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The map label for this gene is ilvC

Identifier: 38233694

GI number: 38233694

Start: 1084631

End: 1085644

Strand: Direct

Name: ilvC

Synonym: DIP1100

Alternate gene names: 38233694

Gene position: 1084631-1085644 (Clockwise)

Preceding gene: 38233693

Following gene: 38233695

Centisome position: 43.58

GC content: 51.28

Gene sequence:

>1014_bases
ATGGCTATCGAACTTCTTTATGATGCAGATGCAGACCTGTCGATCATCCAAGGCCGTAAAGTTGCCGTGATTGGCTACGG
CTCTCAAGGTCATGCTCACGCGCAGTGCCTGCGTGATTCCGGTGTTGAGGTTGTTATCGGTTTGCGTGAAGGCTCTAAGT
CTTCCGAAAAGGCGCAGGAGGCAGGTTTTGAGGTTAAGTCCAACGCCGATGCGGCTGCGTGGGCAGATGTTATCATGCTG
CTCGCTCCAGACACCTCTCAAGCAGAGATCTTTAGCCATGATATTGAGCCAAATCTTAAAGACGGCGATGCCTTGCTGTT
CGGACATGGTCTGAACATCCACTTCGAGCTAATCAAGCCTGCTGTCAATATTACTGTTGGCATGGTTGCTCCTAAGGGGC
CGGGTCATTTGGTTCGTCGTCAATTCGTTGACGGCAAGGGTGTGCCATGTCTGATTGCCGTCGCTCAGGATCCAAAGGGT
GAGGGTAAGGATCTTGCATTGTCGTATGCTGCTGCTATTGGTGGTGCACGCGCGGGTGTTATTCCTACAACCTTCCGTGA
GGAAACCGAAACTGACTTGTTTGGTGAGCAGGTTGTACTTTGTGGTGGTCTTGAGCACCTAATGATGAAAGGCTTTGAGG
TTTTGGCTGAAGCCGGCTATGCGCCAGAGATGGCATACTTTGAGGTTCTTCATGAGATGAAGCTCATTGTTGACCTCATC
TGGGAGGGTGGCATTGAGAACATGAACTACTCGATCTCGGAGACTGCCGAGTTGGGTGGTTATGTTGCTGGTCCTCGCAT
TATCACTCCTGAGGTCAAAGAGAATATGAAGGCTGTGTTGGCTGATATCCAGTCGGGCAAGTTTGTCCGTGACATGGTTG
CTGATGTTGAGGCTGGTCAGCCTGAGCTTAAGCGTTACCGTGAAGAGATCGCCGCGCATCCAATCGAGGCTACGGGATCG
AAACTGCGTGATCTGATGAGCTGGGTAAAGAATCCGCTCGATGAGACTGCCTAG

Upstream 100 bases:

>100_bases
AATTCACGAACGTCTCATTTAATGAGATAAAAATGCAAAAATATCTCAATATGTGATATAAAGGGCAGAAGCCCACAACA
TACGAAAGGACTCCATCCTT

Downstream 100 bases:

>100_bases
TTTTGGATTTTAGGGGGTTAAGGGCCTCGCCTCAGTTGTGAACTGGGGTGAGGCCCTTGCTCTATGTTGGGCTGGCGAGG
TAGAGAGTATCAGTACACAT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MAIELLYDADADLSIIQGRKVAVIGYGSQGHAHAQCLRDSGVEVVIGLREGSKSSEKAQEAGFEVKSNADAAAWADVIML
LAPDTSQAEIFSHDIEPNLKDGDALLFGHGLNIHFELIKPAVNITVGMVAPKGPGHLVRRQFVDGKGVPCLIAVAQDPKG
EGKDLALSYAAAIGGARAGVIPTTFREETETDLFGEQVVLCGGLEHLMMKGFEVLAEAGYAPEMAYFEVLHEMKLIVDLI
WEGGIENMNYSISETAELGGYVAGPRIITPEVKENMKAVLADIQSGKFVRDMVADVEAGQPELKRYREEIAAHPIEATGS
KLRDLMSWVKNPLDETA

Sequences:

>Translated_337_residues
MAIELLYDADADLSIIQGRKVAVIGYGSQGHAHAQCLRDSGVEVVIGLREGSKSSEKAQEAGFEVKSNADAAAWADVIML
LAPDTSQAEIFSHDIEPNLKDGDALLFGHGLNIHFELIKPAVNITVGMVAPKGPGHLVRRQFVDGKGVPCLIAVAQDPKG
EGKDLALSYAAAIGGARAGVIPTTFREETETDLFGEQVVLCGGLEHLMMKGFEVLAEAGYAPEMAYFEVLHEMKLIVDLI
WEGGIENMNYSISETAELGGYVAGPRIITPEVKENMKAVLADIQSGKFVRDMVADVEAGQPELKRYREEIAAHPIEATGS
KLRDLMSWVKNPLDETA
>Mature_336_residues
AIELLYDADADLSIIQGRKVAVIGYGSQGHAHAQCLRDSGVEVVIGLREGSKSSEKAQEAGFEVKSNADAAAWADVIMLL
APDTSQAEIFSHDIEPNLKDGDALLFGHGLNIHFELIKPAVNITVGMVAPKGPGHLVRRQFVDGKGVPCLIAVAQDPKGE
GKDLALSYAAAIGGARAGVIPTTFREETETDLFGEQVVLCGGLEHLMMKGFEVLAEAGYAPEMAYFEVLHEMKLIVDLIW
EGGIENMNYSISETAELGGYVAGPRIITPEVKENMKAVLADIQSGKFVRDMVADVEAGQPELKRYREEIAAHPIEATGSK
LRDLMSWVKNPLDETA

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=314, Percent_Identity=36.9426751592357, Blast_Score=164, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6323387, Length=284, Percent_Identity=32.3943661971831, Blast_Score=115, Evalue=9e-27,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_CORDI (Q6NHN2)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939461.1
- ProteinModelPortal:   Q6NHN2
- SMR:   Q6NHN2
- GeneID:   2650842
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1100
- NMPDR:   fig|257309.1.peg.1052
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- PhylomeDB:   Q6NHN2
- ProtClustDB:   PRK05479
- BioCyc:   CDIP257309:DIP1100-MONOMER
- BRENDA:   1.1.1.86
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36284; Mature: 36153

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: ACT_SITE 109-109

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIELLYDADADLSIIQGRKVAVIGYGSQGHAHAQCLRDSGVEVVIGLREGSKSSEKAQE
CEEEEEECCCCCEEEECCCEEEEEEECCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHH
AGFEVKSNADAAAWADVIMLLAPDTSQAEIFSHDIEPNLKDGDALLFGHGLNIHFELIKP
CCCEECCCCCHHHHHHEEEEECCCCCCHHHHHCCCCCCCCCCCEEEEECCCCEEEEEECC
AVNITVGMVAPKGPGHLVRRQFVDGKGVPCLIAVAQDPKGEGKDLALSYAAAIGGARAGV
CEEEEEEEECCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCC
IPTTFREETETDLFGEQVVLCGGLEHLMMKGFEVLAEAGYAPEMAYFEVLHEMKLIVDLI
CCCCCCCCHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
WEGGIENMNYSISETAELGGYVAGPRIITPEVKENMKAVLADIQSGKFVRDMVADVEAGQ
HCCCCCCCCCCHHHHHHCCCEECCCEEECHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
PELKRYREEIAAHPIEATGSKLRDLMSWVKNPLDETA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AIELLYDADADLSIIQGRKVAVIGYGSQGHAHAQCLRDSGVEVVIGLREGSKSSEKAQE
EEEEEECCCCCEEEECCCEEEEEEECCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHH
AGFEVKSNADAAAWADVIMLLAPDTSQAEIFSHDIEPNLKDGDALLFGHGLNIHFELIKP
CCCEECCCCCHHHHHHEEEEECCCCCCHHHHHCCCCCCCCCCCEEEEECCCCEEEEEECC
AVNITVGMVAPKGPGHLVRRQFVDGKGVPCLIAVAQDPKGEGKDLALSYAAAIGGARAGV
CEEEEEEEECCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCC
IPTTFREETETDLFGEQVVLCGGLEHLMMKGFEVLAEAGYAPEMAYFEVLHEMKLIVDLI
CCCCCCCCHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
WEGGIENMNYSISETAELGGYVAGPRIITPEVKENMKAVLADIQSGKFVRDMVADVEAGQ
HCCCCCCCCCCHHHHHHCCCEECCCEEECHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
PELKRYREEIAAHPIEATGSKLRDLMSWVKNPLDETA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910