Click here to switch to the map view.

The map label for this gene is hemA

Identifier: 38233014

GI number: 38233014

Start: 364800

End: 366116

Strand: Direct

Name: hemA

Synonym: DIP0400

Alternate gene names: 38233014

Gene position: 364800-366116 (Clockwise)

Preceding gene: 38233013

Following gene: 38233015

Centisome position: 14.66

GC content: 57.56

Gene sequence:

>1317_bases
GTGAGTGTTCTAGTGGTGGGTATGTCGCATAGGTCGGCACCCGTTGCACTTCTAGAAAAGCTCAGCATGGACGATGGGGT
GCGGACAAACACCGTTTCCGACTTGGTGGCACGCCCATCGCTGGCCGAGGCGATGATCGTATCGACCTGTAACCGGCTTG
AAGTCTATGCCATGACGTCGAGTTTCCATACCGGCGTCAACGATGTGGTTGAGGTCCTCCACGACATGAGTGGTGTGGAC
ATGGAGGAGCTGCGCGGTTATCTCTATGTGCGCTATGCGGATGCGGCAGCCGAGCACATGATGGAAGTCACCTCTGGTTT
AGACTCCATGGTGGTTGGCGAGCAACAGATTATCGGCCAGGTGCGCACCGCCTACCACAGTGCGACTGAGGCTGGCACGG
TCGGCCCAGCGCTGCATGGTTTGGTGCAGGCGTCGTTGCATACGGGCAAGCGCGTGCACACGGAAACGGATATTGATGAC
GCCGGTGCTTCAATGGTGTCGTTTGCCTGCGATGAGGCGTTGGCTCAGATGTCTGCCACGAACTTTGCAGGCTGCCGTGC
GCTGGTGCTGGGCGCTGGTGCGATGGCGTCGTTGGCTGCTACGCATTTGGGTCGCCTTGGCATTGAGCACATCACGGTGG
CTAACCGCACGTTCGAGCGTGCCCAACGCCTTGCGGATCATGCCGTGGAGGCGGGGGTTGCAGCTTCTGCTATCGAGTTT
GAGCGTCGCATGGACGTGCTGTGCGACGTCGATGTGGTGGTGTCGGCTACGGGCGCGAACACCTTTACCATCGAGGCTGC
CAACATTCCTGCAGCTCATGGCGATTTAATGATGATTGATCTTTCTCTGCCGCGTGATATTAGTGATGATGTTGCCGAGG
TTCCTGGCGTGCACTTGGTCAATATTGAAAAACTTCGTGACGTGGCTTCTTCTGGGGAAGCGAAGGACCATGCAGCGCAG
CGCATTGTGGCCGAGGAGCTAGAGGCCTACACGTCTGCCCAGCGGATTCGGGATGTTGCGCCCGCGGTTGCGGCGTTGCG
ACGCCACGCTTCTAGTCTGATCGATTCAGAATTAGCGCGGTTGTCTACCCGAGTGCCAAGTATGGACGAAGACGACTTCT
CAGAGGTACAGCGCACTGTTCGCCGTGTGGTGGATAAGTTGCTGCATCAGCCGACGGTTCGAGTCAAAGAATTGGCGGCG
CAATCAGGCACGGTGTCCTACGACACGGCCATTCAAGAGCTTTTTGGGCTTGCGGTCGAGGCGACACCTGTTGCTGTGAA
TGTGGATGAACTGCCGGAAAGGATTAACAAGCGATGA

Upstream 100 bases:

>100_bases
CTTTGTTGTGCAATTGGTCACTATAGGCCAGAGTGTTTAATGATCAATCATTCTTATGGTTGATATTGTGGTGAGGGTAA
GCGAGCGGAAAGGTGAGCGC

Downstream 100 bases:

>100_bases
CGTTGAAGATCGGCACCCGTGGAAGCCTGTTAGCTACCACGCAGTCGGGCCATGTTCGCGATGACCTGCGCCCCTATGAG
GCAGAGCTGGTGATCGTGAC

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MSVLVVGMSHRSAPVALLEKLSMDDGVRTNTVSDLVARPSLAEAMIVSTCNRLEVYAMTSSFHTGVNDVVEVLHDMSGVD
MEELRGYLYVRYADAAAEHMMEVTSGLDSMVVGEQQIIGQVRTAYHSATEAGTVGPALHGLVQASLHTGKRVHTETDIDD
AGASMVSFACDEALAQMSATNFAGCRALVLGAGAMASLAATHLGRLGIEHITVANRTFERAQRLADHAVEAGVAASAIEF
ERRMDVLCDVDVVVSATGANTFTIEAANIPAAHGDLMMIDLSLPRDISDDVAEVPGVHLVNIEKLRDVASSGEAKDHAAQ
RIVAEELEAYTSAQRIRDVAPAVAALRRHASSLIDSELARLSTRVPSMDEDDFSEVQRTVRRVVDKLLHQPTVRVKELAA
QSGTVSYDTAIQELFGLAVEATPVAVNVDELPERINKR

Sequences:

>Translated_438_residues
MSVLVVGMSHRSAPVALLEKLSMDDGVRTNTVSDLVARPSLAEAMIVSTCNRLEVYAMTSSFHTGVNDVVEVLHDMSGVD
MEELRGYLYVRYADAAAEHMMEVTSGLDSMVVGEQQIIGQVRTAYHSATEAGTVGPALHGLVQASLHTGKRVHTETDIDD
AGASMVSFACDEALAQMSATNFAGCRALVLGAGAMASLAATHLGRLGIEHITVANRTFERAQRLADHAVEAGVAASAIEF
ERRMDVLCDVDVVVSATGANTFTIEAANIPAAHGDLMMIDLSLPRDISDDVAEVPGVHLVNIEKLRDVASSGEAKDHAAQ
RIVAEELEAYTSAQRIRDVAPAVAALRRHASSLIDSELARLSTRVPSMDEDDFSEVQRTVRRVVDKLLHQPTVRVKELAA
QSGTVSYDTAIQELFGLAVEATPVAVNVDELPERINKR
>Mature_437_residues
SVLVVGMSHRSAPVALLEKLSMDDGVRTNTVSDLVARPSLAEAMIVSTCNRLEVYAMTSSFHTGVNDVVEVLHDMSGVDM
EELRGYLYVRYADAAAEHMMEVTSGLDSMVVGEQQIIGQVRTAYHSATEAGTVGPALHGLVQASLHTGKRVHTETDIDDA
GASMVSFACDEALAQMSATNFAGCRALVLGAGAMASLAATHLGRLGIEHITVANRTFERAQRLADHAVEAGVAASAIEFE
RRMDVLCDVDVVVSATGANTFTIEAANIPAAHGDLMMIDLSLPRDISDDVAEVPGVHLVNIEKLRDVASSGEAKDHAAQR
IVAEELEAYTSAQRIRDVAPAVAALRRHASSLIDSELARLSTRVPSMDEDDFSEVQRTVRRVVDKLLHQPTVRVKELAAQ
SGTVSYDTAIQELFGLAVEATPVAVNVDELPERINKR

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=426, Percent_Identity=28.8732394366197, Blast_Score=169, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_CORDI (Q6NJK1)

Other databases:

- EMBL:   BX248355
- RefSeq:   NP_938781.1
- ProteinModelPortal:   Q6NJK1
- SMR:   Q6NJK1
- GeneID:   2650204
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP0400
- NMPDR:   fig|257309.1.peg.372
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- PhylomeDB:   Q6NJK1
- ProtClustDB:   PRK00045
- BioCyc:   CDIP257309:DIP0400-MONOMER
- BRENDA:   1.2.1.70
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 46919; Mature: 46787

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLVVGMSHRSAPVALLEKLSMDDGVRTNTVSDLVARPSLAEAMIVSTCNRLEVYAMTS
CCEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECC
SFHTGVNDVVEVLHDMSGVDMEELRGYLYVRYADAAAEHMMEVTSGLDSMVVGEQQIIGQ
HHCCCHHHHHHHHHHCCCCCHHHCCCEEEEEEHHHHHHHHHHHHHCCHHHHCCHHHHHHH
VRTAYHSATEAGTVGPALHGLVQASLHTGKRVHTETDIDDAGASMVSFACDEALAQMSAT
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
NFAGCRALVLGAGAMASLAATHLGRLGIEHITVANRTFERAQRLADHAVEAGVAASAIEF
CHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERRMDVLCDVDVVVSATGANTFTIEAANIPAAHGDLMMIDLSLPRDISDDVAEVPGVHLV
HHHHHHHCCCCCEEEECCCCEEEEEECCCCCCCCCEEEEEECCCCCCCHHHHHCCCCEEE
NIEKLRDVASSGEAKDHAAQRIVAEELEAYTSAQRIRDVAPAVAALRRHASSLIDSELAR
EHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSTRVPSMDEDDFSEVQRTVRRVVDKLLHQPTVRVKELAAQSGTVSYDTAIQELFGLAVE
HHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHEE
ATPVAVNVDELPERINKR
CCCEEEEHHHHHHHHCCC
>Mature Secondary Structure 
SVLVVGMSHRSAPVALLEKLSMDDGVRTNTVSDLVARPSLAEAMIVSTCNRLEVYAMTS
CEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECC
SFHTGVNDVVEVLHDMSGVDMEELRGYLYVRYADAAAEHMMEVTSGLDSMVVGEQQIIGQ
HHCCCHHHHHHHHHHCCCCCHHHCCCEEEEEEHHHHHHHHHHHHHCCHHHHCCHHHHHHH
VRTAYHSATEAGTVGPALHGLVQASLHTGKRVHTETDIDDAGASMVSFACDEALAQMSAT
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
NFAGCRALVLGAGAMASLAATHLGRLGIEHITVANRTFERAQRLADHAVEAGVAASAIEF
CHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERRMDVLCDVDVVVSATGANTFTIEAANIPAAHGDLMMIDLSLPRDISDDVAEVPGVHLV
HHHHHHHCCCCCEEEECCCCEEEEEECCCCCCCCCEEEEEECCCCCCCHHHHHCCCCEEE
NIEKLRDVASSGEAKDHAAQRIVAEELEAYTSAQRIRDVAPAVAALRRHASSLIDSELAR
EHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSTRVPSMDEDDFSEVQRTVRRVVDKLLHQPTVRVKELAAQSGTVSYDTAIQELFGLAVE
HHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHEE
ATPVAVNVDELPERINKR
CCCEEEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910