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The map label for this gene is gcp

Identifier: 38233183

GI number: 38233183

Start: 542182

End: 543234

Strand: Direct

Name: gcp

Synonym: DIP0574

Alternate gene names: 38233183

Gene position: 542182-543234 (Clockwise)

Preceding gene: 38233182

Following gene: 38233184

Centisome position: 21.79

GC content: 59.16

Gene sequence:

>1053_bases
ATGATTGTTCTTGGTATTGAGTCGTCGTGTGATGAGACGGGTGTGGGGATTATTGATTTGGCCGATGACGGCACGATGAC
GATTGTGGGGGATGCGGTGGCGTCGTCGATGGAGCAGCATGCGCGTTTTGGTGGTGTGGTTCCGGAGATTGCGTCGCGTG
CTCATTTGGAGTCGATGATTCCGGTGATGAAGGAGGCATTGGCGCAGGCGGGGGTGGAGCGTCCTGATGCGGTGGCTGCG
ACGGTGGGCCCTGGGTTGGCTGGTGCGTTGTTGGTGGGGGCGTCGGCTGCTAAGGCGTATGCGGCTGCGTGGGGTGTTCC
GTTTTATGGTGTGAATCATTTGGGTGGCCATGTGGCGGTGGCGAATTTGGAGGGGGAGGAGTTGCCGCATTCGATTGCGT
TGTTGGTGTCGGGTGGGCATACGCAGATTCTTGAGGTTCAGGCGGTGGGGAAGCCGATGCGGGAGTTGGGGTCGACGCTT
GACGACGCCGCCGGCGAGGCTTATGACAAGGTGGCACGGCTGCTTGGGTTGGGTTACCCAGGCGGGCCGGTTGTGGATAA
GCTTGCTGCTCGCGGTAATCGTAAGGCGATTCGTTTCCCGCGTGGCCTTTCGCGTGCCGACGATCTGCGTGGTGAGCACC
GCTATGATTTTTCGTTTTCGGGTGTGAAAACGTCGGTGGCTCGTTACGTGGAGTCTGCGGAGCGCGAGGGCCGTGTGATT
TCTGTGGAGGATGTGTGTGCGTCGTTCCAGGAGGCTGTGGTGGATGTGTTGACGTCGAAGGCCATCATGGCGTGTAAAGA
TACGGGTGCTTCGGTGCTGTTGCTTGGTGGCGGTGTGGCGGCGAATTCGCGATTGCGGGAGTTGGCGGCGGCGCGATGCC
AAAGTGCGAGCATCGAGTTGCGGGTGCCGAGCTTTAAGTTATGCACGGATAATGGCGTGATGATTGCTGCGGTGGCGTCT
CAGTTGATTCATGAGGGTGCGCAGCCTTCGGGCTTGTCGGTGGGAACGGATACTTCTTTGGAAGTGGAAATCCCGTTGGT
GCATTCGCTGTAG

Upstream 100 bases:

>100_bases
TGTGCGGAAGAATTATTATCAGCCGTCGGGTGCGGATGCTTTTGTGATGGTTCGTCCTGCTGGTTGTGGGGTTGAGTTGA
GTGAAGGTGAGGATGCGTAA

Downstream 100 bases:

>100_bases
GCGTACGGTGTTGAGAGCTGGCACTCTCAGGGGTAGAGTGCCAGTAGGTTGTAACTCACACAGTTGTTCACCCGCGACGA
CGGCTGTGCTGGATTTCCCA

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MIVLGIESSCDETGVGIIDLADDGTMTIVGDAVASSMEQHARFGGVVPEIASRAHLESMIPVMKEALAQAGVERPDAVAA
TVGPGLAGALLVGASAAKAYAAAWGVPFYGVNHLGGHVAVANLEGEELPHSIALLVSGGHTQILEVQAVGKPMRELGSTL
DDAAGEAYDKVARLLGLGYPGGPVVDKLAARGNRKAIRFPRGLSRADDLRGEHRYDFSFSGVKTSVARYVESAEREGRVI
SVEDVCASFQEAVVDVLTSKAIMACKDTGASVLLLGGGVAANSRLRELAAARCQSASIELRVPSFKLCTDNGVMIAAVAS
QLIHEGAQPSGLSVGTDTSLEVEIPLVHSL

Sequences:

>Translated_350_residues
MIVLGIESSCDETGVGIIDLADDGTMTIVGDAVASSMEQHARFGGVVPEIASRAHLESMIPVMKEALAQAGVERPDAVAA
TVGPGLAGALLVGASAAKAYAAAWGVPFYGVNHLGGHVAVANLEGEELPHSIALLVSGGHTQILEVQAVGKPMRELGSTL
DDAAGEAYDKVARLLGLGYPGGPVVDKLAARGNRKAIRFPRGLSRADDLRGEHRYDFSFSGVKTSVARYVESAEREGRVI
SVEDVCASFQEAVVDVLTSKAIMACKDTGASVLLLGGGVAANSRLRELAAARCQSASIELRVPSFKLCTDNGVMIAAVAS
QLIHEGAQPSGLSVGTDTSLEVEIPLVHSL
>Mature_350_residues
MIVLGIESSCDETGVGIIDLADDGTMTIVGDAVASSMEQHARFGGVVPEIASRAHLESMIPVMKEALAQAGVERPDAVAA
TVGPGLAGALLVGASAAKAYAAAWGVPFYGVNHLGGHVAVANLEGEELPHSIALLVSGGHTQILEVQAVGKPMRELGSTL
DDAAGEAYDKVARLLGLGYPGGPVVDKLAARGNRKAIRFPRGLSRADDLRGEHRYDFSFSGVKTSVARYVESAEREGRVI
SVEDVCASFQEAVVDVLTSKAIMACKDTGASVLLLGGGVAANSRLRELAAARCQSASIELRVPSFKLCTDNGVMIAAVAS
QLIHEGAQPSGLSVGTDTSLEVEIPLVHSL

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=339, Percent_Identity=34.2182890855457, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI8923380, Length=331, Percent_Identity=29.9093655589124, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1789445, Length=320, Percent_Identity=43.4375, Blast_Score=234, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI71995670, Length=340, Percent_Identity=31.7647058823529, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17557464, Length=335, Percent_Identity=31.6417910447761, Blast_Score=108, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6322891, Length=348, Percent_Identity=28.448275862069, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6320099, Length=346, Percent_Identity=28.9017341040462, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI20129063, Length=350, Percent_Identity=34.2857142857143, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI21357207, Length=343, Percent_Identity=29.1545189504373, Blast_Score=134, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_CORDI (Q6NJ39)

Other databases:

- EMBL:   BX248355
- RefSeq:   NP_938950.1
- ProteinModelPortal:   Q6NJ39
- SMR:   Q6NJ39
- MEROPS:   M22.001
- GeneID:   2648770
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP0574
- NMPDR:   fig|257309.1.peg.541
- HOGENOM:   HBG304663
- OMA:   PLYGVNH
- PhylomeDB:   Q6NJ39
- ProtClustDB:   PRK09604
- BioCyc:   CDIP257309:DIP0574-MONOMER
- BRENDA:   3.4.24.57
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 36147; Mature: 36147

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVLGIESSCDETGVGIIDLADDGTMTIVGDAVASSMEQHARFGGVVPEIASRAHLESMI
CEEEECCCCCCCCCCEEEEECCCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
PVMKEALAQAGVERPDAVAATVGPGLAGALLVGASAAKAYAAAWGVPFYGVNHLGGHVAV
HHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHCCHHHHHHHHHCCCCCCCHHHCCCEEEE
ANLEGEELPHSIALLVSGGHTQILEVQAVGKPMRELGSTLDDAAGEAYDKVARLLGLGYP
EECCCCCCCCEEEEEEECCCCEEEEEHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
GGPVVDKLAARGNRKAIRFPRGLSRADDLRGEHRYDFSFSGVKTSVARYVESAEREGRVI
CCHHHHHHHHCCCCCEEECCCCCCHHHHCCCCCCCCEEECHHHHHHHHHHHHHHHCCCEE
SVEDVCASFQEAVVDVLTSKAIMACKDTGASVLLLGGGVAANSRLRELAAARCQSASIEL
EHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEE
RVPSFKLCTDNGVMIAAVASQLIHEGAQPSGLSVGTDTSLEVEIPLVHSL
ECCCEEEECCCCEEHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECHHCCC
>Mature Secondary Structure
MIVLGIESSCDETGVGIIDLADDGTMTIVGDAVASSMEQHARFGGVVPEIASRAHLESMI
CEEEECCCCCCCCCCEEEEECCCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
PVMKEALAQAGVERPDAVAATVGPGLAGALLVGASAAKAYAAAWGVPFYGVNHLGGHVAV
HHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHCCHHHHHHHHHCCCCCCCHHHCCCEEEE
ANLEGEELPHSIALLVSGGHTQILEVQAVGKPMRELGSTLDDAAGEAYDKVARLLGLGYP
EECCCCCCCCEEEEEEECCCCEEEEEHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
GGPVVDKLAARGNRKAIRFPRGLSRADDLRGEHRYDFSFSGVKTSVARYVESAEREGRVI
CCHHHHHHHHCCCCCEEECCCCCCHHHHCCCCCCCCEEECHHHHHHHHHHHHHHHCCCEE
SVEDVCASFQEAVVDVLTSKAIMACKDTGASVLLLGGGVAANSRLRELAAARCQSASIEL
EHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEE
RVPSFKLCTDNGVMIAAVASQLIHEGAQPSGLSVGTDTSLEVEIPLVHSL
ECCCEEEECCCCEEHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910