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The map label for this gene is guaB [H]

Identifier: 38233189

GI number: 38233189

Start: 547582

End: 549102

Strand: Direct

Name: guaB [H]

Synonym: DIP0580

Alternate gene names: 38233189

Gene position: 547582-549102 (Clockwise)

Preceding gene: 38233187

Following gene: 38233190

Centisome position: 22.0

GC content: 57.26

Gene sequence:

>1521_bases
ATGACGCAGCAGCGCGTTTCCACTGGTGGCGACGACCCCAATAAGGTAGCCCTCGTGGGATTGACTTTCGATGACGTACT
TCTACTTCCGGACGCTTCTGAGGTAATCCCAAGCGAGGTGTCCACCTCCACTCAGCTGACCCGAAATATCTCCTTGAACA
TCCCAGTTGTTTCCGCAGCTATGGACACCGTGACTGAATCTCGCATGGCCATCGCCATGGCGCGCGAAGGTGGCATGGGT
ATCTTGCACCGTAACCTCTCCATTGAGGAGCAGGCTGCTCACGTTGAGACGGTCAAGCGCTCTGAGTCTGGAATGGTCAC
TGACCCAGTAACCTGTAGCCCAGACATGAGCATCTCCGAAGTAGATGCGCTGTGCGCACGCTTTCGCATTTCTGGTATTC
CGGTTGTGGATTCTGAAGGAAAACTTCTCGGTATTTGTACCAACCGCGACATGCGCTTTGAGCAGAACTTCGACCGCAAG
GTTTCTGAAGTTATGACTCCTATGCCCTTGGTCGTCGCTGAGGAAGGCGTGACCAAGGAACAAGCACTCAGTCTTCTGAG
TACCAACAAGGTTGAGAAGCTGCCTATCGTCGATAAGCAAGGCAAACTCGTCGGTCTGATCACGGTGAAAGACTTCGTCA
AGACCGAGCAGTACCCGAACGCCTCCAAGGACGCTACTGGCCGCCTCTTGGTTGGCGCAGGCATTGGTGTCGGCGAAGAA
TCGTGGACTCGTGCCGGATCGCTTGTCGACGCCGGCGTGGACGTTCTCGTCGTCGATTCCGCGCACGCACATTCCAAGGG
CGTGCTGGACATGGTTTCGCGCGTCAAGCAAGAATGGGGCGATCGTGTCGACGTAATCGGTGGTAACCTCGCAACCCGTT
CCGCAGCCAAGGCCATGATCGAAGCCGGCGCTGACGCCATCAAGGTTGGCATTGGCCCAGGCTCCATCTGCACCACCCGC
GTCGTAGCAGGTGTTGGTGCACCACAGATCACCGCCATCATGGAGGCCTCCGTTCCCGCACACGCAGCAGGTGTACCGAT
CATCGCTGACGGTGGTATGCAGTTCTCCGGCGATATCGCCAAGGCCCTCGCCGCCGGTGCATCCACCGTCATGCTCGGCT
CCATGCTGGCTGGTACCGCAGAGGCCCCAGGCGACATCGTGGTTGTCGGTGGCAAGCAGTACAAGCGCTACCGTGGCATG
GGATCCATGGGTGCTATGCAAGGCCGCGGCCTATCTGGTGAGAAGCGTTCCTATTCCAAGGATCGCTACTTCCAAGCAGA
CGTAAGGAGCGAAGACAAGCTGGTTCCGGAAGGAATCGAAGGCCGCGTACCATTCCGTGGCTCCATCGACGCCATCACCC
ATCAACTCGTCGGCGGCCTGCGCGCTGCCATGGGATACACCGGTTCGGCTACGATTAATGACTTGTGGAACGCACGCTTC
GTTCAAATCACCTCTGCTGGTTTGAAGGAATCACATCCTCACCACATTCAGCAGACCGTCGAAGCACCTAACTACCACTA
A

Upstream 100 bases:

>100_bases
AACTTATTCTCCAATTATGCGTATAGGGGCTAATCTAGGAACATCGTGTACACGCGATAACCTAAGGCAGCCCAAAACGT
ATTTTCTCAGGAGTAAATGC

Downstream 100 bases:

>100_bases
ACCGGAAAAACTGAAAGGTCTTCTTTCATGCGTGATTACGTCGAAATTGGAATGGGTCGCGAGGCCCGCCGTACCTACCA
CCTCGACAGCGTTGCTATCG

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MTQQRVSTGGDDPNKVALVGLTFDDVLLLPDASEVIPSEVSTSTQLTRNISLNIPVVSAAMDTVTESRMAIAMAREGGMG
ILHRNLSIEEQAAHVETVKRSESGMVTDPVTCSPDMSISEVDALCARFRISGIPVVDSEGKLLGICTNRDMRFEQNFDRK
VSEVMTPMPLVVAEEGVTKEQALSLLSTNKVEKLPIVDKQGKLVGLITVKDFVKTEQYPNASKDATGRLLVGAGIGVGEE
SWTRAGSLVDAGVDVLVVDSAHAHSKGVLDMVSRVKQEWGDRVDVIGGNLATRSAAKAMIEAGADAIKVGIGPGSICTTR
VVAGVGAPQITAIMEASVPAHAAGVPIIADGGMQFSGDIAKALAAGASTVMLGSMLAGTAEAPGDIVVVGGKQYKRYRGM
GSMGAMQGRGLSGEKRSYSKDRYFQADVRSEDKLVPEGIEGRVPFRGSIDAITHQLVGGLRAAMGYTGSATINDLWNARF
VQITSAGLKESHPHHIQQTVEAPNYH

Sequences:

>Translated_506_residues
MTQQRVSTGGDDPNKVALVGLTFDDVLLLPDASEVIPSEVSTSTQLTRNISLNIPVVSAAMDTVTESRMAIAMAREGGMG
ILHRNLSIEEQAAHVETVKRSESGMVTDPVTCSPDMSISEVDALCARFRISGIPVVDSEGKLLGICTNRDMRFEQNFDRK
VSEVMTPMPLVVAEEGVTKEQALSLLSTNKVEKLPIVDKQGKLVGLITVKDFVKTEQYPNASKDATGRLLVGAGIGVGEE
SWTRAGSLVDAGVDVLVVDSAHAHSKGVLDMVSRVKQEWGDRVDVIGGNLATRSAAKAMIEAGADAIKVGIGPGSICTTR
VVAGVGAPQITAIMEASVPAHAAGVPIIADGGMQFSGDIAKALAAGASTVMLGSMLAGTAEAPGDIVVVGGKQYKRYRGM
GSMGAMQGRGLSGEKRSYSKDRYFQADVRSEDKLVPEGIEGRVPFRGSIDAITHQLVGGLRAAMGYTGSATINDLWNARF
VQITSAGLKESHPHHIQQTVEAPNYH
>Mature_505_residues
TQQRVSTGGDDPNKVALVGLTFDDVLLLPDASEVIPSEVSTSTQLTRNISLNIPVVSAAMDTVTESRMAIAMAREGGMGI
LHRNLSIEEQAAHVETVKRSESGMVTDPVTCSPDMSISEVDALCARFRISGIPVVDSEGKLLGICTNRDMRFEQNFDRKV
SEVMTPMPLVVAEEGVTKEQALSLLSTNKVEKLPIVDKQGKLVGLITVKDFVKTEQYPNASKDATGRLLVGAGIGVGEES
WTRAGSLVDAGVDVLVVDSAHAHSKGVLDMVSRVKQEWGDRVDVIGGNLATRSAAKAMIEAGADAIKVGIGPGSICTTRV
VAGVGAPQITAIMEASVPAHAAGVPIIADGGMQFSGDIAKALAAGASTVMLGSMLAGTAEAPGDIVVVGGKQYKRYRGMG
SMGAMQGRGLSGEKRSYSKDRYFQADVRSEDKLVPEGIEGRVPFRGSIDAITHQLVGGLRAAMGYTGSATINDLWNARFV
QITSAGLKESHPHHIQQTVEAPNYH

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=468, Percent_Identity=42.9487179487179, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI34328928, Length=468, Percent_Identity=42.9487179487179, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI34328930, Length=468, Percent_Identity=42.9487179487179, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI156616279, Length=468, Percent_Identity=42.9487179487179, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI66933016, Length=479, Percent_Identity=41.9624217118998, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI217035152, Length=463, Percent_Identity=42.7645788336933, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI217035148, Length=468, Percent_Identity=42.3076923076923, Blast_Score=329, Evalue=4e-90,
Organism=Homo sapiens, GI217035150, Length=469, Percent_Identity=40.9381663113006, Blast_Score=306, Evalue=4e-83,
Organism=Homo sapiens, GI50541954, Length=277, Percent_Identity=34.2960288808664, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI50541952, Length=277, Percent_Identity=34.2960288808664, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI50541948, Length=277, Percent_Identity=34.2960288808664, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI50541956, Length=277, Percent_Identity=34.2960288808664, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI156104880, Length=253, Percent_Identity=34.3873517786561, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1788855, Length=493, Percent_Identity=53.5496957403651, Blast_Score=465, Evalue=1e-132,
Organism=Escherichia coli, GI1786293, Length=256, Percent_Identity=33.984375, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=479, Percent_Identity=35.9081419624217, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI71994389, Length=432, Percent_Identity=37.5, Blast_Score=258, Evalue=7e-69,
Organism=Caenorhabditis elegans, GI17560440, Length=289, Percent_Identity=32.5259515570934, Blast_Score=153, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323585, Length=460, Percent_Identity=42.8260869565217, Blast_Score=339, Evalue=7e-94,
Organism=Saccharomyces cerevisiae, GI6323464, Length=454, Percent_Identity=43.6123348017621, Blast_Score=333, Evalue=3e-92,
Organism=Saccharomyces cerevisiae, GI6322012, Length=488, Percent_Identity=40.5737704918033, Blast_Score=332, Evalue=7e-92,
Organism=Saccharomyces cerevisiae, GI6319352, Length=339, Percent_Identity=40.117994100295, Blast_Score=247, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6319353, Length=103, Percent_Identity=47.5728155339806, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24641071, Length=486, Percent_Identity=40.7407407407407, Blast_Score=334, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24641073, Length=486, Percent_Identity=40.7407407407407, Blast_Score=334, Evalue=1e-91,
Organism=Drosophila melanogaster, GI28571163, Length=445, Percent_Identity=40.8988764044944, Blast_Score=301, Evalue=8e-82,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 53321; Mature: 53189

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQRVSTGGDDPNKVALVGLTFDDVLLLPDASEVIPSEVSTSTQLTRNISLNIPVVSAA
CCCCCCCCCCCCCCCEEEEEEECCCEEECCCCHHHCCCHHCCCHHEEEEEEECCCHHHHH
MDTVTESRMAIAMAREGGMGILHRNLSIEEQAAHVETVKRSESGMVTDPVTCSPDMSISE
HHHHHHHHHEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCHHH
VDALCARFRISGIPVVDSEGKLLGICTNRDMRFEQNFDRKVSEVMTPMPLVVAEEGVTKE
HHHHHHHHHCCCCEEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHH
QALSLLSTNKVEKLPIVDKQGKLVGLITVKDFVKTEQYPNASKDATGRLLVGAGIGVGEE
HHHHHHHCCCCCCCCCCCCCCCEEEEEEEHHHHHHCCCCCCCCCCCCEEEEECCCCCCCH
SWTRAGSLVDAGVDVLVVDSAHAHSKGVLDMVSRVKQEWGDRVDVIGGNLATRSAAKAMI
HHHHCCCHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHH
EAGADAIKVGIGPGSICTTRVVAGVGAPQITAIMEASVPAHAAGVPIIADGGMQFSGDIA
HCCCCEEEEECCCCCHHHHHHHHCCCCCCEEHEEECCCCCHHCCCCEEECCCCEECCHHH
KALAAGASTVMLGSMLAGTAEAPGDIVVVGGKQYKRYRGMGSMGAMQGRGLSGEKRSYSK
HHHHCCCHHHHHHHHHHCCCCCCCCEEEECCHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
DRYFQADVRSEDKLVPEGIEGRVPFRGSIDAITHQLVGGLRAAMGYTGSATINDLWNARF
CCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCEE
VQITSAGLKESHPHHIQQTVEAPNYH
EEEECCCCCCCCCHHHHHHHCCCCCC
>Mature Secondary Structure 
TQQRVSTGGDDPNKVALVGLTFDDVLLLPDASEVIPSEVSTSTQLTRNISLNIPVVSAA
CCCCCCCCCCCCCCEEEEEEECCCEEECCCCHHHCCCHHCCCHHEEEEEEECCCHHHHH
MDTVTESRMAIAMAREGGMGILHRNLSIEEQAAHVETVKRSESGMVTDPVTCSPDMSISE
HHHHHHHHHEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCHHH
VDALCARFRISGIPVVDSEGKLLGICTNRDMRFEQNFDRKVSEVMTPMPLVVAEEGVTKE
HHHHHHHHHCCCCEEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHH
QALSLLSTNKVEKLPIVDKQGKLVGLITVKDFVKTEQYPNASKDATGRLLVGAGIGVGEE
HHHHHHHCCCCCCCCCCCCCCCEEEEEEEHHHHHHCCCCCCCCCCCCEEEEECCCCCCCH
SWTRAGSLVDAGVDVLVVDSAHAHSKGVLDMVSRVKQEWGDRVDVIGGNLATRSAAKAMI
HHHHCCCHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHH
EAGADAIKVGIGPGSICTTRVVAGVGAPQITAIMEASVPAHAAGVPIIADGGMQFSGDIA
HCCCCEEEEECCCCCHHHHHHHHCCCCCCEEHEEECCCCCHHCCCCEEECCCCEECCHHH
KALAAGASTVMLGSMLAGTAEAPGDIVVVGGKQYKRYRGMGSMGAMQGRGLSGEKRSYSK
HHHHCCCHHHHHHHHHHCCCCCCCCEEEECCHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
DRYFQADVRSEDKLVPEGIEGRVPFRGSIDAITHQLVGGLRAAMGYTGSATINDLWNARF
CCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCEE
VQITSAGLKESHPHHIQQTVEAPNYH
EEEECCCCCCCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]