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The map label for this gene is uhpT [H]

Identifier: 38234806

GI number: 38234806

Start: 2361757

End: 2363166

Strand: Direct

Name: uhpT [H]

Synonym: DIP2270

Alternate gene names: 38234806

Gene position: 2361757-2363166 (Clockwise)

Preceding gene: 38234805

Following gene: 38234809

Centisome position: 94.9

GC content: 57.52

Gene sequence:

>1410_bases
ATGTTCAGTGTGTTCGATCTCAAGAAAATCCCTAACAAAGGAATACCACTCGAGCAACAACGCAAGATGTGGCTGGGACA
GTTCCTCAAGGCGTTCTTCGTCGTGTTCTTCGTGTACATGTCGATGTACTTCATCAGGAACAACTTCAAAGCCGCACAGC
CGATGCTCAAAGAAGACTTCGGCCTCACCACCCTCCAACTGGGCTACATCGGCCTCGCCTTCTCCATCACCTACGGCATT
GGCAAAACCTTGGTCGGCTACTTCGTAGACGGCCACAACTCCAAGCGCATCATCTCCACTCTGCTGATCTGCGCCTCCAC
CATGGTTCTCCTCATGGGCCTGCTCCTGAGTTACTTCGGCTCAGTCATCGGCATCTTCATCGTCTTGTGGGGCCTTAACG
GTCTATTCCAATCCGCTGGCGGCCCCGCCTCCTATTCGACGATTTCTCGCTGGGCACCCCGAACCAAACGCGGCAAATAC
CTAGGCCTATGGAACGCCTCCCACAACGTCGGTGGCGCACTCGCCGGTGGCCTAGCTCTCTGGGGCGCTAACGTATTCTT
CGGCGGCAACGTCGTCGGCATGTTCATCTTCCCAGCACTGATCGGCCTCACCATCGGTATCATCGGCCTCTTCGTCGGCA
AAGACGACCCCGAAGAACTGGGCTGGAACCGCAGCGAGGAAATCTTCGGCGAAGCTGTGGAAGCAGAAAACTCCCAGGCA
GAAACCATGCCCCAGCGCGAAATCTTCCTTAACTACGTGCTGAAAAACCCCTGGCTGTGGACACTCTGTATCGCCAACGT
CTTCGTCTACATCGTCCGCATTGGTATCGACAACTGGGCACCGCTCTACGTCACCGAGGAACTCCACTTTGACAAGGGCG
ACGCCGTAAACACCATCTTCTACTTCGAGATCGGCGCACTGGTGGCCAGCCTGCTATGGGGCTACGTCTCCGACCTGCTC
AAAGGCCGCCGCGCCATCGTGGCAATCGGCTGCCTGTTCATGATCTACTTCGCCGTCATGCTCTACCGCAACGCCAGCAG
CGTCACCATGGTGAACCTCTCGCTGTTCATCTTGGGCGCACTGATCTTCGGCCCCCAGCTACTCATCGGTGTCTCGCTCG
TCGGCTTCGTGCCTAAGCGCGCAATCAGCGTGGCTAACGGCATGACCGGTACTTTCGGCTACCTCTTTGGCGACTCCATG
GCCAAAGTCGGCCTCGCCGCCATCGCAGACCCCGAGCAAAAAGGCCTCACCGTCTTCGGACACCTCCTCCACGGATGGGG
TGCTGTCTTTACCGTCTTCTACTTCGCACTGACCATCGGCATCGTATTGCTCATGATCGTCGCCGTGGGTGAAGAACGCC
GCATCCGCAAGCTCCAAGCAGCAGAGGCGGTAGGCAAGGCACTCGCCTAG

Upstream 100 bases:

>100_bases
TGTGAGATTTCACATCTTTGAATAACGCGAACTGCGGTTTTGCATATTGACAATAATATTCAATCTTGTGAAGCAGCATA
TTTTCTGTAACGATTCAGAT

Downstream 100 bases:

>100_bases
CAGCTCACCAATAACAAAACTCGCCTGCGGCAATTCCTGCCACAGGCGAGTTCTTTTTTGTTTTACACAGCCACGTCGTT
ATACGGCATCATCACCGAAA

Product: sugar phosphate antiporter

Products: Proton [Cytoplasm]; glucose-6-phosphate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MFSVFDLKKIPNKGIPLEQQRKMWLGQFLKAFFVVFFVYMSMYFIRNNFKAAQPMLKEDFGLTTLQLGYIGLAFSITYGI
GKTLVGYFVDGHNSKRIISTLLICASTMVLLMGLLLSYFGSVIGIFIVLWGLNGLFQSAGGPASYSTISRWAPRTKRGKY
LGLWNASHNVGGALAGGLALWGANVFFGGNVVGMFIFPALIGLTIGIIGLFVGKDDPEELGWNRSEEIFGEAVEAENSQA
ETMPQREIFLNYVLKNPWLWTLCIANVFVYIVRIGIDNWAPLYVTEELHFDKGDAVNTIFYFEIGALVASLLWGYVSDLL
KGRRAIVAIGCLFMIYFAVMLYRNASSVTMVNLSLFILGALIFGPQLLIGVSLVGFVPKRAISVANGMTGTFGYLFGDSM
AKVGLAAIADPEQKGLTVFGHLLHGWGAVFTVFYFALTIGIVLLMIVAVGEERRIRKLQAAEAVGKALA

Sequences:

>Translated_469_residues
MFSVFDLKKIPNKGIPLEQQRKMWLGQFLKAFFVVFFVYMSMYFIRNNFKAAQPMLKEDFGLTTLQLGYIGLAFSITYGI
GKTLVGYFVDGHNSKRIISTLLICASTMVLLMGLLLSYFGSVIGIFIVLWGLNGLFQSAGGPASYSTISRWAPRTKRGKY
LGLWNASHNVGGALAGGLALWGANVFFGGNVVGMFIFPALIGLTIGIIGLFVGKDDPEELGWNRSEEIFGEAVEAENSQA
ETMPQREIFLNYVLKNPWLWTLCIANVFVYIVRIGIDNWAPLYVTEELHFDKGDAVNTIFYFEIGALVASLLWGYVSDLL
KGRRAIVAIGCLFMIYFAVMLYRNASSVTMVNLSLFILGALIFGPQLLIGVSLVGFVPKRAISVANGMTGTFGYLFGDSM
AKVGLAAIADPEQKGLTVFGHLLHGWGAVFTVFYFALTIGIVLLMIVAVGEERRIRKLQAAEAVGKALA
>Mature_469_residues
MFSVFDLKKIPNKGIPLEQQRKMWLGQFLKAFFVVFFVYMSMYFIRNNFKAAQPMLKEDFGLTTLQLGYIGLAFSITYGI
GKTLVGYFVDGHNSKRIISTLLICASTMVLLMGLLLSYFGSVIGIFIVLWGLNGLFQSAGGPASYSTISRWAPRTKRGKY
LGLWNASHNVGGALAGGLALWGANVFFGGNVVGMFIFPALIGLTIGIIGLFVGKDDPEELGWNRSEEIFGEAVEAENSQA
ETMPQREIFLNYVLKNPWLWTLCIANVFVYIVRIGIDNWAPLYVTEELHFDKGDAVNTIFYFEIGALVASLLWGYVSDLL
KGRRAIVAIGCLFMIYFAVMLYRNASSVTMVNLSLFILGALIFGPQLLIGVSLVGFVPKRAISVANGMTGTFGYLFGDSM
AKVGLAAIADPEQKGLTVFGHLLHGWGAVFTVFYFALTIGIVLLMIVAVGEERRIRKLQAAEAVGKALA

