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The map label for this gene is trpC1 [H]

Identifier: 38234889

GI number: 38234889

Start: 2461262

End: 2462719

Strand: Direct

Name: trpC1 [H]

Synonym: DIP2355

Alternate gene names: 38234889

Gene position: 2461262-2462719 (Clockwise)

Preceding gene: 38234888

Following gene: 38234890

Centisome position: 98.9

GC content: 57.2

Gene sequence:

>1458_bases
ATGCAGAATGATTCGTCGACACGCCCCATGCCCACCGTCCTAGAATCCATCGTTTCGGGCCGACGATCCCACCTGCCCGA
AATCCAAGCGCGGATTTCCCACGTGGACCCGGCGCGACTACTGCGTTCCACCCGCTCGCTGTTTCAGTCGTTGGGAGGCC
GTAGCGATGGCGGTCCGGCGTTGCGGGGGAGTGCGCGCTTTATCATGGAGTGTAAGTCCTCTTCGCCATCGCTTGGCATG
ATTCGTGAGGATTATCGCCCTGGCGACATCGCGCGGGTGTATTCACGTTATGCGGCCGGCATTTCGGTGTTGTGCGAGCC
GGATCGTTTTGGCGGCGACTATAACCATCTGGCCACGGTGGCGGCCACGACACATCTGCCGGTGCTGTGCAAGGATTTTA
TTATCCACCCCGCACAGGTTCACGCGGCACGTTATTTTGGGGCGGACGCAATTTTGCTCATGTTGAGTGTGCTTGACGAC
GCCACCTACACCGAGCTCAGCCAGGAAGCAGCACGCTTGGGGTTGGATGTTCTCACCGAGGTTATCGACGAGGTTGAGGT
GGAACGTGCCATTCGGTTGGGGGCCACAATCTTTGGCATTAATCATCGCAATCTGCATGACTTGAGCATTGATTTAAATC
GCTCAGCACGCCTTGCGCAGCTGATTCCCGATAGCGCCGTGATTGTCTCCGAGTCTGGCATTCGGAATAACGAGACGGTT
CGCCAACTCAGCGGGCATTCCAGCGCATTCTTGGTAGGCTCGCAGCTTACTTCTCAGCCAGATGTGGACCGTGCGGCCCG
CGAGCTTGTGTACGGCCTCAATAAGGTGTGCGGTTTGCAGTCACCAAGCGAGGCGCAAGCAGCGCGCGCATCGGGCGCAA
TCTATGGCGGATTAATCTTCGTGGAGTCTAGTCCGCGTAATGTTTCACGTGAAACATCGAAAAAAATCATGGCTGCCGAA
CCTGACCTCACCTATGTCGCCGTCTCACGACGCACCACCGGATGGACCGAAATTATAGGTGGCAACATCGCCGTTGCTCA
GATCCACAGTCCTTACCAGGGCTCCATCGCCGCCGAAAAAGAACTCATTAACCATGTGCGCGGCGAGGTAGGAGACAAGG
TAAAAATCTGGCGTGCAGTCTCCATGACGCATGCCGACGGCTCCCTTGTCGCCGAAGCACTCGCACCCGAGGTAGACAGA
CTCATCCTCGACACCGGCAACGGCGGAACCGGCACCACCTTCGATTGGGCACGCATCCCAGAAGCCGTAAAGGGCAAGAC
TCTTCTCGCCGGCGGCATTGGACCAGACAATGTCACCGAGGCACTCGCCGTTGGCTGCGCGGGACCCGATCTCAACTCCG
GGTTGGAATATCCAGTCGAAGCAGGGAAGTGGGCAGCACACAAAGACGCTACTGCAATCCACTCCACTTTCACCCAAATA
CGTGGTTTTCATTACTAA

Upstream 100 bases:

>100_bases
AATCACGTACCCACCATCGCCGAGGGAGTCGCTAAGGCACAAACAATGCTTGCCGACGGCTCCGTGGAGCGCTGGTTAGC
TATCCACGAGGAGGCAAACT

Downstream 100 bases:

