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The map label for this gene is chrA [H]

Identifier: 38234861

GI number: 38234861

Start: 2431702

End: 2432301

Strand: Direct

Name: chrA [H]

Synonym: DIP2327

Alternate gene names: 38234861

Gene position: 2431702-2432301 (Clockwise)

Preceding gene: 38234860

Following gene: 38234864

Centisome position: 97.71

GC content: 59.33

Gene sequence:

>600_bases
ATGATCCGCGTCATGCTTATCGACGACCACCCCGTAGTCCGCGCCGGACTGCGCTCCATTTTGGACAGCTTCGATGACAT
CACCGTGGTCGCCGAAGCCAGCGACGGCAGCAACATCAACACCAAAGGCATCGACGTTGTTGTCACCGACATCCAAATGC
CAGGCACCGACGGCATCACCCTAACCCGCGCACTCGCCAGCGCCGGCGGCCCTCCAGTGCTCATCCTGACCACCTACGAC
ACCGAGGCAGACATCCTCGCAGCAGTCGAAGCAGGTGCTATGGGCTACCTGCTCAAAGACGCGCCGGAATCGGCACTACA
CGATGCAGTGATCGCCACCTTTGAAGGCCGTCGCACCCTCGCCCCCAAGGTCGCCAACGCCCTCATGCAACGTGTGAGCA
AACCCCGCCAGGCACTCTCGGCTCGCGAGATCGAAATCCTCCAGAACTTGGAACAAGGACTTAGTAACCGCCAACTCGCA
GCCAAACTATTTATTTCCGAGGCAACGGTAAAAACTCACCTCGTGCACATCTACTCCAAGCTCGGCGTAGATAACCGCAC
CGCCGCCATCACGGCAGCACGCCAGCAACGCCTGATTTAA

Upstream 100 bases:

>100_bases
AGCGCGTAGATACCGTTGGTGGCACACTCGTGATTGAATCAGATACATACGGCACCGCACTCGCTTGCCGCATTCCGCTT
ACCAGCCGCCGGGAGACTTC

Downstream 100 bases:

>100_bases
CTCGGAGCGATACGCGAAGGATCACCCAACCGTTCCCCCAACCCCACAAGCACGGCGAACACCACGCCCAGCAGGATGGC
GCAACCTGCCCACACGGGGA

Product: two-component response regulator ChrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MIRVMLIDDHPVVRAGLRSILDSFDDITVVAEASDGSNINTKGIDVVVTDIQMPGTDGITLTRALASAGGPPVLILTTYD
TEADILAAVEAGAMGYLLKDAPESALHDAVIATFEGRRTLAPKVANALMQRVSKPRQALSAREIEILQNLEQGLSNRQLA
AKLFISEATVKTHLVHIYSKLGVDNRTAAITAARQQRLI

Sequences:

>Translated_199_residues
MIRVMLIDDHPVVRAGLRSILDSFDDITVVAEASDGSNINTKGIDVVVTDIQMPGTDGITLTRALASAGGPPVLILTTYD
TEADILAAVEAGAMGYLLKDAPESALHDAVIATFEGRRTLAPKVANALMQRVSKPRQALSAREIEILQNLEQGLSNRQLA
AKLFISEATVKTHLVHIYSKLGVDNRTAAITAARQQRLI
>Mature_199_residues
MIRVMLIDDHPVVRAGLRSILDSFDDITVVAEASDGSNINTKGIDVVVTDIQMPGTDGITLTRALASAGGPPVLILTTYD
TEADILAAVEAGAMGYLLKDAPESALHDAVIATFEGRRTLAPKVANALMQRVSKPRQALSAREIEILQNLEQGLSNRQLA
AKLFISEATVKTHLVHIYSKLGVDNRTAAITAARQQRLI

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=206, Percent_Identity=38.8349514563107, Blast_Score=131, Evalue=2e-32,
Organism=Escherichia coli, GI1788222, Length=194, Percent_Identity=34.020618556701, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1787473, Length=212, Percent_Identity=33.4905660377358, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790102, Length=189, Percent_Identity=34.3915343915344, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1786747, Length=205, Percent_Identity=27.3170731707317, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788546, Length=201, Percent_Identity=29.3532338308458, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1788712, Length=202, Percent_Identity=25.7425742574257, Blast_Score=68, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 21322; Mature: 21322

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVMLIDDHPVVRAGLRSILDSFDDITVVAEASDGSNINTKGIDVVVTDIQMPGTDGIT
CEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEEEEECCCCCCHH
LTRALASAGGPPVLILTTYDTEADILAAVEAGAMGYLLKDAPESALHDAVIATFEGRRTL
HHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCHHHHHHHCCCHHHHHHHHHEEECCCCCH
APKVANALMQRVSKPRQALSAREIEILQNLEQGLSNRQLAAKLFISEATVKTHLVHIYSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LGVDNRTAAITAARQQRLI
HCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MIRVMLIDDHPVVRAGLRSILDSFDDITVVAEASDGSNINTKGIDVVVTDIQMPGTDGIT
CEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEEEEECCCCCCHH
LTRALASAGGPPVLILTTYDTEADILAAVEAGAMGYLLKDAPESALHDAVIATFEGRRTL
HHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCHHHHHHHCCCHHHHHHHHHEEECCCCCH
APKVANALMQRVSKPRQALSAREIEILQNLEQGLSNRQLAAKLFISEATVKTHLVHIYSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LGVDNRTAAITAARQQRLI
HCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]