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The map label for this gene is metX

Identifier: 38233230

GI number: 38233230

Start: 591014

End: 592117

Strand: Reverse

Name: metX

Synonym: DIP0623

Alternate gene names: 38233230

Gene position: 592117-591014 (Counterclockwise)

Preceding gene: 38233231

Following gene: 38233229

Centisome position: 23.79

GC content: 54.44

Gene sequence:

>1104_bases
ATGCTCACCACCACAGGGACGCTCACGCACCAAAAAATCGGAGACTTTTACACCGAAGCCGGAGCGACGCTTCACGACGT
AACCATCGCCTACCAAGCATGGGGCCACTACACCGGCACCAATCTCATCGTTCTCGAACATGCCCTGACCGGCGACTCTA
ACGCTATTTCATGGTGGGACGGACTGATTGGCCCTGGCAAAGCACTCGACACCAACCGCTACTGCATCCTATGCACCAAC
GTGCTCGGAGGATGCAAAGGATCCACCGGACCGAGCAGTCCACACCCAGACGGAAAACCATGGGGATCCAGATTTCCAGC
CCTTTCAATCCGTGACCTTGTCAATGCCGAAAAACAACTTTTCGACCACCTCGGCATCAATAAAATTCACGCAATCATCG
GCGGATCCATGGGAGGCGCACGCACCCTCGAATGGGCTGCACTCCACCCACACATGATGACGACTGGATTCGTCATAGCA
GTCTCAGCACGCGCAAGCGCTTGGCAAATCGGTATTCAAACTGCACAAATCAGCGCCATAGAACTCGACCCCCACTGGAA
CGGCGGCGATTACTACAGCGGTCACGCACCATGGGAAGGAATCGCCGCCGCTCGCCGGATCGCCCACCTCACCTATCGCG
GCGAACTAGAAATAGACGAACGATTCGGCACTTCCGCACAACACGGTGAAAACCCACTCGGCCCCTTCCGAGATCCACAT
CAACGTTTTGCGGTCACGAGCTACCTCCAACACCAAGGCATCAAACTCGCTCAACGATTCGATGCAGGTAGTTACGTCGT
GCTTACCGAAGCCCTCAATCGTCATGACATCGGACGCGGCCGAGGCGGACTCAACAAAGCCCTCAGCGCAATCACAGTCC
CCATCATGATTGCTGGCGTTGATACCGATATTCTCTACCCCTATCACCAGCAAGAACACCTATCACGAAATCTAGGCAAC
CTACTCGCTATGGCAAAAATCAGCTCACCAGTAGGCCACGACGCTTTCCTCACAGAATTCCGACAAATGGAGCGAATCCT
AAGACATTTCATGGAGCTTTCGGAAGGAATCGACGATTCCTTCCGAACCAAACTAGAGCGCTGA

Upstream 100 bases:

>100_bases
GCCACCCTCAAACGGCGGAATTTAGCCAACAACAATAGACTAGACAGAGCTGTCCATGTAGCATGAACTCGATTATCAAC
TGCCACGAGAGGTCGGGGTC

Downstream 100 bases:

>100_bases
GTCGATCACAGATCTAAATAAACTGCAACCACCACGATCGGGTCTGTGGATAACGTATGCAGCCAACTCGTAAATCTTGG
AAAAATATGACAGTTGGAAG

Product: homoserine O-acetyltransferase

Products: NA

Alternate protein names: Homoserine O-trans-acetylase; HTA; Homoserine transacetylase

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MLTTTGTLTHQKIGDFYTEAGATLHDVTIAYQAWGHYTGTNLIVLEHALTGDSNAISWWDGLIGPGKALDTNRYCILCTN
VLGGCKGSTGPSSPHPDGKPWGSRFPALSIRDLVNAEKQLFDHLGINKIHAIIGGSMGGARTLEWAALHPHMMTTGFVIA
VSARASAWQIGIQTAQISAIELDPHWNGGDYYSGHAPWEGIAAARRIAHLTYRGELEIDERFGTSAQHGENPLGPFRDPH
QRFAVTSYLQHQGIKLAQRFDAGSYVVLTEALNRHDIGRGRGGLNKALSAITVPIMIAGVDTDILYPYHQQEHLSRNLGN
LLAMAKISSPVGHDAFLTEFRQMERILRHFMELSEGIDDSFRTKLER

Sequences:

>Translated_367_residues
MLTTTGTLTHQKIGDFYTEAGATLHDVTIAYQAWGHYTGTNLIVLEHALTGDSNAISWWDGLIGPGKALDTNRYCILCTN
VLGGCKGSTGPSSPHPDGKPWGSRFPALSIRDLVNAEKQLFDHLGINKIHAIIGGSMGGARTLEWAALHPHMMTTGFVIA
VSARASAWQIGIQTAQISAIELDPHWNGGDYYSGHAPWEGIAAARRIAHLTYRGELEIDERFGTSAQHGENPLGPFRDPH
QRFAVTSYLQHQGIKLAQRFDAGSYVVLTEALNRHDIGRGRGGLNKALSAITVPIMIAGVDTDILYPYHQQEHLSRNLGN
LLAMAKISSPVGHDAFLTEFRQMERILRHFMELSEGIDDSFRTKLER
>Mature_367_residues
MLTTTGTLTHQKIGDFYTEAGATLHDVTIAYQAWGHYTGTNLIVLEHALTGDSNAISWWDGLIGPGKALDTNRYCILCTN
VLGGCKGSTGPSSPHPDGKPWGSRFPALSIRDLVNAEKQLFDHLGINKIHAIIGGSMGGARTLEWAALHPHMMTTGFVIA
VSARASAWQIGIQTAQISAIELDPHWNGGDYYSGHAPWEGIAAARRIAHLTYRGELEIDERFGTSAQHGENPLGPFRDPH
QRFAVTSYLQHQGIKLAQRFDAGSYVVLTEALNRHDIGRGRGGLNKALSAITVPIMIAGVDTDILYPYHQQEHLSRNLGN
LLAMAKISSPVGHDAFLTEFRQMERILRHFMELSEGIDDSFRTKLER

