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The map label for this gene is rmlB [H]

Identifier: 38232978

GI number: 38232978

Start: 328678

End: 329685

Strand: Reverse

Name: rmlB [H]

Synonym: DIP0362

Alternate gene names: 38232978

Gene position: 329685-328678 (Counterclockwise)

Preceding gene: 38232979

Following gene: 38232977

Centisome position: 13.25

GC content: 53.37

Gene sequence:

>1008_bases
ATGGCTGTGAAACGTATGCTGGTCACCGGCGGCGCCGGTTTTATTGGTTCGAATTTTGTCAGGCGTGTTCTTGCTACCCG
TCCGGAGTATCGGGTCACGGTACTAGATAAGCTGACGTATGCCGGCAACGCCGCAAATTTGGATGGCTGTGATGCCACTT
TGGTTGTGGGCGATATTTGTGATGCACAGTTGGTGGATCGCTTGGTGGCTGATTCGGATGTGGTGGTGCATTTCGCTGCG
GAGTCGCATAACGATAATTCTTTGGTGGATCCGTCGCCGTTTGTTCAGACCAATGTGGTGGGTACGTTTACGTTGTTGGA
GGCTGCGCGTCGCCATGATGTGCGCTTCCATCATGTGTCTACGGATGAGGTTTTTGGTGACTTGGAGTTGGATGATCCGA
ATCGTTTTACCGAGCACACGCCGTATAATCCGTCGTCGCCGTATTCGGCAACGAAGGCCGGGTCGGATCATCTGGTACGC
GCGTGGGTTCGTTCATTTGGATTGCGTGCAACGATTTCTCATTGTTCCAATAATTATGGGCCGTACCAGCACATTGAGAA
GTTTATTCCACGCCAGATCACCAACATTTTAAGTGGGCTCACGCCTAAGTTGTACGGTACGGGCGAGCAGGTGCGCGACT
GGATCCATGTGGATGACCACAATGATGCCGTGATCCGGATTCTAGAAAGCGGTCGCATCGGCCAGACCTATATCATCGGT
GCAGACAATGATCATGTGAACAACAAAACCGTTATCACACTGATCTGTGAGCTCATGGGTGCGGACGGTTTTGAACACGT
TGCAGACCGCCCTGGCCACGATATGCGCTACGCCATGGATTCTTCCACCTTGCGTGCAGAGCTCGGCTGGCAGCCACGTT
TTACCGATACCGATACCGGCATGCGTGAGGGCTTACTGCAGACTATCGAGTGGTATCGCACGCACCGCGACTGGTGGGAG
CCCCAAAAGGCCGCGGTAGAGCAGCGTTATCTAGCCCAAGGGCATTAA

Upstream 100 bases:

>100_bases
GCGAGTTGCTCAAGGAAGTGGATTCTTCGGCGCAGCTGGATGCGTTGTGGCATGCGTGGTTGTATGAGACTGCGTTGCCG
GAGTGCCCACGGTAACATCG

Downstream 100 bases:

>100_bases
AGTTGTGCGCAGATAGCGTTTGATTGAAGGGATAGATTATGCAGGTTCGCCCCACTGCCATTGCCGGTGTTGTTATTGTC
GACCTCGATCTCCACGGCGA

Product: putative dTDP-(glucose or rhamnose)-4,6-dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MAVKRMLVTGGAGFIGSNFVRRVLATRPEYRVTVLDKLTYAGNAANLDGCDATLVVGDICDAQLVDRLVADSDVVVHFAA
ESHNDNSLVDPSPFVQTNVVGTFTLLEAARRHDVRFHHVSTDEVFGDLELDDPNRFTEHTPYNPSSPYSATKAGSDHLVR
AWVRSFGLRATISHCSNNYGPYQHIEKFIPRQITNILSGLTPKLYGTGEQVRDWIHVDDHNDAVIRILESGRIGQTYIIG
ADNDHVNNKTVITLICELMGADGFEHVADRPGHDMRYAMDSSTLRAELGWQPRFTDTDTGMREGLLQTIEWYRTHRDWWE
PQKAAVEQRYLAQGH

Sequences:

>Translated_335_residues
MAVKRMLVTGGAGFIGSNFVRRVLATRPEYRVTVLDKLTYAGNAANLDGCDATLVVGDICDAQLVDRLVADSDVVVHFAA
ESHNDNSLVDPSPFVQTNVVGTFTLLEAARRHDVRFHHVSTDEVFGDLELDDPNRFTEHTPYNPSSPYSATKAGSDHLVR
AWVRSFGLRATISHCSNNYGPYQHIEKFIPRQITNILSGLTPKLYGTGEQVRDWIHVDDHNDAVIRILESGRIGQTYIIG
ADNDHVNNKTVITLICELMGADGFEHVADRPGHDMRYAMDSSTLRAELGWQPRFTDTDTGMREGLLQTIEWYRTHRDWWE
PQKAAVEQRYLAQGH
>Mature_334_residues
AVKRMLVTGGAGFIGSNFVRRVLATRPEYRVTVLDKLTYAGNAANLDGCDATLVVGDICDAQLVDRLVADSDVVVHFAAE
SHNDNSLVDPSPFVQTNVVGTFTLLEAARRHDVRFHHVSTDEVFGDLELDDPNRFTEHTPYNPSSPYSATKAGSDHLVRA
WVRSFGLRATISHCSNNYGPYQHIEKFIPRQITNILSGLTPKLYGTGEQVRDWIHVDDHNDAVIRILESGRIGQTYIIGA
DNDHVNNKTVITLICELMGADGFEHVADRPGHDMRYAMDSSTLRAELGWQPRFTDTDTGMREGLLQTIEWYRTHRDWWEP
QKAAVEQRYLAQGH

Specific function: Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: COG1088

COG function: function code M; dTDP-D-glucose 4,6-dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=338, Percent_Identity=35.7988165680473, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI42516563, Length=327, Percent_Identity=24.1590214067278, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI48994969, Length=347, Percent_Identity=46.1095100864553, Blast_Score=298, Evalue=4e-82,
Organism=Escherichia coli, GI1788353, Length=363, Percent_Identity=44.3526170798898, Blast_Score=290, Evalue=9e-80,
Organism=Escherichia coli, GI1788366, Length=237, Percent_Identity=29.1139240506329, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17568069, Length=326, Percent_Identity=32.2085889570552, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI115532424, Length=329, Percent_Identity=29.1793313069909, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17539532, Length=324, Percent_Identity=25.6172839506173, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17507723, Length=248, Percent_Identity=25.8064516129032, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI133901788, Length=250, Percent_Identity=26.4, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17539422, Length=250, Percent_Identity=26.4, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI133901786, Length=250, Percent_Identity=26.4, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17539424, Length=250, Percent_Identity=26.4, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI133901790, Length=250, Percent_Identity=26.4, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71982035, Length=347, Percent_Identity=25.6484149855908, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356223, Length=322, Percent_Identity=26.3975155279503, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19923002, Length=329, Percent_Identity=26.4437689969605, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 37589; Mature: 37458

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVKRMLVTGGAGFIGSNFVRRVLATRPEYRVTVLDKLTYAGNAANLDGCDATLVVGDIC
CCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCCCCCCCEEEEEECCC
DAQLVDRLVADSDVVVHFAAESHNDNSLVDPSPFVQTNVVGTFTLLEAARRHDVRFHHVS
CHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEECCHHHHHHHHHHHHHCCCEEEEEC
TDEVFGDLELDDPNRFTEHTPYNPSSPYSATKAGSDHLVRAWVRSFGLRATISHCSNNYG
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCC
PYQHIEKFIPRQITNILSGLTPKLYGTGEQVRDWIHVDDHNDAVIRILESGRIGQTYIIG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHEEEECCCCCEEEEEECCCCCCCEEEEE
ADNDHVNNKTVITLICELMGADGFEHVADRPGHDMRYAMDSSTLRAELGWQPRFTDTDTG
CCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCCEEECCCCHHHHHCCCCCCCCCCCCH
MREGLLQTIEWYRTHRDWWEPQKAAVEQRYLAQGH
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVKRMLVTGGAGFIGSNFVRRVLATRPEYRVTVLDKLTYAGNAANLDGCDATLVVGDIC
CCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCCCCCCCEEEEEECCC
DAQLVDRLVADSDVVVHFAAESHNDNSLVDPSPFVQTNVVGTFTLLEAARRHDVRFHHVS
CHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEECCHHHHHHHHHHHHHCCCEEEEEC
TDEVFGDLELDDPNRFTEHTPYNPSSPYSATKAGSDHLVRAWVRSFGLRATISHCSNNYG
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCC
PYQHIEKFIPRQITNILSGLTPKLYGTGEQVRDWIHVDDHNDAVIRILESGRIGQTYIIG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHEEEECCCCCEEEEEECCCCCCCEEEEE
ADNDHVNNKTVITLICELMGADGFEHVADRPGHDMRYAMDSSTLRAELGWQPRFTDTDTG
CCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCCEEECCCCHHHHHCCCCCCCCCCCCH
MREGLLQTIEWYRTHRDWWEPQKAAVEQRYLAQGH
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186; 11796113 [H]