALDWLDAVIELIRGS
KTPAEAKEGLMSGLFSDEEWLRKMGLPLPAIHSQYQKPVRLTEVQAQEILNLRLHRLTGLERDKILQEYDDILKYIARLK
EILASEAEILKIIVGELRELKEKFGDERRTEIVDRSAEISLEDTIVEEDVVVTVSHTGYIKRTAVSQYRSQRRGGKGKTG
MKTKEEDFVEHLFVASSKDFMLFFTDAGKVYQIKVYEIPEGGRATRGKAIVNLLNLQENEQITAILSVKGFDDDRNIIMA
TRLGVVKKSPLREYANIRSGGIIAVNLDDGDKLIAVALTDGRQDVLLASKNGKSIRFHEDDARPMGRVSRGVRGMSLEDD
DVVIGMEIINPNATGSTIFTVTENGFGKRTELDEYRVQSRGGKGIITIKTTERNGCVVDIMQVTDENDLMLITDQGKILR
IPVAQFSVIGRNTQGVRLMTAEQNERIVAVAKLAEKDEGDDGADGGDDLPDAEVVEE
>Mature_857_residues
MLEQSLNKTAVNIEDEMKRSYMDYAMSVIIGRALPDVRDGLKPVHRRCLYAMYDMGNDYNKPYKKSARVVGDVIGKYHPH
GDAAAYDTIVRMAQDFSLRYPLVDGQGNFGSVDGDSPAAMRYTEIRMEQLAHELLNDLEKETVDLGPNYDGSLTEPLVLP
SKFPNLLVNGSSGIAVGMATNIPPHNLTEVINGIIATIENPNISFEELLALIPGPDFPTGGFIYGREGILQGYRTGRGIV
QMRARASIETHKKTERQSIIVTEIPYQVNKANLITKIAELVREKKLEGISDIRDESDRDGMRIVIDLKRDENPQVILNHL
YKQTQMQTSFGINMLAIVAGRPRVLTLRDAIGHFIDHRREIVTRRTIFDLKKAEARAHILEGYKIALDWLDAVIELIRGS
KTPAEAKEGLMSGLFSDEEWLRKMGLPLPAIHSQYQKPVRLTEVQAQEILNLRLHRLTGLERDKILQEYDDILKYIARLK
EILASEAEILKIIVGELRELKEKFGDERRTEIVDRSAEISLEDTIVEEDVVVTVSHTGYIKRTAVSQYRSQRRGGKGKTG
MKTKEEDFVEHLFVASSKDFMLFFTDAGKVYQIKVYEIPEGGRATRGKAIVNLLNLQENEQITAILSVKGFDDDRNIIMA
TRLGVVKKSPLREYANIRSGGIIAVNLDDGDKLIAVALTDGRQDVLLASKNGKSIRFHEDDARPMGRVSRGVRGMSLEDD
DVVIGMEIINPNATGSTIFTVTENGFGKRTELDEYRVQSRGGKGIITIKTTERNGCVVDIMQVTDENDLMLITDQGKILR
IPVAQFSVIGRNTQGVRLMTAEQNERIVAVAKLAEKDEGDDGADGGDDLPDAEVVEE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=346, Percent_Identity=23.4104046242775, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI19913406, Length=315, Percent_Identity=26.031746031746, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1788562, Length=862, Percent_Identity=57.07656612529, Blast_Score=947, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=700, Percent_Identity=35.4285714285714, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI212645845, Length=209, Percent_Identity=28.7081339712919, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=172, Percent_Identity=30.8139534883721, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17136538, Length=493, Percent_Identity=23.3265720081136, Blast_Score=74, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 95820; Mature: 95820

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQSLNKTAVNIEDEMKRSYMDYAMSVIIGRALPDVRDGLKPVHRRCLYAMYDMGNDYN
CCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
KPYKKSARVVGDVIGKYHPHGDAAAYDTIVRMAQDFSLRYPLVDGQGNFGSVDGDSPAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEECCEECCCCCCCCCCCCCCCHH
RYTEIRMEQLAHELLNDLEKETVDLGPNYDGSLTEPLVLPSKFPNLLVNGSSGIAVGMAT
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCEECCCCCCCEEEECCCCEEEEEEC
NIPPHNLTEVINGIIATIENPNISFEELLALIPGPDFPTGGFIYGREGILQGYRTGRGIV
CCCCCHHHHHHHHHEEEECCCCCCHHHHHHHCCCCCCCCCCEEECCHHHHHHHHCCCCCE
QMRARASIETHKKTERQSIIVTEIPYQVNKANLITKIAELVREKKLEGISDIRDESDRDG
EHHHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCC
MRIVIDLKRDENPQVILNHLYKQTQMQTSFGINMLAIVAGRPRVLTLRDAIGHFIDHRRE
CEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEHHHHHHHHHHHHHH
