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The map label for this gene is manC

Identifier: 39546334

GI number: 39546334

Start: 2188501

End: 2189937

Strand: Reverse

Name: manC

Synonym: STM2105.S

Alternate gene names: 39546334

Gene position: 2189937-2188501 (Counterclockwise)

Preceding gene: 16765436

Following gene: 16765434

Centisome position: 45.08

GC content: 60.61

Gene sequence:

>1437_bases
ATGCGTCAGACAAAACTTTACCCGGTTGTGATGGCCGGTGGCTCCGGTAGCCGATTGTGGCCGCTTTCTCGCGTGCTTTA
TCCAAAACAGTTTCTGTGCCTGAAAGGCGATCTCACCATGCTGCAAACCACCATTTGCCGTCTGAACGGCGTGGAGTGCG
AAAGCCCGCTGGTGATCTGTAACGAACAGCACCGTTTTATCGTTGCCGAACAGCTCCGCCAGCTCAATAAGCTGACGGAG
AACATTATTCTTGAGCCCGCCGGGCGCAATACCGCGCCGGCGATTGCGCTGGCGGCGCTGGCGGCGACGCGCCAGCATAC
GGACTGCGATCCGCTGATGCTGGTACTGGCGGCGGATCATGCAATCGCCAATGAAGAGGCCTTCCGCGACGCGGTGCGCG
GCGCCATGCCCTATGCCGACGCGGGCAAACTGGTGACCTTCGGTATCGTGCCGGATCTGCCGGAAACCGGCTATGGCTAT
ATCCGGCGCGGTGATGTCGTGCCGGGCGCGACGGATGCGGTGGCTTTTGAGGTGGCGCAGTTCGTTGAGAAGCCGGGGCT
GGAAACCGCTCAGGCCTACGTCGCCAGCGGCGATTACTACTGGAACAGCGGCATGTTTCTGTTCCGCGCCGGACGCTATC
TGGAAGAGCTGAAAAAGTTCCGCCCCGATATTCTGGCCGCCTGTGAACAGGCGATGCGCGGCGTCGATCCGGATCTTGAC
TTCATTCGTGTGGATGAAGAGGCCTTCCTCGCCTGTCCGGAAGAGTCCATTGACTACGCGGTGATGGAGCGAACGGCGGA
CGCGGTGGTGATGCCGATGGATGCGGGCTGGAGCGATGTCGGCTCGTGGTCCTCGCTGTGGGAAATCAGCGCCCACACCC
CGGAGGGAAACGTCCACCACGGCGACGTCATCAGCCATAAAACGGAAAACAGCTACGTTTACGCCGAATCCGGCCTGGTG
ACCACCGTCGGCGTGAAGGATCTGGTGGTGGTGCAGACCAAAGACGCCGTGCTGATTGCCGATCGCCACGCGGTGCAGGA
CGTGAAAAAGGTGGTGGAGAAGATCAAGGCCGACGGACGCCATGAGCACCACATGCACCGCGAGGTTTACCGCCCGTGGG
GCAAATACGACTCCATCGACGCGGGCGAGCGCTATCAGGTGAAGCGTATTACCGTCAAGCCGGGGGAAGGACTGTCGGTG
CAGATGCACCATCACCGCGCCGAGCACTGGGTGGTGGTGGCGGGGACCGCCAGAGTCACCATCAACGGCGAGGTTAAGCT
GCTCGGTGAAAACGAGTCCATCTATATTCCGCTGGGGGCGACCCACTGCCTGGAAAATCCGGGAAAAATACCGCTCGATT
TAATTGAAGTGCGTTCCGGCTCGTATCTCGAAGAGGACGACGTGGTGCGGTTCGAGGATCGTTACGGGCGGGTCTGA

Upstream 100 bases:

>100_bases
CCATGCCGAAAAACAACACGACGGCACGTGAATACGCCGAACGCACGCTCAATAAAGAGAACGTGCTACGCCAATTTATT
GCAGATATTCGGGGATGATA

Downstream 100 bases:

>100_bases
CGCCTGCAATTATGCCCGGTAAGCGCAACGCGCCATCCGGCAATGAATAACAATAACGATGCTGGCCATTTACGGTCAGG
GCTAACTGTTGCCTGAAGAA

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MRQTKLYPVVMAGGSGSRLWPLSRVLYPKQFLCLKGDLTMLQTTICRLNGVECESPLVICNEQHRFIVAEQLRQLNKLTE
NIILEPAGRNTAPAIALAALAATRQHTDCDPLMLVLAADHAIANEEAFRDAVRGAMPYADAGKLVTFGIVPDLPETGYGY
IRRGDVVPGATDAVAFEVAQFVEKPGLETAQAYVASGDYYWNSGMFLFRAGRYLEELKKFRPDILAACEQAMRGVDPDLD
FIRVDEEAFLACPEESIDYAVMERTADAVVMPMDAGWSDVGSWSSLWEISAHTPEGNVHHGDVISHKTENSYVYAESGLV
TTVGVKDLVVVQTKDAVLIADRHAVQDVKKVVEKIKADGRHEHHMHREVYRPWGKYDSIDAGERYQVKRITVKPGEGLSV
QMHHHRAEHWVVVAGTARVTINGEVKLLGENESIYIPLGATHCLENPGKIPLDLIEVRSGSYLEEDDVVRFEDRYGRV

Sequences:

>Translated_478_residues
MRQTKLYPVVMAGGSGSRLWPLSRVLYPKQFLCLKGDLTMLQTTICRLNGVECESPLVICNEQHRFIVAEQLRQLNKLTE
NIILEPAGRNTAPAIALAALAATRQHTDCDPLMLVLAADHAIANEEAFRDAVRGAMPYADAGKLVTFGIVPDLPETGYGY
IRRGDVVPGATDAVAFEVAQFVEKPGLETAQAYVASGDYYWNSGMFLFRAGRYLEELKKFRPDILAACEQAMRGVDPDLD
FIRVDEEAFLACPEESIDYAVMERTADAVVMPMDAGWSDVGSWSSLWEISAHTPEGNVHHGDVISHKTENSYVYAESGLV
TTVGVKDLVVVQTKDAVLIADRHAVQDVKKVVEKIKADGRHEHHMHREVYRPWGKYDSIDAGERYQVKRITVKPGEGLSV
QMHHHRAEHWVVVAGTARVTINGEVKLLGENESIYIPLGATHCLENPGKIPLDLIEVRSGSYLEEDDVVRFEDRYGRV
>Mature_478_residues
MRQTKLYPVVMAGGSGSRLWPLSRVLYPKQFLCLKGDLTMLQTTICRLNGVECESPLVICNEQHRFIVAEQLRQLNKLTE
NIILEPAGRNTAPAIALAALAATRQHTDCDPLMLVLAADHAIANEEAFRDAVRGAMPYADAGKLVTFGIVPDLPETGYGY
IRRGDVVPGATDAVAFEVAQFVEKPGLETAQAYVASGDYYWNSGMFLFRAGRYLEELKKFRPDILAACEQAMRGVDPDLD
FIRVDEEAFLACPEESIDYAVMERTADAVVMPMDAGWSDVGSWSSLWEISAHTPEGNVHHGDVISHKTENSYVYAESGLV
TTVGVKDLVVVQTKDAVLIADRHAVQDVKKVVEKIKADGRHEHHMHREVYRPWGKYDSIDAGERYQVKRITVKPGEGLSV
QMHHHRAEHWVVVAGTARVTINGEVKLLGENESIYIPLGATHCLENPGKIPLDLIEVRSGSYLEEDDVVRFEDRYGRV

Specific function: Involved in the biosynthesis of the capsular polysaccharide colanic acid

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family

Homologues:

Organism=Escherichia coli, GI1788362, Length=478, Percent_Identity=90.7949790794979, Blast_Score=880, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MANC_SALTY (P26340)

Other databases:

- EMBL:   X59886
- EMBL:   AE006468
- PIR:   S16290
- ProteinModelPortal:   P26340
- GenomeReviews:   AE006468_GR
- NMPDR:   fig|99287.1.peg.2030
- HOGENOM:   HBG422488
- OMA:   AEHRMVA
- ProtClustDB:   PRK15460
- BioCyc:   STYP99287:STM2105-MONOMER
- BRENDA:   2.7.7.22
- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710
- Gene3D:   G3DSA:2.60.120.10
- TIGRFAMs:   TIGR01479

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase; SSF51182 RmlC_like_cupin

EC number: =2.7.7.13

Molecular weight: Translated: 53126; Mature: 53126

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQTKLYPVVMAGGSGSRLWPLSRVLYPKQFLCLKGDLTMLQTTICRLNGVECESPLVIC
CCCCEEEEEEEECCCCCCCCHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCEEEE
NEQHRFIVAEQLRQLNKLTENIILEPAGRNTAPAIALAALAATRQHTDCDPLMLVLAADH
CCCCCCHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCC
AIANEEAFRDAVRGAMPYADAGKLVTFGIVPDLPETGYGYIRRGDVVPGATDAVAFEVAQ
HHCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCEEEECCCCCCCCHHHHHHHHH
FVEKPGLETAQAYVASGDYYWNSGMFLFRAGRYLEELKKFRPDILAACEQAMRGVDPDLD
HHHCCCCCHHHHEEECCCEEECCCEEEEEHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCC
FIRVDEEAFLACPEESIDYAVMERTADAVVMPMDAGWSDVGSWSSLWEISAHTPEGNVHH
EEEECCHHEEECCCHHCCHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCC
GDVISHKTENSYVYAESGLVTTVGVKDLVVVQTKDAVLIADRHAVQDVKKVVEKIKADGR
CCCCCCCCCCCEEEECCCEEEEECCCEEEEEEECCEEEEECHHHHHHHHHHHHHHHCCCC
HEHHMHREVYRPWGKYDSIDAGERYQVKRITVKPGEGLSVQMHHHRAEHWVVVAGTARVT
HHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEECCCCCEEEEEEEEEEEE
INGEVKLLGENESIYIPLGATHCLENPGKIPLDLIEVRSGSYLEEDDVVRFEDRYGRV
ECCEEEEEECCCEEEEECCHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEHHHCCCC
>Mature Secondary Structure
MRQTKLYPVVMAGGSGSRLWPLSRVLYPKQFLCLKGDLTMLQTTICRLNGVECESPLVIC
CCCCEEEEEEEECCCCCCCCHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCEEEE
NEQHRFIVAEQLRQLNKLTENIILEPAGRNTAPAIALAALAATRQHTDCDPLMLVLAADH
CCCCCCHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCC
AIANEEAFRDAVRGAMPYADAGKLVTFGIVPDLPETGYGYIRRGDVVPGATDAVAFEVAQ
HHCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCEEEECCCCCCCCHHHHHHHHH
FVEKPGLETAQAYVASGDYYWNSGMFLFRAGRYLEELKKFRPDILAACEQAMRGVDPDLD
HHHCCCCCHHHHEEECCCEEECCCEEEEEHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCC
FIRVDEEAFLACPEESIDYAVMERTADAVVMPMDAGWSDVGSWSSLWEISAHTPEGNVHH
EEEECCHHEEECCCHHCCHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCC
GDVISHKTENSYVYAESGLVTTVGVKDLVVVQTKDAVLIADRHAVQDVKKVVEKIKADGR
CCCCCCCCCCCEEEECCCEEEEECCCEEEEEEECCEEEEECHHHHHHHHHHHHHHHCCCC
HEHHMHREVYRPWGKYDSIDAGERYQVKRITVKPGEGLSVQMHHHRAEHWVVVAGTARVT
HHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEECCCCCEEEEEEEEEEEE
INGEVKLLGENESIYIPLGATHCLENPGKIPLDLIEVRSGSYLEEDDVVRFEDRYGRV
ECCEEEEEECCCEEEEECCHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1712067; 11677609