Click here to switch to the map view.

The map label for this gene is hypA1

Identifier: 38637680

GI number: 38637680

Start: 8525

End: 8884

Strand: Direct

Name: hypA1

Synonym: PHG012

Alternate gene names: 38637680

Gene position: 8525-8884 (Clockwise)

Preceding gene: 38637679

Following gene: 38637681

Centisome position: 1.89

GC content: 63.33

Gene sequence:

>360_bases
ATGCATGAGCTCAGCCTGGCGGGTGGCATCTTGCAGTTGCTCGAAGACGCTGCGCGGCGCGAACGATTTGCTCGGGTCAC
GCTCTTGCGCCTCGAGGCAGGCAAGTTGTGTGGCGTGGAGGTACGCGCGCTGCGTTTCGCGCTCGAGGCCATTGCTTCGG
GAACCTGCCTGGAGGGCGCTTGTATCGAGATCGAGGAACCTGAGGGACAGGCCTGGTGCCTGCAGTGCAATGCAGCGGTT
GCTTTGGCGGAGCGTGGCGCACCATGCAGCGGATGCGGCGGCTACCGGCTCCAGCCCACTGCGGGGACCGAGTTGCGTGT
TATGGACATGCTGGTCGAAGATCACTGGTGTCCTGAATGA

Upstream 100 bases:

>100_bases
GCGGCCGATGTGCGGCGCAGCATCGGCATTCTGGTCGCGGCGTATGATCCTTGCGTCCCCTATACGGTGGAGTTCGCGGA
GTCTTTGGGAGATACTGTCC

Downstream 100 bases:

>100_bases
AAAATTCATTGAATCAGGACACCAGGGTGAAGCGATCTGCGAGAAGAAAGGAGTAGGCGAAAATGTGCGTCATATGTGGA
TGCAATACCAATCACGAGAC

Product: HypA1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 119; Mature: 119

Protein sequence:

>119_residues
MHELSLAGGILQLLEDAARRERFARVTLLRLEAGKLCGVEVRALRFALEAIASGTCLEGACIEIEEPEGQAWCLQCNAAV
ALAERGAPCSGCGGYRLQPTAGTELRVMDMLVEDHWCPE

Sequences:

>Translated_119_residues
MHELSLAGGILQLLEDAARRERFARVTLLRLEAGKLCGVEVRALRFALEAIASGTCLEGACIEIEEPEGQAWCLQCNAAV
ALAERGAPCSGCGGYRLQPTAGTELRVMDMLVEDHWCPE
>Mature_119_residues
MHELSLAGGILQLLEDAARRERFARVTLLRLEAGKLCGVEVRALRFALEAIASGTCLEGACIEIEEPEGQAWCLQCNAAV
ALAERGAPCSGCGGYRLQPTAGTELRVMDMLVEDHWCPE

Specific function: Probably plays a role in a hydrogenase nickel cofactor insertion step

COG id: COG0375

COG function: function code R; Zn finger protein HypA/HybF (possibly regulating hydrogenase expression)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hypA/hybF family

Homologues:

Organism=Escherichia coli, GI1789365, Length=113, Percent_Identity=36.283185840708, Blast_Score=74, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HYPA_CUPNH (P31901)

Other databases:

- EMBL:   AY305378
- EMBL:   X70183
- PIR:   S29975
- RefSeq:   NP_942654.1
- GeneID:   2656433
- GenomeReviews:   AY305378_GR
- KEGG:   reh:PHG012
- HOGENOM:   HBG688671
- OMA:   MHEASLA
- PhylomeDB:   P31901
- ProtClustDB:   CLSK923798
- BioCyc:   REUT381666:PHG012-MONOMER
- HAMAP:   MF_00213
- InterPro:   IPR000688
- InterPro:   IPR020538

Pfam domain/function: PF01155 HypA

EC number: NA

Molecular weight: Translated: 12858; Mature: 12858

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS01249 HYPA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

6.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
9.2 %Cys+Met (Translated Protein)
6.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
9.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHELSLAGGILQLLEDAARRERFARVTLLRLEAGKLCGVEVRALRFALEAIASGTCLEGA
CCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCE
CIEIEEPEGQAWCLQCNAAVALAERGAPCSGCGGYRLQPTAGTELRVMDMLVEDHWCPE
EEEEECCCCCEEEEECCCEEEECCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MHELSLAGGILQLLEDAARRERFARVTLLRLEAGKLCGVEVRALRFALEAIASGTCLEGA
CCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCE
CIEIEEPEGQAWCLQCNAAVALAERGAPCSGCGGYRLQPTAGTELRVMDMLVEDHWCPE
EEEEECCCCCEEEEECCCEEEECCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948488; 8352644