Specific function: Transport protein for sugar phosphate uptake [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI256219598, Length=374, Percent_Identity=23.2620320855615, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI4503847, Length=374, Percent_Identity=23.2620320855615, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI256219483, Length=374, Percent_Identity=23.2620320855615, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI256219543, Length=289, Percent_Identity=24.2214532871972, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI223717983, Length=424, Percent_Identity=24.7641509433962, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI38093649, Length=424, Percent_Identity=24.7641509433962, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI46361976, Length=405, Percent_Identity=22.4691358024691, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI2367259, Length=461, Percent_Identity=48.590021691974, Blast_Score=407, Evalue=1e-115,
Organism=Escherichia coli, GI1788573, Length=463, Percent_Identity=30.6695464362851, Blast_Score=204, Evalue=7e-54,
Organism=Escherichia coli, GI87082310, Length=441, Percent_Identity=30.3854875283447, Blast_Score=176, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17542316, Length=370, Percent_Identity=26.7567567567568, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI133901854, Length=481, Percent_Identity=24.5322245322245, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI133901856, Length=481, Percent_Identity=24.5322245322245, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI133930953, Length=467, Percent_Identity=21.8415417558887, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17564202, Length=387, Percent_Identity=22.9974160206718, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17564204, Length=387, Percent_Identity=22.9974160206718, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24656866, Length=487, Percent_Identity=22.3819301848049, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45550478, Length=487, Percent_Identity=22.3819301848049, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24656861, Length=474, Percent_Identity=22.5738396624473, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 51504; Mature: 51504

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS50850 MFS ; PS00942 GLPT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSVFDLKKIPNKGIPLEQQRKMWLGQFLKAFFVVFFVYMSMYFIRNNFKAAQPMLKEDF
CCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHCC
GLTTLQLGYIGLAFSITYGIGKTLVGYFVDGHNSKRIISTLLICASTMVLLMGLLLSYFG
CCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SVIGIFIVLWGLNGLFQSAGGPASYSTISRWAPRTKRGKYLGLWNASHNVGGALAGGLAL
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHH
WGANVFFGGNVVGMFIFPALIGLTIGIIGLFVGKDDPEELGWNRSEEIFGEAVEAENSQA
HCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHCCCCHH
ETMPQREIFLNYVLKNPWLWTLCIANVFVYIVRIGIDNWAPLYVTEELHFDKGDAVNTIF
HCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEH
YFEIGALVASLLWGYVSDLLKGRRAIVAIGCLFMIYFAVMLYRNASSVTMVNLSLFILGA
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHH
LIFGPQLLIGVSLVGFVPKRAISVANGMTGTFGYLFGDSMAKVGLAAIADPEQKGLTVFG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHCCCCCCCHHHHH
HLLHGWGAVFTVFYFALTIGIVLLMIVAVGEERRIRKLQAAEAVGKALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFSVFDLKKIPNKGIPLEQQRKMWLGQFLKAFFVVFFVYMSMYFIRNNFKAAQPMLKEDF
CCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHCC
GLTTLQLGYIGLAFSITYGIGKTLVGYFVDGHNSKRIISTLLICASTMVLLMGLLLSYFG
CCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SVIGIFIVLWGLNGLFQSAGGPASYSTISRWAPRTKRGKYLGLWNASHNVGGALAGGLAL
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHH
WGANVFFGGNVVGMFIFPALIGLTIGIIGLFVGKDDPEELGWNRSEEIFGEAVEAENSQA
HCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHCCCCHH
ETMPQREIFLNYVLKNPWLWTLCIANVFVYIVRIGIDNWAPLYVTEELHFDKGDAVNTIF
HCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEH
YFEIGALVASLLWGYVSDLLKGRRAIVAIGCLFMIYFAVMLYRNASSVTMVNLSLFILGA
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHH
LIFGPQLLIGVSLVGFVPKRAISVANGMTGTFGYLFGDSMAKVGLAAIADPEQKGLTVFG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHCCCCCCCHHHHH
HLLHGWGAVFTVFYFALTIGIVLLMIVAVGEERRIRKLQAAEAVGKALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; glucose-6-phosphate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + glucose-6-phosphate [Periplasm] = Proton [Cytoplasm] + glucose-6-phosphate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]