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The map label for this gene is mmdA [C]

Identifier: 38233346

GI number: 38233346

Start: 716559

End: 718115

Strand: Direct

Name: mmdA [C]

Synonym: DIP0740

Alternate gene names: 38233346

Gene position: 716559-718115 (Clockwise)

Preceding gene: 38233345

Following gene: 38233347

Centisome position: 28.79

GC content: 55.62

Gene sequence:

>1557_bases
ATGGCTAAAGAATTGTCGATGGCCGAGCGCCTCGAAAAGCTGGCAGCTGCTAAGGCCGAGGTAAGCCTTGGCGGTGGTCA
AGCCAAGATTGATAAGCAGCACGAAAAGGGCAAGCTTACTGCTCGCGAGCGTATCGACGCGCTTGTCGACGACGGCACCT
TCTTTGAAACTGGCATGTTTGCTAAGCATCGCACCACTCACTTTGGTATGGACAAGGCGAATGCCCCAGCAGATGGTGTT
GTGACTGGTTCCGGAGCTGTGTTCGGTCGCCCTGTCCACATCGCTTCTCAAGACTTCACCGTCATGGGTGGTTCTGCAGG
TGAGACGCAGTCCAACAAGGTCGCTGCGATGATGGAGGCTTCGGCCACCACCGGTACGCCGTTCATCTTCATTAATGACT
CCGGCGGAGCTCGTGTCCAGGAGGGTATCGACTCCCTGTCCGGTTACGGCAAGGTGTTCTACCAAAACGTGCTGCTATCG
GGTCTGGTCCCACAGGTCTCGATCATCGCTGGCCCTTGTGCCGGTGGTGCAGCATACTCGCCAGCGCTGACTGACTTCAT
CATCCAGACCCGCAAGGCCAACATGTTCATTACTGGCCCCGGTGTGATCAAGTCCGTTACTGGCGAAGAAGTCACCTCTG
ATGCACTTGGTGGTGCAGACGCACACATGACCAAGGCCGGCAACATCCACTTCATTGCTGATGACGACGAGCAAGCCGTC
CTGATCGCTCAGAAGCTGCTGAGCTTCCTGCCTCAGAACAACACTGAGGAGCCACCTGTGGTGGATCCTGACCCAGTAGT
TGAGCCTGATCCAGAGCTGCGTGACATTGTTCCTGTGGAAGGCAAGAAGGGCTACGATGTCCGCGACATCATCAGCCGTG
TAGTCGACCGCGGTGACTTCCTCGAGGTCCAGGCAGGCTACGCTACAAACATCGTGGTTGGTTTTGCACGTATCGTCGGC
CGTACTGTCGGTATCATCGCTAACCAGCCAAACGTGATGTCGGGTGTCCTAGACATCAACTCTTCTGACAAGGGCAGCCA
GTTCATCCGTTTCTGCAACGCTTTCAACATTCCACTCGTTACCTTCGTGGACGTTCCAGGCTTTATGCCAGGTGTTGCTC
AAGAGCACGGCGGTATCATCCGTCACGGTGCAAAGATGCTTTACGCATACTCCGCAGCATCGGTACCAAAGGTGACCATC
GAGCTGCGTAAGTCCTACGGTGGCGCTCACTTGGCAATGTGCTCCAAGGACCTTGGTGCAGACCGTGTCTTCGCATGGCC
AACTGCTGAGATCGCTGTGATGGGTGCAGAAGGTGCCGTCAACGTGGTTTTCCGTAAGGAAATTGAGGCTGCCGAAGACA
AGGACGCAAAGCGCGAAGAGCTTATCCAGCTGTACAAGGATACGTTCTCCACACCATTTATGGCCGCATCCCGTGGTTTG
GTGGACGACATCATCGATCCAGCAGAGACTCGCCTGCACATCGCCAATGCACTTGAGGTTCTGACCAACAAGCGCGTTAC
CCGCCCTGCTAAGAAGCACGGCTTGGGACCAGTGTAA

Upstream 100 bases:

>100_bases
CGATAACCAAGCGGTCTTGGAACCAATCACCTACAAGGTCACCGTGGGCGGTCGCAGCCAGACCGTCAAGGTTGAGCCAG
CTGAATAAGGAGTTTGACTA

Downstream 100 bases:

>100_bases
GGAAGCGTCAGTCATGAGCGATTTAAACAACGAGCAACTGCTTCAACTAGTCAACGAGTTAAGCGCGCGCCTCGATTCCG
CAGAATCAGAGATCAAAGAG

Product: methylmalonyl-CoA decarboxylase, alpha-subunit

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MAKELSMAERLEKLAAAKAEVSLGGGQAKIDKQHEKGKLTARERIDALVDDGTFFETGMFAKHRTTHFGMDKANAPADGV
VTGSGAVFGRPVHIASQDFTVMGGSAGETQSNKVAAMMEASATTGTPFIFINDSGGARVQEGIDSLSGYGKVFYQNVLLS
GLVPQVSIIAGPCAGGAAYSPALTDFIIQTRKANMFITGPGVIKSVTGEEVTSDALGGADAHMTKAGNIHFIADDDEQAV
LIAQKLLSFLPQNNTEEPPVVDPDPVVEPDPELRDIVPVEGKKGYDVRDIISRVVDRGDFLEVQAGYATNIVVGFARIVG
RTVGIIANQPNVMSGVLDINSSDKGSQFIRFCNAFNIPLVTFVDVPGFMPGVAQEHGGIIRHGAKMLYAYSAASVPKVTI
ELRKSYGGAHLAMCSKDLGADRVFAWPTAEIAVMGAEGAVNVVFRKEIEAAEDKDAKREELIQLYKDTFSTPFMAASRGL
VDDIIDPAETRLHIANALEVLTNKRVTRPAKKHGLGPV

Sequences:

>Translated_518_residues
MAKELSMAERLEKLAAAKAEVSLGGGQAKIDKQHEKGKLTARERIDALVDDGTFFETGMFAKHRTTHFGMDKANAPADGV
VTGSGAVFGRPVHIASQDFTVMGGSAGETQSNKVAAMMEASATTGTPFIFINDSGGARVQEGIDSLSGYGKVFYQNVLLS
GLVPQVSIIAGPCAGGAAYSPALTDFIIQTRKANMFITGPGVIKSVTGEEVTSDALGGADAHMTKAGNIHFIADDDEQAV
LIAQKLLSFLPQNNTEEPPVVDPDPVVEPDPELRDIVPVEGKKGYDVRDIISRVVDRGDFLEVQAGYATNIVVGFARIVG
RTVGIIANQPNVMSGVLDINSSDKGSQFIRFCNAFNIPLVTFVDVPGFMPGVAQEHGGIIRHGAKMLYAYSAASVPKVTI
ELRKSYGGAHLAMCSKDLGADRVFAWPTAEIAVMGAEGAVNVVFRKEIEAAEDKDAKREELIQLYKDTFSTPFMAASRGL
VDDIIDPAETRLHIANALEVLTNKRVTRPAKKHGLGPV
>Mature_517_residues
AKELSMAERLEKLAAAKAEVSLGGGQAKIDKQHEKGKLTARERIDALVDDGTFFETGMFAKHRTTHFGMDKANAPADGVV
TGSGAVFGRPVHIASQDFTVMGGSAGETQSNKVAAMMEASATTGTPFIFINDSGGARVQEGIDSLSGYGKVFYQNVLLSG
LVPQVSIIAGPCAGGAAYSPALTDFIIQTRKANMFITGPGVIKSVTGEEVTSDALGGADAHMTKAGNIHFIADDDEQAVL
IAQKLLSFLPQNNTEEPPVVDPDPVVEPDPELRDIVPVEGKKGYDVRDIISRVVDRGDFLEVQAGYATNIVVGFARIVGR
TVGIIANQPNVMSGVLDINSSDKGSQFIRFCNAFNIPLVTFVDVPGFMPGVAQEHGGIIRHGAKMLYAYSAASVPKVTIE
LRKSYGGAHLAMCSKDLGADRVFAWPTAEIAVMGAEGAVNVVFRKEIEAAEDKDAKREELIQLYKDTFSTPFMAASRGLV
DDIIDPAETRLHIANALEVLTNKRVTRPAKKHGLGPV

