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The map label for this gene is rfbC [H]

Identifier: 38232977

GI number: 38232977

Start: 327293

End: 328639

Strand: Reverse

Name: rfbC [H]

Synonym: DIP0361

Alternate gene names: 38232977

Gene position: 328639-327293 (Counterclockwise)

Preceding gene: 38232978

Following gene: 38232976

Centisome position: 13.21

GC content: 57.16

Gene sequence:

>1347_bases
ATGCAGGTTCGCCCCACTGCCATTGCCGGTGTTGTTATTGTCGACCTCGATCTCCACGGCGATAATCGTGGATGGTTTAA
GGAGAACTGGCAGCGGGAGAAAATGGTGGCGGCGGGCTTGCCGGATTTCCAACCAGTACAAAACAACATTTCTTTCAATG
CTGAACGTGGCGTAACGCGTGGTTTACATGCTGAGCCGTGGGACAAGTTTGTTTCGGTGGCTCATGGTGAGGTGTTTGGT
GCGTGGTGTGACCTGCGCGAGGGTTCTGACACCTTCGGCGAGGTAGTTACCTGCACCATTACCCCTCATACTGCGGTGTT
TGTGCCGCGTGGGGTGGCCAATGGTTTTCAGGCACTGGTAGACAACACAAGTTACACCTACTTGGTCAACGACCATTGGT
CGCCGGACGCTACTTATACTGCGGTGAATCTGGACATGATTGATTGGCCGCTTCCTCCCACGGAGATTTCGGAAAAGGAT
CGTTGCCACCCCCAGCTTGCCGAGGCCACCCCGATGCCACCACGTCGCATTCTCATCACCGGCGCCCATGGCCAGTTGGG
GCGTGCGCTAGCCGAGTTGTTGCCGGATGCCGAGTTGTGTTCGCATGTGGATTTCGATGTGGTTCATCCCCCGCAGCGCT
CGTGGCGCCAGTATGAGGCGATTATTAACTGCGCGGCCTATAACAATGTGGATGCGGCAGAAGATGATCGTGCTCGCGCA
TGGGAGGTCAATGCTGTTGCCCCAGCAAGGCTGGCCCAGATTGCTACGGAGAATAATCTGACGTTGGTGCATGTGTCGAC
GGATTTCATTTTCGACGGCACCACGTCCGTGCATGAGGAGACGGAAGCGCCGTCGCCGTTGTCGGTGTATGGGGCGTCGA
AGGCGGCGGGTGATATTGCGGCTGCTGTGACACCGAAACACTATGTGGTGCGTACGTCGTGGGTCTTTGGCCAAGGTGGC
AACTTTGTGGAAACCATGCGTTCGTTGGCGCAGCGCGGGATTCGCCCCAATGTGATTAGCGACCAGCGTGGTCGTCCAAC
CCATGCAGCGGATTTGGCGGCCGGTATTGTGCATTTGCTGCGCAGCAGCGCAGATTATGGTGTGTACAACCTTTCTAATT
CTGGCGATGTGGTCGGCCGCGATGATCTTGCCCGCGCAGTATTTGAACACTGTGGGGTATCCGGTGAGGCGGTCACATCT
GTTACCACAGCCGAGTACGAGGTCCACAGAGGCCCGTTGGCCAAGCGCCCCGCGGAGTCGACGTTCAACTTGGACAAGAT
TGTGGCCACGGGTTTTCAACCGCGCCCATGGCGGGATGCTGTGCGGGATTACTTGGGCACCAAGTAG

Upstream 100 bases:

>100_bases
GCGACTGGTGGGAGCCCCAAAAGGCCGCGGTAGAGCAGCGTTATCTAGCCCAAGGGCATTAAAGTTGTGCGCAGATAGCG
TTTGATTGAAGGGATAGATT

Downstream 100 bases:

>100_bases
GCTTAGGATCCATGAAGGGCATCATTCTCGCCGGCGGTTCTGGCACTCGTTTGCACCCCATTACGTTGGGGATTTCTAAG
CAGCTTATGCCGATCTACGA

Product: putative bifunctional protein

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MQVRPTAIAGVVIVDLDLHGDNRGWFKENWQREKMVAAGLPDFQPVQNNISFNAERGVTRGLHAEPWDKFVSVAHGEVFG
AWCDLREGSDTFGEVVTCTITPHTAVFVPRGVANGFQALVDNTSYTYLVNDHWSPDATYTAVNLDMIDWPLPPTEISEKD
RCHPQLAEATPMPPRRILITGAHGQLGRALAELLPDAELCSHVDFDVVHPPQRSWRQYEAIINCAAYNNVDAAEDDRARA
WEVNAVAPARLAQIATENNLTLVHVSTDFIFDGTTSVHEETEAPSPLSVYGASKAAGDIAAAVTPKHYVVRTSWVFGQGG
NFVETMRSLAQRGIRPNVISDQRGRPTHAADLAAGIVHLLRSSADYGVYNLSNSGDVVGRDDLARAVFEHCGVSGEAVTS
VTTAEYEVHRGPLAKRPAESTFNLDKIVATGFQPRPWRDAVRDYLGTK

Sequences:

>Translated_448_residues
MQVRPTAIAGVVIVDLDLHGDNRGWFKENWQREKMVAAGLPDFQPVQNNISFNAERGVTRGLHAEPWDKFVSVAHGEVFG
AWCDLREGSDTFGEVVTCTITPHTAVFVPRGVANGFQALVDNTSYTYLVNDHWSPDATYTAVNLDMIDWPLPPTEISEKD
RCHPQLAEATPMPPRRILITGAHGQLGRALAELLPDAELCSHVDFDVVHPPQRSWRQYEAIINCAAYNNVDAAEDDRARA
WEVNAVAPARLAQIATENNLTLVHVSTDFIFDGTTSVHEETEAPSPLSVYGASKAAGDIAAAVTPKHYVVRTSWVFGQGG
NFVETMRSLAQRGIRPNVISDQRGRPTHAADLAAGIVHLLRSSADYGVYNLSNSGDVVGRDDLARAVFEHCGVSGEAVTS
VTTAEYEVHRGPLAKRPAESTFNLDKIVATGFQPRPWRDAVRDYLGTK
>Mature_448_residues
MQVRPTAIAGVVIVDLDLHGDNRGWFKENWQREKMVAAGLPDFQPVQNNISFNAERGVTRGLHAEPWDKFVSVAHGEVFG
AWCDLREGSDTFGEVVTCTITPHTAVFVPRGVANGFQALVDNTSYTYLVNDHWSPDATYTAVNLDMIDWPLPPTEISEKD
RCHPQLAEATPMPPRRILITGAHGQLGRALAELLPDAELCSHVDFDVVHPPQRSWRQYEAIINCAAYNNVDAAEDDRARA
WEVNAVAPARLAQIATENNLTLVHVSTDFIFDGTTSVHEETEAPSPLSVYGASKAAGDIAAAVTPKHYVVRTSWVFGQGG
NFVETMRSLAQRGIRPNVISDQRGRPTHAADLAAGIVHLLRSSADYGVYNLSNSGDVVGRDDLARAVFEHCGVSGEAVTS
VTTAEYEVHRGPLAKRPAESTFNLDKIVATGFQPRPWRDAVRDYLGTK

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose [H]

COG id: COG1898

COG function: function code M; dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family [H]

Homologues:

Organism=Homo sapiens, GI11034825, Length=307, Percent_Identity=24.4299674267101, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI33519455, Length=305, Percent_Identity=24.5901639344262, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1788352, Length=274, Percent_Identity=34.6715328467153, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788350, Length=160, Percent_Identity=31.25, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- ProDom:   PD001462 [H]

Pfam domain/function: PF00908 dTDP_sugar_isom [H]

EC number: =5.1.3.13 [H]

Molecular weight: Translated: 49056; Mature: 49056

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVRPTAIAGVVIVDLDLHGDNRGWFKENWQREKMVAAGLPDFQPVQNNISFNAERGVTR
CCCCCCEEEEEEEEEEEEECCCCCCHHHCCHHHHHHHCCCCCCCHHHCCCCCCCCCCCCC
GLHAEPWDKFVSVAHGEVFGAWCDLREGSDTFGEVVTCTITPHTAVFVPRGVANGFQALV
CCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEEECCCEEEEECCCHHHHHHHHH
DNTSYTYLVNDHWSPDATYTAVNLDMIDWPLPPTEISEKDRCHPQLAEATPMPPRRILIT
CCCCEEEEECCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHCCCCCCCEEEEE
GAHGQLGRALAELLPDAELCSHVDFDVVHPPQRSWRQYEAIINCAAYNNVDAAEDDRARA
CCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
WEVNAVAPARLAQIATENNLTLVHVSTDFIFDGTTSVHEETEAPSPLSVYGASKAAGDIA
EEECCCCHHHHHHHHCCCCEEEEEEEECEEECCCCCHHHHCCCCCCEEEECCCCCCCCEE
AAVTPKHYVVRTSWVFGQGGNFVETMRSLAQRGIRPNVISDQRGRPTHAADLAAGIVHLL
EEECCCEEEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
RSSADYGVYNLSNSGDVVGRDDLARAVFEHCGVSGEAVTSVTTAEYEVHRGPLAKRPAES
HCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECEEEECCCCCCCCCCCC
TFNLDKIVATGFQPRPWRDAVRDYLGTK
CCCHHHHHHCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MQVRPTAIAGVVIVDLDLHGDNRGWFKENWQREKMVAAGLPDFQPVQNNISFNAERGVTR
CCCCCCEEEEEEEEEEEEECCCCCCHHHCCHHHHHHHCCCCCCCHHHCCCCCCCCCCCCC
GLHAEPWDKFVSVAHGEVFGAWCDLREGSDTFGEVVTCTITPHTAVFVPRGVANGFQALV
CCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEEECCCEEEEECCCHHHHHHHHH
DNTSYTYLVNDHWSPDATYTAVNLDMIDWPLPPTEISEKDRCHPQLAEATPMPPRRILIT
CCCCEEEEECCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHCCCCCCCEEEEE
GAHGQLGRALAELLPDAELCSHVDFDVVHPPQRSWRQYEAIINCAAYNNVDAAEDDRARA
CCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
WEVNAVAPARLAQIATENNLTLVHVSTDFIFDGTTSVHEETEAPSPLSVYGASKAAGDIA
EEECCCCHHHHHHHHCCCCEEEEEEEECEEECCCCCHHHHCCCCCCEEEECCCCCCCCEE
AAVTPKHYVVRTSWVFGQGGNFVETMRSLAQRGIRPNVISDQRGRPTHAADLAAGIVHLL
EEECCCEEEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
RSSADYGVYNLSNSGDVVGRDDLARAVFEHCGVSGEAVTSVTTAEYEVHRGPLAKRPAES
HCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECEEEECCCCCCCCCCCC
TFNLDKIVATGFQPRPWRDAVRDYLGTK
CCCHHHHHHCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA