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The map label for this gene is gntP [H]

Identifier: 38232876

GI number: 38232876

Start: 216891

End: 218279

Strand: Direct

Name: gntP [H]

Synonym: DIP0253

Alternate gene names: 38232876

Gene position: 216891-218279 (Clockwise)

Preceding gene: 38232875

Following gene: 38232879

Centisome position: 8.72

GC content: 63.28

Gene sequence:

>1389_bases
ATGGAAGATTGGGTTCCCACCCTTAGTGCTGGCCCCTTATTGGGGATCGCCGCCGCGGCGATTGCACTCATTTTGGTCCT
CGTCATTGTGTTCAAGCTCCACGCTTTCCTCACACTGATCATCGTTTCCGCAGCTACCGGACTCGCCGCCGGCATCCCAC
TGGAGGGCATCGTGCCCACCATGACCAAAGGCTTCGGAAGTACACTCGCCTCAGTTGCCCTCCTCGTCGGCCTCGGAGCA
ATGCTCGGCCGGCTTGTCGAAACCTCCGGCGGTGCAAAAAGCCTCGCCGAAACCCTCGTCGCCCGCTTCGGTGAACAACG
CGCCCCCTTCGCCCTCGGCGTAGCCTCCCTGCTGATGGGTTTCCCCATCTTCTTCGACGCCGGCCTGATCGTCATGCTGC
CCGTCATCTTCGCCGTGGCACGCCGACTCAACGGCCCCGTCCTGGCCTACGGCATCCCCGCCGCCGGCGCGTTCTCCGTC
ATGCACATCTACCTGCCACCGCACCCAGGGCCAATCTCAGCTGCAGAATTCTACAGCGCAGACATCGGCCTCGTCATGCT
CCTCGGCCTAATCATCGCGATCCCTACCTGGCTGATCTCCGGCCTCTGGCTCGGTAAAACCCTCGGCCGCCGCTACCCAC
TGCCAGTTCCTGACATCCTAGCCGGTGGCCCCCAAGCAACCGACGTGAAAAACCCCGCCACACCAGGGCTTATCGTCTCC
CTCTTGTTGCTTCCTATGCTGCTCATCTTCGGCAACACCAGCATGGGCCTTGCCACCTCCGCAGGCTGGGTAGACAAGAG
CTCGAGCCTCGTGCGCGCCCTACAATTCGTGGGCAGCACCCCCATTGCCTTGCTGATCTCAACCCTCGTGGCGCTGTACT
TCCTCGGCATTCGTCGCGGCCAGCCCAAAGCTGACCTAGAAAAGCTTCTCGACGGTGCCCTCGGACCCATCTGCTCCGTC
GTATTGATCACCGGTGCCGGTGGCATGTTCGGTGGCGTACTGCGCACCTCCGGCATCGGCGACGCCCTAGCCGACTCCAT
GTCCGACCTCGGTGTCCCCGTCGTCCTCGGCTGTTGGCTCGTCGCCGCCATCCTGCGCCTCGCCCAAGGCTCGGCCACCG
TGGCACTGACCACCGCCGCAGCACTGATGGCACCCGCCGTCGCCGCCGGCGGCTACAGCGAATTCCAAATCGCACTCATG
GTGCTGGCCTCCGCAGCCGGCTCCGTTTTCGCAGGCCACGTCAACGACTCTGGCTTCTGGCTCGTCGGCCGCCTCATGGG
TATGGACGTTGCCACGACCCTGCGCACCTGGACACTCAACCAAGCGCTCGTTGGAGCCGTGGGCTTTGTATTCGTCCTCG
TCTTCTACGGAGTCAGCTTTGCCTTCTAA

Upstream 100 bases:

>100_bases
GCAATCCATAAGGAGGTATAAGTCTCATATAAGTGTGGAGTATGCATGCATACACATACATTAGAGGGGTCTTTTATTTT
GTAACCAAGGAGAAAATCCG

Downstream 100 bases:

>100_bases
CTACGCTCGCTGAGCCACCTAGCTGCGGCATCAGCAATCTGAGCAGGGGAGTCGGTCACATCAAAAACGTGGCCGACTTC
GTCATTTTCCAAAGGCTGCA

Product: gluconate permease

Products: gluconate [Cytoplasm]; L-idonate [Cytoplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MEDWVPTLSAGPLLGIAAAAIALILVLVIVFKLHAFLTLIIVSAATGLAAGIPLEGIVPTMTKGFGSTLASVALLVGLGA
MLGRLVETSGGAKSLAETLVARFGEQRAPFALGVASLLMGFPIFFDAGLIVMLPVIFAVARRLNGPVLAYGIPAAGAFSV
MHIYLPPHPGPISAAEFYSADIGLVMLLGLIIAIPTWLISGLWLGKTLGRRYPLPVPDILAGGPQATDVKNPATPGLIVS
LLLLPMLLIFGNTSMGLATSAGWVDKSSSLVRALQFVGSTPIALLISTLVALYFLGIRRGQPKADLEKLLDGALGPICSV
VLITGAGGMFGGVLRTSGIGDALADSMSDLGVPVVLGCWLVAAILRLAQGSATVALTTAAALMAPAVAAGGYSEFQIALM
VLASAAGSVFAGHVNDSGFWLVGRLMGMDVATTLRTWTLNQALVGAVGFVFVLVFYGVSFAF

Sequences:

