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The map label for this gene is gpsA

Identifier: 38233720

GI number: 38233720

Start: 1115316

End: 1116311

Strand: Direct

Name: gpsA

Synonym: DIP1130

Alternate gene names: 38233720

Gene position: 1115316-1116311 (Clockwise)

Preceding gene: 38233718

Following gene: 38233721

Centisome position: 44.82

GC content: 53.31

Gene sequence:

>996_bases
ATGAAGATCGGTGTGATGGGTGCCGGTTCTTGGGGAACTACCTTGGCTAAAGTCTTTTCAGACGCAGGCTGTGATGTCAC
CTTGTGGGCACGTCGTGAAGAAGTTGCCCGAGAAATCAACACCGAGCACACAAATTCCACCTATCTTCGAGGTATTGCGT
TGCCGCACACCCTCACGGCCACAACGCAGCCAACGCAGGCGCTGTGCGATGCCGATGTGGTTGTCCTCGCGGTTCCCAGC
CAAACATTGCGTGGAAATCTTGCTGAATGGTGTGCGGATATTCCGCAGGATGCTTTGTTGCTGAGCTTGGCAAAAGGCAT
CGAAAAAGAGACATTTTTGCGCATGAGTGAAGTAATCGCGGAGGTAACGGGTGCGCAACCTGACAAAGTGGCTGTCTTGT
CAGGTCCGAATCTGGCTCGAGAGATTGCAGAGGAACAACCAGCAGCCACCGTTATTGCCTGCACAAACGAGAAAAATGCC
CAGCGTATCCAGCATGCTTTGGCGGCTCCTTATTTCCGTCCGTATACCAACACAGATGTCATCGGTTGCGAGATCGGCGG
GGCTTGCAAAAATGTGATCGCTCTCGCCTGCGGTATGGCATCTGGCAGGGGGCTAGGAGAGAACACTCTGGCAACGTTGA
TGACGCGTGGTCTAGCGGAGATCTCACGTTTGGGAGTAGCCATGGGTGCAGATCCGCGAACCCTATCAGGTTTAGCTGGG
TTGGGAGACTTGGTAGCTACATGTTCATCGCCGTTGTCACGTAACCGAACCTTTGGTGCCCGTTTGGGTGAAGGCAAGAC
TTTAGACGAAGCCCGTGCAGCGACAAACGGGCAAGTAGCCGAAGGAGTTATATCCTCGCAATCTATTGCGCGGCTAGCAG
ATTCCTTGGGGGTTGATATGCCCATTACCCGTGCGGTATTTGGAGTATGTCATCGTGACCAAAATGTTGCCGACATGGTG
GCTGCATTGATGGGGCGTACCAAGAAATCTGAGTAG

Upstream 100 bases:

>100_bases
CGCATAGCAATAGTCTTATGTATAGGGAGATGCTGGGAACAGATATAGTCGAATACAACGAGTTTTATGGAGTGTATCCG
TGCGAATTAGGAGGCAAGTG

Downstream 100 bases:

>100_bases
CTACAGGGTAGAGTTTCCGTCTGTGAGCCAAAATCTTTCAGCACAGAACTCTTCAGAAACTCCTCGTATTAAAGTTGCCA
TCATCTATGGTGGTCGTAGC

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MKIGVMGAGSWGTTLAKVFSDAGCDVTLWARREEVAREINTEHTNSTYLRGIALPHTLTATTQPTQALCDADVVVLAVPS
QTLRGNLAEWCADIPQDALLLSLAKGIEKETFLRMSEVIAEVTGAQPDKVAVLSGPNLAREIAEEQPAATVIACTNEKNA
QRIQHALAAPYFRPYTNTDVIGCEIGGACKNVIALACGMASGRGLGENTLATLMTRGLAEISRLGVAMGADPRTLSGLAG
LGDLVATCSSPLSRNRTFGARLGEGKTLDEARAATNGQVAEGVISSQSIARLADSLGVDMPITRAVFGVCHRDQNVADMV
AALMGRTKKSE

Sequences:

>Translated_331_residues
MKIGVMGAGSWGTTLAKVFSDAGCDVTLWARREEVAREINTEHTNSTYLRGIALPHTLTATTQPTQALCDADVVVLAVPS
QTLRGNLAEWCADIPQDALLLSLAKGIEKETFLRMSEVIAEVTGAQPDKVAVLSGPNLAREIAEEQPAATVIACTNEKNA
QRIQHALAAPYFRPYTNTDVIGCEIGGACKNVIALACGMASGRGLGENTLATLMTRGLAEISRLGVAMGADPRTLSGLAG
LGDLVATCSSPLSRNRTFGARLGEGKTLDEARAATNGQVAEGVISSQSIARLADSLGVDMPITRAVFGVCHRDQNVADMV
AALMGRTKKSE
>Mature_331_residues
MKIGVMGAGSWGTTLAKVFSDAGCDVTLWARREEVAREINTEHTNSTYLRGIALPHTLTATTQPTQALCDADVVVLAVPS
QTLRGNLAEWCADIPQDALLLSLAKGIEKETFLRMSEVIAEVTGAQPDKVAVLSGPNLAREIAEEQPAATVIACTNEKNA
QRIQHALAAPYFRPYTNTDVIGCEIGGACKNVIALACGMASGRGLGENTLATLMTRGLAEISRLGVAMGADPRTLSGLAG
LGDLVATCSSPLSRNRTFGARLGEGKTLDEARAATNGQVAEGVISSQSIARLADSLGVDMPITRAVFGVCHRDQNVADMV
AALMGRTKKSE

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=343, Percent_Identity=29.1545189504373, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI24307999, Length=344, Percent_Identity=29.3604651162791, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI1790037, Length=328, Percent_Identity=39.6341463414634, Blast_Score=221, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI32564399, Length=345, Percent_Identity=30.1449275362319, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI193210136, Length=354, Percent_Identity=29.6610169491525, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI32564403, Length=354, Percent_Identity=29.6610169491525, Blast_Score=130, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17507425, Length=348, Percent_Identity=27.0114942528736, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI193210134, Length=342, Percent_Identity=26.3157894736842, Blast_Score=94, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6320181, Length=359, Percent_Identity=32.3119777158774, Blast_Score=146, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6324513, Length=351, Percent_Identity=30.4843304843305, Blast_Score=146, Evalue=6e-36,
Organism=Drosophila melanogaster, GI17136204, Length=337, Percent_Identity=27.299703264095, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17136200, Length=337, Percent_Identity=27.299703264095, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17136202, Length=337, Percent_Identity=27.299703264095, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI22026922, Length=349, Percent_Identity=26.0744985673352, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI45551945, Length=342, Percent_Identity=25.4385964912281, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI281362270, Length=289, Percent_Identity=26.643598615917, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24648969, Length=301, Percent_Identity=24.9169435215947, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_CORDI (P61738)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939487.1
- ProteinModelPortal:   P61738
- SMR:   P61738
- GeneID:   2649932
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1130
- NMPDR:   fig|257309.1.peg.1078
- HOGENOM:   HBG586392
- OMA:   SQTLRGN
- PhylomeDB:   P61738
- ProtClustDB:   PRK00094
- BioCyc:   CDIP257309:DIP1130-MONOMER
- BRENDA:   1.1.1.94
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 34706; Mature: 34706

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 190-190 BINDING 105-105 BINDING 105-105 BINDING 139-139 BINDING 254-254 BINDING 281-281

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGVMGAGSWGTTLAKVFSDAGCDVTLWARREEVAREINTEHTNSTYLRGIALPHTLTA
CEEEEECCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCCCCCCHHEEEEECCCEEEC
TTQPTQALCDADVVVLAVPSQTLRGNLAEWCADIPQDALLLSLAKGIEKETFLRMSEVIA
CCCCHHHHHCCCEEEEEECCHHHHCCHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHH
EVTGAQPDKVAVLSGPNLAREIAEEQPAATVIACTNEKNAQRIQHALAAPYFRPYTNTDV
HHHCCCCCEEEEECCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCE
IGCEIGGACKNVIALACGMASGRGLGENTLATLMTRGLAEISRLGVAMGADPRTLSGLAG
EEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
LGDLVATCSSPLSRNRTFGARLGEGKTLDEARAATNGQVAEGVISSQSIARLADSLGVDM
HHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
PITRAVFGVCHRDQNVADMVAALMGRTKKSE
CHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKIGVMGAGSWGTTLAKVFSDAGCDVTLWARREEVAREINTEHTNSTYLRGIALPHTLTA
CEEEEECCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCCCCCCHHEEEEECCCEEEC
TTQPTQALCDADVVVLAVPSQTLRGNLAEWCADIPQDALLLSLAKGIEKETFLRMSEVIA
CCCCHHHHHCCCEEEEEECCHHHHCCHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHH
EVTGAQPDKVAVLSGPNLAREIAEEQPAATVIACTNEKNAQRIQHALAAPYFRPYTNTDV
HHHCCCCCEEEEECCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCE
IGCEIGGACKNVIALACGMASGRGLGENTLATLMTRGLAEISRLGVAMGADPRTLSGLAG
EEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
LGDLVATCSSPLSRNRTFGARLGEGKTLDEARAATNGQVAEGVISSQSIARLADSLGVDM
HHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
PITRAVFGVCHRDQNVADMVAALMGRTKKSE
CHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910