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The map label for this gene is ccmA

Identifier: 38637878

GI number: 38637878

Start: 231803

End: 232486

Strand: Direct

Name: ccmA

Synonym: PHG214

Alternate gene names: 38637878

Gene position: 231803-232486 (Clockwise)

Preceding gene: 38637877

Following gene: 38637879

Centisome position: 51.27

GC content: 72.95

Gene sequence:

>684_bases
GTGCCAGCCCGCTCGCCCGAGCCGTTGCCTGATCATTCGTCGGTCTGCTCGCCCGGCTGCGCAGACCTTCCCATCCTTGC
CGCCAGCGGGCTCGGCTTCTCCCGTGCGGGACGGGTCGTGTTCAGCGGCATCGATCTCGCTCTCGGCCCCGGCGATCTAC
TCCAGGTGCTGGGCGCCAACGGCAGCGGCAAGACCAGCCTGCTGCGCGTACTGAGCGGCCTAGTGGCTCCGGACGAGGGC
GAACTGCACTGGCGCGGACGGCCGGTTCGCGCCGGCGACCCGTCCTTGCTGCAGGCGCTGGCCTATGTCGGCCACGCCAA
CGGCATCGATCCCGAACTGAGTCCCGTGGAGAACCTGCGCTTCGCCGCACGCCTGGCGGGCGTCGCCGCCACACCCGACA
ACGTGCAGGCCGCGCTGGCCGCGTTCGGGCTGGAGCGCGTCATGCATGCGCCGGCGCGGTCGCTGTCGCAAGGCCTGCGC
CGGCGCGCGGCGCTGGCGCGGCTGGCGCTGGCGCGGCGCGAACTGTGGCTGCTGGACGAGCCGGTGACGTCGCTCGACGC
CGACGCCGCTGCGCGCTTCCAGGCACAGCTCGACGATCACCTGCGCGCGGGCGGCATGGCCATCGTCGCCACGCACGCGC
TGCTGCCGGGCGCCAGGACCTTAAGGCTGGACGCCCGGTCATGA

Upstream 100 bases:

>100_bases
CTCGACTTATCTAGCCAACAAGGAAAAGACCTGCATCGACTGCCACAAGGGCATCGCCCACCATCTTCCCGACGTGTCCA
AGGCCGGGGAGAAATGACAC

Downstream 100 bases:

>100_bases
CCCGCACCCTGGCCGCCATCATCATGCACGACCTGTCGCTTTCGTGGCGACGGCGCGGCAGCCTGCTCGGCAGCGTGGTG
TTCTTCGTGATCGCCACCAG

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MPARSPEPLPDHSSVCSPGCADLPILAASGLGFSRAGRVVFSGIDLALGPGDLLQVLGANGSGKTSLLRVLSGLVAPDEG
ELHWRGRPVRAGDPSLLQALAYVGHANGIDPELSPVENLRFAARLAGVAATPDNVQAALAAFGLERVMHAPARSLSQGLR
RRAALARLALARRELWLLDEPVTSLDADAAARFQAQLDDHLRAGGMAIVATHALLPGARTLRLDARS

Sequences:

>Translated_227_residues
MPARSPEPLPDHSSVCSPGCADLPILAASGLGFSRAGRVVFSGIDLALGPGDLLQVLGANGSGKTSLLRVLSGLVAPDEG
ELHWRGRPVRAGDPSLLQALAYVGHANGIDPELSPVENLRFAARLAGVAATPDNVQAALAAFGLERVMHAPARSLSQGLR
RRAALARLALARRELWLLDEPVTSLDADAAARFQAQLDDHLRAGGMAIVATHALLPGARTLRLDARS
>Mature_226_residues
PARSPEPLPDHSSVCSPGCADLPILAASGLGFSRAGRVVFSGIDLALGPGDLLQVLGANGSGKTSLLRVLSGLVAPDEGE
LHWRGRPVRAGDPSLLQALAYVGHANGIDPELSPVENLRFAARLAGVAATPDNVQAALAAFGLERVMHAPARSLSQGLRR
RAALARLALARRELWLLDEPVTSLDADAAARFQAQLDDHLRAGGMAIVATHALLPGARTLRLDARS

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI153792144, Length=192, Percent_Identity=25, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI116734710, Length=146, Percent_Identity=30.1369863013699, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI27436953, Length=154, Percent_Identity=29.2207792207792, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI47078218, Length=185, Percent_Identity=28.1081081081081, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI45446740, Length=185, Percent_Identity=28.1081081081081, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI6005701, Length=171, Percent_Identity=25.7309941520468, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI9961250, Length=192, Percent_Identity=27.0833333333333, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI4505771, Length=192, Percent_Identity=27.0833333333333, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI9961252, Length=192, Percent_Identity=27.0833333333333, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI105990541, Length=184, Percent_Identity=26.6304347826087, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI156105685, Length=193, Percent_Identity=29.5336787564767, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI87082064, Length=190, Percent_Identity=40.5263157894737, Blast_Score=123, Evalue=9e-30,
Organism=Escherichia coli, GI48994943, Length=188, Percent_Identity=29.7872340425532, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790467, Length=182, Percent_Identity=31.8681318681319, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87081791, Length=192, Percent_Identity=28.6458333333333, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI1788165, Length=174, Percent_Identity=32.183908045977, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1787370, Length=193, Percent_Identity=29.0155440414508, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI87081709, Length=170, Percent_Identity=31.1764705882353, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87081782, Length=173, Percent_Identity=24.8554913294798, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787792, Length=201, Percent_Identity=29.8507462686567, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI87081834, Length=192, Percent_Identity=30.7291666666667, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789032, Length=159, Percent_Identity=29.559748427673, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1787029, Length=184, Percent_Identity=28.804347826087, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786703, Length=192, Percent_Identity=31.25, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787182, Length=196, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786563, Length=191, Percent_Identity=30.3664921465969, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI87082267, Length=176, Percent_Identity=26.1363636363636, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1787712, Length=173, Percent_Identity=28.3236994219653, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789593, Length=204, Percent_Identity=25.9803921568627, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790544, Length=187, Percent_Identity=30.4812834224599, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI48994997, Length=184, Percent_Identity=29.8913043478261, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1789864, Length=202, Percent_Identity=27.7227722772277, Blast_Score=61, Evalue=7e-11,
Organism=Escherichia coli, GI1789751, Length=210, Percent_Identity=29.0476190476191, Blast_Score=60, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI115533608, Length=177, Percent_Identity=27.1186440677966, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17565586, Length=158, Percent_Identity=25.9493670886076, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI116007184, Length=180, Percent_Identity=24.4444444444444, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221500365, Length=180, Percent_Identity=24.4444444444444, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19920532, Length=178, Percent_Identity=28.0898876404494, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24580930, Length=178, Percent_Identity=28.0898876404494, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24666092, Length=180, Percent_Identity=27.2222222222222, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCMA_CUPNH (Q7WXC1)

Other databases:

- EMBL:   AY305378
- RefSeq:   NP_942852.1
- ProteinModelPortal:   Q7WXC1
- SMR:   Q7WXC1
- GeneID:   2656656
- GenomeReviews:   AY305378_GR
- KEGG:   reh:PHG214
- HOGENOM:   HBG758042
- OMA:   SARRGED
- PhylomeDB:   Q7WXC1
- ProtClustDB:   PRK13538
- BioCyc:   REUT381666:PHG214-MONOMER
- HAMAP:   MF_01707
- InterPro:   IPR003439
- InterPro:   IPR005895
- InterPro:   IPR003593
- PANTHER:   PTHR19222:SF5
- SMART:   SM00382
- TIGRFAMs:   TIGR01189

Pfam domain/function: PF00005 ABC_tran

EC number: =3.6.3.41

Molecular weight: Translated: 23653; Mature: 23522

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51243 CCMA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPARSPEPLPDHSSVCSPGCADLPILAASGLGFSRAGRVVFSGIDLALGPGDLLQVLGAN
CCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCHHHCCCEEEECCCEEECCHHHHHHHCCC
GSGKTSLLRVLSGLVAPDEGELHWRGRPVRAGDPSLLQALAYVGHANGIDPELSPVENLR
CCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHH
FAARLAGVAATPDNVQAALAAFGLERVMHAPARSLSQGLRRRAALARLALARRELWLLDE
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PVTSLDADAAARFQAQLDDHLRAGGMAIVATHALLPGARTLRLDARS
CHHHCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHCCCCEEEEEECCC
>Mature Secondary Structure 
PARSPEPLPDHSSVCSPGCADLPILAASGLGFSRAGRVVFSGIDLALGPGDLLQVLGAN
CCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCHHHCCCEEEECCCEEECCHHHHHHHCCC
GSGKTSLLRVLSGLVAPDEGELHWRGRPVRAGDPSLLQALAYVGHANGIDPELSPVENLR
CCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHH
FAARLAGVAATPDNVQAALAAFGLERVMHAPARSLSQGLRRRAALARLALARRELWLLDE
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PVTSLDADAAARFQAQLDDHLRAGGMAIVATHALLPGARTLRLDARS
CHHHCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12948488