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The map label for this gene is pstP [H]

Identifier: 38232693

GI number: 38232693

Start: 50037

End: 51494

Strand: Reverse

Name: pstP [H]

Synonym: DIP0057

Alternate gene names: 38232693

Gene position: 51494-50037 (Counterclockwise)

Preceding gene: 38232694

Following gene: 38232692

Centisome position: 2.07

GC content: 58.57

Gene sequence:

>1458_bases
TTGATGCTGAGGTTGAATTATGCAGCGGCTTCCGATCGGGGGCTGGTGCGAGGCAATAATGAGGACTCGGCGTATGCGGG
TCCTCACCTCATTGCGCTTGCCGACGGCATGGGTGGTCATGCGGCTGGCGAGGTTGCTTCGCAGTTGATGATTAATCATT
TGATGCGTCTCGACGCCGACGTCGACGACAACGACATGCTGGCGTTGTTGGCATCGGTAGCTGACGACGCCAACCGTGCC
ATCGCTCAAGGTGTCCGCGATGTTCCGGAAACCGACGGCATGGGCACCACGCTAACGGCGCTGATGTTTAACGGTGCCGA
TTTGGCGATGTGCCATGTGGGTGATTCCCGTGGTTATCGTCTCCGCGATGGCGCGTTGGAACAGATCACGGTGGATGACA
CCTATGTGCAGTCCCTCGTGGATAAGGGGCAGCTGGCCCCTGAGGATGTGTCCACGCACCCGCAGCGCTCAATGATTTTG
AAGGCTTATACTGGTCGCCCAGTTGAGCCCACGTTGAAGATGATTGATATTCGCCCTGGCGATCGTTTCTTGTTGTGCTC
GGATGGATTGTCTGATCCGGTCACGCATTCGACGATTGAGACGACTCTGCAGCAGGGCACGCCCCAAGAGGCTGCTCGCC
GGTTGGTTGATTTGGCGCTTCGTTCGGGTGGCCCCGATAACGTCACGGTTGTGGTGGCAGATGTTGTAGAGGCAGATGGC
TCGGATAAGTCCGCTGCTGCCGCATCGTTGCCGGTCACACCGCTGACGGTGGGTGCTCTTAATTCGGGTATGCCGGAGGA
TCCCCGCCCAGATACGGCGGCGGGACGGGCTGCGATGGCGATTGCACAGCGTCAGCCCCAGGTGATCCTTCCGGATCCGG
AGCCTGTCAAGGAGGCTACGCCGAGCCCACGACGCCGCATGGTGGCCGTGATTAGTGCGCTGGTGGTATTGGCTGTGCTG
ATCAGTGCTGGTTGGTGGGGTTCTTCGATGGTGAAGAACAACTACTATGTCACCACCGCGGATTCGGATTCTGCGCAGGG
CGCGTTGGTCATCGAAAACGGTATCGACGTCTCTTTGCTGGGCAAATCCTTGCACAGCACGTACCAGTTCGCTTGTTTGA
GCCCCGAGGGGGATCTCACGTTTGTGGATTCTGCCGACGCAGAAAAATCTTGCCATCGGTTCCGGTTGAGCGATCTGAAG
GAGTCGGCACGCGGACAGGTGTCCACGCTTCCCGACGGCAGCTACGACGAAGTGCAGCAGCAGCTGCAGCGCTTGGCAGA
ACAAACCCTGCCAGCATGTATTACTCGTCAGGCTGCGCATCCAAAGGATAAGGATAAAAAGAAGCCAGCGGCACCGTCGA
GTGCAGCCCCTACGACTACAAAGGCGGCGTCGCCAAGCAGTACCGGCTCCCCCGATGATCTCTCCACACCTGGCGAAACC
TGCAGGGAGGTCAAATAA

Upstream 100 bases:

>100_bases
GCAATGGCACGTATGTGGGCGGTTATCGCATTGATCAGCCGGAGAAGGTTTCTGCTGGTAGTGACATTAAGATTGGTCGT
ACAACGGTGAGGTTGGTTGC

Downstream 100 bases:

>100_bases
ATGACCTCCCTACGACGCATTACCGCACGCCCCGTGGAATTCGGGCTACTCGTGATGGCAACCCTGCTCATCGCAGTCAC
CCTAATTAACCTCAACATGG

Product: putative phosphoprotein phosphatase

Products: NA

Alternate protein names: Mycobacterial Ser/Thr phosphatase; Mstp; Possible serine/threonine phosphatase Ppp [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MMLRLNYAAASDRGLVRGNNEDSAYAGPHLIALADGMGGHAAGEVASQLMINHLMRLDADVDDNDMLALLASVADDANRA
IAQGVRDVPETDGMGTTLTALMFNGADLAMCHVGDSRGYRLRDGALEQITVDDTYVQSLVDKGQLAPEDVSTHPQRSMIL
KAYTGRPVEPTLKMIDIRPGDRFLLCSDGLSDPVTHSTIETTLQQGTPQEAARRLVDLALRSGGPDNVTVVVADVVEADG
SDKSAAAASLPVTPLTVGALNSGMPEDPRPDTAAGRAAMAIAQRQPQVILPDPEPVKEATPSPRRRMVAVISALVVLAVL
ISAGWWGSSMVKNNYYVTTADSDSAQGALVIENGIDVSLLGKSLHSTYQFACLSPEGDLTFVDSADAEKSCHRFRLSDLK
ESARGQVSTLPDGSYDEVQQQLQRLAEQTLPACITRQAAHPKDKDKKKPAAPSSAAPTTTKAASPSSTGSPDDLSTPGET
CREVK

Sequences:

>Translated_485_residues
MMLRLNYAAASDRGLVRGNNEDSAYAGPHLIALADGMGGHAAGEVASQLMINHLMRLDADVDDNDMLALLASVADDANRA
IAQGVRDVPETDGMGTTLTALMFNGADLAMCHVGDSRGYRLRDGALEQITVDDTYVQSLVDKGQLAPEDVSTHPQRSMIL
KAYTGRPVEPTLKMIDIRPGDRFLLCSDGLSDPVTHSTIETTLQQGTPQEAARRLVDLALRSGGPDNVTVVVADVVEADG
SDKSAAAASLPVTPLTVGALNSGMPEDPRPDTAAGRAAMAIAQRQPQVILPDPEPVKEATPSPRRRMVAVISALVVLAVL
ISAGWWGSSMVKNNYYVTTADSDSAQGALVIENGIDVSLLGKSLHSTYQFACLSPEGDLTFVDSADAEKSCHRFRLSDLK
ESARGQVSTLPDGSYDEVQQQLQRLAEQTLPACITRQAAHPKDKDKKKPAAPSSAAPTTTKAASPSSTGSPDDLSTPGET
CREVK
>Mature_485_residues
MMLRLNYAAASDRGLVRGNNEDSAYAGPHLIALADGMGGHAAGEVASQLMINHLMRLDADVDDNDMLALLASVADDANRA
IAQGVRDVPETDGMGTTLTALMFNGADLAMCHVGDSRGYRLRDGALEQITVDDTYVQSLVDKGQLAPEDVSTHPQRSMIL
KAYTGRPVEPTLKMIDIRPGDRFLLCSDGLSDPVTHSTIETTLQQGTPQEAARRLVDLALRSGGPDNVTVVVADVVEADG
SDKSAAAASLPVTPLTVGALNSGMPEDPRPDTAAGRAAMAIAQRQPQVILPDPEPVKEATPSPRRRMVAVISALVVLAVL
ISAGWWGSSMVKNNYYVTTADSDSAQGALVIENGIDVSLLGKSLHSTYQFACLSPEGDLTFVDSADAEKSCHRFRLSDLK
ESARGQVSTLPDGSYDEVQQQLQRLAEQTLPACITRQAAHPKDKDKKKPAAPSSAAPTTTKAASPSSTGSPDDLSTPGET
CREVK

Specific function: The only predicted protein phosphatase in M.tuberculosis, it dephosphorylates at least 5 protein kinases (pknA, pknB, pknD, pknE and pknF) and the penicillin-binding protein PBPA [H]

COG id: COG0631

COG function: function code T; Serine/threonine protein phosphatase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential). Note=May be localized to the outside of the cell [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PP2C-like domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015655
- InterPro:   IPR001932
- InterPro:   IPR014045 [H]

Pfam domain/function: PF00481 PP2C [H]

EC number: =3.1.3.16 [H]

Molecular weight: Translated: 51292; Mature: 51292

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLRLNYAAASDRGLVRGNNEDSAYAGPHLIALADGMGGHAAGEVASQLMINHLMRLDAD
CEEEEEECCCCCCCCEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
VDDNDMLALLASVADDANRAIAQGVRDVPETDGMGTTLTALMFNGADLAMCHVGDSRGYR
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHEECCCCEEEEEECCCCCCE
LRDGALEQITVDDTYVQSLVDKGQLAPEDVSTHPQRSMILKAYTGRPVEPTLKMIDIRPG
ECCCCCCEEECCHHHHHHHHHCCCCCCCCCCCCCCHHEEEEECCCCCCCCCEEEEEECCC
DRFLLCSDGLSDPVTHSTIETTLQQGTPQEAARRLVDLALRSGGPDNVTVVVADVVEADG
CEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEHHCCC
SDKSAAAASLPVTPLTVGALNSGMPEDPRPDTAAGRAAMAIAQRQPQVILPDPEPVKEAT
CCCCCHHCCCCCCCEEHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEECCCCCCHHHCC
PSPRRRMVAVISALVVLAVLISAGWWGSSMVKNNYYVTTADSDSAQGALVIENGIDVSLL
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCEEEEECCCCCCCCEEEEECCCCHHHH
GKSLHSTYQFACLSPEGDLTFVDSADAEKSCHRFRLSDLKESARGQVSTLPDGSYDEVQQ
HHHHHCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHH
QLQRLAEQTLPACITRQAAHPKDKDKKKPAAPSSAAPTTTKAASPSSTGSPDDLSTPGET
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
CREVK
HHCCC
>Mature Secondary Structure
MMLRLNYAAASDRGLVRGNNEDSAYAGPHLIALADGMGGHAAGEVASQLMINHLMRLDAD
CEEEEEECCCCCCCCEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
VDDNDMLALLASVADDANRAIAQGVRDVPETDGMGTTLTALMFNGADLAMCHVGDSRGYR
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHEECCCCEEEEEECCCCCCE
LRDGALEQITVDDTYVQSLVDKGQLAPEDVSTHPQRSMILKAYTGRPVEPTLKMIDIRPG
ECCCCCCEEECCHHHHHHHHHCCCCCCCCCCCCCCHHEEEEECCCCCCCCCEEEEEECCC
DRFLLCSDGLSDPVTHSTIETTLQQGTPQEAARRLVDLALRSGGPDNVTVVVADVVEADG
CEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEHHCCC
SDKSAAAASLPVTPLTVGALNSGMPEDPRPDTAAGRAAMAIAQRQPQVILPDPEPVKEAT
CCCCCHHCCCCCCCEEHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEECCCCCCHHHCC
PSPRRRMVAVISALVVLAVLISAGWWGSSMVKNNYYVTTADSDSAQGALVIENGIDVSLL
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCEEEEECCCCCCCCEEEEECCCCHHHH
GKSLHSTYQFACLSPEGDLTFVDSADAEKSCHRFRLSDLKESARGQVSTLPDGSYDEVQQ
HHHHHCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHH
QLQRLAEQTLPACITRQAAHPKDKDKKKPAAPSSAAPTTTKAASPSSTGSPDDLSTPGET
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
CREVK
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]