Specific function: Unknown

COG id: COG2021

COG function: function code E; Homoserine acetyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. HTA family

Homologues:

Organism=Saccharomyces cerevisiae, GI6324052, Length=216, Percent_Identity=37.037037037037, Blast_Score=146, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): METX_CORDI (Q6NIZ3)

Other databases:

- EMBL:   BX248355
- RefSeq:   NP_938997.1
- ProteinModelPortal:   Q6NIZ3
- SMR:   Q6NIZ3
- GeneID:   2649047
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP0623
- NMPDR:   fig|257309.1.peg.588
- HOGENOM:   HBG692920
- OMA:   VSFTSDW
- PhylomeDB:   Q6NIZ3
- ProtClustDB:   PRK00175
- BioCyc:   CDIP257309:DIP0623-MONOMER
- BRENDA:   2.3.1.31
- GO:   GO:0005737
- HAMAP:   MF_00296
- InterPro:   IPR000073
- InterPro:   IPR008220
- PIRSF:   PIRSF000443
- TIGRFAMs:   TIGR01392

Pfam domain/function: PF00561 Abhydrolase_1

EC number: =2.3.1.31

Molecular weight: Translated: 40280; Mature: 40280

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: ACT_SITE 136-136 ACT_SITE 333-333

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTTTGTLTHQKIGDFYTEAGATLHDVTIAYQAWGHYTGTNLIVLEHALTGDSNAISWWD
CCCCCCCCHHHHHHHHHHHCCCEEEHEEEEEEECCCCCCCEEEEEEEEECCCCCCCHHHH
GLIGPGKALDTNRYCILCTNVLGGCKGSTGPSSPHPDGKPWGSRFPALSIRDLVNAEKQL
CCCCCCCCCCCCCEEEEEECHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
FDHLGINKIHAIIGGSMGGARTLEWAALHPHMMTTGFVIAVSARASAWQIGIQTAQISAI
HHHCCHHHHHHHHCCCCCCCCEEEEEECCCHHHHCCEEEEEECCCCEEEEEEEEEEEEEE
ELDPHWNGGDYYSGHAPWEGIAAARRIAHLTYRGELEIDERFGTSAQHGENPLGPFRDPH
EECCCCCCCCCCCCCCCHHHHHHHHHHHHEEECCCEEEHHHCCCCCCCCCCCCCCCCCHH
QRFAVTSYLQHQGIKLAQRFDAGSYVVLTEALNRHDIGRGRGGLNKALSAITVPIMIAGV
HHHHHHHHHHHCCCHHHHHCCCCCEEEEEEHHCCCCCCCCCCCHHHHHHHHEEEEEEEEC
DTDILYPYHQQEHLSRNLGNLLAMAKISSPVGHDAFLTEFRQMERILRHFMELSEGIDDS
CCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
FRTKLER
HHHHCCC
>Mature Secondary Structure
MLTTTGTLTHQKIGDFYTEAGATLHDVTIAYQAWGHYTGTNLIVLEHALTGDSNAISWWD
CCCCCCCCHHHHHHHHHHHCCCEEEHEEEEEEECCCCCCCEEEEEEEEECCCCCCCHHHH
GLIGPGKALDTNRYCILCTNVLGGCKGSTGPSSPHPDGKPWGSRFPALSIRDLVNAEKQL
CCCCCCCCCCCCCEEEEEECHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
FDHLGINKIHAIIGGSMGGARTLEWAALHPHMMTTGFVIAVSARASAWQIGIQTAQISAI
HHHCCHHHHHHHHCCCCCCCCEEEEEECCCHHHHCCEEEEEECCCCEEEEEEEEEEEEEE
ELDPHWNGGDYYSGHAPWEGIAAARRIAHLTYRGELEIDERFGTSAQHGENPLGPFRDPH
EECCCCCCCCCCCCCCCHHHHHHHHHHHHEEECCCEEEHHHCCCCCCCCCCCCCCCCCHH
QRFAVTSYLQHQGIKLAQRFDAGSYVVLTEALNRHDIGRGRGGLNKALSAITVPIMIAGV
HHHHHHHHHHHCCCHHHHHCCCCCEEEEEEHHCCCCCCCCCCCHHHHHHHHEEEEEEEEC
DTDILYPYHQQEHLSRNLGNLLAMAKISSPVGHDAFLTEFRQMERILRHFMELSEGIDDS
CCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
FRTKLER
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910