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The map label for this gene is sdaA [H]

Identifier: 38233102

GI number: 38233102

Start: 455277

End: 456653

Strand: Direct

Name: sdaA [H]

Synonym: DIP0490

Alternate gene names: 38233102

Gene position: 455277-456653 (Clockwise)

Preceding gene: 38233101

Following gene: 38233103

Centisome position: 18.29

GC content: 55.7

Gene sequence:

>1377_bases
ATGTTCATCAGCTGCTTCGATATGTTCAAGATTGGTATCGGCCCATCGAGTTCTCACACGCTTGGCCCTATGAAGGCTGG
CAAGGCATTCGTCGATACGCTTGAAGAGCGTGACCTGCTTGATCGAGTCACCCGCGTGCGTGCCGACGTCTACGGCTCAC
TGTCGCTGACCGGCATCGGCCACGCGACCGACAAGGCCATCATCATGGGATTAGCAGGATTCGAGCCAGAAACCGTGGAC
ATCGACGCCATGCCAGGATTCCTCGAAATCGTCGCCTCCTTGCAACGCCTTGCACTAGCAGGCGGGAAGAAGACGGTGGA
CTTCAGCCGAACCGAAGGCATCGTCTTCCACAACACCTGCCTGCAACTGCACGAAAACGGCATGACCATCACCGCATTTG
AAGGCGACGAGGTCTTGTTGACCAAGGCATATTTCTCCATCGGCGGTGGATTTATCGTCGATAAAGAGCACTTTGGCCTA
CCTGTCGAAGACACCGCCGTAGTACCTTTCCCTTACAACACCGCCGAGGAAGTGCTCGCACACTGCGATCGCGAGGGGAT
GAGCATTCCAGAGTTCGCATGGCGCAATGAGGTTGCGGCAAACGGTGAAGAAGCCGTGCGCGAACACCTAGCTAAGGTAT
GGAAAGTCATGCAAAGCGGCATCGAGCGTGGTTCCTCAGCAGAAGGAATCCTGCCAGGTGACCTACGAGTACCACGCCGT
GCCAAGGCACTTCGTGAGCGCCTCGAAGCCACCAGCGAAAATGAACCACTACGCATGATGAGCTGGCTTAACATGTTCGC
CATGGCCGTCAACGAGGAAAATGCCTCCGGTGGCCGTGTAGTGACCTCGCCTACAAACGGTGCCTGCGGCGTTCTTCCTG
CTGTGTTGTCCTACTGGGATCGATTGGTCAAACCAGTTGGTGAGCAAGAAGTGATTGACTACCTGCTGACCTGCGGCGTG
GTGGGCGCTTTGTACAAGAAGAACGCCTCCATCTCGGGTGCTGAGGTCGGTTGCCAAGGTGAGGTCGGCGTGGCCTGCTC
AATGGCAGCGGCAGGTATTGCACAACTCATGGGAGCAACTCCTGCGCAGGCTTTCGCCGCAGCGGAGATCGCCATGGAAC
ATAATTTGGGTCTTACCTGTGATCCAGTGTGCGGCCAAGTCCAAGTTCCTTGCATCGAACGCAATGCAATTGCTGCTGTG
ACCTCGGTTAATGCGGCAAATATGTCGCTACAGCGTGGTTCTACCCCTACCGTCTCGCTGGATCAGGTTATCCAGACGAT
GTACCAAACCGGTAAGGATATGGACTCCAAATACCGTGAGACGTCCCTTGGTGGCCTCGCTAAAGTCTTAATGCCACGAC
TTATGCCGTGTAGCTGA

Upstream 100 bases:

>100_bases
TTCGAATTACTTGGTCTTCGGCATGGGCCTGTTGGCACTGTGCACCATCGTCTACAGCATCGTCCAGGCTTTCTAGAGTT
CGGGTTAAGGAGCATACATC

Downstream 100 bases:

>100_bases
TAAACCCCCTGCTGCCGATTGCCTCATCATGAGGTGGTCGGCAGTTTTCCCATATCCCACTTTCAAGGAGTATTCCTTAT
GATTTCACGCAGAAGTTTCC

Product: L-serine dehydratase 1

Products: NA

Alternate protein names: SDH 1; L-serine deaminase 1; L-SD1 [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MFISCFDMFKIGIGPSSSHTLGPMKAGKAFVDTLEERDLLDRVTRVRADVYGSLSLTGIGHATDKAIIMGLAGFEPETVD
IDAMPGFLEIVASLQRLALAGGKKTVDFSRTEGIVFHNTCLQLHENGMTITAFEGDEVLLTKAYFSIGGGFIVDKEHFGL
PVEDTAVVPFPYNTAEEVLAHCDREGMSIPEFAWRNEVAANGEEAVREHLAKVWKVMQSGIERGSSAEGILPGDLRVPRR
AKALRERLEATSENEPLRMMSWLNMFAMAVNEENASGGRVVTSPTNGACGVLPAVLSYWDRLVKPVGEQEVIDYLLTCGV
VGALYKKNASISGAEVGCQGEVGVACSMAAAGIAQLMGATPAQAFAAAEIAMEHNLGLTCDPVCGQVQVPCIERNAIAAV
TSVNAANMSLQRGSTPTVSLDQVIQTMYQTGKDMDSKYRETSLGGLAKVLMPRLMPCS

Sequences:

>Translated_458_residues
MFISCFDMFKIGIGPSSSHTLGPMKAGKAFVDTLEERDLLDRVTRVRADVYGSLSLTGIGHATDKAIIMGLAGFEPETVD
IDAMPGFLEIVASLQRLALAGGKKTVDFSRTEGIVFHNTCLQLHENGMTITAFEGDEVLLTKAYFSIGGGFIVDKEHFGL
PVEDTAVVPFPYNTAEEVLAHCDREGMSIPEFAWRNEVAANGEEAVREHLAKVWKVMQSGIERGSSAEGILPGDLRVPRR
AKALRERLEATSENEPLRMMSWLNMFAMAVNEENASGGRVVTSPTNGACGVLPAVLSYWDRLVKPVGEQEVIDYLLTCGV
VGALYKKNASISGAEVGCQGEVGVACSMAAAGIAQLMGATPAQAFAAAEIAMEHNLGLTCDPVCGQVQVPCIERNAIAAV
TSVNAANMSLQRGSTPTVSLDQVIQTMYQTGKDMDSKYRETSLGGLAKVLMPRLMPCS
>Mature_458_residues
MFISCFDMFKIGIGPSSSHTLGPMKAGKAFVDTLEERDLLDRVTRVRADVYGSLSLTGIGHATDKAIIMGLAGFEPETVD
IDAMPGFLEIVASLQRLALAGGKKTVDFSRTEGIVFHNTCLQLHENGMTITAFEGDEVLLTKAYFSIGGGFIVDKEHFGL
PVEDTAVVPFPYNTAEEVLAHCDREGMSIPEFAWRNEVAANGEEAVREHLAKVWKVMQSGIERGSSAEGILPGDLRVPRR
AKALRERLEATSENEPLRMMSWLNMFAMAVNEENASGGRVVTSPTNGACGVLPAVLSYWDRLVKPVGEQEVIDYLLTCGV
VGALYKKNASISGAEVGCQGEVGVACSMAAAGIAQLMGATPAQAFAAAEIAMEHNLGLTCDPVCGQVQVPCIERNAIAAV
TSVNAANMSLQRGSTPTVSLDQVIQTMYQTGKDMDSKYRETSLGGLAKVLMPRLMPCS

Specific function: Deaminates also threonine, particularly when it is present in high concentration [H]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1788116, Length=448, Percent_Identity=62.9464285714286, Blast_Score=591, Evalue=1e-170,
Organism=Escherichia coli, GI1789161, Length=448, Percent_Identity=62.2767857142857, Blast_Score=578, Evalue=1e-166,
Organism=Escherichia coli, GI48994925, Length=448, Percent_Identity=59.375, Blast_Score=559, Evalue=1e-160,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 49034; Mature: 49034

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFISCFDMFKIGIGPSSSHTLGPMKAGKAFVDTLEERDLLDRVTRVRADVYGSLSLTGIG
CEEEHEEHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
HATDKAIIMGLAGFEPETVDIDAMPGFLEIVASLQRLALAGGKKTVDFSRTEGIVFHNTC
CCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEHHH
LQLHENGMTITAFEGDEVLLTKAYFSIGGGFIVDKEHFGLPVEDTAVVPFPYNTAEEVLA
HHHHCCCCEEEEECCCCEEEEEHHHHCCCCEEEEHHHCCCCCCCCEEECCCCCCHHHHHH
HCDREGMSIPEFAWRNEVAANGEEAVREHLAKVWKVMQSGIERGSSAEGILPGDLRVPRR
HHCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
AKALRERLEATSENEPLRMMSWLNMFAMAVNEENASGGRVVTSPTNGACGVLPAVLSYWD
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHH
RLVKPVGEQEVIDYLLTCGVVGALYKKNASISGAEVGCQGEVGVACSMAAAGIAQLMGAT
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
PAQAFAAAEIAMEHNLGLTCDPVCGQVQVPCIERNAIAAVTSVNAANMSLQRGSTPTVSL
HHHHHHHHHHHHHCCCCCEECCCCCCEECCEECCCCEEEEEECCHHCCEECCCCCCCCCH
DQVIQTMYQTGKDMDSKYRETSLGGLAKVLMPRLMPCS
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFISCFDMFKIGIGPSSSHTLGPMKAGKAFVDTLEERDLLDRVTRVRADVYGSLSLTGIG
CEEEHEEHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
HATDKAIIMGLAGFEPETVDIDAMPGFLEIVASLQRLALAGGKKTVDFSRTEGIVFHNTC
CCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEHHH
LQLHENGMTITAFEGDEVLLTKAYFSIGGGFIVDKEHFGLPVEDTAVVPFPYNTAEEVLA
HHHHCCCCEEEEECCCCEEEEEHHHHCCCCEEEEHHHCCCCCCCCEEECCCCCCHHHHHH
HCDREGMSIPEFAWRNEVAANGEEAVREHLAKVWKVMQSGIERGSSAEGILPGDLRVPRR
HHCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
AKALRERLEATSENEPLRMMSWLNMFAMAVNEENASGGRVVTSPTNGACGVLPAVLSYWD
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHH
RLVKPVGEQEVIDYLLTCGVVGALYKKNASISGAEVGCQGEVGVACSMAAAGIAQLMGAT
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
PAQAFAAAEIAMEHNLGLTCDPVCGQVQVPCIERNAIAAVTSVNAANMSLQRGSTPTVSL
HHHHHHHHHHHHHCCCCCEECCCCCCEECCEECCCCEEEEEECCHHCCEECCCCCCCCCH
DQVIQTMYQTGKDMDSKYRETSLGGLAKVLMPRLMPCS
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2504697; 8436113; 9097040; 9278503 [H]