Click here to switch to the map view.

The map label for this gene is glpK [H]

Identifier: 38234771

GI number: 38234771

Start: 2323066

End: 2324586

Strand: Reverse

Name: glpK [H]

Synonym: DIP2235

Alternate gene names: 38234771

Gene position: 2324586-2323066 (Counterclockwise)

Preceding gene: 38234772

Following gene: 38234767

Centisome position: 93.41

GC content: 57.59

Gene sequence:

>1521_bases
ATGAATCAACCACAGTATGTTGCTGCGATTGACCAAGGAACGACGTCGACACGCTGCATCATTTTCGACCACAACGGCCA
ACAAGTAGGCGTTGGCCAGTACGAACACGAACAAATCTTCCCCCAAAAAGGCTGGGTAGAGCACAACCCAATGGAAATCT
GGGCCAACACGCGCCAAGCCGTTGGGACAGCACTCGCCGAAAGCGACGTCTCCCGTGAAGACATCGTAGCCGTAGGCATA
ACAAACCAGCGTGAAACCACGGTGGTCTGGAACAAAACTACTGGTGAACCCATATATAACGCCATTGTGTGGCAGGACAC
CCGCACTAACTCCATCTGCTCGGAGTTAGCCCAAGGCGACCCTGCCCGGTGGCAAAAACGTACCGGTTTGCTCATCAACT
CATACCCCGCGGGCCCCCGACTCAAGTGGATATTGGACAACGTCGAGGGTGCCCGCGAACTAGCAGAGAACGGCGATTTG
CTCTTCGGAACCATTGATACGTGGTTGCTGTGGAACCTGACCGGCGGTGCCGAGGGTGACAACGGCCAGCCTGCCGTTCA
CGCTACCGACGTAACCAATGCCTCCCGCACCCTACTCATGGATCTGGAATCCCTGCAATGGGATGAGGAACTATGTGCCG
CGTTGGATATTCCAATGCAGGTGTTGCCAGAGATTCGTCCTTCAGTTGGTAACTTCGGCCAAGTACGTGCACGTGGATCA
CTAGCTGGTGTTCCGATCCGCGCCATCCTCGGTGACCAGCAAGCCGCAATGTTCGGACAGGCATGCTTCCGGCCAGGTGA
TGCCAAATGTACATACGGCACGGGGTTGTTCCTTCTGGAGAACACAGGCAAAACCCCGAAGCATTCCGAAAACGGTTTGC
TCACCACCGTGTGTTTCCAGCTCGAAGGCGAAAAACCGGTCTATGCCCTCGAAGGATCCGTTGCCATGGGGGGCTCGCTC
GTCCAATGGCTACGCGACAACCTTCAAATCATCCCGAACTCGCCCGCCATTGAAAACCTCGCACGCGAAGTACCCGACAA
CGGTGGCGTGTACATCGTCCCCGCATTCTCCGGACTATTCGCACCACGCTGGCGCCCCGACGCCCGCGGGGTCATCGTGG
GCCTGACCCGCTTTGCCAACCGCAAGCACCTCGCCCGCGCAGTACTCGAGGCCACCGCCTACCAAGTGCGCGAAGTGATC
GATGCCATGGTCGCGGATTCCGGAGTAGAACTCACCGAAATGCGTGTCGACGGCGGCATGGTCATGAACGAACTGCTCAT
GCAATTCCAAGCCGACGTCCTACGATCCGACGTCACGCGCCCCAAGAACATCGAGACCACAGCCACCGGCGTAGCCTACG
CAGCCGGCCTCGGCGTGGGCTACTGGGACAGCCTCGACGTACTCCGCAACATGAACGAAGTGGACAAAACCTGGCACGCC
AAGATGGACGCCGACAAGATCGACGAGCTCCTTGCCGAATGGAACAAAGCAGTCGAACGCACCTACAACTGGGAAAACTA
A

Upstream 100 bases:

>100_bases
CTGGGGCTATGCCTGGGTTCCGATCGTCGGCCCCATGATCGCCGCAGTCTTCTGCGGAGTGCTGGCCACTGTAGTGCTGT
AGTGAAAGGGAACCACACCA

Downstream 100 bases:

>100_bases
CTGCCTCCTGAAATAACAGCAAACCCGACGAACTATCCAGCTCGTCGGGTTTGTTTTGTGGGGTTGGGTTTGATGATTGT
GCTGTGCATCCAGATCTCTT

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MNQPQYVAAIDQGTTSTRCIIFDHNGQQVGVGQYEHEQIFPQKGWVEHNPMEIWANTRQAVGTALAESDVSREDIVAVGI
TNQRETTVVWNKTTGEPIYNAIVWQDTRTNSICSELAQGDPARWQKRTGLLINSYPAGPRLKWILDNVEGARELAENGDL
LFGTIDTWLLWNLTGGAEGDNGQPAVHATDVTNASRTLLMDLESLQWDEELCAALDIPMQVLPEIRPSVGNFGQVRARGS
LAGVPIRAILGDQQAAMFGQACFRPGDAKCTYGTGLFLLENTGKTPKHSENGLLTTVCFQLEGEKPVYALEGSVAMGGSL
VQWLRDNLQIIPNSPAIENLAREVPDNGGVYIVPAFSGLFAPRWRPDARGVIVGLTRFANRKHLARAVLEATAYQVREVI
DAMVADSGVELTEMRVDGGMVMNELLMQFQADVLRSDVTRPKNIETTATGVAYAAGLGVGYWDSLDVLRNMNEVDKTWHA
KMDADKIDELLAEWNKAVERTYNWEN

Sequences:

>Translated_506_residues
MNQPQYVAAIDQGTTSTRCIIFDHNGQQVGVGQYEHEQIFPQKGWVEHNPMEIWANTRQAVGTALAESDVSREDIVAVGI
TNQRETTVVWNKTTGEPIYNAIVWQDTRTNSICSELAQGDPARWQKRTGLLINSYPAGPRLKWILDNVEGARELAENGDL
LFGTIDTWLLWNLTGGAEGDNGQPAVHATDVTNASRTLLMDLESLQWDEELCAALDIPMQVLPEIRPSVGNFGQVRARGS
LAGVPIRAILGDQQAAMFGQACFRPGDAKCTYGTGLFLLENTGKTPKHSENGLLTTVCFQLEGEKPVYALEGSVAMGGSL
VQWLRDNLQIIPNSPAIENLAREVPDNGGVYIVPAFSGLFAPRWRPDARGVIVGLTRFANRKHLARAVLEATAYQVREVI
DAMVADSGVELTEMRVDGGMVMNELLMQFQADVLRSDVTRPKNIETTATGVAYAAGLGVGYWDSLDVLRNMNEVDKTWHA
KMDADKIDELLAEWNKAVERTYNWEN
>Mature_506_residues
MNQPQYVAAIDQGTTSTRCIIFDHNGQQVGVGQYEHEQIFPQKGWVEHNPMEIWANTRQAVGTALAESDVSREDIVAVGI
TNQRETTVVWNKTTGEPIYNAIVWQDTRTNSICSELAQGDPARWQKRTGLLINSYPAGPRLKWILDNVEGARELAENGDL
LFGTIDTWLLWNLTGGAEGDNGQPAVHATDVTNASRTLLMDLESLQWDEELCAALDIPMQVLPEIRPSVGNFGQVRARGS
LAGVPIRAILGDQQAAMFGQACFRPGDAKCTYGTGLFLLENTGKTPKHSENGLLTTVCFQLEGEKPVYALEGSVAMGGSL
VQWLRDNLQIIPNSPAIENLAREVPDNGGVYIVPAFSGLFAPRWRPDARGVIVGLTRFANRKHLARAVLEATAYQVREVI
DAMVADSGVELTEMRVDGGMVMNELLMQFQADVLRSDVTRPKNIETTATGVAYAAGLGVGYWDSLDVLRNMNEVDKTWHA
KMDADKIDELLAEWNKAVERTYNWEN

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI4504007, Length=449, Percent_Identity=49.6659242761693, Blast_Score=445, Evalue=1e-125,
Organism=Homo sapiens, GI189409120, Length=449, Percent_Identity=49.6659242761693, Blast_Score=445, Evalue=1e-125,
Organism=Homo sapiens, GI42794763, Length=454, Percent_Identity=48.8986784140969, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI41393575, Length=512, Percent_Identity=46.09375, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI88196792, Length=520, Percent_Identity=31.3461538461538, Blast_Score=296, Evalue=2e-80,
Organism=Escherichia coli, GI1790361, Length=507, Percent_Identity=49.9013806706114, Blast_Score=505, Evalue=1e-144,
Organism=Escherichia coli, GI1787789, Length=488, Percent_Identity=25.8196721311475, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790005, Length=498, Percent_Identity=23.4939759036145, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789987, Length=432, Percent_Identity=25, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17535599, Length=509, Percent_Identity=42.6326129666012, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71986140, Length=532, Percent_Identity=26.8796992481203, Blast_Score=158, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI71986147, Length=264, Percent_Identity=30.3030303030303, Blast_Score=108, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6321755, Length=505, Percent_Identity=37.6237623762376, Blast_Score=307, Evalue=3e-84,
Organism=Drosophila melanogaster, GI17864214, Length=512, Percent_Identity=44.3359375, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24654573, Length=441, Percent_Identity=45.578231292517, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24655555, Length=510, Percent_Identity=38.6274509803922, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24655560, Length=510, Percent_Identity=38.6274509803922, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24655570, Length=510, Percent_Identity=38.6274509803922, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24655574, Length=510, Percent_Identity=38.6274509803922, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24655565, Length=510, Percent_Identity=38.6274509803922, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI19922058, Length=536, Percent_Identity=34.1417910447761, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24652871, Length=502, Percent_Identity=34.6613545816733, Blast_Score=288, Evalue=5e-78,
Organism=Drosophila melanogaster, GI21357867, Length=535, Percent_Identity=27.1028037383178, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24656367, Length=524, Percent_Identity=27.8625954198473, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24656372, Length=377, Percent_Identity=28.1167108753316, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI45552909, Length=353, Percent_Identity=25.4957507082153, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 55771; Mature: 55771

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQPQYVAAIDQGTTSTRCIIFDHNGQQVGVGQYEHEQIFPQKGWVEHNPMEIWANTRQA
CCCCCEEEEECCCCCCEEEEEEECCCCEECCCCCHHHHCCCCCCCCCCCCHHHHCCHHHH
VGTALAESDVSREDIVAVGITNQRETTVVWNKTTGEPIYNAIVWQDTRTNSICSELAQGD
HHHHHHHCCCCCCCEEEEEECCCCCEEEEEECCCCCCHHEEEEECCCCCHHHHHHHHCCC
PARWQKRTGLLINSYPAGPRLKWILDNVEGARELAENGDLLFGTIDTWLLWNLTGGAEGD
HHHHHHHCCEEEECCCCCCCEEEEECCHHHHHHHHHCCCEEEEEECEEEEEEECCCCCCC
NGQPAVHATDVTNASRTLLMDLESLQWDEELCAALDIPMQVLPEIRPSVGNFGQVRARGS
CCCCCEEEECCCCCCHHEEEEHHHCCCHHHHHHHHCCCHHHHHHHCCCCCCCCEEEECCC
LAGVPIRAILGDQQAAMFGQACFRPGDAKCTYGTGLFLLENTGKTPKHSENGLLTTVCFQ
CCCCCCHHHHCCHHHHHHHHHHCCCCCCEEEECCEEEEEECCCCCCCCCCCCEEEEEEEE
LEGEKPVYALEGSVAMGGSLVQWLRDNLQIIPNSPAIENLAREVPDNGGVYIVPAFSGLF
ECCCCCEEEECCCHHCCHHHHHHHHCCCEECCCCHHHHHHHHHCCCCCCEEEEECCCCCC
APRWRPDARGVIVGLTRFANRKHLARAVLEATAYQVREVIDAMVADSGVELTEMRVDGGM
CCCCCCCCCEEEEEHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCH
VMNELLMQFQADVLRSDVTRPKNIETTATGVAYAAGLGVGYWDSLDVLRNMNEVDKTWHA
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCHHHHHHHHHC
KMDADKIDELLAEWNKAVERTYNWEN
CCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNQPQYVAAIDQGTTSTRCIIFDHNGQQVGVGQYEHEQIFPQKGWVEHNPMEIWANTRQA
CCCCCEEEEECCCCCCEEEEEEECCCCEECCCCCHHHHCCCCCCCCCCCCHHHHCCHHHH
VGTALAESDVSREDIVAVGITNQRETTVVWNKTTGEPIYNAIVWQDTRTNSICSELAQGD
HHHHHHHCCCCCCCEEEEEECCCCCEEEEEECCCCCCHHEEEEECCCCCHHHHHHHHCCC
PARWQKRTGLLINSYPAGPRLKWILDNVEGARELAENGDLLFGTIDTWLLWNLTGGAEGD
HHHHHHHCCEEEECCCCCCCEEEEECCHHHHHHHHHCCCEEEEEECEEEEEEECCCCCCC
NGQPAVHATDVTNASRTLLMDLESLQWDEELCAALDIPMQVLPEIRPSVGNFGQVRARGS
CCCCCEEEECCCCCCHHEEEEHHHCCCHHHHHHHHCCCHHHHHHHCCCCCCCCEEEECCC
LAGVPIRAILGDQQAAMFGQACFRPGDAKCTYGTGLFLLENTGKTPKHSENGLLTTVCFQ
CCCCCCHHHHCCHHHHHHHHHHCCCCCCEEEECCEEEEEECCCCCCCCCCCCEEEEEEEE
LEGEKPVYALEGSVAMGGSLVQWLRDNLQIIPNSPAIENLAREVPDNGGVYIVPAFSGLF
ECCCCCEEEECCCHHCCHHHHHHHHCCCEECCCCHHHHHHHHHCCCCCCEEEEECCCCCC
APRWRPDARGVIVGLTRFANRKHLARAVLEATAYQVREVIDAMVADSGVELTEMRVDGGM
CCCCCCCCCEEEEEHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCH
VMNELLMQFQADVLRSDVTRPKNIETTATGVAYAAGLGVGYWDSLDVLRNMNEVDKTWHA
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCHHHHHHHHHC
KMDADKIDELLAEWNKAVERTYNWEN
CCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA