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The map label for this gene is hepT [H]

Identifier: 38233043

GI number: 38233043

Start: 393735

End: 394727

Strand: Direct

Name: hepT [H]

Synonym: DIP0429

Alternate gene names: 38233043

Gene position: 393735-394727 (Clockwise)

Preceding gene: 161598678

Following gene: 38233044

Centisome position: 15.82

GC content: 57.8

Gene sequence:

>993_bases
ATGGGCAACGGTACGCGAGTTGATCTCGGCGAGCAAAACCTCAATGAGGAGATTGCGGCCGGAATGATCCGCGTCGAGGA
TCTCTTACGGGAAGAACTTTCCAAAGGAGAAGATTTTCTCGTAGAAAAGGTCATGCACCTAGCGGAGGCAGGCGGGAAAC
GATTCCGCCCGATGTTTGCGCTGCTGGCATCGCAGTATGGCTCGCAGCCAATGAGCGAGAACGTTATCAAAGCTGCGGTG
GTGGTGGAAATGACCCACCTCGCCACGTTGTATCACGACGACGTGATGGACGAGGCCGACAAACGCCGTGGCGTTGATAG
CGCCAACTTCAGGTGGAACAACTCTGTCGCTATCTTGGCTGGAGACATCCTCCTCGCGCACGTGGCTCGCCTCATGGCCG
ACCTTGGTGTAGAAACCGTGGCGCACTTCTCGGAGACGTTCGCAGAACTGGTCACCGGTCAGATGCGTGAAACCATCGGT
GCCCGCGATGGTGATCCCATCGAGCACTACCTCAACGTGATCAATGAAAAGACTGGCGTATTGATTGCTTCCGCTGGATT
CCTTGGCTCCATGCATGCGGGAGCCTCAGCCGAACATGTAGAGGCGTTGCGCGCCTACGGCCGAGCCATCGGCATGGTTT
TCCAGATCGTGGACGACATCATCGACATCTTCTCCGATACCACCGATTCTGGTAAGACCCCTGGCACCGATCTTCGTGAG
GGTGTGTTCACCCTCCCTGTGCTCTATGCGCTGAGCGAAGACACCGCCGTTGGAGAAGAACTACGCTCCATCCTCACCGG
CCCGCTTACCGACGACGCCACCGTCGCGCACGCCCTCGACCTCCTTGCCCGTTCCACAGGTCGCGAACGCGCGCTTGCCG
ACGTCCACCGCTATCTCGAAGAAGCCGAGCGTCAATTGGCTCTCTTGCCACAGAACTCAACCACGGATGCCCTTCGTAGT
CTCGCGCACTATACCGTGAAACGAGTCGGATAA

Upstream 100 bases:

>100_bases
AATTACTCACGTGCCCCATTGTGGCATGTATGTGTAGAAGTACGAGTATTTCGACTACGGTTAGGGGGTTAGCTGAACAC
GAGACAAAGGTAGTTGAGGA

Downstream 100 bases:

>100_bases
CCTGCTGATTTGCTGTTTGGCTAGGGTGCTGTGCTAAATTTTATCAAGCACGCCAGGTTGCCCGAGCGGCCAAAGGGAGC
GGACTGTAAATCCGTCGGCA

Product: putative polyprenyl diphosphate synthase component

Products: NA

Alternate protein names: HEPPP synthase subunit 2 [H]

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MGNGTRVDLGEQNLNEEIAAGMIRVEDLLREELSKGEDFLVEKVMHLAEAGGKRFRPMFALLASQYGSQPMSENVIKAAV
VVEMTHLATLYHDDVMDEADKRRGVDSANFRWNNSVAILAGDILLAHVARLMADLGVETVAHFSETFAELVTGQMRETIG
ARDGDPIEHYLNVINEKTGVLIASAGFLGSMHAGASAEHVEALRAYGRAIGMVFQIVDDIIDIFSDTTDSGKTPGTDLRE
GVFTLPVLYALSEDTAVGEELRSILTGPLTDDATVAHALDLLARSTGRERALADVHRYLEEAERQLALLPQNSTTDALRS
LAHYTVKRVG

Sequences:

>Translated_330_residues
MGNGTRVDLGEQNLNEEIAAGMIRVEDLLREELSKGEDFLVEKVMHLAEAGGKRFRPMFALLASQYGSQPMSENVIKAAV
VVEMTHLATLYHDDVMDEADKRRGVDSANFRWNNSVAILAGDILLAHVARLMADLGVETVAHFSETFAELVTGQMRETIG
ARDGDPIEHYLNVINEKTGVLIASAGFLGSMHAGASAEHVEALRAYGRAIGMVFQIVDDIIDIFSDTTDSGKTPGTDLRE
GVFTLPVLYALSEDTAVGEELRSILTGPLTDDATVAHALDLLARSTGRERALADVHRYLEEAERQLALLPQNSTTDALRS
LAHYTVKRVG
>Mature_329_residues
GNGTRVDLGEQNLNEEIAAGMIRVEDLLREELSKGEDFLVEKVMHLAEAGGKRFRPMFALLASQYGSQPMSENVIKAAVV
VEMTHLATLYHDDVMDEADKRRGVDSANFRWNNSVAILAGDILLAHVARLMADLGVETVAHFSETFAELVTGQMRETIGA
RDGDPIEHYLNVINEKTGVLIASAGFLGSMHAGASAEHVEALRAYGRAIGMVFQIVDDIIDIFSDTTDSGKTPGTDLREG
VFTLPVLYALSEDTAVGEELRSILTGPLTDDATVAHALDLLARSTGRERALADVHRYLEEAERQLALLPQNSTTDALRSL
AHYTVKRVG

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=309, Percent_Identity=28.8025889967638, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1789578, Length=323, Percent_Identity=32.1981424148607, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1786623, Length=230, Percent_Identity=30.4347826086957, Blast_Score=78, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17505681, Length=306, Percent_Identity=28.7581699346405, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319475, Length=228, Percent_Identity=31.5789473684211, Blast_Score=105, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6325188, Length=238, Percent_Identity=26.0504201680672, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24651612, Length=291, Percent_Identity=31.6151202749141, Blast_Score=122, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 35917; Mature: 35786

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNGTRVDLGEQNLNEEIAAGMIRVEDLLREELSKGEDFLVEKVMHLAEAGGKRFRPMFA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHH
LLASQYGSQPMSENVIKAAVVVEMTHLATLYHDDVMDEADKRRGVDSANFRWNNSVAILA
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCEEEHH
GDILLAHVARLMADLGVETVAHFSETFAELVTGQMRETIGARDGDPIEHYLNVINEKTGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCE
LIASAGFLGSMHAGASAEHVEALRAYGRAIGMVFQIVDDIIDIFSDTTDSGKTPGTDLRE
EEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
GVFTLPVLYALSEDTAVGEELRSILTGPLTDDATVAHALDLLARSTGRERALADVHRYLE
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
EAERQLALLPQNSTTDALRSLAHYTVKRVG
HHHHHHCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GNGTRVDLGEQNLNEEIAAGMIRVEDLLREELSKGEDFLVEKVMHLAEAGGKRFRPMFA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHH
LLASQYGSQPMSENVIKAAVVVEMTHLATLYHDDVMDEADKRRGVDSANFRWNNSVAILA
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCEEEHH
GDILLAHVARLMADLGVETVAHFSETFAELVTGQMRETIGARDGDPIEHYLNVINEKTGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCE
LIASAGFLGSMHAGASAEHVEALRAYGRAIGMVFQIVDDIIDIFSDTTDSGKTPGTDLRE
EEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
GVFTLPVLYALSEDTAVGEELRSILTGPLTDDATVAHALDLLARSTGRERALADVHRYLE
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
EAERQLALLPQNSTTDALRSLAHYTVKRVG
HHHHHHCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7629164 [H]