Click here to switch to the map view.

The map label for this gene is glmS

Identifier: 38234271

GI number: 38234271

Start: 1737994

End: 1739871

Strand: Reverse

Name: glmS

Synonym: DIP1700

Alternate gene names: 38234271

Gene position: 1739871-1737994 (Counterclockwise)

Preceding gene: 38234274

Following gene: 38234270

Centisome position: 69.91

GC content: 53.19

Gene sequence:

>1878_bases
ATGTGTGGAATCGTTGGATTTGTAGGCAGGACATCGGTACCTGACCGTGATTATTTTGCTCTCGATGTGGTTCTCGAAGG
GCTACGGCGCTTGGAATATCGAGGATACGATTCTGCAGGCGTTGCCGTAGTTGCTGACGGTGCTGTGAGCTTCCGTAAAA
AAGCTGGCAAGGTGCAAGCCCTAGAACAAGAACTGGAAACAAGCCCCATGCCGCAATCGTGCCTAGGTATTGGGCACACG
CGGTGGGCAACCCATGGTGGCCCTACCGATGCCAATGCGCACCCACATGTTGTCGATGGTGGCAAGCTTGCCGTCGTACA
CAACGGCATCATTGAAAACTTTGCTGAACTAAAATCCGAGCTATTGGGCTTTGGGCACAACTTCGTCTCAGAAACGGATA
CCGAAGTAGCCGCAACCCTTCTGGGACACATTTTTAATAATGAAGCTAACAAAGACCTCACTCGTGCCATGCAGCTGACC
TGCCAGCGCCTAGAGGGAGCTTTTACCCTTCTAGCAATTCACGCAGAAACTCCGGATCGCATTGTTGCAGCGCGTCGAAA
CTCCCCACTTGTTATCGGCGTGGGCGAGGGCGAAAACTTCCTCGGCTCCGATGTGTCTGGGTTTATCGACTACACCAAGA
ACGCCGTGGAGATGGATAACGACCAGATCGTGACCATAACTGCCGATGGCTACCACATCACCGACTTCCAGGGCAATCAC
GCCGAAGGCAAGCCATTTGTGGTGGAGTGGGACGCACAAGCTGCTGAAAAAGGCGGCTATGAGTTCTTCATGGAAAAAGA
AATCCATGAGCAGCCTGCTGCTGTTCGAGATACCCTCATGGGGCGTTTCGACGAGTCCGGCAAGCTCACCCTAGATGAGT
TGCGTATCGACGAATCTACGCTGCGCAGCATTGACAAAATTATTGTGATTGCTTGCGGTACCGCAGCATATGCTGGTCAC
GTTGCACGTTATGCCATCGAGCATTGGTGCCGTATCCCAACCGAGGTGGAGCTTGCACACGAGTTCCGCTACCGCGACCC
CATTGTGAATGAGAAAACCCTCGTGGTGACTTTGTCACAGTCGGGTGAAACTATGGATACGCTCATGGCTGTTCGCCACG
CACGCGAACAAGGTGCGAAGGTGATTGCTATTTGTAACACCAATGGTTCTTCCATTCCTCGCGAATCAGACGCCTGCCTA
TACACCCATGCAGGACCAGAAATTGCTGTGGCCTCCACCAAGGCATTCTTGGCACAGATCACCGCAACGTACCTTTTGGG
CCTGTACCTAGCTCAGCTGCGTGGCAACATGTTTGCTGACGAGGTCAATGCTGTTCTGGGTGAGCTCCGCACTATCCCTG
ACAAAGTATCGGCAGTTCTTGATGGGGTAGAAGACCAAGTAAAGACCTTGGCGCAGGACATGAAGGATGCAACCTCGGTG
TTGTTCCTCGGCCGCCATGTTGGTTTCCCTGTGGCTCTAGAAGGCGCACTGAAGCTCAAAGAGTTGGCCTACTTGCATGC
TGAAGGTTTTGCCGCCGGTGAGCTCAAGCATGGTCCTATCGCACTGATTGAGGAAGGGCAGCCCGTCTTCGTTATCGTTC
CGTCGCCACGCGGTCGTGATTCTTTGCATGCGAAGGTCGTGTCTAACATTCAAGAAGTTCGCGCACGTGGTGCCATCACG
ATCGTTATCGCAGAAGAAGGCGATGATGCTGTGGAGGCATACGCAAACCACATCATTCGTATTCCACAAGCGCCGACTTT
GATGCAGCCACTGTTGGCCACCGTTCCACTGCAGATTTTTGCATGCGGTGTTGCGGCAGCCAAGGGATTCGACGTGGATC
AACCACGTAACTTGGCCAAGTCTGTGACGGTGGAGTAG

Upstream 100 bases:

>100_bases
CACCAGACATGAGCACCATTGTCGCACATCAAAGAATGAGATGCTGACCTACTAGCTGCAGAAACTGCACTAGCACAAAG
AATGCAATATAGTGCGATGT

Downstream 100 bases:

>100_bases
AACACTCACTATGGCAGGCAAGGGTCGAATACCAGATAGTGACATTCAGGCGATTCGTGAGCGAACCCCCATCGAGGAAA
TCGTAGGGGAATATGTTCAG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 625; Mature: 625

Protein sequence:

>625_residues
MCGIVGFVGRTSVPDRDYFALDVVLEGLRRLEYRGYDSAGVAVVADGAVSFRKKAGKVQALEQELETSPMPQSCLGIGHT
RWATHGGPTDANAHPHVVDGGKLAVVHNGIIENFAELKSELLGFGHNFVSETDTEVAATLLGHIFNNEANKDLTRAMQLT
CQRLEGAFTLLAIHAETPDRIVAARRNSPLVIGVGEGENFLGSDVSGFIDYTKNAVEMDNDQIVTITADGYHITDFQGNH
AEGKPFVVEWDAQAAEKGGYEFFMEKEIHEQPAAVRDTLMGRFDESGKLTLDELRIDESTLRSIDKIIVIACGTAAYAGH
VARYAIEHWCRIPTEVELAHEFRYRDPIVNEKTLVVTLSQSGETMDTLMAVRHAREQGAKVIAICNTNGSSIPRESDACL
YTHAGPEIAVASTKAFLAQITATYLLGLYLAQLRGNMFADEVNAVLGELRTIPDKVSAVLDGVEDQVKTLAQDMKDATSV
LFLGRHVGFPVALEGALKLKELAYLHAEGFAAGELKHGPIALIEEGQPVFVIVPSPRGRDSLHAKVVSNIQEVRARGAIT
IVIAEEGDDAVEAYANHIIRIPQAPTLMQPLLATVPLQIFACGVAAAKGFDVDQPRNLAKSVTVE

Sequences:

>Translated_625_residues
MCGIVGFVGRTSVPDRDYFALDVVLEGLRRLEYRGYDSAGVAVVADGAVSFRKKAGKVQALEQELETSPMPQSCLGIGHT
RWATHGGPTDANAHPHVVDGGKLAVVHNGIIENFAELKSELLGFGHNFVSETDTEVAATLLGHIFNNEANKDLTRAMQLT
CQRLEGAFTLLAIHAETPDRIVAARRNSPLVIGVGEGENFLGSDVSGFIDYTKNAVEMDNDQIVTITADGYHITDFQGNH
AEGKPFVVEWDAQAAEKGGYEFFMEKEIHEQPAAVRDTLMGRFDESGKLTLDELRIDESTLRSIDKIIVIACGTAAYAGH
VARYAIEHWCRIPTEVELAHEFRYRDPIVNEKTLVVTLSQSGETMDTLMAVRHAREQGAKVIAICNTNGSSIPRESDACL
YTHAGPEIAVASTKAFLAQITATYLLGLYLAQLRGNMFADEVNAVLGELRTIPDKVSAVLDGVEDQVKTLAQDMKDATSV
LFLGRHVGFPVALEGALKLKELAYLHAEGFAAGELKHGPIALIEEGQPVFVIVPSPRGRDSLHAKVVSNIQEVRARGAIT
IVIAEEGDDAVEAYANHIIRIPQAPTLMQPLLATVPLQIFACGVAAAKGFDVDQPRNLAKSVTVE
>Mature_625_residues
MCGIVGFVGRTSVPDRDYFALDVVLEGLRRLEYRGYDSAGVAVVADGAVSFRKKAGKVQALEQELETSPMPQSCLGIGHT
RWATHGGPTDANAHPHVVDGGKLAVVHNGIIENFAELKSELLGFGHNFVSETDTEVAATLLGHIFNNEANKDLTRAMQLT
CQRLEGAFTLLAIHAETPDRIVAARRNSPLVIGVGEGENFLGSDVSGFIDYTKNAVEMDNDQIVTITADGYHITDFQGNH
AEGKPFVVEWDAQAAEKGGYEFFMEKEIHEQPAAVRDTLMGRFDESGKLTLDELRIDESTLRSIDKIIVIACGTAAYAGH
VARYAIEHWCRIPTEVELAHEFRYRDPIVNEKTLVVTLSQSGETMDTLMAVRHAREQGAKVIAICNTNGSSIPRESDACL
YTHAGPEIAVASTKAFLAQITATYLLGLYLAQLRGNMFADEVNAVLGELRTIPDKVSAVLDGVEDQVKTLAQDMKDATSV
LFLGRHVGFPVALEGALKLKELAYLHAEGFAAGELKHGPIALIEEGQPVFVIVPSPRGRDSLHAKVVSNIQEVRARGAIT
IVIAEEGDDAVEAYANHIIRIPQAPTLMQPLLATVPLQIFACGVAAAKGFDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI4826742, Length=690, Percent_Identity=35.6521739130435, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI205277386, Length=692, Percent_Identity=36.4161849710983, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI29570798, Length=206, Percent_Identity=33.9805825242718, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1790167, Length=630, Percent_Identity=45.5555555555556, Blast_Score=492, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17532899, Length=724, Percent_Identity=32.8729281767956, Blast_Score=366, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17539970, Length=436, Percent_Identity=36.9266055045872, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17532897, Length=459, Percent_Identity=35.9477124183007, Blast_Score=270, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6322745, Length=437, Percent_Identity=38.4439359267735, Blast_Score=271, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6323731, Length=437, Percent_Identity=27.6887871853547, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6323730, Length=207, Percent_Identity=40.5797101449275, Blast_Score=146, Evalue=8e-36,
Organism=Drosophila melanogaster, GI21357745, Length=692, Percent_Identity=34.393063583815, Blast_Score=401, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_CORDI (Q6NG33)

