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The map label for this gene is cpsG [H]

Identifier: 16765434

GI number: 16765434

Start: 2187020

End: 2188390

Strand: Reverse

Name: cpsG [H]

Synonym: STM2104

Alternate gene names: 16765434

Gene position: 2188390-2187020 (Counterclockwise)

Preceding gene: 39546334

Following gene: 16765433

Centisome position: 45.05

GC content: 61.71

Gene sequence:

>1371_bases
ATGACAAAATTAACCTGTTTCAAGGCCTACGACATTCGCGGCAGGCTGGGCGAAGAGCTCAATGAAGATATCGCGTGGCG
GATTGGCCGCGCTTACGGCGAATATTTAAAACCGAAAACCGTCGTGCTGGGCGGCGACGTGCGCCTGACCAGCGAGGCGC
TGAAGCTGGCGCTGGCGAAAGGGTTACAGGACGCGGGCGTCGACGTGCTGGATATCGGTATGTCCGGCACCGAAGAGATT
TACTTCGCCACCTTCCACCTTGGCGTGGACGGCGGTATTGAAGTGACCGCCAGCCATAATCCGATGGACTACAACGGTAT
GAAGCTGGTGCGCGAGGGCGCCCGCCCGATAAGCGGCGACACCGGTCTGCGCGACGTTCAGCGTCTGGCGGAAGCGGGCG
ACTTCCCGCCGGTGAACGAGGCCGCGCGCGGCAGCTACAGACAAATCAGCCTGCGCGACGCCTACATCGACCACCTGCTC
GGCTATATCAGTGTTAACAATCTCACCCCGCTGAAGCTGGTGTTTAACGCCGGCAATGGGGCGGCGGGGCCGGTCATTGA
CGCCATCGAAGCGCGCCTGAAGGCGCTGGGCGCGCCGGTGGAGTTCATCAAAATCCACAACACCCCGGACGGCACCTTCC
CGAACGGCATTCCCAACCCGTTGCTGCCGGAGTGTCGCGACGACACCCGCAAGGCCGTTATTGAACACGGGGCGGACATG
GGTATCGCCTTTGACGGCGACTTCGACCGCTGCTTCCTGTTCGATGAGAAAGGGCAGTTTATCGAGGGGTACTACATCGT
CGGGCTGCTGGCGGAAGCATTTCTGGAAAAACACCCGGGGGCGAAGATTATCCACGACCCGCGCCTGACCTGGAACACGG
AGGCAGTGGTGACGGCGGCGGGCGGGACGCCGGTGATGTCAAAAACCGGGCACGCCTTTATCAAGGAGCGGATGCGTACG
GAGGATGCCATTTATGGCGGGGAAATGAGCGCGCATCACTATTTTCGTGATTTTGCCTACTGCGACAGCGGGATGATCCC
GTGGCTGCTGGTGGCGGAGCTGGTGTGCCTGAAGAGACAGTCGCTGGGTGAGCTGGTTCGCGACCGGATGGCGGCGTTCC
CGGCGAGCGGGGAAATCAACAGCAGACTGGCGGAGCCGGCGGCGGCCATTGCGCGGGTGGAAGCGCACTTTGCGGAAGAG
GCGCAGGCAGTGGACCGCACGGACGGCCTCAGCATGTCGTTCGCCGACTGGCGTTTCAACCTGCGCTCGTCAAACACCGA
ACCGGTGGTGCGCCTGAATGTGGAATCACGCGGCGATATTCCGCTGATGGAAGCGCGAACACGCACTCTGCTGGCGCTGC
TGAATCAGTAA

Upstream 100 bases:

>100_bases
TATGCCCGGTAAGCGCAACGCGCCATCCGGCAATGAATAACAATAACGATGCTGGCCATTTACGGTCAGGGCTAACTGTT
GCCTGAAGAAGGGGAAGCAC

Downstream 100 bases:

>100_bases
CGTCAGATCTCCCCTTACCGCCTGCGGGTAAGGGGCCAATCACAGGAACAACGATGACAAATCTAAAAAAGCGCGAACGA
GCCAAAACCAATGCATCGTT

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MTKLTCFKAYDIRGRLGEELNEDIAWRIGRAYGEYLKPKTVVLGGDVRLTSEALKLALAKGLQDAGVDVLDIGMSGTEEI
YFATFHLGVDGGIEVTASHNPMDYNGMKLVREGARPISGDTGLRDVQRLAEAGDFPPVNEAARGSYRQISLRDAYIDHLL
GYISVNNLTPLKLVFNAGNGAAGPVIDAIEARLKALGAPVEFIKIHNTPDGTFPNGIPNPLLPECRDDTRKAVIEHGADM
GIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLEKHPGAKIIHDPRLTWNTEAVVTAAGGTPVMSKTGHAFIKERMRT
EDAIYGGEMSAHHYFRDFAYCDSGMIPWLLVAELVCLKRQSLGELVRDRMAAFPASGEINSRLAEPAAAIARVEAHFAEE
AQAVDRTDGLSMSFADWRFNLRSSNTEPVVRLNVESRGDIPLMEARTRTLLALLNQ

Sequences:

>Translated_456_residues
MTKLTCFKAYDIRGRLGEELNEDIAWRIGRAYGEYLKPKTVVLGGDVRLTSEALKLALAKGLQDAGVDVLDIGMSGTEEI
YFATFHLGVDGGIEVTASHNPMDYNGMKLVREGARPISGDTGLRDVQRLAEAGDFPPVNEAARGSYRQISLRDAYIDHLL
GYISVNNLTPLKLVFNAGNGAAGPVIDAIEARLKALGAPVEFIKIHNTPDGTFPNGIPNPLLPECRDDTRKAVIEHGADM
GIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLEKHPGAKIIHDPRLTWNTEAVVTAAGGTPVMSKTGHAFIKERMRT
EDAIYGGEMSAHHYFRDFAYCDSGMIPWLLVAELVCLKRQSLGELVRDRMAAFPASGEINSRLAEPAAAIARVEAHFAEE
AQAVDRTDGLSMSFADWRFNLRSSNTEPVVRLNVESRGDIPLMEARTRTLLALLNQ
>Mature_455_residues
TKLTCFKAYDIRGRLGEELNEDIAWRIGRAYGEYLKPKTVVLGGDVRLTSEALKLALAKGLQDAGVDVLDIGMSGTEEIY
FATFHLGVDGGIEVTASHNPMDYNGMKLVREGARPISGDTGLRDVQRLAEAGDFPPVNEAARGSYRQISLRDAYIDHLLG
YISVNNLTPLKLVFNAGNGAAGPVIDAIEARLKALGAPVEFIKIHNTPDGTFPNGIPNPLLPECRDDTRKAVIEHGADMG
IAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLEKHPGAKIIHDPRLTWNTEAVVTAAGGTPVMSKTGHAFIKERMRTE
DAIYGGEMSAHHYFRDFAYCDSGMIPWLLVAELVCLKRQSLGELVRDRMAAFPASGEINSRLAEPAAAIARVEAHFAEEA
QAVDRTDGLSMSFADWRFNLRSSNTEPVVRLNVESRGDIPLMEARTRTLLALLNQ

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=456, Percent_Identity=89.4736842105263, Blast_Score=860, Evalue=0.0,
Organism=Escherichia coli, GI1789566, Length=466, Percent_Identity=26.3948497854077, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.8 [H]

Molecular weight: Translated: 50003; Mature: 49871

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLTCFKAYDIRGRLGEELNEDIAWRIGRAYGEYLKPKTVVLGGDVRLTSEALKLALAK
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEHHHHHHHHHHH
GLQDAGVDVLDIGMSGTEEIYFATFHLGVDGGIEVTASHNPMDYNGMKLVREGARPISGD
CHHHCCCCEEEECCCCCCEEEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHCCCCCCCC
TGLRDVQRLAEAGDFPPVNEAARGSYRQISLRDAYIDHLLGYISVNNLTPLKLVFNAGNG
CCHHHHHHHHHCCCCCCCCHHHCCCCEEEEHHHHHHHHHHHHHEECCCCEEEEEEECCCC
AAGPVIDAIEARLKALGAPVEFIKIHNTPDGTFPNGIPNPLLPECRDDTRKAVIEHGADM
CCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCC
GIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLEKHPGAKIIHDPRLTWNTEAVVTAA
EEEECCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCCEEECCCCEECCCEEEEEC
GGTPVMSKTGHAFIKERMRTEDAIYGGEMSAHHYFRDFAYCDSGMIPWLLVAELVCLKRQ
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
SLGELVRDRMAAFPASGEINSRLAEPAAAIARVEAHFAEEAQAVDRTDGLSMSFADWRFN
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHEEEE
LRSSNTEPVVRLNVESRGDIPLMEARTRTLLALLNQ
ECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKLTCFKAYDIRGRLGEELNEDIAWRIGRAYGEYLKPKTVVLGGDVRLTSEALKLALAK
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEHHHHHHHHHHH
GLQDAGVDVLDIGMSGTEEIYFATFHLGVDGGIEVTASHNPMDYNGMKLVREGARPISGD
CHHHCCCCEEEECCCCCCEEEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHCCCCCCCC
TGLRDVQRLAEAGDFPPVNEAARGSYRQISLRDAYIDHLLGYISVNNLTPLKLVFNAGNG
CCHHHHHHHHHCCCCCCCCHHHCCCCEEEEHHHHHHHHHHHHHEECCCCEEEEEEECCCC
AAGPVIDAIEARLKALGAPVEFIKIHNTPDGTFPNGIPNPLLPECRDDTRKAVIEHGADM
CCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCC
GIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLEKHPGAKIIHDPRLTWNTEAVVTAA
EEEECCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCCEEECCCCEECCCEEEEEC
GGTPVMSKTGHAFIKERMRTEDAIYGGEMSAHHYFRDFAYCDSGMIPWLLVAELVCLKRQ
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
SLGELVRDRMAAFPASGEINSRLAEPAAAIARVEAHFAEEAQAVDRTDGLSMSFADWRFN
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHEEEE
LRSSNTEPVVRLNVESRGDIPLMEARTRTLLALLNQ
ECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1383393 [H]