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The map label for this gene is mutM [C]

Identifier: 38234839

GI number: 38234839

Start: 2399933

End: 2400787

Strand: Direct

Name: mutM [C]

Synonym: DIP2304

Alternate gene names: 38234839

Gene position: 2399933-2400787 (Clockwise)

Preceding gene: 38234837

Following gene: 38234840

Centisome position: 96.44

GC content: 58.48

Gene sequence:

>855_bases
ATGCCCGAAGGTCACGTCATCCATCGCTTCGCAGACCAACTCAACCAGCATTTCGCCAGCACACAGGCAACACCGGACAC
ACAACCCCGCCGCCCGCTACTGGTCACCTCCCCACAAGGTCGCTTTGTCACAGAGGCCGCCCAACTCAACGGTCATGCAC
TCGACCACGCCGAGGCATGGGGCAAACACCTTTTCCTCTGCTTTGATAGCGATAACCCAGCCCACATCGTCCACATCCAC
CTCGGGCTTATCGGAAGCATGCGCTTAGAAGACCCAGCCAATGTGTGGGGTCAGATTCGATTCCGGATCGAAGACCCAGA
ACTGCCCACCACCAGCGCGGTAGCAGCAAACCTGCGCGGCCCACAGTGGTGCAGGTTGATTACGGAGGCGGAAATGACCA
CCGCCACCGCAAAGCTCGGCGCCGATCCGCTACGCGACGACGCCAACTTCCTAGCGATCAAAACAAAAGTGGCGCGCTCG
CGTCGCAGTATCGGTTCCCTGCTGATGGATCAGAAACTCTTTGCCGGCGTGGGCAATATCTACCGTGCCGAAACACTCTT
CCGCCTGGGAATTAGCCCCTTTATCCTCGGCAAAGATGTAGCAGAGCTCGACCTCATCTGGCAGGACCTGCGTTTTCTTA
TGCGCGAGGGGGTGAACAGGGGTCGGATTGATACTGTTCGCCCGGAGCACACACCGGAGGCGATGGGGCGGCCGCCACGC
AAGGATGACCACGGTGGCGAGGTGTATGTGTATCGTCGCTATGGTCAGCCGTGTTATGTGTGTGGCACGCCGATCCTTGA
GTGCACGATGGAGGGTCGTAATCTTTTTTGGTGTCCTACCTGCCAACCTGATTAG

Upstream 100 bases:

>100_bases
TAAAGTTCTTCATGCCCCCTATGATACGCAACTCCTTTAATTGTGCAACTATTGTTCACAATTACCTATTTATTCTTGGG
GTGGCCTATCCTTAACAACC

Downstream 100 bases:

>100_bases
CAACTGGCTACGCTGGTAGTCATGTTCGCGTACAGCACTGAGGCGATTCGCCTGTCGGAAAACCCTATGATTGCGGCTGC
GCAGCCGGATGCGTTGATGA

Product: putative DNA repair glycosylase

Products: NA

Alternate protein names: Putative DNA-(apurinic or apyrimidinic site) lyase Rv2464c/MT2539; Putative AP lyase Rv2464c/MT2539 [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MPEGHVIHRFADQLNQHFASTQATPDTQPRRPLLVTSPQGRFVTEAAQLNGHALDHAEAWGKHLFLCFDSDNPAHIVHIH
LGLIGSMRLEDPANVWGQIRFRIEDPELPTTSAVAANLRGPQWCRLITEAEMTTATAKLGADPLRDDANFLAIKTKVARS
RRSIGSLLMDQKLFAGVGNIYRAETLFRLGISPFILGKDVAELDLIWQDLRFLMREGVNRGRIDTVRPEHTPEAMGRPPR
KDDHGGEVYVYRRYGQPCYVCGTPILECTMEGRNLFWCPTCQPD

Sequences:

>Translated_284_residues
MPEGHVIHRFADQLNQHFASTQATPDTQPRRPLLVTSPQGRFVTEAAQLNGHALDHAEAWGKHLFLCFDSDNPAHIVHIH
LGLIGSMRLEDPANVWGQIRFRIEDPELPTTSAVAANLRGPQWCRLITEAEMTTATAKLGADPLRDDANFLAIKTKVARS
RRSIGSLLMDQKLFAGVGNIYRAETLFRLGISPFILGKDVAELDLIWQDLRFLMREGVNRGRIDTVRPEHTPEAMGRPPR
KDDHGGEVYVYRRYGQPCYVCGTPILECTMEGRNLFWCPTCQPD
>Mature_283_residues
PEGHVIHRFADQLNQHFASTQATPDTQPRRPLLVTSPQGRFVTEAAQLNGHALDHAEAWGKHLFLCFDSDNPAHIVHIHL
GLIGSMRLEDPANVWGQIRFRIEDPELPTTSAVAANLRGPQWCRLITEAEMTTATAKLGADPLRDDANFLAIKTKVARSR
RSIGSLLMDQKLFAGVGNIYRAETLFRLGISPFILGKDVAELDLIWQDLRFLMREGVNRGRIDTVRPEHTPEAMGRPPRK
DDHGGEVYVYRRYGQPCYVCGTPILECTMEGRNLFWCPTCQPD

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA b

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=236, Percent_Identity=29.6610169491525, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786932, Length=296, Percent_Identity=26.3513513513513, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR012319
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 31945; Mature: 31814

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEGHVIHRFADQLNQHFASTQATPDTQPRRPLLVTSPQGRFVTEAAQLNGHALDHAEAW
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCEEEHHHHCCCCCCHHHHHC
GKHLFLCFDSDNPAHIVHIHLGLIGSMRLEDPANVWGQIRFRIEDPELPTTSAVAANLRG
CCEEEEEECCCCCCEEEEEEEEEEECCCCCCCCCCEEEEEEEEECCCCCCHHHHHHCCCC
PQWCRLITEAEMTTATAKLGADPLRDDANFLAIKTKVARSRRSIGSLLMDQKLFAGVGNI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCH
YRAETLFRLGISPFILGKDVAELDLIWQDLRFLMREGVNRGRIDTVRPEHTPEAMGRPPR
HHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCC
KDDHGGEVYVYRRYGQPCYVCGTPILECTMEGRNLFWCPTCQPD
CCCCCCEEEEEEECCCEEEEECCCCEEEEECCCEEEECCCCCCC
>Mature Secondary Structure 
PEGHVIHRFADQLNQHFASTQATPDTQPRRPLLVTSPQGRFVTEAAQLNGHALDHAEAW
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCEEEHHHHCCCCCCHHHHHC
GKHLFLCFDSDNPAHIVHIHLGLIGSMRLEDPANVWGQIRFRIEDPELPTTSAVAANLRG
CCEEEEEECCCCCCEEEEEEEEEEECCCCCCCCCCEEEEEEEEECCCCCCHHHHHHCCCC
PQWCRLITEAEMTTATAKLGADPLRDDANFLAIKTKVARSRRSIGSLLMDQKLFAGVGNI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCH
YRAETLFRLGISPFILGKDVAELDLIWQDLRFLMREGVNRGRIDTVRPEHTPEAMGRPPR
HHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCC
KDDHGGEVYVYRRYGQPCYVCGTPILECTMEGRNLFWCPTCQPD
CCCCCCEEEEEEECCCEEEEECCCCEEEEECCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]