Other databases:

- EMBL:   BX248359
- RefSeq:   NP_940038.1
- ProteinModelPortal:   Q6NG33
- SMR:   Q6NG33
- GeneID:   2650293
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1700
- NMPDR:   fig|257309.1.peg.1629
- HOGENOM:   HBG645312
- OMA:   ITIVIAE
- PhylomeDB:   Q6NG33
- ProtClustDB:   PRK00331
- BioCyc:   CDIP257309:DIP1700-MONOMER
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 67667; Mature: 67667

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 620-620

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGFVGRTSVPDRDYFALDVVLEGLRRLEYRGYDSAGVAVVADGAVSFRKKAGKVQA
CCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHCCHHHH
LEQELETSPMPQSCLGIGHTRWATHGGPTDANAHPHVVDGGKLAVVHNGIIENFAELKSE
HHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEECHHHHHHHHHHHH
LLGFGHNFVSETDTEVAATLLGHIFNNEANKDLTRAMQLTCQRLEGAFTLLAIHAETPDR
HHHCCCHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCC
IVAARRNSPLVIGVGEGENFLGSDVSGFIDYTKNAVEMDNDQIVTITADGYHITDFQGNH
EEEECCCCCEEEEECCCCCCCCCCHHHHHHHCCCCEECCCCEEEEEEECCEEEECCCCCC
AEGKPFVVEWDAQAAEKGGYEFFMEKEIHEQPAAVRDTLMGRFDESGKLTLDELRIDEST
CCCCCEEEEECCHHHHCCCCEEEEHHHHHHCCHHHHHHHHHCCCCCCCEEHHHHCCCHHH
LRSIDKIIVIACGTAAYAGHVARYAIEHWCRIPTEVELAHEFRYRDPIVNEKTLVVTLSQ
HHHHCEEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEEEECC
SGETMDTLMAVRHAREQGAKVIAICNTNGSSIPRESDACLYTHAGPEIAVASTKAFLAQI
CCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEEECCCCCEEEHHHHHHHHHH
TATYLLGLYLAQLRGNMFADEVNAVLGELRTIPDKVSAVLDGVEDQVKTLAQDMKDATSV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHH
LFLGRHVGFPVALEGALKLKELAYLHAEGFAAGELKHGPIALIEEGQPVFVIVPSPRGRD
HHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCH
SLHAKVVSNIQEVRARGAITIVIAEEGDDAVEAYANHIIRIPQAPTLMQPLLATVPLQIF
HHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHH
ACGVAAAKGFDVDQPRNLAKSVTVE
HHHHHHHCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MCGIVGFVGRTSVPDRDYFALDVVLEGLRRLEYRGYDSAGVAVVADGAVSFRKKAGKVQA
CCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHCCHHHH
LEQELETSPMPQSCLGIGHTRWATHGGPTDANAHPHVVDGGKLAVVHNGIIENFAELKSE
HHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEECHHHHHHHHHHHH
LLGFGHNFVSETDTEVAATLLGHIFNNEANKDLTRAMQLTCQRLEGAFTLLAIHAETPDR
HHHCCCHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCC
IVAARRNSPLVIGVGEGENFLGSDVSGFIDYTKNAVEMDNDQIVTITADGYHITDFQGNH
EEEECCCCCEEEEECCCCCCCCCCHHHHHHHCCCCEECCCCEEEEEEECCEEEECCCCCC
AEGKPFVVEWDAQAAEKGGYEFFMEKEIHEQPAAVRDTLMGRFDESGKLTLDELRIDEST
CCCCCEEEEECCHHHHCCCCEEEEHHHHHHCCHHHHHHHHHCCCCCCCEEHHHHCCCHHH
LRSIDKIIVIACGTAAYAGHVARYAIEHWCRIPTEVELAHEFRYRDPIVNEKTLVVTLSQ
HHHHCEEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEEEECC
SGETMDTLMAVRHAREQGAKVIAICNTNGSSIPRESDACLYTHAGPEIAVASTKAFLAQI
CCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEEECCCCCEEEHHHHHHHHHH
TATYLLGLYLAQLRGNMFADEVNAVLGELRTIPDKVSAVLDGVEDQVKTLAQDMKDATSV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHH
LFLGRHVGFPVALEGALKLKELAYLHAEGFAAGELKHGPIALIEEGQPVFVIVPSPRGRD
HHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCH
SLHAKVVSNIQEVRARGAITIVIAEEGDDAVEAYANHIIRIPQAPTLMQPLLATVPLQIF
HHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHH
ACGVAAAKGFDVDQPRNLAKSVTVE
HHHHHHHCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910