| Definition | Corynebacterium diphtheriae NCTC 13129 chromosome, complete genome. |
|---|---|
| Accession | NC_002935 |
| Length | 2,488,635 |
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The map label for this gene is nedA [H]
Identifier: 38233152
GI number: 38233152
Start: 512872
End: 515037
Strand: Direct
Name: nedA [H]
Synonym: DIP0543
Alternate gene names: 38233152
Gene position: 512872-515037 (Clockwise)
Preceding gene: 38233151
Following gene: 38233153
Centisome position: 20.61
GC content: 47.09
Gene sequence:
>2166_bases GTGCATTCCTCAAACCGAACCTACAGCCGTGCAATTCTCGGCCTCAGTGCAGCATTAACACTTTCATTCACATCGCTTGT CGCGCCAGTGAATGCAGAAGAGCTCGAAACTGTTGTGCCTGCTATCGCAGAACAAGAAGGAGAAGCACCTGCGACATTGC CGAGCGCTGAAACTGGACTCTTCGATGCTGCGCCACCAAAGCCTGTTGCCCGCGGGGCGGCTGGAGATCTGCAATTGCCG GCGGTGAATGAAGAAGAAGTTTTTGAGGAGGGGCGAGTTATTCGTCCACCAGATGAGAATGGAAAACGGTGCTACCGAAT TCCTGCTCTTATTACAGCTAAAGACGGTAGCCTTCTTCTTGCATTTGACGATCGATATGGGCCGGATGAAAAAAGTAAAA CATGGTGCCGAGATGCGCCGTATGATCCTGGTAAGTCTTCAGCAACCATAAAGCAGACTGATATTGCGCTTTATCGATCA GTTAACGATGGTAAATCTTTTGAAAACTATGGTTTTATTGCTCAAGGAACTAAAGATAGCCGTGGTTTGTCATATACAGA TCCAGCATTGGTTGTTGATAGGTCCTCGGGAAAAATCTTCGCCTTTTTTGTACGCGGATATGATAAACGCGTAGCGCAAG CAGTGTCGGGATATCACAGCGGTAATGTTGAGGGGCCAATTACCAATCGAAATGTACAAGATACTATTGTTATTGAGTCG GAAGATAACGGCCGTACATGGAAGAATATGAAGCTAATCAGCAACTTAACGGACAAAGTTGTTGTTGGTGGTAAGACATA CACCGGTAGGGGACGATTTGTAACGTCAGGTTCTGGTGTGCAACTAAAATTTGGACTGCATGCTGGCCGGCTTATAGTGC CGATCGCTGTCGATATCGATCCAAGTGACTCGGCAAAATTTGTAAACCTAGCAATTTACTCTGATGACGGGGGCGATACG TGGGAAATCGGTGAAGGCGTTGCTGGTGTCGGATATGTTAGCGGTGATGAGAACAAAATCATCGAGCTTTCTGATGGTCG ATTGATGATGAATTCTAAAGAATTTAAAGGCGGAATGAGGTGGTCATCGTATTCCGAAGATCAAGGGAAAACATGGTCTG ATCCAGTCGATCACCTGATTGCACCGCCTGATCATCCTAATATGTACAACGCCGGAATTAACGTCGGTTTAATTAAGGCA TATCCCAATGCGGTTAAAGGGAGCGCAGCGTCGAAAGTATTGCTTTTCTCGGCGCCGATCAATCGACGTAACGGCAGTGA TTATGGTGTTGATGGTCGTGAAAACGGCTGGGTTATGGGTTCTTGCGATGACGGAAAGACGTGGTCCTTTGGGCGTCAAG TTGAAAAGAACCGTTTTCAGTATTCAAGCATGACGGTTATGTCGGACGGCAGCATCGGTATGGTCTACGAATCAGGTACC CGTGAAGAAGGAATGAACCTGAAATTTGCCAAGTTCAACATGGCATGGCTAGGCGCAGATTGTCTCAGCAATGAGGCATT GGGTTTGACAGGCGATATTGATAAGGAAATCGTCGCGGCGCAAGAAAAGGCTGCTGCTGCGACTAAAGAAGCTCAAGAAG CTGCGGAGAAGGTTGAAAAGTTAACTGAAGAGTTGGCTGCTGCTCGTAAAGAAAATGACGAGCTCAAGACTCAGGTAAAG GAATCTGAGGAAGCCGTTGGGGATCTAGCTGACAAGGTATTTAAGCTAGAGAACGCCGTCACGGAAGCAAAAAAGAAAGC TACTGTAGCTGAAAAGGCAGTATCCGACGCTCTCGCTAAACTGCAAGAAGCTGAGTCGATTGCGGAAGAGCAAAAGGCTA AAGCTGAATCTGCAGCCGCAGAAGCTCAGGCATTGCGTGAAAAGCTGGAGAAACTTGAAGGAAGCATTCTTACTGCAAAG GAGAATTCAGAAGCAGAAGAAAGCGCTGATCTATCAAGTACAGCGAGGGATGCTGCTGATACAGCTCGTCGCGCTGCTAC GGATGCAAACGGTGCACTTTCTGGTCAAAAGCAAAATGAAGAAAAGCCAGCTATGGGCTTGATGGGAATCTTGAAAGTGC TTGCGGGGATCATTCCACTGGTAGCGATCATTGCGACTATATTCCAAACATTCCGTTTGCCTTTTAACATTCCTGGAATG AGGTAG
Upstream 100 bases:
>100_bases CCGATCTCTCCTCAAATCCCTCATGAGCAAACTCTAACTATAGGACGTCAGACGTCTGATGTCAGATGGTGAACGTTGTT CCTCCCTGAAAGGTTGGCCT
Downstream 100 bases:
>100_bases GCAAATATTTATCAAGTGGGGTAGGCCGTTTGTTACTGGTTTACCCCACTTCATCTGCCGCAAGTGATATGCGACATGCC GACGGTGGTAAGTTTTCTCA
Product: putative sialidase
Products: NA
Alternate protein names: Neuraminidase [H]
Number of amino acids: Translated: 721; Mature: 721
Protein sequence:
>721_residues MHSSNRTYSRAILGLSAALTLSFTSLVAPVNAEELETVVPAIAEQEGEAPATLPSAETGLFDAAPPKPVARGAAGDLQLP AVNEEEVFEEGRVIRPPDENGKRCYRIPALITAKDGSLLLAFDDRYGPDEKSKTWCRDAPYDPGKSSATIKQTDIALYRS VNDGKSFENYGFIAQGTKDSRGLSYTDPALVVDRSSGKIFAFFVRGYDKRVAQAVSGYHSGNVEGPITNRNVQDTIVIES EDNGRTWKNMKLISNLTDKVVVGGKTYTGRGRFVTSGSGVQLKFGLHAGRLIVPIAVDIDPSDSAKFVNLAIYSDDGGDT WEIGEGVAGVGYVSGDENKIIELSDGRLMMNSKEFKGGMRWSSYSEDQGKTWSDPVDHLIAPPDHPNMYNAGINVGLIKA YPNAVKGSAASKVLLFSAPINRRNGSDYGVDGRENGWVMGSCDDGKTWSFGRQVEKNRFQYSSMTVMSDGSIGMVYESGT REEGMNLKFAKFNMAWLGADCLSNEALGLTGDIDKEIVAAQEKAAAATKEAQEAAEKVEKLTEELAAARKENDELKTQVK ESEEAVGDLADKVFKLENAVTEAKKKATVAEKAVSDALAKLQEAESIAEEQKAKAESAAAEAQALREKLEKLEGSILTAK ENSEAEESADLSSTARDAADTARRAATDANGALSGQKQNEEKPAMGLMGILKVLAGIIPLVAIIATIFQTFRLPFNIPGM R
Sequences:
>Translated_721_residues MHSSNRTYSRAILGLSAALTLSFTSLVAPVNAEELETVVPAIAEQEGEAPATLPSAETGLFDAAPPKPVARGAAGDLQLP AVNEEEVFEEGRVIRPPDENGKRCYRIPALITAKDGSLLLAFDDRYGPDEKSKTWCRDAPYDPGKSSATIKQTDIALYRS VNDGKSFENYGFIAQGTKDSRGLSYTDPALVVDRSSGKIFAFFVRGYDKRVAQAVSGYHSGNVEGPITNRNVQDTIVIES EDNGRTWKNMKLISNLTDKVVVGGKTYTGRGRFVTSGSGVQLKFGLHAGRLIVPIAVDIDPSDSAKFVNLAIYSDDGGDT WEIGEGVAGVGYVSGDENKIIELSDGRLMMNSKEFKGGMRWSSYSEDQGKTWSDPVDHLIAPPDHPNMYNAGINVGLIKA YPNAVKGSAASKVLLFSAPINRRNGSDYGVDGRENGWVMGSCDDGKTWSFGRQVEKNRFQYSSMTVMSDGSIGMVYESGT REEGMNLKFAKFNMAWLGADCLSNEALGLTGDIDKEIVAAQEKAAAATKEAQEAAEKVEKLTEELAAARKENDELKTQVK ESEEAVGDLADKVFKLENAVTEAKKKATVAEKAVSDALAKLQEAESIAEEQKAKAESAAAEAQALREKLEKLEGSILTAK ENSEAEESADLSSTARDAADTARRAATDANGALSGQKQNEEKPAMGLMGILKVLAGIIPLVAIIATIFQTFRLPFNIPGM R >Mature_721_residues MHSSNRTYSRAILGLSAALTLSFTSLVAPVNAEELETVVPAIAEQEGEAPATLPSAETGLFDAAPPKPVARGAAGDLQLP AVNEEEVFEEGRVIRPPDENGKRCYRIPALITAKDGSLLLAFDDRYGPDEKSKTWCRDAPYDPGKSSATIKQTDIALYRS VNDGKSFENYGFIAQGTKDSRGLSYTDPALVVDRSSGKIFAFFVRGYDKRVAQAVSGYHSGNVEGPITNRNVQDTIVIES EDNGRTWKNMKLISNLTDKVVVGGKTYTGRGRFVTSGSGVQLKFGLHAGRLIVPIAVDIDPSDSAKFVNLAIYSDDGGDT WEIGEGVAGVGYVSGDENKIIELSDGRLMMNSKEFKGGMRWSSYSEDQGKTWSDPVDHLIAPPDHPNMYNAGINVGLIKA YPNAVKGSAASKVLLFSAPINRRNGSDYGVDGRENGWVMGSCDDGKTWSFGRQVEKNRFQYSSMTVMSDGSIGMVYESGT REEGMNLKFAKFNMAWLGADCLSNEALGLTGDIDKEIVAAQEKAAAATKEAQEAAEKVEKLTEELAAARKENDELKTQVK ESEEAVGDLADKVFKLENAVTEAKKKATVAEKAVSDALAKLQEAESIAEEQKAKAESAAAEAQALREKLEKLEGSILTAK ENSEAEESADLSSTARDAADTARRAATDANGALSGQKQNEEKPAMGLMGILKVLAGIIPLVAIIATIFQTFRLPFNIPGM R
Specific function: To release sialic acids for use as carbon and energy sources for this non-pathogenic bacterium while in pathogenic microorganisms, sialidases have been suggested to be pathogenic factors [H]
COG id: COG4409
COG function: function code G; Neuraminidase (sialidase)
Gene ontology:
Cell location: Secreted [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Contains 1 F5/8 type C domain [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR018905 - InterPro: IPR002860 - InterPro: IPR000421 - InterPro: IPR008979 - InterPro: IPR013783 - InterPro: IPR014756 - InterPro: IPR011040 - InterPro: IPR006311 [H]
Pfam domain/function: PF02012 BNR; PF00754 F5_F8_type_C; PF10633 NPCBM_assoc [H]
EC number: =3.2.1.18 [H]
Molecular weight: Translated: 77525; Mature: 77525
Theoretical pI: Translated: 4.74; Mature: 4.74
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 2.6 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 2.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MHSSNRTYSRAILGLSAALTLSFTSLVAPVNAEELETVVPAIAEQEGEAPATLPSAETGL CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC FDAAPPKPVARGAAGDLQLPAVNEEEVFEEGRVIRPPDENGKRCYRIPALITAKDGSLLL CCCCCCCCHHCCCCCCCCCCCCCHHHHHHCCCEECCCCCCCCEEEEECEEEEECCCCEEE AFDDRYGPDEKSKTWCRDAPYDPGKSSATIKQTDIALYRSVNDGKSFENYGFIAQGTKDS EECCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHEEEEEECCCCCCCCCCCEEEECCCCC RGLSYTDPALVVDRSSGKIFAFFVRGYDKRVAQAVSGYHSGNVEGPITNRNVQDTIVIES CCCCCCCCEEEEECCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEE EDNGRTWKNMKLISNLTDKVVVGGKTYTGRGRFVTSGSGVQLKFGLHAGRLIVPIAVDID CCCCCCHHHHHHHHCCCCCEEECCEEECCCCEEEECCCCEEEEECCCCCCEEEEEEEECC PSDSAKFVNLAIYSDDGGDTWEIGEGVAGVGYVSGDENKIIELSDGRLMMNSKEFKGGMR CCCCCEEEEEEEEECCCCCEEECCCCCCEEEEEECCCCCEEEEECCEEEECCHHHCCCCC WSSYSEDQGKTWSDPVDHLIAPPDHPNMYNAGINVGLIKAYPNAVKGSAASKVLLFSAPI CCCCCCCCCCCCCCCHHHCCCCCCCCCCEECCCCEEEEECCCCCCCCCCCCEEEEEECCC NRRNGSDYGVDGRENGWVMGSCDDGKTWSFGRQVEKNRFQYSSMTVMSDGSIGMVYESGT CCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHEEEEEEEEEECCCEEEEECCCC REEGMNLKFAKFNMAWLGADCLSNEALGLTGDIDKEIVAAQEKAAAATKEAQEAAEKVEK CCCCCCEEEEEEEEEEECHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH LTEELAAARKENDELKTQVKESEEAVGDLADKVFKLENAVTEAKKKATVAEKAVSDALAK HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH LQEAESIAEEQKAKAESAAAEAQALREKLEKLEGSILTAKENSEAEESADLSSTARDAAD HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHH TARRAATDANGALSGQKQNEEKPAMGLMGILKVLAGIIPLVAIIATIFQTFRLPFNIPGM HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC R C >Mature Secondary Structure MHSSNRTYSRAILGLSAALTLSFTSLVAPVNAEELETVVPAIAEQEGEAPATLPSAETGL CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC FDAAPPKPVARGAAGDLQLPAVNEEEVFEEGRVIRPPDENGKRCYRIPALITAKDGSLLL CCCCCCCCHHCCCCCCCCCCCCCHHHHHHCCCEECCCCCCCCEEEEECEEEEECCCCEEE AFDDRYGPDEKSKTWCRDAPYDPGKSSATIKQTDIALYRSVNDGKSFENYGFIAQGTKDS EECCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHEEEEEECCCCCCCCCCCEEEECCCCC RGLSYTDPALVVDRSSGKIFAFFVRGYDKRVAQAVSGYHSGNVEGPITNRNVQDTIVIES CCCCCCCCEEEEECCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEE EDNGRTWKNMKLISNLTDKVVVGGKTYTGRGRFVTSGSGVQLKFGLHAGRLIVPIAVDID CCCCCCHHHHHHHHCCCCCEEECCEEECCCCEEEECCCCEEEEECCCCCCEEEEEEEECC PSDSAKFVNLAIYSDDGGDTWEIGEGVAGVGYVSGDENKIIELSDGRLMMNSKEFKGGMR CCCCCEEEEEEEEECCCCCEEECCCCCCEEEEEECCCCCEEEEECCEEEECCHHHCCCCC WSSYSEDQGKTWSDPVDHLIAPPDHPNMYNAGINVGLIKAYPNAVKGSAASKVLLFSAPI CCCCCCCCCCCCCCCHHHCCCCCCCCCCEECCCCEEEEECCCCCCCCCCCCEEEEEECCC NRRNGSDYGVDGRENGWVMGSCDDGKTWSFGRQVEKNRFQYSSMTVMSDGSIGMVYESGT CCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHEEEEEEEEEECCCEEEEECCCC REEGMNLKFAKFNMAWLGADCLSNEALGLTGDIDKEIVAAQEKAAAATKEAQEAAEKVEK CCCCCCEEEEEEEEEEECHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH LTEELAAARKENDELKTQVKESEEAVGDLADKVFKLENAVTEAKKKATVAEKAVSDALAK HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH LQEAESIAEEQKAKAESAAAEAQALREKLEKLEGSILTAKENSEAEESADLSSTARDAAD HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHH TARRAATDANGALSGQKQNEEKPAMGLMGILKVLAGIIPLVAIIATIFQTFRLPFNIPGM HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC R C
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 1400240; 8591030 [H]