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The map label for this gene is wecA [H]

Identifier: 38233638

GI number: 38233638

Start: 1026086

End: 1027255

Strand: Direct

Name: wecA [H]

Synonym: DIP1044

Alternate gene names: 38233638

Gene position: 1026086-1027255 (Clockwise)

Preceding gene: 38233637

Following gene: 38233639

Centisome position: 41.23

GC content: 52.56

Gene sequence:

>1170_bases
ATGGGTGCTGGTGCCGGTGTTGCCGGTGTGCCCATGCGTGAGCTTGCACTGATCATTCTCGTTGCAGCTTCGCTGACGTT
TTTGACCACGGGGATAGTTCGCTACGCTGTGGTCAAAAGCGGGCGAATGGGCGAAATCCGTGAGCGAGATGTCCATACCC
AGCCCAAGCCGCGTCTTGGTGGTGTGGCGATGTTTTCTGGTTTTATCGGCGCAGTATTCTTGGCCGACCAGCTTCCAGCC
TTGACTAGAGGGTTTAAGCCGGTCACTCCGGAGATGAGCGCCGTTTTCTGGGCCGGTGCGATTATCGTCATCGTGGGTAT
TCTCGACGATCTGTTTGAGCTGGACGCGATTACTAAACTTGCGGGTCAAGTTCTAGGTGCGGCCGTCATGAGCATCTTGG
GGCTTACATGGACTTTGGTCTATCTGCCATTTGGTGGTGGCTCGACGCTTGTTCTTGATCAGGTTGCTTCAACTTTGGTT
ACGGTGCTGTTTACAGTCACTTTGATTAACGCAATCAACTTTGTGGATGGCCTCGATGGTTTAGCCGCTGGTTTGGGCAT
GATCGCTGGTTTATCTATCTTGTTGTTTTCTATGACGGTTCTCCACGATCAAGGTGGCATGGTATCGGCATATCCACCAG
CAATTATTGCGGCTTCCCTCGTGGGCATGTGTGCAGGATTTTTGCCGCACAACTTTGAGCCGGCTCGCATTTTCATGGGT
GATTCTGGCTCCATGCTCATCGGATTATTGCTTGCGGCAGCGTCAACGTCGGCTAGTGGCAAGATCGATATGAGTCTGTA
CGGCACAGTTGACGTGATCGCCTTGATGTCTCCGATCATTGTGGTGATAGCGGCAGTCTTTATTCCGATGCTTGATTTGG
TGATGGCCATTGTCCGGCGTGTTCGCAAAGGAAAATCACCGTTTTCTGCTGATAAGATGCATCTGCATCACCGGCTATTG
TCTTTGGGGCATACGCATAGGCGGGTCGTGTTGGTGCTTTATCTTTGGGTGTCCGTGGTCGCTTTTGGTGCGGTTGCGTT
CTCGATTGTTCCCCCCGTTTTTGCCACCGTTGGTGTGATTACGGCTATCGTGTTCGCAGTACTTGCCAGTAGGGGGCCGG
TCATACGTGCCCAAAAGGAAGCGCATCGTCGTGAACATCCGCTCTCATAG

Upstream 100 bases:

>100_bases
TGACCTGTCCGGTGATCATCCGCGAATTCTTCGTGAAGGCGCGATCTCAGCGGAACGAGTCGCAGAAGTGTTGGAAGTCG
ACGTGGAGACGCTTCGATAG

Downstream 100 bases:

>100_bases
ACTTAAAGGAAAGTTTCGTGATTACATCTGACCAATCGAACGCTTCGCAGTTCGACGACCACCGCAGGCCGTTATTACGA
GCGCTCAAATTTGGAGCCAT

Product: glycosyl trasferase

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-Phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MGAGAGVAGVPMRELALIILVAASLTFLTTGIVRYAVVKSGRMGEIRERDVHTQPKPRLGGVAMFSGFIGAVFLADQLPA
LTRGFKPVTPEMSAVFWAGAIIVIVGILDDLFELDAITKLAGQVLGAAVMSILGLTWTLVYLPFGGGSTLVLDQVASTLV
TVLFTVTLINAINFVDGLDGLAAGLGMIAGLSILLFSMTVLHDQGGMVSAYPPAIIAASLVGMCAGFLPHNFEPARIFMG
DSGSMLIGLLLAAASTSASGKIDMSLYGTVDVIALMSPIIVVIAAVFIPMLDLVMAIVRRVRKGKSPFSADKMHLHHRLL
SLGHTHRRVVLVLYLWVSVVAFGAVAFSIVPPVFATVGVITAIVFAVLASRGPVIRAQKEAHRREHPLS

Sequences:

>Translated_389_residues
MGAGAGVAGVPMRELALIILVAASLTFLTTGIVRYAVVKSGRMGEIRERDVHTQPKPRLGGVAMFSGFIGAVFLADQLPA
LTRGFKPVTPEMSAVFWAGAIIVIVGILDDLFELDAITKLAGQVLGAAVMSILGLTWTLVYLPFGGGSTLVLDQVASTLV
TVLFTVTLINAINFVDGLDGLAAGLGMIAGLSILLFSMTVLHDQGGMVSAYPPAIIAASLVGMCAGFLPHNFEPARIFMG
DSGSMLIGLLLAAASTSASGKIDMSLYGTVDVIALMSPIIVVIAAVFIPMLDLVMAIVRRVRKGKSPFSADKMHLHHRLL
SLGHTHRRVVLVLYLWVSVVAFGAVAFSIVPPVFATVGVITAIVFAVLASRGPVIRAQKEAHRREHPLS
>Mature_388_residues
GAGAGVAGVPMRELALIILVAASLTFLTTGIVRYAVVKSGRMGEIRERDVHTQPKPRLGGVAMFSGFIGAVFLADQLPAL
TRGFKPVTPEMSAVFWAGAIIVIVGILDDLFELDAITKLAGQVLGAAVMSILGLTWTLVYLPFGGGSTLVLDQVASTLVT
VLFTVTLINAINFVDGLDGLAAGLGMIAGLSILLFSMTVLHDQGGMVSAYPPAIIAASLVGMCAGFLPHNFEPARIFMGD
SGSMLIGLLLAAASTSASGKIDMSLYGTVDVIALMSPIIVVIAAVFIPMLDLVMAIVRRVRKGKSPFSADKMHLHHRLLS
LGHTHRRVVLVLYLWVSVVAFGAVAFSIVPPVFATVGVITAIVFAVLASRGPVIRAQKEAHRREHPLS

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55), the lipid intermediate involved in the synthesis of various bacter

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=308, Percent_Identity=27.9220779220779, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000715 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 40873; Mature: 40742

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCCCCEECHHHHHHHCCCCC
>Mature Secondary Structure 
GAGAGVAGVPMRELALIILVAASLTFLTTGIVRYAVVKSGRMGEIRERDVHTQPKPRLG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCC
GVAMFSGFIGAVFLADQLPALTRGFKPVTPEMSAVFWAGAIIVIVGILDDLFELDAITKL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGQVLGAAVMSILGLTWTLVYLPFGGGSTLVLDQVASTLVTVLFTVTLINAINFVDGLDG
HHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAGLGMIAGLSILLFSMTVLHDQGGMVSAYPPAIIAASLVGMCAGFLPHNFEPARIFMG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEC
DSGSMLIGLLLAAASTSASGKIDMSLYGTVDVIALMSPIIVVIAAVFIPMLDLVMAIVRR
CCCHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRKGKSPFSADKMHLHHRLLSLGHTHRRVVLVLYLWVSVVAFGAVAFSIVPPVFATVGVI
HHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAIVFAVLASRGPVIRAQKEAHRREHPLS
HHHHHHHHHCCCCCEECHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]