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The map label for this gene is uppS2

Identifier: 38234283

GI number: 38234283

Start: 1749363

End: 1750100

Strand: Reverse

Name: uppS2

Synonym: DIP1712

Alternate gene names: 38234283

Gene position: 1750100-1749363 (Counterclockwise)

Preceding gene: 38234284

Following gene: 38234282

Centisome position: 70.32

GC content: 53.93

Gene sequence:

>738_bases
GTGACCAAGCAACTCGTACCTCCACAGATTCCGCAAGAGTTCCTCCCGCGGCACATCGCGCTCGTCATGGACGGCAACGG
ACGATGGGCAACTAATCGAGGACTCAAGCGCACCGAAGGCCATAAGCGCGGTGAAGCTGTTCTCCTCGATATGGTTGACG
CTTGTATCGCTATGGGTATTCCGTATCTGTCTGCCTACGCCTTTTCCACCGAAAATTGGCGGCGCTCTACCGACGAAGTC
CGCTTCCTCATGGGATTTAACCGCGACGTCCTGCGGCGCCAACGTGATGCCCTTAACGCAAAAGGAGTGCGAGTTCGTTG
GGTAGGACGGCGCCCACGACTGTGGCGCAGCGTTATTAGAGAATTGGAAGCTGCAGAAGAGCTCACCAAGGACAACACCA
CCATGACGCTTGCTATGTGCGTTAACTACGGTGGCCGCGCAGAAATCGTCGATGCCGCCCGTGAGATCGCTCGTCGATCA
GCAGTCGGAACACTACGCCCCGAGGAGATCACTGAAGATTCCTTCACGCAGTTCCTCGACGAGCCTGATATGCCCGATGT
TGATTTGTTCTTGCGCCCATCAGGGGAAAAGCGCACATCTAATTTCTTGTTGTGGCAGTCTGCTTATGCGGAAATGGTGT
ATCAAAACAAATTGTTCCCTGATTACACACCTGAGGATTTGTTTGCAGCAGTCGAAGAATATGCTCTACGTGATCGCCGG
TTTGGGGGTACCAAATGA

Upstream 100 bases:

>100_bases
GCCCATGCACTCATCCGATCCCATTTGTCATGGCATGTGGAACGCGGTCTTGCCAGCCTCAATGTGCTTGACCAAGTGTG
ATAGTGGCAGAATAGTCGGG

Downstream 100 bases:

>100_bases
CAACTACGCAGCCCACATCTCAACAGATCAGGCGATGGCGCCAGTATCTTGCCAATGAACGCGCTGAAGCCGCATTGTAT
CGGGAGCTCGCGCACCGCAA

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase 2; Di-trans,poly-cis-decaprenylcistransferase 2; Undecaprenyl diphosphate synthase 2; UDS 2

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MTKQLVPPQIPQEFLPRHIALVMDGNGRWATNRGLKRTEGHKRGEAVLLDMVDACIAMGIPYLSAYAFSTENWRRSTDEV
RFLMGFNRDVLRRQRDALNAKGVRVRWVGRRPRLWRSVIRELEAAEELTKDNTTMTLAMCVNYGGRAEIVDAAREIARRS
AVGTLRPEEITEDSFTQFLDEPDMPDVDLFLRPSGEKRTSNFLLWQSAYAEMVYQNKLFPDYTPEDLFAAVEEYALRDRR
FGGTK

Sequences:

>Translated_245_residues
MTKQLVPPQIPQEFLPRHIALVMDGNGRWATNRGLKRTEGHKRGEAVLLDMVDACIAMGIPYLSAYAFSTENWRRSTDEV
RFLMGFNRDVLRRQRDALNAKGVRVRWVGRRPRLWRSVIRELEAAEELTKDNTTMTLAMCVNYGGRAEIVDAAREIARRS
AVGTLRPEEITEDSFTQFLDEPDMPDVDLFLRPSGEKRTSNFLLWQSAYAEMVYQNKLFPDYTPEDLFAAVEEYALRDRR
FGGTK
>Mature_244_residues
TKQLVPPQIPQEFLPRHIALVMDGNGRWATNRGLKRTEGHKRGEAVLLDMVDACIAMGIPYLSAYAFSTENWRRSTDEVR
FLMGFNRDVLRRQRDALNAKGVRVRWVGRRPRLWRSVIRELEAAEELTKDNTTMTLAMCVNYGGRAEIVDAAREIARRSA
VGTLRPEEITEDSFTQFLDEPDMPDVDLFLRPSGEKRTSNFLLWQSAYAEMVYQNKLFPDYTPEDLFAAVEEYALRDRRF
GGTK

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=225, Percent_Identity=35.5555555555556, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI45580742, Length=225, Percent_Identity=35.5555555555556, Blast_Score=143, Evalue=2e-34,
Organism=Escherichia coli, GI1786371, Length=245, Percent_Identity=40, Blast_Score=180, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI71993029, Length=225, Percent_Identity=31.5555555555556, Blast_Score=114, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6319474, Length=215, Percent_Identity=33.0232558139535, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323748, Length=233, Percent_Identity=27.0386266094421, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI18857969, Length=229, Percent_Identity=32.3144104803493, Blast_Score=119, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS2_CORDI (P60481)

Other databases:

- EMBL:   BX248359
- RefSeq:   NP_940050.1
- ProteinModelPortal:   P60481
- SMR:   P60481
- GeneID:   2650305
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1712
- NMPDR:   fig|257309.1.peg.1641
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- ProtClustDB:   PRK14829
- BioCyc:   CDIP257309:DIP1712-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 28254; Mature: 28122

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 24-24

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKQLVPPQIPQEFLPRHIALVMDGNGRWATNRGLKRTEGHKRGEAVLLDMVDACIAMGI
CCCCCCCCCCCHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
PYLSAYAFSTENWRRSTDEVRFLMGFNRDVLRRQRDALNAKGVRVRWVGRRPRLWRSVIR
HHHHHHHCCCCHHHCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHH
ELEAAEELTKDNTTMTLAMCVNYGGRAEIVDAAREIARRSAVGTLRPEEITEDSFTQFLD
HHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHC
EPDMPDVDLFLRPSGEKRTSNFLLWQSAYAEMVYQNKLFPDYTPEDLFAAVEEYALRDRR
CCCCCCCEEEECCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCC
FGGTK
CCCCC
>Mature Secondary Structure 
TKQLVPPQIPQEFLPRHIALVMDGNGRWATNRGLKRTEGHKRGEAVLLDMVDACIAMGI
CCCCCCCCCCHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
PYLSAYAFSTENWRRSTDEVRFLMGFNRDVLRRQRDALNAKGVRVRWVGRRPRLWRSVIR
HHHHHHHCCCCHHHCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHH
ELEAAEELTKDNTTMTLAMCVNYGGRAEIVDAAREIARRSAVGTLRPEEITEDSFTQFLD
HHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHC
EPDMPDVDLFLRPSGEKRTSNFLLWQSAYAEMVYQNKLFPDYTPEDLFAAVEEYALRDRR
CCCCCCCEEEECCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCC
FGGTK
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910