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The map label for this gene is coaD

Identifier: 38233729

GI number: 38233729

Start: 1124750

End: 1125229

Strand: Direct

Name: coaD

Synonym: DIP1139

Alternate gene names: 38233729

Gene position: 1124750-1125229 (Clockwise)

Preceding gene: 38233728

Following gene: 38233730

Centisome position: 45.2

GC content: 48.12

Gene sequence:

>480_bases
ATGCGTAAAGCAGTGTGCCCAGGATCTTTTGACCCAGTGACTATGGGGCATCTTGACATCATCGGAAGGGCGGCCCAGCA
ATACGACGAGGTCACCGTTTTAGTGACTGCTAACCCCAATAAGCCCTCAGGTATGTTCACCGTCGATGAACGCCTTGCCC
TTATTAAAGAATCCACTGCGCATTTTGTGAATGTCAAAGTGGATAACTGGGCAGGACTCCTTGTTGATTACACTACGGCC
AACGGGATCGATGCAATCGTCAAAGGGCTTCGAACGGCACTGGATTACGAATATGAGCTACCCATGGCTCAGATGAACCG
AAAGCTAGCTGGTGTGGACACCCTGTTTTTGATGACAGATCCACAATATGGTTACATTTCTTCTACCCTCTGTAAGGAAG
TAACAAAATATGGTGGGGACGTCTCAGATATGTTGCCACCAGCTGTAGCCGCAGCGATTGTGGAGAAAGTAAAAAGCTAA

Upstream 100 bases:

>100_bases
TTCGTGCCTACCACTCAGAAGCTAAAAAAACGCACATTCGGGATTGCACGAATGGACATGGCCGTTTTCCATGCTGAGCT
CGTAGAGGAGTAAAAACATC

Downstream 100 bases:

>100_bases
GTATAGGATTTGTACTTGTTGTTTTAATAATCGTAATAATCGGTTGTTTACTTCAACTTCTAGTAAGACTTCTTCTCCTA
GTCGCATTGGCATTAGTGGT

Product: phosphopantetheine adenylyltransferase

Products: NA

Alternate protein names: Dephospho-CoA pyrophosphorylase; Pantetheine-phosphate adenylyltransferase; PPAT

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MRKAVCPGSFDPVTMGHLDIIGRAAQQYDEVTVLVTANPNKPSGMFTVDERLALIKESTAHFVNVKVDNWAGLLVDYTTA
NGIDAIVKGLRTALDYEYELPMAQMNRKLAGVDTLFLMTDPQYGYISSTLCKEVTKYGGDVSDMLPPAVAAAIVEKVKS

Sequences:

>Translated_159_residues
MRKAVCPGSFDPVTMGHLDIIGRAAQQYDEVTVLVTANPNKPSGMFTVDERLALIKESTAHFVNVKVDNWAGLLVDYTTA
NGIDAIVKGLRTALDYEYELPMAQMNRKLAGVDTLFLMTDPQYGYISSTLCKEVTKYGGDVSDMLPPAVAAAIVEKVKS
>Mature_159_residues
MRKAVCPGSFDPVTMGHLDIIGRAAQQYDEVTVLVTANPNKPSGMFTVDERLALIKESTAHFVNVKVDNWAGLLVDYTTA
NGIDAIVKGLRTALDYEYELPMAQMNRKLAGVDTLFLMTDPQYGYISSTLCKEVTKYGGDVSDMLPPAVAAAIVEKVKS

Specific function: Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate

COG id: COG0669

COG function: function code H; Phosphopantetheine adenylyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial CoaD family

Homologues:

Organism=Escherichia coli, GI1790065, Length=157, Percent_Identity=40.1273885350318, Blast_Score=142, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAD_CORDI (Q6NHJ8)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939496.1
- ProteinModelPortal:   Q6NHJ8
- SMR:   Q6NHJ8
- GeneID:   2649941
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1139
- NMPDR:   fig|257309.1.peg.1087
- HOGENOM:   HBG288308
- OMA:   VRQIAAM
- PhylomeDB:   Q6NHJ8
- ProtClustDB:   PRK00168
- BioCyc:   CDIP257309:DIP1139-MONOMER
- BRENDA:   2.7.7.3
- GO:   GO:0005737
- HAMAP:   MF_00151
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR001980
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR01020
- TIGRFAMs:   TIGR01510
- TIGRFAMs:   TIGR00125

Pfam domain/function: PF01467 CTP_transf_2

EC number: =2.7.7.3

Molecular weight: Translated: 17305; Mature: 17305

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKAVCPGSFDPVTMGHLDIIGRAAQQYDEVTVLVTANPNKPSGMFTVDERLALIKESTA
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEHHHHHHHHHHCCC
HFVNVKVDNWAGLLVDYTTANGIDAIVKGLRTALDYEYELPMAQMNRKLAGVDTLFLMTD
EEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHCCHHCCCEEEEEEEC
PQYGYISSTLCKEVTKYGGDVSDMLPPAVAAAIVEKVKS
CCCCHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRKAVCPGSFDPVTMGHLDIIGRAAQQYDEVTVLVTANPNKPSGMFTVDERLALIKESTA
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEHHHHHHHHHHCCC
HFVNVKVDNWAGLLVDYTTANGIDAIVKGLRTALDYEYELPMAQMNRKLAGVDTLFLMTD
EEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHCCHHCCCEEEEEEEC
PQYGYISSTLCKEVTKYGGDVSDMLPPAVAAAIVEKVKS
CCCCHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910