>100_bases
TGCTAACCTAAGTAGCATATGATGTAGCGTTCCGCCGGAGAATAAGGAATTCTAGAGGGCATGATCAAACCACTTCTGCT
CGCCATCGGCTGCGTCAGCG

Product: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: Indole-3-glycerol phosphate synthase; IGPS; N-(5'-phospho-ribosyl)anthranilate isomerase; PRAI [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MQNDSSTRPMPTVLESIVSGRRSHLPEIQARISHVDPARLLRSTRSLFQSLGGRSDGGPALRGSARFIMECKSSSPSLGM
IREDYRPGDIARVYSRYAAGISVLCEPDRFGGDYNHLATVAATTHLPVLCKDFIIHPAQVHAARYFGADAILLMLSVLDD
ATYTELSQEAARLGLDVLTEVIDEVEVERAIRLGATIFGINHRNLHDLSIDLNRSARLAQLIPDSAVIVSESGIRNNETV
RQLSGHSSAFLVGSQLTSQPDVDRAARELVYGLNKVCGLQSPSEAQAARASGAIYGGLIFVESSPRNVSRETSKKIMAAE
PDLTYVAVSRRTTGWTEIIGGNIAVAQIHSPYQGSIAAEKELINHVRGEVGDKVKIWRAVSMTHADGSLVAEALAPEVDR
LILDTGNGGTGTTFDWARIPEAVKGKTLLAGGIGPDNVTEALAVGCAGPDLNSGLEYPVEAGKWAAHKDATAIHSTFTQI
RGFHY

Sequences:

>Translated_485_residues
MQNDSSTRPMPTVLESIVSGRRSHLPEIQARISHVDPARLLRSTRSLFQSLGGRSDGGPALRGSARFIMECKSSSPSLGM
IREDYRPGDIARVYSRYAAGISVLCEPDRFGGDYNHLATVAATTHLPVLCKDFIIHPAQVHAARYFGADAILLMLSVLDD
ATYTELSQEAARLGLDVLTEVIDEVEVERAIRLGATIFGINHRNLHDLSIDLNRSARLAQLIPDSAVIVSESGIRNNETV
RQLSGHSSAFLVGSQLTSQPDVDRAARELVYGLNKVCGLQSPSEAQAARASGAIYGGLIFVESSPRNVSRETSKKIMAAE
PDLTYVAVSRRTTGWTEIIGGNIAVAQIHSPYQGSIAAEKELINHVRGEVGDKVKIWRAVSMTHADGSLVAEALAPEVDR
LILDTGNGGTGTTFDWARIPEAVKGKTLLAGGIGPDNVTEALAVGCAGPDLNSGLEYPVEAGKWAAHKDATAIHSTFTQI
RGFHY
>Mature_485_residues
MQNDSSTRPMPTVLESIVSGRRSHLPEIQARISHVDPARLLRSTRSLFQSLGGRSDGGPALRGSARFIMECKSSSPSLGM
IREDYRPGDIARVYSRYAAGISVLCEPDRFGGDYNHLATVAATTHLPVLCKDFIIHPAQVHAARYFGADAILLMLSVLDD
ATYTELSQEAARLGLDVLTEVIDEVEVERAIRLGATIFGINHRNLHDLSIDLNRSARLAQLIPDSAVIVSESGIRNNETV
RQLSGHSSAFLVGSQLTSQPDVDRAARELVYGLNKVCGLQSPSEAQAARASGAIYGGLIFVESSPRNVSRETSKKIMAAE
PDLTYVAVSRRTTGWTEIIGGNIAVAQIHSPYQGSIAAEKELINHVRGEVGDKVKIWRAVSMTHADGSLVAEALAPEVDR
LILDTGNGGTGTTFDWARIPEAVKGKTLLAGGIGPDNVTEALAVGCAGPDLNSGLEYPVEAGKWAAHKDATAIHSTFTQI
RGFHY