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=523, Percent_Identity=52.0076481835564, Blast_Score=538, Evalue=1e-153,
Organism=Homo sapiens, GI295821216, Length=543, Percent_Identity=50.0920810313076, Blast_Score=526, Evalue=1e-149,
Organism=Homo sapiens, GI11545863, Length=517, Percent_Identity=34.0425531914894, Blast_Score=266, Evalue=5e-71,
Organism=Homo sapiens, GI134142062, Length=348, Percent_Identity=23.8505747126437, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI38679974, Length=438, Percent_Identity=24.2009132420091, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI38679971, Length=438, Percent_Identity=24.2009132420091, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI38679977, Length=438, Percent_Identity=24.2009132420091, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI38679967, Length=438, Percent_Identity=24.2009132420091, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI38679960, Length=438, Percent_Identity=24.2009132420091, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1788655, Length=255, Percent_Identity=28.6274509803922, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI25147362, Length=509, Percent_Identity=50.8840864440079, Blast_Score=531, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI25147359, Length=509, Percent_Identity=50.8840864440079, Blast_Score=531, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17552936, Length=530, Percent_Identity=34.9056603773585, Blast_Score=290, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI71997163, Length=313, Percent_Identity=25.2396166134185, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24586065, Length=529, Percent_Identity=34.2155009451796, Blast_Score=272, Evalue=5e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 55103; Mature: 54972

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKELSMAERLEKLAAAKAEVSLGGGQAKIDKQHEKGKLTARERIDALVDDGTFFETGMF
CCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHCCCCHHHHHHHHHHCCCCEEECCCC
AKHRTTHFGMDKANAPADGVVTGSGAVFGRPVHIASQDFTVMGGSAGETQSNKVAAMMEA
CCCCCCCCCCCCCCCCCCCEEECCCCEECCEEEECCCCEEEECCCCCCCCCCCEEEEEEC
SATTGTPFIFINDSGGARVQEGIDSLSGYGKVFYQNVLLSGLVPQVSIIAGPCAGGAAYS
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCC
PALTDFIIQTRKANMFITGPGVIKSVTGEEVTSDALGGADAHMTKAGNIHFIADDDEQAV
HHHHHHHHHHCCCCEEEECCCCEECCCCCHHHHHHCCCCCCCEECCCCEEEEECCCCCHH
LIAQKLLSFLPQNNTEEPPVVDPDPVVEPDPELRDIVPVEGKKGYDVRDIISRVVDRGDF
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHCCCCE
LEVQAGYATNIVVGFARIVGRTVGIIANQPNVMSGVLDINSSDKGSQFIRFCNAFNIPLV
EEEECCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEE
TFVDVPGFMPGVAQEHGGIIRHGAKMLYAYSAASVPKVTIELRKSYGGAHLAMCSKDLGA
EEECCCCCCCCHHHHCCCHHHHCHHEEEEECCCCCCEEEEEEHHCCCCEEEEEHHHCCCC
DRVFAWPTAEIAVMGAEGAVNVVFRKEIEAAEDKDAKREELIQLYKDTFSTPFMAASRGL
CCEEECCCCEEEEEECCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHCCC
VDDIIDPAETRLHIANALEVLTNKRVTRPAKKHGLGPV
HHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCC
>Mature Secondary Structure 
AKELSMAERLEKLAAAKAEVSLGGGQAKIDKQHEKGKLTARERIDALVDDGTFFETGMF
CCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHCCCCHHHHHHHHHHCCCCEEECCCC
AKHRTTHFGMDKANAPADGVVTGSGAVFGRPVHIASQDFTVMGGSAGETQSNKVAAMMEA
CCCCCCCCCCCCCCCCCCCEEECCCCEECCEEEECCCCEEEECCCCCCCCCCCEEEEEEC
SATTGTPFIFINDSGGARVQEGIDSLSGYGKVFYQNVLLSGLVPQVSIIAGPCAGGAAYS
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCC
PALTDFIIQTRKANMFITGPGVIKSVTGEEVTSDALGGADAHMTKAGNIHFIADDDEQAV
HHHHHHHHHHCCCCEEEECCCCEECCCCCHHHHHHCCCCCCCEECCCCEEEEECCCCCHH
LIAQKLLSFLPQNNTEEPPVVDPDPVVEPDPELRDIVPVEGKKGYDVRDIISRVVDRGDF
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHCCCCE
LEVQAGYATNIVVGFARIVGRTVGIIANQPNVMSGVLDINSSDKGSQFIRFCNAFNIPLV
EEEECCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEE
TFVDVPGFMPGVAQEHGGIIRHGAKMLYAYSAASVPKVTIELRKSYGGAHLAMCSKDLGA
EEECCCCCCCCHHHHCCCHHHHCHHEEEEECCCCCCEEEEEEHHCCCCEEEEEHHHCCCC
DRVFAWPTAEIAVMGAEGAVNVVFRKEIEAAEDKDAKREELIQLYKDTFSTPFMAASRGL
CCEEECCCCEEEEEECCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHCCC
VDDIIDPAETRLHIANALEVLTNKRVTRPAKKHGLGPV
HHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]