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The map label for this gene is pbpA [H]

Identifier: 38232691

GI number: 38232691

Start: 47230

End: 48690

Strand: Reverse

Name: pbpA [H]

Synonym: DIP0055

Alternate gene names: 38232691

Gene position: 48690-47230 (Counterclockwise)

Preceding gene: 38232692

Following gene: 38232690

Centisome position: 1.96

GC content: 58.93

Gene sequence:

>1461_bases
ATGAACCGATCTATCCGATTCACCAGCGTGTTCGCGCTGCTGCTGATCCTGATTTTGTTGGTCAACTTGACGATCATTCA
GGGTTTTAGTCAGGAAAAATACGCGCATAATGCGCTTAATCGACGCGGCTTTATTGAGTTGAAGTCGCAGGCCCGCGGCC
AGATCTCCACTGGCGGGCAGGTACTAGCCGAGTCCTACCAGGATGAGGAGGGGTTCTACCAGCGTCGTTACGTGACCAAC
CCTGCGATCTATGGTCCGATCGAAGGCTACCTTTCTGATATTTATGGGGCTTCGGGCATGGAGTCCAACCTCAACGGTGT
ACTCAGTGGCACGGATTCTTCCGTGTCAGTGCGCCGCTGGACAGATGAGCTTTTGGGCCGCAAACACAGCGGAGCCAACG
TTGAGCTCACCTTGCTGCCACAGGTGCAAGAGGTGGCATACAACCAGATGGCCAATGCTGGCTATGAGGGCGCAGTTGTG
GCGATCAAGCCGTCGACAGGCGAAATCCTTGCTATGGCATCAACCCCTAGCTACGACCCCTCGGCGATCGTCAACCCCGA
TACCGCTGAGCAAACATGGGCTGCGTTGAACGCCGACCCCGGCAACCCGCTGCTCAACCACGCCACCCAAGAGACGCTGC
CACCAGGTTCTACCTTCAAGGTGATTACCACGGCTGCTGGCCTTAACGCTGGTTACGGCCCGGGCTCGATGCTCACGGGG
CAAGATCGCATTACGCTTCCCGACGGCATCACCACCTTGGAAAACTATGCAGGGCAAACCTGTGCCGGTTCCCAAAACGT
CACCTTGGCTACCGCATTCCAGTACTCGTGCAATACCGCATTCGTGCAGATGGGTATTGATGTTGGCAAAGAAAAGTTCG
ACGAGGCCGCCCATGCTTTCGGCGTGAATGATCGCTACGATCTTGGCGTCGACATGGCCCCTGGCACCATCGGTGACGTG
TCGGATCCGTCGGCACGCGGGCAGTCGTCGATCGGCCAGCGCGACGTTGCCATGTCTGTGCTCCACAACGCCGTCGTGGC
CGCCACCGTGGCCAATGGTGGCAAGCGCATGGAGCCGCACCTTGTGAACCGGATCGTCGGCCAAGACCTCAAGGTGATTA
AGGAGACTAAGCCGCACCAGATCAACGAGGCTGTTACCCCCGAGGTAGCCGCCACGTTGACGGACCTAATGCGACTATCG
GAACGCCACACGGCTGGTTATACCGGTGCCGACATTGCCTCCAAGACTGGTACCGCCGAGCACGGTGAGGATTCCCGTAA
TTCCAACCCGCACGCCTGGTACATCGCGTTCGGTCCTTCCGCCAATGCCGACGTTGCCGTGGCCGTGGTGGTGAAAAACG
GTGGCGATGCCGGTCAAGCCGCCACCGGTGGTTCCGTGGCCGCACCCATTGGCCGCGCCGTCATCGCAGCAGCACAAGCA
GCCCTAGCAGCACGAGGATAG

Upstream 100 bases:

>100_bases
TTCTCGGACTGATCCTTAGGATCTCCCACTCCACACAAGCCGCCGCCAACGACGTGGTGTCTATGGACGAGCAGGCGGCA
CGAGGTCAGGAGGCCCACCG

Downstream 100 bases:

>100_bases
AGGGGAGACATCATGACACAATCACAGTCACCTGATCCGGCACTGCAGGCACTCGTCGGTTCCGACTACGCCCTGCAATG
GGTGGTGGGCAACGGTGGAA

Product: putative secreted penicillin-binding protein

Products: NA

Alternate protein names: PBPA [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MNRSIRFTSVFALLLILILLVNLTIIQGFSQEKYAHNALNRRGFIELKSQARGQISTGGQVLAESYQDEEGFYQRRYVTN
PAIYGPIEGYLSDIYGASGMESNLNGVLSGTDSSVSVRRWTDELLGRKHSGANVELTLLPQVQEVAYNQMANAGYEGAVV
AIKPSTGEILAMASTPSYDPSAIVNPDTAEQTWAALNADPGNPLLNHATQETLPPGSTFKVITTAAGLNAGYGPGSMLTG
QDRITLPDGITTLENYAGQTCAGSQNVTLATAFQYSCNTAFVQMGIDVGKEKFDEAAHAFGVNDRYDLGVDMAPGTIGDV
SDPSARGQSSIGQRDVAMSVLHNAVVAATVANGGKRMEPHLVNRIVGQDLKVIKETKPHQINEAVTPEVAATLTDLMRLS
ERHTAGYTGADIASKTGTAEHGEDSRNSNPHAWYIAFGPSANADVAVAVVVKNGGDAGQAATGGSVAAPIGRAVIAAAQA
ALAARG

Sequences:

>Translated_486_residues
MNRSIRFTSVFALLLILILLVNLTIIQGFSQEKYAHNALNRRGFIELKSQARGQISTGGQVLAESYQDEEGFYQRRYVTN
PAIYGPIEGYLSDIYGASGMESNLNGVLSGTDSSVSVRRWTDELLGRKHSGANVELTLLPQVQEVAYNQMANAGYEGAVV
AIKPSTGEILAMASTPSYDPSAIVNPDTAEQTWAALNADPGNPLLNHATQETLPPGSTFKVITTAAGLNAGYGPGSMLTG
QDRITLPDGITTLENYAGQTCAGSQNVTLATAFQYSCNTAFVQMGIDVGKEKFDEAAHAFGVNDRYDLGVDMAPGTIGDV
SDPSARGQSSIGQRDVAMSVLHNAVVAATVANGGKRMEPHLVNRIVGQDLKVIKETKPHQINEAVTPEVAATLTDLMRLS
ERHTAGYTGADIASKTGTAEHGEDSRNSNPHAWYIAFGPSANADVAVAVVVKNGGDAGQAATGGSVAAPIGRAVIAAAQA
ALAARG
>Mature_486_residues
MNRSIRFTSVFALLLILILLVNLTIIQGFSQEKYAHNALNRRGFIELKSQARGQISTGGQVLAESYQDEEGFYQRRYVTN
PAIYGPIEGYLSDIYGASGMESNLNGVLSGTDSSVSVRRWTDELLGRKHSGANVELTLLPQVQEVAYNQMANAGYEGAVV
AIKPSTGEILAMASTPSYDPSAIVNPDTAEQTWAALNADPGNPLLNHATQETLPPGSTFKVITTAAGLNAGYGPGSMLTG
QDRITLPDGITTLENYAGQTCAGSQNVTLATAFQYSCNTAFVQMGIDVGKEKFDEAAHAFGVNDRYDLGVDMAPGTIGDV
SDPSARGQSSIGQRDVAMSVLHNAVVAATVANGGKRMEPHLVNRIVGQDLKVIKETKPHQINEAVTPEVAATLTDLMRLS
ERHTAGYTGADIASKTGTAEHGEDSRNSNPHAWYIAFGPSANADVAVAVVVKNGGDAGQAATGGSVAAPIGRAVIAAAQA
ALAARG

Specific function: Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Probable). Note=Localized to the division site (septum) along with newly synthesized peptidoglycan, between segregated nucleoids (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=374, Percent_Identity=26.2032085561497, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI1786272, Length=433, Percent_Identity=24.7113163972286, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 51025; Mature: 51025

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRSIRFTSVFALLLILILLVNLTIIQGFSQEKYAHNALNRRGFIELKSQARGQISTGGQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEECCCCCCCCCCCHH
VLAESYQDEEGFYQRRYVTNPAIYGPIEGYLSDIYGASGMESNLNGVLSGTDSSVSVRRW
HHHHHHCCCCCHHHHHEECCCCEECCHHHHHHHHCCCCCCCCCCCEEEECCCCCEEHHHH
TDELLGRKHSGANVELTLLPQVQEVAYNQMANAGYEGAVVAIKPSTGEILAMASTPSYDP
HHHHHCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEECCCCCCC
SAIVNPDTAEQTWAALNADPGNPLLNHATQETLPPGSTFKVITTAAGLNAGYGPGSMLTG
CCEECCCCHHHHHHEECCCCCCHHHHHCHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCC
QDRITLPDGITTLENYAGQTCAGSQNVTLATAFQYSCNTAFVQMGIDVGKEKFDEAAHAF
CCCEECCCCHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEEEEECCHHCHHHHHHHHHHC
GVNDRYDLGVDMAPGTIGDVSDPSARGQSSIGQRDVAMSVLHNAVVAATVANGGKRMEPH
CCCCCCCCCCEECCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHEEEECCCCCCCCHH
LVNRIVGQDLKVIKETKPHQINEAVTPEVAATLTDLMRLSERHTAGYTGADIASKTGTAE
HHHHHHCCHHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCC
HGEDSRNSNPHAWYIAFGPSANADVAVAVVVKNGGDAGQAATGGSVAAPIGRAVIAAAQA
CCCCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
ALAARG
HHHCCC
>Mature Secondary Structure
MNRSIRFTSVFALLLILILLVNLTIIQGFSQEKYAHNALNRRGFIELKSQARGQISTGGQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEECCCCCCCCCCCHH
VLAESYQDEEGFYQRRYVTNPAIYGPIEGYLSDIYGASGMESNLNGVLSGTDSSVSVRRW
HHHHHHCCCCCHHHHHEECCCCEECCHHHHHHHHCCCCCCCCCCCEEEECCCCCEEHHHH
TDELLGRKHSGANVELTLLPQVQEVAYNQMANAGYEGAVVAIKPSTGEILAMASTPSYDP
HHHHHCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEECCCCCCC
SAIVNPDTAEQTWAALNADPGNPLLNHATQETLPPGSTFKVITTAAGLNAGYGPGSMLTG
CCEECCCCHHHHHHEECCCCCCHHHHHCHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCC
QDRITLPDGITTLENYAGQTCAGSQNVTLATAFQYSCNTAFVQMGIDVGKEKFDEAAHAF
CCCEECCCCHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEEEEECCHHCHHHHHHHHHHC
GVNDRYDLGVDMAPGTIGDVSDPSARGQSSIGQRDVAMSVLHNAVVAATVANGGKRMEPH
CCCCCCCCCCEECCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHEEEECCCCCCCCHH
LVNRIVGQDLKVIKETKPHQINEAVTPEVAATLTDLMRLSERHTAGYTGADIASKTGTAE
HHHHHHCCHHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCC
HGEDSRNSNPHAWYIAFGPSANADVAVAVVVKNGGDAGQAATGGSVAAPIGRAVIAAAQA
CCCCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
ALAARG
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA