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The map label for this gene is betA [H]

Identifier: 38234743

GI number: 38234743

Start: 2289560

End: 2291272

Strand: Direct

Name: betA [H]

Synonym: DIP2202

Alternate gene names: 38234743

Gene position: 2289560-2291272 (Clockwise)

Preceding gene: 38234728

Following gene: 38234748

Centisome position: 92.0

GC content: 57.44

Gene sequence:

>1713_bases
GTGGTTATCGTGGGTGGCGGTTCCGCCGGCTCCGTGCTCGCCAATCGCCTCTCCGAAGACCCCGACACAAGCGTGATGGT
GCTGGAAGCCGGTCGCTCCGACTCCCTGTGGGACCTATTCATCCACATGCCCGCAGCATTCTCTTTCCCCATCGGCAACA
AGTACTACGACTGGGCTTATGAGTCCGAGCCGGAACCACACATGAACGGTCGCCGCATCTACCACGCCCGCGGCAAGGTT
CTCGGCGGCTCTAGCTCCATCAACGGCATGATCTTCCAGCGCGGTAACCCTATGGATTACGAGAAGTGGGGCGCGTTGCC
AGGCATGCAGAACTGGGACTTCAAGCACGTGCTGCCGTACTTCAATAAGATGGAAACCGCACTAGGTGCCGATGCTAACG
ATCCCCGTCGCGGCCACACCGGCCCACTGAAGCTCACCCGCGGTCCAGCTACCACCCCGCTGTTCCAAGCATTTTTCCGT
TCCGTTCAAGAGGCCGGTTACAACCTGACTAACGACGTCAACGGTTACCGCCAAGAGGGATTCGCCCCCTTTGACCGCAA
CATCTTGAAGGGCAAGCGCCTTTCTGCTGCTCGCGCTTATTTGCACCCAGTTATGGATCGTACCAACCTTGAGGTGCGCA
CTCGTGCGCTGACCACTCGGATTTTATTCAACGAGGCTGGCACACAGGCCACCGGTGTTGAGTATGAGTGGAAGGGCAAG
AAGCGTCGTGTAATGGCCAAGAAGGTCATTTTGTGCGGTGGCGCCTTCAACACCCCACAGTTGTTGCAGGTCAGCGGCGT
GGGCGACCGTGAAGTGCTGGAAAAGGCCGGCGTTGACGTGGTCAAACATCTGCCAGGTGTGGGCGCTAACTTGCAGGACC
ACTTGGAGGTGTACGTCCAGTACAACGTGACAAAGCCGGTGTCGGTGCAGCCGAACTACAAGATGACGCGTCGTCCGTTT
ATCGGTTTGCAGTGGTTGCTGACCAAGAAGGGCCCTGTGGCTTCTTCCCACTTTGAGGCCGGCGGCTTCGCCCGTTCAAA
TGACGACGAAGCATACCCGAACTTGATGTTCCACTTCCTGCCGATGGCCATTCGTTACGACGGCACCCAGCCGGAAGGCG
ATCACGGTTTCCAGTTCCACGTAGGCCCTATGTACTCCGATACCTTGGGCCATGTGCACATTACCTCGCCGGACCCTAAG
GCCAAACCAGAGATCATCTTTAATTACTTGGCCACTGAACAGGATCGTCGCGAGTGGGTAGAGGCCGTGCACGTTTCGCG
TCGCCTCCTAGATACGGATGCGATGAAGGAATACACCGACGGCGAGATTTCACCCGGCGCGGACGTGCAGACCGATGAGG
AGATCTTGGAGTGGGTGCGTAACGACGCCGAAACTGCCCTGCACCCATCATGTACTGCGAAGATGGGCTCGGCTGACGAC
GCCATGGCGGTGGTCAATCCGGAAAACATGCAGGTTCACGGTATTGATGGCTTGTATGTGTGCGATGCTTCTGCAATGCC
GATTATTACTAACGGCAACATCTACGCACCTGTGATCATGATGGCAGAGAAGGCTGCCGATCTGATTAAGGGCATTAAGC
CGCTGGCACCGATCGACGTTCCGTTCTACAAGGCTAAGCAGGGCATGCCGCTCTATGCCGAGGGCGAGAAGGTTCGCGAT
CACACGAAGGCTATTCCTGGCGCTGACCACTAG

Upstream 100 bases:

>100_bases
TGAAAGGAAAAGGAGATATATGAGTCTACGAAACCGACTCCGCACCTCAATTTCTAAGCACGACACAGACGGCGAATTTA
TTCAAGATCGGACACGCGAT

Downstream 100 bases:

>100_bases
CCTTCTGGCACGGAACTCAGTGGCGCTGGTGGGCGTTGGTGGGCGCGCCACCCCCGCTCACCCCGAAAAAGACGGCACTT
CACACCAAATCTGCTCAAAC

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MVIVGGGSAGSVLANRLSEDPDTSVMVLEAGRSDSLWDLFIHMPAAFSFPIGNKYYDWAYESEPEPHMNGRRIYHARGKV
LGGSSSINGMIFQRGNPMDYEKWGALPGMQNWDFKHVLPYFNKMETALGADANDPRRGHTGPLKLTRGPATTPLFQAFFR
SVQEAGYNLTNDVNGYRQEGFAPFDRNILKGKRLSAARAYLHPVMDRTNLEVRTRALTTRILFNEAGTQATGVEYEWKGK
KRRVMAKKVILCGGAFNTPQLLQVSGVGDREVLEKAGVDVVKHLPGVGANLQDHLEVYVQYNVTKPVSVQPNYKMTRRPF
IGLQWLLTKKGPVASSHFEAGGFARSNDDEAYPNLMFHFLPMAIRYDGTQPEGDHGFQFHVGPMYSDTLGHVHITSPDPK
AKPEIIFNYLATEQDRREWVEAVHVSRRLLDTDAMKEYTDGEISPGADVQTDEEILEWVRNDAETALHPSCTAKMGSADD
AMAVVNPENMQVHGIDGLYVCDASAMPIITNGNIYAPVIMMAEKAADLIKGIKPLAPIDVPFYKAKQGMPLYAEGEKVRD
HTKAIPGADH

Sequences:

>Translated_570_residues
MVIVGGGSAGSVLANRLSEDPDTSVMVLEAGRSDSLWDLFIHMPAAFSFPIGNKYYDWAYESEPEPHMNGRRIYHARGKV
LGGSSSINGMIFQRGNPMDYEKWGALPGMQNWDFKHVLPYFNKMETALGADANDPRRGHTGPLKLTRGPATTPLFQAFFR
SVQEAGYNLTNDVNGYRQEGFAPFDRNILKGKRLSAARAYLHPVMDRTNLEVRTRALTTRILFNEAGTQATGVEYEWKGK
KRRVMAKKVILCGGAFNTPQLLQVSGVGDREVLEKAGVDVVKHLPGVGANLQDHLEVYVQYNVTKPVSVQPNYKMTRRPF
IGLQWLLTKKGPVASSHFEAGGFARSNDDEAYPNLMFHFLPMAIRYDGTQPEGDHGFQFHVGPMYSDTLGHVHITSPDPK
AKPEIIFNYLATEQDRREWVEAVHVSRRLLDTDAMKEYTDGEISPGADVQTDEEILEWVRNDAETALHPSCTAKMGSADD
AMAVVNPENMQVHGIDGLYVCDASAMPIITNGNIYAPVIMMAEKAADLIKGIKPLAPIDVPFYKAKQGMPLYAEGEKVRD
HTKAIPGADH
>Mature_570_residues
MVIVGGGSAGSVLANRLSEDPDTSVMVLEAGRSDSLWDLFIHMPAAFSFPIGNKYYDWAYESEPEPHMNGRRIYHARGKV
LGGSSSINGMIFQRGNPMDYEKWGALPGMQNWDFKHVLPYFNKMETALGADANDPRRGHTGPLKLTRGPATTPLFQAFFR
SVQEAGYNLTNDVNGYRQEGFAPFDRNILKGKRLSAARAYLHPVMDRTNLEVRTRALTTRILFNEAGTQATGVEYEWKGK
KRRVMAKKVILCGGAFNTPQLLQVSGVGDREVLEKAGVDVVKHLPGVGANLQDHLEVYVQYNVTKPVSVQPNYKMTRRPF
IGLQWLLTKKGPVASSHFEAGGFARSNDDEAYPNLMFHFLPMAIRYDGTQPEGDHGFQFHVGPMYSDTLGHVHITSPDPK
AKPEIIFNYLATEQDRREWVEAVHVSRRLLDTDAMKEYTDGEISPGADVQTDEEILEWVRNDAETALHPSCTAKMGSADD
AMAVVNPENMQVHGIDGLYVCDASAMPIITNGNIYAPVIMMAEKAADLIKGIKPLAPIDVPFYKAKQGMPLYAEGEKVRD
HTKAIPGADH

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=554, Percent_Identity=45.8483754512635, Blast_Score=480, Evalue=1e-135,
Organism=Escherichia coli, GI1786503, Length=558, Percent_Identity=48.2078853046595, Blast_Score=513, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17532301, Length=552, Percent_Identity=44.3840579710145, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24642048, Length=593, Percent_Identity=35.0758853288364, Blast_Score=293, Evalue=3e-79,
Organism=Drosophila melanogaster, GI45551458, Length=567, Percent_Identity=34.5679012345679, Blast_Score=278, Evalue=5e-75,
Organism=Drosophila melanogaster, GI45549471, Length=567, Percent_Identity=34.5679012345679, Blast_Score=278, Evalue=7e-75,
Organism=Drosophila melanogaster, GI24642042, Length=567, Percent_Identity=35.0970017636684, Blast_Score=272, Evalue=4e-73,
Organism=Drosophila melanogaster, GI17137792, Length=552, Percent_Identity=33.5144927536232, Blast_Score=266, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24642059, Length=568, Percent_Identity=34.1549295774648, Blast_Score=251, Evalue=8e-67,
Organism=Drosophila melanogaster, GI18859995, Length=563, Percent_Identity=33.5701598579041, Blast_Score=244, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24642039, Length=566, Percent_Identity=33.3922261484099, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24642037, Length=570, Percent_Identity=32.1052631578947, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24642035, Length=579, Percent_Identity=30.3972366148532, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24642055, Length=581, Percent_Identity=31.3253012048193, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24650267, Length=576, Percent_Identity=30.9027777777778, Blast_Score=223, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24642051, Length=572, Percent_Identity=29.3706293706294, Blast_Score=202, Evalue=7e-52,
Organism=Drosophila melanogaster, GI18859993, Length=577, Percent_Identity=28.2495667244367, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24645930, Length=577, Percent_Identity=25.8232235701906, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24642057, Length=574, Percent_Identity=27.0034843205575, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 63242; Mature: 63242

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIVGGGSAGSVLANRLSEDPDTSVMVLEAGRSDSLWDLFIHMPAAFSFPIGNKYYDWAY
CEEECCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCEEECCCCCCEECCCC
ESEPEPHMNGRRIYHARGKVLGGSSSINGMIFQRGNPMDYEKWGALPGMQNWDFKHVLPY
CCCCCCCCCCCEEEEECCCEECCCCCCCEEEEECCCCCCHHHHCCCCCCCCCCHHHHHHH
FNKMETALGADANDPRRGHTGPLKLTRGPATTPLFQAFFRSVQEAGYNLTNDVNGYRQEG
HHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHCC
FAPFDRNILKGKRLSAARAYLHPVMDRTNLEVRTRALTTRILFNEAGTQATGVEYEWKGK
CCCHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEHHHHHEEEEECCCCCCCCCCEEEECCC
KRRVMAKKVILCGGAFNTPQLLQVSGVGDREVLEKAGVDVVKHLPGVGANLQDHLEVYVQ
HHHHHHHEEEEECCCCCCCCEEEEECCCHHHHHHHHCHHHHHHCCCCCCCHHCEEEEEEE
YNVTKPVSVQPNYKMTRRPFIGLQWLLTKKGPVASSHFEAGGFARSNDDEAYPNLMFHFL
ECCCCCEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
PMAIRYDGTQPEGDHGFQFHVGPMYSDTLGHVHITSPDPKAKPEIIFNYLATEQDRREWV
HHHEEECCCCCCCCCCEEEEECCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCHHHHHHH
EAVHVSRRLLDTDAMKEYTDGEISPGADVQTDEEILEWVRNDAETALHPSCTAKMGSADD
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCHHHHCCCCHHCCCCCCCC
AMAVVNPENMQVHGIDGLYVCDASAMPIITNGNIYAPVIMMAEKAADLIKGIKPLAPIDV
CEEEECCCCEEEECCCEEEEECCCCCCEEECCCEEEHHHHHHHHHHHHHHCCCCCCCCCC
PFYKAKQGMPLYAEGEKVRDHTKAIPGADH
CHHHHCCCCCEEECCCHHHHHHHCCCCCCC
>Mature Secondary Structure
MVIVGGGSAGSVLANRLSEDPDTSVMVLEAGRSDSLWDLFIHMPAAFSFPIGNKYYDWAY
CEEECCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCEEECCCCCCEECCCC
ESEPEPHMNGRRIYHARGKVLGGSSSINGMIFQRGNPMDYEKWGALPGMQNWDFKHVLPY
CCCCCCCCCCCEEEEECCCEECCCCCCCEEEEECCCCCCHHHHCCCCCCCCCCHHHHHHH
FNKMETALGADANDPRRGHTGPLKLTRGPATTPLFQAFFRSVQEAGYNLTNDVNGYRQEG
HHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHCC
FAPFDRNILKGKRLSAARAYLHPVMDRTNLEVRTRALTTRILFNEAGTQATGVEYEWKGK
CCCHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEHHHHHEEEEECCCCCCCCCCEEEECCC
KRRVMAKKVILCGGAFNTPQLLQVSGVGDREVLEKAGVDVVKHLPGVGANLQDHLEVYVQ
HHHHHHHEEEEECCCCCCCCEEEEECCCHHHHHHHHCHHHHHHCCCCCCCHHCEEEEEEE
YNVTKPVSVQPNYKMTRRPFIGLQWLLTKKGPVASSHFEAGGFARSNDDEAYPNLMFHFL
ECCCCCEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
PMAIRYDGTQPEGDHGFQFHVGPMYSDTLGHVHITSPDPKAKPEIIFNYLATEQDRREWV
HHHEEECCCCCCCCCCEEEEECCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCHHHHHHH
EAVHVSRRLLDTDAMKEYTDGEISPGADVQTDEEILEWVRNDAETALHPSCTAKMGSADD
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCHHHHCCCCHHCCCCCCCC
AMAVVNPENMQVHGIDGLYVCDASAMPIITNGNIYAPVIMMAEKAADLIKGIKPLAPIDV
CEEEECCCCEEEECCCEEEEECCCCCCEEECCCEEEHHHHHHHHHHHHHHCCCCCCCCCC
PFYKAKQGMPLYAEGEKVRDHTKAIPGADH
CHHHHCCCCCEEECCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA