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The map label for this gene is sdaC [H]

Identifier: 38233101

GI number: 38233101

Start: 453909

End: 455252

Strand: Direct

Name: sdaC [H]

Synonym: DIP0489

Alternate gene names: 38233101

Gene position: 453909-455252 (Clockwise)

Preceding gene: 38233100

Following gene: 38233102

Centisome position: 18.24

GC content: 53.87

Gene sequence:

>1344_bases
GTGTCTCAGATTGTTTCCCACTCAGCATCTGCTGGGGTCCGCGATGGTGTAGCACCATCAGAATCACCTGCCTCATCTAG
CGCGCCTTCTTGGCGTAAAACCGACACCGTATGGAGCTTGAGCCTCTTCGGCACAGCAATCGGTGCGGGCGTATTGTTCC
TCCCCATCAACGCCGGTATCGGCGGAATCATCCCCATGCTCGTCATGGCCGTCGTTGCGTACCCGATGGCCCACTGGGCA
CACCGAGGTCTTACTCGTTTCATCCTTTCAGCATCCAAGGAAGACGCAGACCTAACGGACGTCGTCGATGAGCACTTCGG
CCACAAGGCCGGCGCATTTATCACCGTCTTGTACTTCTTGTCGGTCTACCCGATCTTGTTGGTCTACTCAGTTACTATCA
CCAACACCGTGAACTCCTTCTTGGAAAACCAGCTGGGAATCACCCCGCTGCCACGCTGGTTGATGTCGCTCATCTTGGTC
GGCGGACTTATCTTCGTAGTCAGCCTCGGTCGCACGGTGATCGTCAAGGCCATGTCGGTTTTGGTATTCCCCTTCATCGC
CATCTTGGTTGTGCTCTCTGTTTACTTGATCCCTAAGTGGAACACCGCACTATTCCAGACCTTCGACCTGCGCACTTCAG
CTGAGGCTTCCGGTCATAGCATCTGGGTTACCCTGCTGCTTCTCGTCCCAGTGATGGTTTTCTCCTTCAACCACTCGCCA
ATCATTTCCTCCTTCGCCCAGGAAAAGCGTGCTGAGTATGGTCAGTGGGCTGACTACAAGACCGGTCGCATTCTTAGCGC
CGCCCAGATCTTGATGGTCGTTGTGGTTATGTTCTTTGTGTTCTCTTGCGCATTGAGCTTGTCGCCAGCCGACCTCGCTG
CTGCTAAAGAACAAAACATCACCATCTTGTCCTACTTGGCTAATCACTTTGATAACCCTGTGATTCAGTGGGCTGCTCCC
ATTATTGCCATGATTGCTGTGGCAAAGTCCTTCCTTGGCCACTACCTCGGTGCTGCTGAAGGTTTCCAAGGCTTGATTGC
TTCGGGTGCTGCTTCTAAGGGCAAGACTGTTGATACTCAAAGCCGTGCGCTGGTGCTGGGCACTCTCGCCTTCATGCTGA
TCTCTTCGTGGCTGGTGGCATGGCTGAACCCATCCATCCTCGGAATGATCGAGACGATGTGTGGTCCTACGATCGCCATC
CTGCTCTTCCTGATGCCTATGTACGCCATCCATAAGGTTCCGGCATTGGCTAAGTACCGTGGTCGTATTTCGAATTACTT
GGTCTTCGGCATGGGCCTGTTGGCACTGTGCACCATCGTCTACAGCATCGTCCAGGCTTTCTAG

Upstream 100 bases:

>100_bases
TTGCTTACAATGTGGGTTTATGTTGGAAATGGTGGGGTGAACTGCCGTTTTCTAGTCAAGGTCGTTGGTTTGTGCTTCGA
GAGAGAACGGAAGAACTATC

Downstream 100 bases:

>100_bases
AGTTCGGGTTAAGGAGCATACATCATGTTCATCAGCTGCTTCGATATGTTCAAGATTGGTATCGGCCCATCGAGTTCTCA
CACGCTTGGCCCTATGAAGG

Product: serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSQIVSHSASAGVRDGVAPSESPASSSAPSWRKTDTVWSLSLFGTAIGAGVLFLPINAGIGGIIPMLVMAVVAYPMAHWA
HRGLTRFILSASKEDADLTDVVDEHFGHKAGAFITVLYFLSVYPILLVYSVTITNTVNSFLENQLGITPLPRWLMSLILV
GGLIFVVSLGRTVIVKAMSVLVFPFIAILVVLSVYLIPKWNTALFQTFDLRTSAEASGHSIWVTLLLLVPVMVFSFNHSP
IISSFAQEKRAEYGQWADYKTGRILSAAQILMVVVVMFFVFSCALSLSPADLAAAKEQNITILSYLANHFDNPVIQWAAP
IIAMIAVAKSFLGHYLGAAEGFQGLIASGAASKGKTVDTQSRALVLGTLAFMLISSWLVAWLNPSILGMIETMCGPTIAI
LLFLMPMYAIHKVPALAKYRGRISNYLVFGMGLLALCTIVYSIVQAF

Sequences:

>Translated_447_residues
MSQIVSHSASAGVRDGVAPSESPASSSAPSWRKTDTVWSLSLFGTAIGAGVLFLPINAGIGGIIPMLVMAVVAYPMAHWA
HRGLTRFILSASKEDADLTDVVDEHFGHKAGAFITVLYFLSVYPILLVYSVTITNTVNSFLENQLGITPLPRWLMSLILV
GGLIFVVSLGRTVIVKAMSVLVFPFIAILVVLSVYLIPKWNTALFQTFDLRTSAEASGHSIWVTLLLLVPVMVFSFNHSP
IISSFAQEKRAEYGQWADYKTGRILSAAQILMVVVVMFFVFSCALSLSPADLAAAKEQNITILSYLANHFDNPVIQWAAP
IIAMIAVAKSFLGHYLGAAEGFQGLIASGAASKGKTVDTQSRALVLGTLAFMLISSWLVAWLNPSILGMIETMCGPTIAI
LLFLMPMYAIHKVPALAKYRGRISNYLVFGMGLLALCTIVYSIVQAF
>Mature_446_residues
SQIVSHSASAGVRDGVAPSESPASSSAPSWRKTDTVWSLSLFGTAIGAGVLFLPINAGIGGIIPMLVMAVVAYPMAHWAH
RGLTRFILSASKEDADLTDVVDEHFGHKAGAFITVLYFLSVYPILLVYSVTITNTVNSFLENQLGITPLPRWLMSLILVG
GLIFVVSLGRTVIVKAMSVLVFPFIAILVVLSVYLIPKWNTALFQTFDLRTSAEASGHSIWVTLLLLVPVMVFSFNHSPI
ISSFAQEKRAEYGQWADYKTGRILSAAQILMVVVVMFFVFSCALSLSPADLAAAKEQNITILSYLANHFDNPVIQWAAPI
IAMIAVAKSFLGHYLGAAEGFQGLIASGAASKGKTVDTQSRALVLGTLAFMLISSWLVAWLNPSILGMIETMCGPTIAIL
LFLMPMYAIHKVPALAKYRGRISNYLVFGMGLLALCTIVYSIVQAF

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=420, Percent_Identity=61.6666666666667, Blast_Score=514, Evalue=1e-147,
Organism=Escherichia coli, GI1789504, Length=443, Percent_Identity=48.3069977426637, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1789211, Length=422, Percent_Identity=37.6777251184834, Blast_Score=272, Evalue=4e-74,
Organism=Escherichia coli, GI145693183, Length=440, Percent_Identity=28.1818181818182, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1789961, Length=395, Percent_Identity=28.1012658227848, Blast_Score=126, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 48272; Mature: 48140

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SQIVSHSASAGVRDGVAPSESPASSSAPSWRKTDTVWSLSLFGTAIGAGVLFLPINAGI
CCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCC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HHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]