IVTRRTIFDLKKAEARAHILEGYKIALDWLDAVIELIRGSKTPAEAKEGLMSGLFSDEEW
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHH
LRKMGLPLPAIHSQYQKPVRLTEVQAQEILNLRLHRLTGLERDKILQEYDDILKYIARLK
HHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
EILASEAEILKIIVGELRELKEKFGDERRTEIVDRSAEISLEDTIVEEDVVVTVSHTGYI
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEHHHEECCCEEEEEECCCCH
KRTAVSQYRSQRRGGKGKTGMKTKEEDFVEHLFVASSKDFMLFFTDAGKVYQIKVYEIPE
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCC
GGRATRGKAIVNLLNLQENEQITAILSVKGFDDDRNIIMATRLGVVKKSPLREYANIRSG
CCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCCCEEEEEHHCHHCCCHHHHHHCCCCC
GIIAVNLDDGDKLIAVALTDGRQDVLLASKNGKSIRFHEDDARPMGRVSRGVRGMSLEDD
CEEEEEECCCCEEEEEEEECCCCEEEEECCCCCEEEEECCCCCHHHHHHHCCCCCCCCCC
DVVIGMEIINPNATGSTIFTVTENGFGKRTELDEYRVQSRGGKGIITIKTTERNGCVVDI
CEEEEEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCEEEEEEEECCCCCEEEE
MQVTDENDLMLITDQGKILRIPVAQFSVIGRNTQGVRLMTAEQNERIVAVAKLAEKDEGD
EEECCCCCEEEEECCCCEEEEEHHHHHEECCCCCCEEEEEECCCCCEEEEEHHHHCCCCC
DGADGGDDLPDAEVVEE
CCCCCCCCCCCHHHCCC
>Mature Secondary Structure
MLEQSLNKTAVNIEDEMKRSYMDYAMSVIIGRALPDVRDGLKPVHRRCLYAMYDMGNDYN
CCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
KPYKKSARVVGDVIGKYHPHGDAAAYDTIVRMAQDFSLRYPLVDGQGNFGSVDGDSPAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEECCEECCCCCCCCCCCCCCCHH
RYTEIRMEQLAHELLNDLEKETVDLGPNYDGSLTEPLVLPSKFPNLLVNGSSGIAVGMAT
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCEECCCCCCCEEEECCCCEEEEEEC
NIPPHNLTEVINGIIATIENPNISFEELLALIPGPDFPTGGFIYGREGILQGYRTGRGIV
CCCCCHHHHHHHHHEEEECCCCCCHHHHHHHCCCCCCCCCCEEECCHHHHHHHHCCCCCE
QMRARASIETHKKTERQSIIVTEIPYQVNKANLITKIAELVREKKLEGISDIRDESDRDG
EHHHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCC
MRIVIDLKRDENPQVILNHLYKQTQMQTSFGINMLAIVAGRPRVLTLRDAIGHFIDHRRE
CEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEHHHHHHHHHHHHHH
IVTRRTIFDLKKAEARAHILEGYKIALDWLDAVIELIRGSKTPAEAKEGLMSGLFSDEEW
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHH
LRKMGLPLPAIHSQYQKPVRLTEVQAQEILNLRLHRLTGLERDKILQEYDDILKYIARLK
HHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
EILASEAEILKIIVGELRELKEKFGDERRTEIVDRSAEISLEDTIVEEDVVVTVSHTGYI
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEHHHEECCCEEEEEECCCCH
KRTAVSQYRSQRRGGKGKTGMKTKEEDFVEHLFVASSKDFMLFFTDAGKVYQIKVYEIPE
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCC
GGRATRGKAIVNLLNLQENEQITAILSVKGFDDDRNIIMATRLGVVKKSPLREYANIRSG
CCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCCCEEEEEHHCHHCCCHHHHHHCCCCC
GIIAVNLDDGDKLIAVALTDGRQDVLLASKNGKSIRFHEDDARPMGRVSRGVRGMSLEDD
CEEEEEECCCCEEEEEEEECCCCEEEEECCCCCEEEEECCCCCHHHHHHHCCCCCCCCCC
DVVIGMEIINPNATGSTIFTVTENGFGKRTELDEYRVQSRGGKGIITIKTTERNGCVVDI
CEEEEEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCEEEEEEEECCCCCEEEE
MQVTDENDLMLITDQGKILRIPVAQFSVIGRNTQGVRLMTAEQNERIVAVAKLAEKDEGD
EEECCCCCEEEEECCCCEEEEEHHHHHEECCCCCCEEEEEECCCCCEEEEEHHHHCCCCC
DGADGGDDLPDAEVVEE
CCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609; 8849216 [H]