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The map label for this gene is msrA

Identifier: 38234796

GI number: 38234796

Start: 2352676

End: 2353338

Strand: Reverse

Name: msrA

Synonym: DIP2260

Alternate gene names: 38234796

Gene position: 2353338-2352676 (Counterclockwise)

Preceding gene: 38234799

Following gene: 38234792

Centisome position: 94.56

GC content: 59.28

Gene sequence:

>663_bases
ATGGGATGGTTATTTGGCGCACCGCGCTTAGTAGAAGAAAAAGACGCACTCAAAGGCGGACCACACCCGGTCCTGCCCAA
CCCACAGCCACACGCTGTACTAGGAACCCTTCGAGGTCAACCAGGCACCGAAACCATATATATAGGTATCGGCTGTTACT
GGGGAGCAGAAAAACTGTTCTGGGAAACCCCAGGCGTGGTGTACACCTCCGTAGGCTTCGCCGGTGGAATCACACCGAAC
CCCACCTACCGTGAAACCTGCACCGGACGCACCAACCACACCGAAATCGTCGAAGTCGTCTACGACCCAACACAGGTCAC
CTTTGACGAACTCGTGGTCAAAGCCATGGAAGCACACGACCCCACCCAAGGCTACCGACAAGGCAACGACACCGGAACGC
AGTACCGCTCCGCGATCTACACCGCTGGCCCCAACGCCGAACAGCAGGCACAACGTGCCCGCGAGATCGTAGAACACTAC
GCCCCCAAACTTGCCGCAGCCGGCCTCGGACGCATCACCACCGAAATCCTGCCACTCGCCAGCACCCCAGCCGGCGAATA
CTACATGGCCGAGGACGAGCACCAGCAGTACCTGCACAAAAACCCACTAGGATACTGCCCGCACCACTCCACCGGAGTGG
CCTGCGGAATCCCAGAGGCGTAG

Upstream 100 bases:

>100_bases
GGCAACAATTATTTGGCGAAATGTGTCTTTCGTGGTCAGAAAAACGAAGAACTGCACGAAATTGTGGAACATAATTCCCA
AAGTGCACGTTGATGTCGAT

Downstream 100 bases:

>100_bases
TTCTAGGGCTGCAATGAGAAAGCTTATGTCGCTAAGGAGGGCTAGGTATTTCGCTGGACAAACTCCGTCGTGAAGCTGAG
AAATCAGCAGAATATAACGT

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MGWLFGAPRLVEEKDALKGGPHPVLPNPQPHAVLGTLRGQPGTETIYIGIGCYWGAEKLFWETPGVVYTSVGFAGGITPN
PTYRETCTGRTNHTEIVEVVYDPTQVTFDELVVKAMEAHDPTQGYRQGNDTGTQYRSAIYTAGPNAEQQAQRAREIVEHY
APKLAAAGLGRITTEILPLASTPAGEYYMAEDEHQQYLHKNPLGYCPHHSTGVACGIPEA

Sequences:

>Translated_220_residues
MGWLFGAPRLVEEKDALKGGPHPVLPNPQPHAVLGTLRGQPGTETIYIGIGCYWGAEKLFWETPGVVYTSVGFAGGITPN
PTYRETCTGRTNHTEIVEVVYDPTQVTFDELVVKAMEAHDPTQGYRQGNDTGTQYRSAIYTAGPNAEQQAQRAREIVEHY
APKLAAAGLGRITTEILPLASTPAGEYYMAEDEHQQYLHKNPLGYCPHHSTGVACGIPEA
>Mature_219_residues
GWLFGAPRLVEEKDALKGGPHPVLPNPQPHAVLGTLRGQPGTETIYIGIGCYWGAEKLFWETPGVVYTSVGFAGGITPNP
TYRETCTGRTNHTEIVEVVYDPTQVTFDELVVKAMEAHDPTQGYRQGNDTGTQYRSAIYTAGPNAEQQAQRAREIVEHYA
PKLAAAGLGRITTEILPLASTPAGEYYMAEDEHQQYLHKNPLGYCPHHSTGVACGIPEA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=212, Percent_Identity=47.1698113207547, Blast_Score=178, Evalue=4e-45,
Organism=Homo sapiens, GI208609995, Length=188, Percent_Identity=50, Blast_Score=175, Evalue=3e-44,
Organism=Homo sapiens, GI208609993, Length=128, Percent_Identity=49.21875, Blast_Score=114, Evalue=6e-26,
Organism=Escherichia coli, GI1790665, Length=202, Percent_Identity=49.009900990099, Blast_Score=174, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17533973, Length=154, Percent_Identity=35.0649350649351, Blast_Score=81, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320881, Length=187, Percent_Identity=32.620320855615, Blast_Score=96, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24664627, Length=154, Percent_Identity=36.3636363636364, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI45553131, Length=149, Percent_Identity=36.241610738255, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24664631, Length=154, Percent_Identity=35.0649350649351, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_CORDI (Q6NEL2)

Other databases:

- EMBL:   BX248360
- RefSeq:   NP_940563.1
- ProteinModelPortal:   Q6NEL2
- SMR:   Q6NEL2
- GeneID:   2650056
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP2260
- NMPDR:   fig|257309.1.peg.2154
- HOGENOM:   HBG748152
- OMA:   VYFAEAY
- PhylomeDB:   Q6NEL2
- ProtClustDB:   PRK00058
- BioCyc:   CDIP257309:DIP2260-MONOMER
- BRENDA:   1.8.4.11
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 23950; Mature: 23819

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: ACT_SITE 52-52

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGWLFGAPRLVEEKDALKGGPHPVLPNPQPHAVLGTLRGQPGTETIYIGIGCYWGAEKLF
CCCCCCCCCHHCHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEEECCCHHE
WETPGVVYTSVGFAGGITPNPTYRETCTGRTNHTEIVEVVYDPTQVTFDELVVKAMEAHD
ECCCCEEEEECCCCCCCCCCCCCHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCC
PTQGYRQGNDTGTQYRSAIYTAGPNAEQQAQRAREIVEHYAPKLAAAGLGRITTEILPLA
CHHHHCCCCCCHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
STPAGEYYMAEDEHQQYLHKNPLGYCPHHSTGVACGIPEA
CCCCCCEEECCHHHHHHHHCCCCCCCCCCCCCEECCCCCC
>Mature Secondary Structure 
GWLFGAPRLVEEKDALKGGPHPVLPNPQPHAVLGTLRGQPGTETIYIGIGCYWGAEKLF
CCCCCCCCHHCHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEEECCCHHE
WETPGVVYTSVGFAGGITPNPTYRETCTGRTNHTEIVEVVYDPTQVTFDELVVKAMEAHD
ECCCCEEEEECCCCCCCCCCCCCHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCC
PTQGYRQGNDTGTQYRSAIYTAGPNAEQQAQRAREIVEHYAPKLAAAGLGRITTEILPLA
CHHHHCCCCCCHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
STPAGEYYMAEDEHQQYLHKNPLGYCPHHSTGVACGIPEA
CCCCCCEEECCHHHHHHHHCCCCCCCCCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910