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The map label for this gene is coaE

Identifier: 38233742

GI number: 38233742

Start: 1140082

End: 1140684

Strand: Direct

Name: coaE

Synonym: DIP1152

Alternate gene names: 38233742

Gene position: 1140082-1140684 (Clockwise)

Preceding gene: 38233738

Following gene: 38233743

Centisome position: 45.81

GC content: 50.08

Gene sequence:

>603_bases
ATGCGGATTATTGGATTAACTGGCGGTATTGGTAGTGGTAAATCTACGGTTGCGAGGATTTGGCAAGGCTGCGGAGCGAT
TGTTATCGACGCCGATGCAATTGCTCGCGTCCTAATGGAACCTGGTTCGACAGTACTTGAAGAAGTTTCGCAAGTTTTTG
GCCGCGATCTTCTTGATGCAGAAGGAAAACTTCGGCGAGCGGAGTTGGCTGCGCGTGCTTTTATTTCTGAAGAGAAAACA
GCGCAACTAAATTCCATTACTCATCCGGCAATTAGGCGTCAGATTAGAAGGGGTATTGAGTGCGCTAGGGCGGAAGGGGT
TCAAGTCCTAGTGCTTGACCATCCGCTGTTGTTTGAATCTGGAATGTCGGATCTGGTGGACGACGTGGTTGTAGTGGACG
TTCCGGCTGAGCTGAGAGTTCGCAGGCTTGTGGATTTGAGGGGGCTAAAGGAGGAAGATGCACGCCATCGGATTATGCGA
CAGATGAGCGATGAGGATCGCCGAATGAGGGCGGATTATGTGATTGATAACTCTGGATCTAGAGATGTGTTGGAGCGTTT
GGCTCGTGAATTATGGCAACGCTTCGCCACTCAAGTGGAATGA

Upstream 100 bases:

>100_bases
CAATCAATTCTAATGAGTCTTATGGGTATAATTGGATCTAGGTCACATTTTGATCTTTTTGGGGTGGAGTGGTGTGAAAG
CGGTTGGGTACAGTACGAGT

Downstream 100 bases:

>100_bases
GCTGGGGTTATATATTTTGAAGTTGGGTCGGTCGCTGCGGTGACGTGGTCTTAATTACTGTCGCCTAACTGGATTTTGGT
AGGTAACCCGTTCCAAAATG

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MRIIGLTGGIGSGKSTVARIWQGCGAIVIDADAIARVLMEPGSTVLEEVSQVFGRDLLDAEGKLRRAELAARAFISEEKT
AQLNSITHPAIRRQIRRGIECARAEGVQVLVLDHPLLFESGMSDLVDDVVVVDVPAELRVRRLVDLRGLKEEDARHRIMR
QMSDEDRRMRADYVIDNSGSRDVLERLARELWQRFATQVE

Sequences:

>Translated_200_residues
MRIIGLTGGIGSGKSTVARIWQGCGAIVIDADAIARVLMEPGSTVLEEVSQVFGRDLLDAEGKLRRAELAARAFISEEKT
AQLNSITHPAIRRQIRRGIECARAEGVQVLVLDHPLLFESGMSDLVDDVVVVDVPAELRVRRLVDLRGLKEEDARHRIMR
QMSDEDRRMRADYVIDNSGSRDVLERLARELWQRFATQVE
>Mature_200_residues
MRIIGLTGGIGSGKSTVARIWQGCGAIVIDADAIARVLMEPGSTVLEEVSQVFGRDLLDAEGKLRRAELAARAFISEEKT
AQLNSITHPAIRRQIRRGIECARAEGVQVLVLDHPLLFESGMSDLVDDVVVVDVPAELRVRRLVDLRGLKEEDARHRIMR
QMSDEDRRMRADYVIDNSGSRDVLERLARELWQRFATQVE

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=187, Percent_Identity=35.2941176470588, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI191252795, Length=187, Percent_Identity=35.2941176470588, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI110227607, Length=192, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=6e-24,
Organism=Homo sapiens, GI110227605, Length=192, Percent_Identity=33.3333333333333, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI110227603, Length=192, Percent_Identity=33.3333333333333, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI110227601, Length=192, Percent_Identity=33.3333333333333, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI205277394, Length=192, Percent_Identity=33.3333333333333, Blast_Score=106, Evalue=1e-23,
Organism=Escherichia coli, GI1786292, Length=182, Percent_Identity=37.9120879120879, Blast_Score=109, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17554944, Length=186, Percent_Identity=38.7096774193548, Blast_Score=130, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI25143409, Length=178, Percent_Identity=29.7752808988764, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320402, Length=185, Percent_Identity=38.3783783783784, Blast_Score=119, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24644728, Length=194, Percent_Identity=36.5979381443299, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24658602, Length=200, Percent_Identity=26.5, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_CORDI (Q6NHI5)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939509.1
- ProteinModelPortal:   Q6NHI5
- SMR:   Q6NHI5
- GeneID:   2648817
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1152
- NMPDR:   fig|257309.1.peg.1100
- HOGENOM:   HBG650290
- OMA:   IIAREVV
- PhylomeDB:   Q6NHI5
- BioCyc:   CDIP257309:DIP1152-MONOMER
- BRENDA:   2.7.1.24
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 22400; Mature: 22400

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS51219 DPCK; PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIIGLTGGIGSGKSTVARIWQGCGAIVIDADAIARVLMEPGSTVLEEVSQVFGRDLLDA
CEEEEECCCCCCCHHHHHHHHHCCCEEEECHHHHHHHHHCCCHHHHHHHHHHHCCHHHCC
EGKLRRAELAARAFISEEKTAQLNSITHPAIRRQIRRGIECARAEGVQVLVLDHPLLFES
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHC
GMSDLVDDVVVVDVPAELRVRRLVDLRGLKEEDARHRIMRQMSDEDRRMRADYVIDNSGS
CHHHHHHCEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHCEEECCCCC
RDVLERLARELWQRFATQVE
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRIIGLTGGIGSGKSTVARIWQGCGAIVIDADAIARVLMEPGSTVLEEVSQVFGRDLLDA
CEEEEECCCCCCCHHHHHHHHHCCCEEEECHHHHHHHHHCCCHHHHHHHHHHHCCHHHCC
EGKLRRAELAARAFISEEKTAQLNSITHPAIRRQIRRGIECARAEGVQVLVLDHPLLFES
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHC
GMSDLVDDVVVVDVPAELRVRRLVDLRGLKEEDARHRIMRQMSDEDRRMRADYVIDNSGS
CHHHHHHCEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHCEEECCCCC
RDVLERLARELWQRFATQVE
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910