>Translated_462_residues
MEDWVPTLSAGPLLGIAAAAIALILVLVIVFKLHAFLTLIIVSAATGLAAGIPLEGIVPTMTKGFGSTLASVALLVGLGA
MLGRLVETSGGAKSLAETLVARFGEQRAPFALGVASLLMGFPIFFDAGLIVMLPVIFAVARRLNGPVLAYGIPAAGAFSV
MHIYLPPHPGPISAAEFYSADIGLVMLLGLIIAIPTWLISGLWLGKTLGRRYPLPVPDILAGGPQATDVKNPATPGLIVS
LLLLPMLLIFGNTSMGLATSAGWVDKSSSLVRALQFVGSTPIALLISTLVALYFLGIRRGQPKADLEKLLDGALGPICSV
VLITGAGGMFGGVLRTSGIGDALADSMSDLGVPVVLGCWLVAAILRLAQGSATVALTTAAALMAPAVAAGGYSEFQIALM
VLASAAGSVFAGHVNDSGFWLVGRLMGMDVATTLRTWTLNQALVGAVGFVFVLVFYGVSFAF
>Mature_462_residues
MEDWVPTLSAGPLLGIAAAAIALILVLVIVFKLHAFLTLIIVSAATGLAAGIPLEGIVPTMTKGFGSTLASVALLVGLGA
MLGRLVETSGGAKSLAETLVARFGEQRAPFALGVASLLMGFPIFFDAGLIVMLPVIFAVARRLNGPVLAYGIPAAGAFSV
MHIYLPPHPGPISAAEFYSADIGLVMLLGLIIAIPTWLISGLWLGKTLGRRYPLPVPDILAGGPQATDVKNPATPGLIVS
LLLLPMLLIFGNTSMGLATSAGWVDKSSSLVRALQFVGSTPIALLISTLVALYFLGIRRGQPKADLEKLLDGALGPICSV
VLITGAGGMFGGVLRTSGIGDALADSMSDLGVPVVLGCWLVAAILRLAQGSATVALTTAAALMAPAVAAGGYSEFQIALM
VLASAAGSVFAGHVNDSGFWLVGRLMGMDVATTLRTWTLNQALVGAVGFVFVLVFYGVSFAF

Specific function: Transport Of Gluconate And L-Idonate. [C]

COG id: COG2610

COG function: function code GE; H+/gluconate symporter and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gntP permease family [H]

Homologues:

Organism=Escherichia coli, GI1790716, Length=448, Percent_Identity=36.6071428571429, Blast_Score=268, Evalue=6e-73,
Organism=Escherichia coli, GI1789097, Length=456, Percent_Identity=37.280701754386, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI48994939, Length=432, Percent_Identity=36.5740740740741, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI48994935, Length=435, Percent_Identity=35.1724137931034, Blast_Score=255, Evalue=4e-69,
Organism=Escherichia coli, GI1790776, Length=437, Percent_Identity=32.7231121281465, Blast_Score=231, Evalue=9e-62,
Organism=Escherichia coli, GI2367370, Length=447, Percent_Identity=36.0178970917226, Blast_Score=224, Evalue=7e-60,
Organism=Escherichia coli, GI1788707, Length=421, Percent_Identity=32.541567695962, Blast_Score=194, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003474 [H]

Pfam domain/function: PF02447 GntP_permease [H]

EC number: NA

Molecular weight: Translated: 47304; Mature: 47304

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDWVPTLSAGPLLGIAAAAIALILVLVIVFKLHAFLTLIIVSAATGLAAGIPLEGIVPT
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
MTKGFGSTLASVALLVGLGAMLGRLVETSGGAKSLAETLVARFGEQRAPFALGVASLLMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
FPIFFDAGLIVMLPVIFAVARRLNGPVLAYGIPAAGAFSVMHIYLPPHPGPISAAEFYSA
HHHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEECCCCCCCCHHHHHHC
DIGLVMLLGLIIAIPTWLISGLWLGKTLGRRYPLPVPDILAGGPQATDVKNPATPGLIVS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHH
LLLLPMLLIFGNTSMGLATSAGWVDKSSSLVRALQFVGSTPIALLISTLVALYFLGIRRG
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
QPKADLEKLLDGALGPICSVVLITGAGGMFGGVLRTSGIGDALADSMSDLGVPVVLGCWL
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHH
VAAILRLAQGSATVALTTAAALMAPAVAAGGYSEFQIALMVLASAAGSVFAGHVNDSGFW
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEECCCCCCCHH
LVGRLMGMDVATTLRTWTLNQALVGAVGFVFVLVFYGVSFAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEDWVPTLSAGPLLGIAAAAIALILVLVIVFKLHAFLTLIIVSAATGLAAGIPLEGIVPT
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
MTKGFGSTLASVALLVGLGAMLGRLVETSGGAKSLAETLVARFGEQRAPFALGVASLLMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
FPIFFDAGLIVMLPVIFAVARRLNGPVLAYGIPAAGAFSVMHIYLPPHPGPISAAEFYSA
HHHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEECCCCCCCCHHHHHHC
DIGLVMLLGLIIAIPTWLISGLWLGKTLGRRYPLPVPDILAGGPQATDVKNPATPGLIVS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHH
LLLLPMLLIFGNTSMGLATSAGWVDKSSSLVRALQFVGSTPIALLISTLVALYFLGIRRG
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
QPKADLEKLLDGALGPICSVVLITGAGGMFGGVLRTSGIGDALADSMSDLGVPVVLGCWL
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHH
VAAILRLAQGSATVALTTAAALMAPAVAAGGYSEFQIALMVLASAAGSVFAGHVNDSGFW
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEECCCCCCCHH
LVGRLMGMDVATTLRTWTLNQALVGAVGFVFVLVFYGVSFAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: gluconate [Periplasm]; Proton [Periplasm]; L-idonate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + gluconate [Periplasm] = Proton [Cytoplasm] + gluconate [Cytoplasm] Proton [Periplasm] + L-idonate [Periplasm] = L-idonate [Cytoplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3020045; 7584049; 9384377 [H]