Specific function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain [H]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=485, Percent_Identity=40.8247422680412, Blast_Score=328, Evalue=4e-91,
Organism=Saccharomyces cerevisiae, GI6322638, Length=215, Percent_Identity=32.5581395348837, Blast_Score=103, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS; PF00697 PRAI [H]

EC number: =4.1.1.48; =5.3.1.24 [H]

Molecular weight: Translated: 52094; Mature: 52094

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNDSSTRPMPTVLESIVSGRRSHLPEIQARISHVDPARLLRSTRSLFQSLGGRSDGGPA
CCCCCCCCCHHHHHHHHHCCHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCC
LRGSARFIMECKSSSPSLGMIREDYRPGDIARVYSRYAAGISVLCEPDRFGGDYNHLATV
CCCCCEEEEEECCCCCCCCCHHCCCCCCHHHHHHHHHHCCCEEEECCHHCCCCHHHHHHH
AATTHLPVLCKDFIIHPAQVHAARYFGADAILLMLSVLDDATYTELSQEAARLGLDVLTE
HHHHCCHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VIDEVEVERAIRLGATIFGINHRNLHDLSIDLNRSARLAQLIPDSAVIVSESGIRNNETV
HHHHHHHHHHHHHCCEEEECCCCCEEEEEEECCCCHHHHHHCCCCEEEEECCCCCCCHHH
RQLSGHSSAFLVGSQLTSQPDVDRAARELVYGLNKVCGLQSPSEAQAARASGAIYGGLIF
HHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEEE
VESSPRNVSRETSKKIMAAEPDLTYVAVSRRTTGWTEIIGGNIAVAQIHSPYQGSIAAEK
EECCCCCCCHHHHHCEEECCCCEEEEEEECCCCCHHHHHCCCEEEEEECCCCCCCHHHHH
ELINHVRGEVGDKVKIWRAVSMTHADGSLVAEALAPEVDRLILDTGNGGTGTTFDWARIP
HHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHCC
EAVKGKTLLAGGIGPDNVTEALAVGCAGPDLNSGLEYPVEAGKWAAHKDATAIHSTFTQI
HHHCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RGFHY
CCCCC
>Mature Secondary Structure
MQNDSSTRPMPTVLESIVSGRRSHLPEIQARISHVDPARLLRSTRSLFQSLGGRSDGGPA
CCCCCCCCCHHHHHHHHHCCHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCC
LRGSARFIMECKSSSPSLGMIREDYRPGDIARVYSRYAAGISVLCEPDRFGGDYNHLATV
CCCCCEEEEEECCCCCCCCCHHCCCCCCHHHHHHHHHHCCCEEEECCHHCCCCHHHHHHH
AATTHLPVLCKDFIIHPAQVHAARYFGADAILLMLSVLDDATYTELSQEAARLGLDVLTE
HHHHCCHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VIDEVEVERAIRLGATIFGINHRNLHDLSIDLNRSARLAQLIPDSAVIVSESGIRNNETV
HHHHHHHHHHHHHCCEEEECCCCCEEEEEEECCCCHHHHHHCCCCEEEEECCCCCCCHHH
RQLSGHSSAFLVGSQLTSQPDVDRAARELVYGLNKVCGLQSPSEAQAARASGAIYGGLIF
HHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEEE
VESSPRNVSRETSKKIMAAEPDLTYVAVSRRTTGWTEIIGGNIAVAQIHSPYQGSIAAEK
EECCCCCCCHHHHHCEEECCCCEEEEEEECCCCCHHHHHCCCEEEEEECCCCCCCHHHHH
ELINHVRGEVGDKVKIWRAVSMTHADGSLVAEALAPEVDRLILDTGNGGTGTTFDWARIP
HHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHCC
EAVKGKTLLAGGIGPDNVTEALAVGCAGPDLNSGLEYPVEAGKWAAHKDATAIHSTFTQI
HHHCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RGFHY
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3808947; 12948626 [H]